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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Evolution and Developmental Diversity of Skin Spines in Pufferfishes

Authors:
Shono T, Thiery AP, Cooper RL, Kurokawa D, Britz R, Okabe M, Fraser GJ
Citation:
iScience. 2019 Jun 19. pii: S2589-0042(19)30185-3. doi: 10.1016/j.isci.2019.06.003. [Epub ahead of print]
Epub:
Yes
Abstract:
Teleost fishes develop remarkable varieties of skin ornaments. The developmental basis of these structures is poorly understood...
Link:
https://www.cell.com/iscience/fulltext/S2589-0042(19)30185-3
Delivery Method:
microinjection
Organism or Cell Type:
Takifugu niphobles (pufferfish)
Citation Extract:
Shono T, Thiery AP, Cooper RL, Kurokawa D, Britz R, Okabe M, Fraser GJ. Evolution and Developmental Diversity of Skin Spines in Pufferfishes. iScience. 2019 Jun 19. pii: S2589-0042(19)30185-3. doi: 10.1016/j.isci.2019.06.003. [Epub ahead of print].

Regulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14

Authors:
Xiao Y, Chen J, Wan Y, Gao Q, Jing N, Zheng Y, Zhu X
Citation:
Cell Discov. 2019;5(1):37 doi:10.1038/s41421-019-0106-x
Epub:
Not Epub
Abstract:
RNA-binding proteins with intrinsically disordered regions (IDRs) such as Rbm14 can phase separate in vitro. To what extent the...
Link:
https://www.nature.com/articles/s41421-019-0106-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xiao Y, Chen J, Wan Y, Gao Q, Jing N, Zheng Y, Zhu X. Regulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14. Cell Discov. 2019;5(1):37 doi:10.1038/s41421-019-0106-x.

ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response

Authors:
Adeyemo AA, Zaghloul NA, Chen G, Doumatey AP, Leitch CC, Hostelley TL, Nesmith JE, Zhou J, Bentley AR, Shriner D, Fasanmade O, Okafor G, Eghan B Jr, Agyenim-Boateng K, Chandrasekharappa S, Adeleye J, Balogun W, Owusu S, Amoah A, Acheampong J, Johnson T, Oli J, Adebamowo C; South Africa Zulu Type 2 Diabetes Case-Control Study, Collins F, Dunston G, Rotimi CN
Citation:
Nat Commun. 2019 Jul 19;10(1):3195. doi: 10.1038/s41467-019-10967-7
Epub:
Not Epub
Abstract:
Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major...
Link:
https://www.nature.com/articles/s41467-019-10967-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Adeyemo AA, Zaghloul NA, Chen G, Doumatey AP, Leitch CC, Hostelley TL, Nesmith JE, Zhou J, Bentley AR, Shriner D, Fasanmade O, Okafor G, Eghan B Jr, Agyenim-Boateng K, Chandrasekharappa S, Adeleye J, Balogun W, Owusu S, Amoah A, Acheampong J, Johnson T, Oli J, Adebamowo C; South Africa Zulu Type 2 Diabetes Case-Control Study, Collins F, Dunston G, Rotimi CN. ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response. Nat Commun. 2019 Jul 19;10(1):3195. doi: 10.1038/s41467-019-10967-7.

Alternative splicing regulates stochastic NLRP3 activity

Authors:
Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E
Citation:
Nat Commun. 2019 Jul 19;10(1):3238. doi: 10.1038/s41467-019-11076-1
Epub:
Not Epub
Abstract:
Leucine-rich repeat (LRR) domains are evolutionarily conserved in proteins that function in development and immunity. Here we...
Link:
https://www.nature.com/articles/s41467-019-11076-1
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: human monocyte-derived macrophages (hMDMs)
Citation Extract:
Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E. Alternative splicing regulates stochastic NLRP3 activity. Nat Commun. 2019 Jul 19;10(1):3238. doi: 10.1038/s41467-019-11076-1.

Adaptive correction of craniofacial defects in pre-metamorphic Xenopus laevis tadpoles involves thyroid hormone-independent tissue remodeling

Authors:
Pinet K, Deolankar M, Leung B, McLaughlin KA
Citation:
Development. 2019 Jul 22;146(14). pii: dev175893. doi: 10.1242/dev.175893
Epub:
Not Epub
Abstract:
Although it is well established that some organisms can regenerate lost structures, the ability to remodel existing malformed...
Link:
https://dev.biologists.org/content/146/14/dev175893
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Pinet K, Deolankar M, Leung B, McLaughlin KA. Adaptive correction of craniofacial defects in pre-metamorphic Xenopus laevis tadpoles involves thyroid hormone-independent tissue remodeling. Development. 2019 Jul 22;146(14). pii: dev175893. doi: 10.1242/dev.175893.

