Citation:
Chin Med J (Engl). 2013 Dec;126(23):4583-4
Abstract:
The TBX1 gene is considered to be the most important gene in the aetiology of DiGeorge syndrome (DGS). DGS is a human disorder characterised by a number of phenotypic features involving abnormal development of pharyngeal arches, facial dysmorphogenesis and cardiac outflow tract anomalies. Retinoic acid (RA) deficiency also produces DGS-like phenotypes. The affectd tissues in DGS are derivatives of neural crest cells (NCCs), which originate from the border between the neural plate and non-neural ectoderm, migrate to specific destinations in the body, and generate a variety of derivatives. In our study, we have explored the hypothesis that tbx1 affects NCC development in zebrafish by regulating RA signaling.
Epub:
Not Epub
Link to Publication:
http://www.cmj.org/ch/reader/create_pdf.aspx?file_no=20130936&year_id=2013&quarter_id=23&falg=1
Organism or Cell Type:
zebrafish
Delivery Method:
microinjection