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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12143 scientific papers returned from the database with the search filters currently being used below.

Mutations in CSPP1 Cause Primary Cilia Abnormalities and Joubert Syndrome with or without Jeune Asphyxiating Thoracic Dystrophy

Authors:
Tuz K, Bachmann-Gagescu R, O'Day DR, Hua K, Isabella CR, Phelps IG, Stolarski AE, O'Roak BJ, Dempsey JC, Lourenco C, Alswaid A, Bönnemann CG, Medne L, Nampoothiri S, Stark Z, Leventer RJ, Topçu M, Cansu A, Jagadeesh S, Done S, Ishak GE, Glass IA, Shendure J, Neuhauss SC, Haldeman-Englert CR, Doherty D, Ferland RJ
Citation:
Am J Hum Genet. 2013 Dec 18. pii: S0002-9297(13)00534-X. doi: 10.1016/j.ajhg.2013.11.019. [Epub ahead of print]
Epub:
Yes
Abstract:
Joubert syndrome (JBTS) is a recessive ciliopathy in which a subset of affected individuals also have the skeletal dysplasia...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tuz K, Bachmann-Gagescu R, O'Day DR, Hua K, Isabella CR, Phelps IG, Stolarski AE, O'Roak BJ, Dempsey JC, Lourenco C, Alswaid A, Bönnemann CG, Medne L, Nampoothiri S, Stark Z, Leventer RJ, Topçu M, Cansu A, Jagadeesh S, Done S, Ishak GE, Glass IA, Shendure J, Neuhauss SC, Haldeman-Englert CR, Doherty D, Ferland RJ. Mutations in CSPP1 Cause Primary Cilia Abnormalities and Joubert Syndrome with or without Jeune Asphyxiating Thoracic Dystrophy. Am J Hum Genet. 2013 Dec 18. pii: S0002-9297(13)00534-X. doi: 10.1016/j.ajhg.2013.11.019. [Epub ahead of print].

Identification of Pax3 and Zic1 targets in the developing neural crest.

Authors:
Bae CJ, Park BY, Lee YH, Tobias JW, Hong CS, Saint-Jeannet JP
Citation:
Dev Biol. 2013 Dec 17. pii: S0012-1606(13)00656-8. doi: 10.1016/j.ydbio.2013.12.011. [Epub ahead of print]
Epub:
Yes
Abstract:
The neural crest (NC) is a multipotent population of migratory cells unique to the vertebrate embryo, contributing to the...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Bae CJ, Park BY, Lee YH, Tobias JW, Hong CS, Saint-Jeannet JP. Identification of Pax3 and Zic1 targets in the developing neural crest. . Dev Biol. 2013 Dec 17. pii: S0012-1606(13)00656-8. doi: 10.1016/j.ydbio.2013.12.011. [Epub ahead of print].

Cellular trafficking determines the exon skipping activity of Pip6a-PMO in mdx skeletal and cardiac muscle cells.

Authors:
Lehto T, Castillo Alvarez A, Gauck S, Gait MJ, Coursindel T, Wood MJ, Lebleu B, Boisguerin P
Citation:
Nucleic Acids Res. 2013 Dec 23. [Epub ahead of print]
Epub:
Yes
Abstract:
Cell-penetrating peptide-mediated delivery of phosphorodiamidate morpholino oligomers (PMOs) has shown great promise for exon-...
Delivery Method:
Incubation of Pip6a modified and unmodified oligos
Organism or Cell Type:
Mouse H2k mdx myoblasts and primary cardiomyocytes
Citation Extract:
Lehto T, Castillo Alvarez A, Gauck S, Gait MJ, Coursindel T, Wood MJ, Lebleu B, Boisguerin P. Cellular trafficking determines the exon skipping activity of Pip6a-PMO in mdx skeletal and cardiac muscle cells. . Nucleic Acids Res. 2013 Dec 23. [Epub ahead of print].

Dysferlin is essential for endocytosis in the sea star oocyte

Authors:
Oulhen N, Onorato TM, Ramos I, Wessel GM
Citation:
Dev Biol. 2013 Dec 21. pii: S0012-1606(13)00675-1. doi: 10.1016/j.ydbio.2013.12.018. [Epub ahead of print]
Epub:
Yes
Abstract:
Dysferlin is a calcium-binding transmembrane protein involved in membrane fusion and membrane repair. In humans, mutations in...
Delivery Method:
microinjection
Organism or Cell Type:
Patiria miniata
Citation Extract:
Oulhen N, Onorato TM, Ramos I, Wessel GM. Dysferlin is essential for endocytosis in the sea star oocyte. Dev Biol. 2013 Dec 21. pii: S0012-1606(13)00675-1. doi: 10.1016/j.ydbio.2013.12.018. [Epub ahead of print] .