Jmjd6a regulates GSK3β RNA splicing in Xenopus laevis eye development

Authors:
Shin JY, Son J, Kim WS, Gwak J, Ju BG
Citation:
PLoS One. 2019 Jul 30;14(7):e0219800. doi: 10.1371/journal.pone.0219800. eCollection 2019
Epub:
Not Epub
Abstract:
It has been suggested that Jmjd6 plays an important role in gene regulation through its demethylation or hydroxylation activity...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219800
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Shin JY, Son J, Kim WS, Gwak J, Ju BG. Jmjd6a regulates GSK3β RNA splicing in Xenopus laevis eye development. PLoS One. 2019 Jul 30;14(7):e0219800. doi: 10.1371/journal.pone.0219800. eCollection 2019.

Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts

Authors:
Molinari E, Ramsbottom SA, Srivastava S, Booth P, Alkanderi S, McLafferty SM, Devlin LA, White K, Gunay-Aygun M, Miles CG, Sayer JA
Citation:
Sci Rep. 2019 Jul 25;9(1):10828. doi: 10.1038/s41598-019-47243-z
Epub:
Not Epub
Abstract:
Joubert syndrome (JBTS) is an incurable multisystem ciliopathy syndrome. The most commonly mutated gene in JBTS patients with a...
Link:
https://www.nature.com/articles/s41598-019-47243-z
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: primary human fibroblasts
Citation Extract:
Molinari E, Ramsbottom SA, Srivastava S, Booth P, Alkanderi S, McLafferty SM, Devlin LA, White K, Gunay-Aygun M, Miles CG, Sayer JA. Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts. Sci Rep. 2019 Jul 25;9(1):10828. doi: 10.1038/s41598-019-47243-z.

Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine-seeking behavior

Authors:
Namba MD, Kupchik YM, Spencer SM, Garcia-Keller C, Goenaga JG, Powell GL, Vicino IA, Hogue IB, Gipson CD
Citation:
Addict Biol. 2019 Jul 22:e12797. doi: 10.1111/adb.12797. [Epub ahead of print]
Epub:
Yes
Abstract:
Nicotine self-administration is associated with decreased expression of the glial glutamate transporter (GLT-1) and the cystine...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1111/adb.12797
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
rats
Citation Extract:
Namba MD, Kupchik YM, Spencer SM, Garcia-Keller C, Goenaga JG, Powell GL, Vicino IA, Hogue IB, Gipson CD. Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine-seeking behavior. Addict Biol. 2019 Jul 22:e12797. doi: 10.1111/adb.12797. [Epub ahead of print].

Triptolide preserves glomerular barrier function via the inhibition of p53-mediated increase of GADD45B

Authors:
Zhai X, Wang L, Xu C, Hou Q, Zhang L, Li Z, Qin W, Liu Z, Chen Z
Citation:
Arch Biochem Biophys. 2019 Jul 19;671:210-217. doi: 10.1016/j.abb.2019.07.012. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Podocytes are important to glomerular filtration barrier integrity and maintenance of size selectivity in protein filtration in...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0003986119303091
Organism or Cell Type:
zebrafish
Citation Extract:
Zhai X, Wang L, Xu C, Hou Q, Zhang L, Li Z, Qin W, Liu Z, Chen Z. Triptolide preserves glomerular barrier function via the inhibition of p53-mediated increase of GADD45B. Arch Biochem Biophys. 2019 Jul 19;671:210-217. doi: 10.1016/j.abb.2019.07.012. [Epub ahead of print].

Exons 45-55 skipping using mutation-tailored cocktails of antisense morpholinos in the DMD gene

Authors:
Echigoya Y, Lim KRQ, Melo D, Bao B, Trieu N, Mizobe Y, Maruyama R, Mamchaoui K, Tanihata J, Aoki Y, Takeda S, Mouly V, Duddy W, Yokota T
Citation:
Molec Ther. 2019;[Epub ahead of print] doi:10.1016/j.ymthe.2019.07.012
Epub:
Yes
Abstract:
Mutations in the dystrophin (DMD) gene and consequent loss of dystrophin cause Duchenne muscular dystrophy (DMD). A promising...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1525001619303259
Organism or Cell Type:
cell culture
Citation Extract:
Echigoya Y, Lim KRQ, Melo D, Bao B, Trieu N, Mizobe Y, Maruyama R, Mamchaoui K, Tanihata J, Aoki Y, Takeda S, Mouly V, Duddy W, Yokota T. Exons 45-55 skipping using mutation-tailored cocktails of antisense morpholinos in the DMD gene. Molec Ther. 2019;[Epub ahead of print] doi:10.1016/j.ymthe.2019.07.012.

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