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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
Genes required for functional glycosylation of dystroglycan are conserved in zebrafish
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Citation:
Genomics. 2008 Sep;92(3):159-67. Epub 2008 Jul 15. Epub:
Not Epub Abstract:
Mutations in human genes encoding proteins involved in alpha-dystroglycan glycosylation result in dystroglycanopathies: severe... Delivery Method:
Microinjection Organism or Cell Type:
zebrafish Citation Extract: Moore CJ, Goh HT, Hewitt JE. Genes required for functional glycosylation of dystroglycan are conserved in zebrafish. Genomics. 2008 Sep;92(3):159-67. Epub 2008 Jul 15.. |
Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143
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Citation:
Mech Dev. 2011 Jan-Feb;128(1-2):18-28. Epub 2010 Sep 30 Epub:
Not Epub Abstract:
Cardiogenesis proceeds with concomitant changes in hemodynamics to accommodate the circulatory demands of developing organs and... Organism or Cell Type:
zebrafish Citation Extract: Miyasaka KY, Kida YS, Banjo T, Ueki Y, Nagayama K, Matsumoto T, Sato M, Ogura T. Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143. Mech Dev. 2011 Jan-Feb;128(1-2):18-28. Epub 2010 Sep 30. |
HIV Tat peptide enhances cellular delivery of antisense morpholino oligomers
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Citation:
Antisense Nucleic Acid Drug Dev. 2003 Feb;13(1):31-43 Epub:
Not Epub Abstract:
Phosphorodiamidate morpholino oligomers (PMO) are uncharged antisense molecules that bind complementary sequences of RNA,... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: various Hela Citation Extract: Moulton HM, Hase MC, Smith KM, Iversen PL. HIV Tat peptide enhances cellular delivery of antisense morpholino oligomers. Antisense Nucleic Acid Drug Dev. 2003 Feb;13(1):31-43. |
Improved Antisense Oligonucleotide Design to Suppress Aberrant SMN2 Gene Transcript Processing: Towards a Treatment for Spinal Muscular Atrophy
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Citation:
PLoS ONE. 2013;8(4):e62114. doi:10.1371/journal.pone.0062114 Epub:
Not Epub Abstract:
Spinal muscular atrophy (SMA) is caused by loss of the Survival Motor Neuron 1 (SMN1) gene, resulting in reduced SMN protein.... Delivery Method:
ICV in vivo, DNA-MO complexes with lipofectin in vitro Organism or Cell Type:
mouse SMA model Citation Extract: Mitrpant C, Porensky P, Zhou H, Price L, Muntoni F, Fletcher S, Wilton SD, Burghes AHM. Improved Antisense Oligonucleotide Design to Suppress Aberrant SMN2 Gene Transcript Processing: Towards a Treatment for Spinal Muscular Atrophy. PLoS ONE. 2013;8(4):e62114. doi:10.1371/journal.pone.0062114. |
In Vivo Delivery of Morpholino Oligos by Cell-Penetrating Peptides
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Citation:
Curr Pharm Des. 2013;19(16):2963-9 Epub:
Not Epub Abstract:
Morpholino oligos (Morpholinos) are widely used tools for knocking down gene expression and are currently in a clinical trial... Delivery Method:
peptide-coupled Citation Extract: Moulton HM. In Vivo Delivery of Morpholino Oligos by Cell-Penetrating Peptides. Curr Pharm Des. 2013;19(16):2963-9. |
Inhibition of HSV-1 ocular infection with morpholino oligomers targeting ICP0 and ICP27
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Citation:
Antiviral Res. 2009 Nov;84(2):131-41. Epub 2009 Aug 7. Epub:
Not Epub Abstract:
Alternative therapies are needed for HSV-1 infections in patients refractory to treatment with Acyclovir (ACV) and its... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: Rabbit skin (RS) cells, Vero cells Citation Extract: Moerdyk-Schauwecker M, Stein DA, Eide K, Blouch RE, Bildfell R, Iversen P, Jin L. Inhibition of HSV-1 ocular infection with morpholino oligomers targeting ICP0 and ICP27. Antiviral Res. 2009 Nov;84(2):131-41. Epub 2009 Aug 7.. |
Inhibition of Intracellular Growth of Salmonella enterica serovar typhimurium in Tissue Culture by Antisense Peptide-Phosphorodiamidate Morpholino Oligomer
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Citation:
Antimicrob Agents Chemother. 2009 Jul 6. [Epub ahead of print] Epub:
Not Epub Abstract:
Two types of phosphorodiamidate morpholino oligomers (PMOs) were tested for inhibition of growth of Salmonella enterica serovar... Delivery Method:
peptide-coupled Organism or Cell Type:
Salmonella enterica serovar typhimurium & infected macrophages Citation Extract: Mitev GM, Mellbye BL, Iversen PL, Geller BL. Inhibition of Intracellular Growth of Salmonella enterica serovar typhimurium in Tissue Culture by Antisense Peptide-Phosphorodiamidate Morpholino Oligomer. Antimicrob Agents Chemother. 2009 Jul 6. [Epub ahead of print]. |
Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates
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Citation:
Hum. Mol. Genet. 2011 March 9 [Epub ahead of print] doi:10.1093/hmg/ddr090 Epub:
Not Epub Abstract:
BUBR1 is a central molecule of the spindle assembly checkpoint. Germline mutations in the BUB1B gene encoding BUBR1 cause... Organism or Cell Type:
medaka Citation Extract: Miyamoto T, Porazinski S, Wang H, Borovina A, Ciruna B, Shimizu A, Kajii T, Kikuchi A, Furutani-Seiki M, Matsuura S. Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates. Hum. Mol. Genet. 2011 March 9 [Epub ahead of print] doi:10.1093/hmg/ddr090 . |
Loss of BRCC3 Deubiquitinating Enzyme Leads to Abnormal Angiogenesis and Is Associated with Syndromic Moyamoya
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Citation:
Am J Hum Genet. 2011 May 18. [Epub ahead of print] Epub:
Not Epub Abstract:
Moyamoya is a cerebrovascular angiopathy characterized by a progressive stenosis of the terminal part of the intracranial... Organism or Cell Type:
zebrafish Citation Extract: Miskinyte S, Butler MG, Hervé D, Sarret C, Nicolino M, Petralia JD, Bergametti F, Arnould M, Pham VN, Gore AV, Spengos K, Gazal S, Woimant F, Steinberg GK, Weinstein BM, Tournier-Lasserve E. Loss of BRCC3 Deubiquitinating Enzyme Leads to Abnormal Angiogenesis and Is Associated with Syndromic Moyamoya. Am J Hum Genet. 2011 May 18. [Epub ahead of print]. |
Loss of plakophilin 2 disrupts heart development in zebrafish
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Citation:
Int J Dev Biol. 2012;[Epub ahead of print] doi: 10.1387/ijdb.113390mm Epub:
Not Epub Abstract:
ABSTRACT The desmosomal armadillo protein plakophilin 2 is the only plakophilin expressed in the heart, and mutations in the... Delivery Method:
Microinjection Organism or Cell Type:
zebrafish Citation Extract: Moriarty MA, Ryan R, Lalor P, Dockery P, Byrnes L, Grealy M. Loss of plakophilin 2 disrupts heart development in zebrafish. Int J Dev Biol. 2012;[Epub ahead of print] doi: 10.1387/ijdb.113390mm. |