Protocadherin-18b interacts with Nap1 to control motor axon growth and arborization in zebrafish

Authors:
Biswas S, Phan D, Hao LT, Beattie CE, Jontes JD
Citation:
Mol Biol Cell. 2013 Dec 26. [Epub ahead of print]
Epub:
Yes
Abstract:
The proper assembly of neural circuits during development requires the precise control of axon outgrowth, guidance and...
Organism or Cell Type:
Zebrafish
Citation Extract:
Biswas S, Phan D, Hao LT, Beattie CE, Jontes JD. Protocadherin-18b interacts with Nap1 to control motor axon growth and arborization in zebrafish. Mol Biol Cell. 2013 Dec 26. [Epub ahead of print].

The differentiation and movement of presomitic mesoderm progenitor cells are controlled by Mesogenin 1

Authors:
Fior R, Maxwell AA, Ma TP, Vezzaro A, Moens CB, Amacher SL, Lewis J, Saúde L
Citation:
Development. 2012 Dec;139(24):4656-65. doi: 10.1242/dev.078923
Epub:
Not Epub
Abstract:
Somites are formed from the presomitic mesoderm (PSM) and give rise to the axial skeleton and skeletal muscles. The PSM is...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fior R, Maxwell AA, Ma TP, Vezzaro A, Moens CB, Amacher SL, Lewis J, Saúde L. The differentiation and movement of presomitic mesoderm progenitor cells are controlled by Mesogenin 1. Development. 2012 Dec;139(24):4656-65. doi: 10.1242/dev.078923.

VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus

Authors:
Ciau-Uitz A, Pinheiro P, Kirmizitas A, Zuo J, Patient R
Citation:
Development. 2013 Jun;140(12):2632-42. doi: 10.1242/dev.090829
Epub:
Not Epub
Abstract:
The first haematopoietic stem cells share a common origin with the dorsal aorta and derive from putative adult haemangioblasts...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Ciau-Uitz A, Pinheiro P, Kirmizitas A, Zuo J, Patient R. VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus. Development. 2013 Jun;140(12):2632-42. doi: 10.1242/dev.090829.

PTK7 modulates Wnt signaling activity via LRP6

Authors:
Bin-Nun N, Lichtig H, Malyarova A, Levy M, Elias S, Frank D
Citation:
Development. 2013 Dec 18. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Protein tyrosine kinase 7 (PTK7) is a transmembrane protein expressed in the developing Xenopus neural plate. PTK7 regulates...
Organism or Cell Type:
Xenopus
Citation Extract:
Bin-Nun N, Lichtig H, Malyarova A, Levy M, Elias S, Frank D. PTK7 modulates Wnt signaling activity via LRP6. Development. 2013 Dec 18. [Epub ahead of print].

Analysis of Pseudoxanthoma Elasticum-Causing Missense Mutants of ABCC6 In Vivo; Pharmacological Correction of the Mislocalized Proteins

Authors:
Pomozi V, Brampton C, Fülöp K, Chen LH, Apana A, Li Q, Uitto J, Le Saux O, Váradi A
Citation:
J Invest Dermatol. 2013 Nov 11. doi: 10.1038/jid.2013.482. [Epub ahead of print]
Epub:
Yes
Abstract:
Mutations in the ABCC6 gene cause soft-tissue calcification in pseudoxanthoma elasticum (PXE) and, in some patients,...
Organism or Cell Type:
Zebrafish
Citation Extract:
Pomozi V, Brampton C, Fülöp K, Chen LH, Apana A, Li Q, Uitto J, Le Saux O, Váradi A. Analysis of Pseudoxanthoma Elasticum-Causing Missense Mutants of ABCC6 In Vivo; Pharmacological Correction of the Mislocalized Proteins. J Invest Dermatol. 2013 Nov 11. doi: 10.1038/jid.2013.482. [Epub ahead of print].

Post-transcriptional regulation of wnt8a is essential to zebrafish axis development

Authors:
Wylie AD, Fleming JA, Whitener AE, Lekven AC
Citation:
Dev Biol. 2013 Dec 11. pii: S0012-1606(13)00648-9. doi: 10.1016/j.ydbio.2013.12.003. [Epub ahead of print]
Epub:
Yes
Abstract:
wnt8a is essential for normal patterning during vertebrate embryonic development, and either gain or loss-of-function gene...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wylie AD, Fleming JA, Whitener AE, Lekven AC. Post-transcriptional regulation of wnt8a is essential to zebrafish axis development. Dev Biol. 2013 Dec 11. pii: S0012-1606(13)00648-9. doi: 10.1016/j.ydbio.2013.12.003. [Epub ahead of print].

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