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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells.

Authors:
Fieber CB, Eldridge J, Taha TA, Obeid LM, Muise-Helmericks RC.
Citation:
Exp Cell Res. 2006 Apr 15;312(7):1164-73. Epub 2006 Mar 9
Epub:
Not Epub
Abstract:
Akt kinase is an important downstream effector of VEGF in primary endothelial cells (EC), promoting angiogenesis by increased...
Delivery Method:
transfection
Organism or Cell Type:
Cell Culture: human umbilical vein endothelial cells (HUVECs)
Citation Extract:
Fieber CB, Eldridge J, Taha TA, Obeid LM, Muise-Helmericks RC.. Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells.. Exp Cell Res. 2006 Apr 15;312(7):1164-73. Epub 2006 Mar 9.

Morpholino antisense oligonucleotide induced dystrophin exon 23 skipping in mdx mouse muscle

Authors:
Fletcher S, Gebski BL, Mann CJ, Wilton SD
Citation:
Hum Mol Genet. 2003 Aug 1;12(15):1801-11
Epub:
Not Epub
Abstract:
The mdx mouse model of muscular dystrophy arose due to a nonsense mutation in exon 23 of the dystrophin gene. We have...
Delivery Method:
cationic lipoplex: a number of leash designs and chemistries
Organism or Cell Type:
mdx mice, cell culture: mdx
Citation Extract:
Fletcher S, Gebski BL, Mann CJ, Wilton SD. Morpholino antisense oligonucleotide induced dystrophin exon 23 skipping in mdx mouse muscle. Hum Mol Genet. 2003 Aug 1;12(15):1801-11.

Morpholino Oligomer-Mediated Exon Skipping Averts the Onset of Dystrophic Pathology in the mdx Mouse

Authors:
Fletcher S, Honeyman K, Fall AM, Harding PL, Johnsen RD, Steinhaus JP, Moulton HM, Iversen PL, Wilton SD
Citation:
Mol Ther. 2007 Sep;15(9):1587-92. Epub 2007 Jun 19.
Epub:
Not Epub
Abstract:
Duchenne and Becker muscular dystrophies are allelic disorders arising from mutations in the dystrophin gene. Duchenne muscular...
Delivery Method:
peptide-coupled
Organism or Cell Type:
MDX mice
Citation Extract:
Fletcher S, Honeyman K, Fall AM, Harding PL, Johnsen RD, Steinhaus JP, Moulton HM, Iversen PL, Wilton SD. Morpholino Oligomer-Mediated Exon Skipping Averts the Onset of Dystrophic Pathology in the mdx Mouse. Mol Ther. 2007 Sep;15(9):1587-92. Epub 2007 Jun 19..

Morpholino phenocopies of sqt, oep, and ntl mutations

Authors:
Feldman B, Stemple DL
Citation:
Genesis. 2001 Jul;30(3):175-7
Epub:
Not Epub
Abstract:
No abstract available.
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Feldman B, Stemple DL. Morpholino phenocopies of sqt, oep, and ntl mutations. Genesis. 2001 Jul;30(3):175-7.

Multiple functions of Cerberus cooperate to induce heart downstream of Nodal

Authors:
Foley AC, Korol O, Timmer AM, Mercola M
Citation:
Dev Biol. 2007 Mar 1;303(1):57-65. Epub 2006 Oct 26.
Epub:
Not Epub
Abstract:
The TGFbeta family member Nodal has been implicated in heart induction through misexpression of a dominant negative version of...
Organism or Cell Type:
Xenopus
Citation Extract:
Foley AC, Korol O, Timmer AM, Mercola M. Multiple functions of Cerberus cooperate to induce heart downstream of Nodal. Dev Biol. 2007 Mar 1;303(1):57-65. Epub 2006 Oct 26..

Mutation of zebrafish dihydrolipoamide branched-chain transacylase E2 results in motor dysfunction and models maple syrup urine disease

Authors:
Friedrich T, Lambert AM, Masino MA, Downes GB
Citation:
Dis Model Mech. 2012 Mar;5(2):248-58. Epub 2011 Nov 1
Epub:
Not Epub
Abstract:
Analysis of zebrafish mutants that demonstrate abnormal locomotive behavior can elucidate the molecular requirements for neural...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Friedrich T, Lambert AM, Masino MA, Downes GB. Mutation of zebrafish dihydrolipoamide branched-chain transacylase E2 results in motor dysfunction and models maple syrup urine disease. Dis Model Mech. 2012 Mar;5(2):248-58. Epub 2011 Nov 1.

