Citation:
Chem Commun. 2014;[Epub ahead of print] doi: 10.1039/C4CC08075K
Abstract:
We report the development of a small fluorescent molecule, BDNCA3-D2, herein referred to as PT-Yellow. Soaking zebrafish embryos in PT-Yellow or intraperitoneal injection into adults results in non-toxic in vivo fluorescent labeling of the renal proximal tubules, the major site of blood filtrate reabsorption and a common target of injury in acute kidney injury. We demonstrate the applicability of this new compound as a rapid and simple readout for zebrafish kidney filtration and proximal tubule reabsorption function.
Epub:
Yes
Link to Publication:
http://pubs.rsc.org/en/content/articlelanding/2014/cc/c4cc08075k#!divAbstract
Organism or Cell Type:
zebrafish
Delivery Method:
microinjection