Citation:
RSC Adv. 2014. 4:1951-1954. doi:10.1039/C3RA45257C
Abstract:
A guanidinium-linked morpholino pentamer is synthesized and evaluated for cellular penetration properties. A regular morpholino and the pentamer conjugate can exhibit antisense effects when designed against Gli1-transcription factors of the Hh signalling pathway, which is a potential target for cancer therapy. Evidence was found from luciferase assays and western blot analysis.
Epub:
Not Epub
Link to Publication:
http://pubs.rsc.org/en/Content/ArticleLanding/2014/RA/c3ra45257c#!divAbstract
Organism or Cell Type:
cell culture