Neonatal growth and regeneration of beta cells are regulated by the Wnt/beta-catenin signaling in normal and diabetic rats

Authors:
Figeac F, Uzan B, Faro M, Chelali N, Portha B, Movassat J
Citation:
Am J Physiol Endocrinol Metab. 2009 Nov 17. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Wnt/beta-catenin signaling is critical for a variety of fondamental cellular processes. Here we investigated the implication of...
Delivery Method:
Endo-Porter in culture, s.c. injection in vivo
Organism or Cell Type:
cell culture: INS-1 cells (clone 368) and Wistar rat pups
Citation Extract:
Figeac F, Uzan B, Faro M, Chelali N, Portha B, Movassat J. Neonatal growth and regeneration of beta cells are regulated by the Wnt/beta-catenin signaling in normal and diabetic rats. Am J Physiol Endocrinol Metab. 2009 Nov 17. [Epub ahead of print].

Neuropilin-1a is involved in trunk motor axon outgrowth in embryonic zebrafish

Authors:
Feldner J, Becker T, Goishi K, Schweitzer J, Lee P, Schachner M, Klagsbrun M, Becker CG
Citation:
Dev Dyn. 2005 Nov;234(3):535-49.
Epub:
Not Epub
Abstract:
Neuropilin-1, a receptor for axon-repellent semaphorins and vascular endothelial growth factor (VEGF), functions both in...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Feldner J, Becker T, Goishi K, Schweitzer J, Lee P, Schachner M, Klagsbrun M, Becker CG. Neuropilin-1a is involved in trunk motor axon outgrowth in embryonic zebrafish. Dev Dyn. 2005 Nov;234(3):535-49..

Nodal/activin signaling establishes oral-aboral polarity in the early sea urchin embryo

Authors:
Flowers VL, Courteau GR, Poustka AJ, Weng W, Venuti JM
Citation:
Dev Dyn. 2004 Dec;231(4):727-40.
Epub:
Not Epub
Abstract:
Components of the Wnt signaling pathway are involved in patterning the sea urchin primary or animal-vegetal (AV) axis, but the...
Delivery Method:
Microinjection
Organism or Cell Type:
L. variegatus
Citation Extract:
Flowers VL, Courteau GR, Poustka AJ, Weng W, Venuti JM. Nodal/activin signaling establishes oral-aboral polarity in the early sea urchin embryo. Dev Dyn. 2004 Dec;231(4):727-40..

NPHP4 Variants Are Associated With Pleiotropic Heart Malformations

Authors:
French VM, van de Laar IMBH, Wessels MW, Christan Rohe C, Roos-Hesselink JW, Wang W, Frohn-Mulder IME Severijnen L-A, de Graaf BM, Schot R, Breedveld G, Mientjes E, van Tienhoven M, Jadot E, Jiang Z, Verkerk A, Swagemakers S, Venselaar H, Rahimi Z, Najmabadi H, Meijers-Heijboer H, de Graaff E, Helbing WA, Willemsen R, Devriendt K, Belmont JW, Oostra BA, Amack JD, Bertoli-Avella AM
Citation:
Circ Res. 2012;[Epub ahead of print] doi:10.1161/CIRCRESAHA.112.269795
Epub:
Not Epub
Abstract:
Rationale: Congenital heart malformations are a major cause of morbidity and mortality, especially in young children. Failure...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
French VM, van de Laar IMBH, Wessels MW, Christan Rohe C, Roos-Hesselink JW, Wang W, Frohn-Mulder IME Severijnen L-A, de Graaf BM, Schot R, Breedveld G, Mientjes E, van Tienhoven M, Jadot E, Jiang Z, Verkerk A, Swagemakers S, Venselaar H, Rahimi Z, Najmabadi H, Meijers-Heijboer H, de Graaff E, Helbing WA, Willemsen R, Devriendt K, Belmont JW, Oostra BA, Amack JD, Bertoli-Avella AM. NPHP4 Variants Are Associated With Pleiotropic Heart Malformations. Circ Res. 2012;[Epub ahead of print] doi:10.1161/CIRCRESAHA.112.269795.

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