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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 277 scientific papers returned from the database with the search filters currently being used below.
There are 277 scientific papers returned from the database with the search filters currently being used below.
Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides
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Citation:
Nucleic Acid Ther. 2021 Feb 9. doi: 10.1089/nat.2020.0907. Online ahead of print Epub:
Yes Abstract:
Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease caused by frameshift or nonsense mutations in the DMD gene... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture:CXMDJ immortalized myoblasts Citation Extract: Tone Y, Mamchaoui K, Tsoumpra MK, Hashimoto Y, Terada R, Maruyama R, Gait MJ, Arzumanov AA, McClorey G, Imamura M, Takeda S, Yokota T, Wood MJA, Mouly V, Aoki Y. Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides. Nucleic Acid Ther. 2021 Feb 9. doi: 10.1089/nat.2020.0907. Online ahead of print. |
Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo
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Citation:
mBio. 2021;12(1):e02411-20. doi:10.1128/mBio.02411-20 Epub:
Not Epub Abstract:
Most antimicrobials currently in the clinical pipeline are modifications of existing classes of antibiotics and are considered... Delivery Method:
peptide-linked Organism or Cell Type:
Pseudomonas aeruginosa as biofilm or murine pneumonial infection Citation Extract: Moustafa DA, Wu AW, Zamora D, Daly SM, Sturge CR, Pybus C, Geller BL, Goldberg JB, Greenberg DE. Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo. mBio. 2021;12(1):e02411-20. doi:10.1128/mBio.02411-20. |
Discovery and mechanistic characterization of a novel AhR receptor ligand that induces apoptosis in cancer cells
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Citation:
Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-131951/v1 Epub:
Not Epub Abstract:
Background: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and a member of the bHLH/PAS (basic... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: Hepa 1 Citation Extract: O'Donnell E, Jang HS, Liefwalker D, Kerkvliet N, Kolluri SK. Discovery and mechanistic characterization of a novel AhR receptor ligand that induces apoptosis in cancer cells. Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-131951/v1. |
MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice
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Citation:
EMBO Mol Med. 2020;13:e12993 doi:10.15252/emmm.202012993 Epub:
Not Epub Abstract:
Antisense oligonucleotide (AO)‐mediated exon‐skipping therapies show promise in Duchenne muscular dystrophy (DMD), a... Delivery Method:
unlinked MOTS‐c peptide Organism or Cell Type:
mouse mdx Citation Extract: Ran N, Lin C, Leng L, Han G, Geng M, Wu Y, Bittner S, Moulton H, Yin H. MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice. EMBO Mol Med. 2020;13:e12993 doi:10.15252/emmm.202012993. |
Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers for In Situ Live-Cell Molecular Imaging of Dengue Virus Replication
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Citation:
Int J Molec Sci. 2020;21(23):1422-0067 doi:10.3390/ijms21239260 Epub:
Not Epub Abstract:
Current methods to detect and monitor pathogens in biological systems are largely limited by the tradeoffs between spatial... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: Vero, BHK-21 Citation Extract: Victorio CB, Novera W, Tham JY, Watanabe S, Vasudevan SG, Chacko A-M. Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers for In Situ Live-Cell Molecular Imaging of Dengue Virus Replication. Int J Molec Sci. 2020;21(23):1422-0067 doi:10.3390/ijms21239260. |
Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino oligomers
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Citation:
J Antimicrob Chemother. 2021 Jan 19;76(2):413-417. doi: 10.1093/jac/dkaa460. PMID: 33164048; PMCID: PMC7717290 Epub:
Yes Abstract:
Background: As the causative agent of COVID-19, SARS-CoV-2 is a pathogen of immense importance to global public health.... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: Vero-E6 and SARS-CoV-2 Citation Extract: Rosenke K, Leventhal S, Moulton HM, Hatlevig S, Hawman D, Feldmann H, Stein DA. Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino oligomers. J Antimicrob Chemother. 2021 Jan 19;76(2):413-417. doi: 10.1093/jac/dkaa460. PMID: 33164048; PMCID: PMC7717290. |
Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics
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Citation:
PLoS ONE. 2020;15(9):e0239467. doi:10.1371/journal.pone.0239467 Epub:
Not Epub Abstract:
Dystrophin plays a vital role in maintaining muscle health, yet low mRNA expression, lengthy transcription time and the... Delivery Method:
PIP6a peptide-linked; intravenous (i.v.) Organism or Cell Type:
mdx & C57BL/6J mice Citation Extract: Hildyard JCW, Rawson F, Wells DJ, Piercy RJ. Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics. PLoS ONE. 2020;15(9):e0239467. doi:10.1371/journal.pone.0239467. |
In vivo Pharmacokinetic and Biodistribution profile of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides
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Citation:
Poster at 2015 Oligonucleotide Therapeutics Society meeting Epub:
Not Epub Abstract:
Antisense oligonucleotide (AON) induced exon skipping is one of the most promising strategies for treating Duchene muscular... Delivery Method:
Pip6A peptide-linked; subcutaneous (s.c.) or intravenous (i.v.) Organism or Cell Type:
mdx mice Citation Extract: Burki U, Blain A, Greally E, O’Donovan L, Gait M, Laval S, Straub V. In vivo Pharmacokinetic and Biodistribution profile of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides. Poster at 2015 Oligonucleotide Therapeutics Society meeting. |
Morpholino Oligomer-Induced Dystrophin Isoforms to Map the Functional Domains in the Dystrophin Protein
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Citation:
Molec Ther. 2020 Aug 21;22:263-272. doi:10.1016/j.omtn.2020.08.019 Epub:
Not Epub Abstract:
Dystrophin plays a crucial role in maintaining sarcolemma stability during muscle contractions, and mutations that prevent the... Delivery Method:
(RxR)4 peptide-linked; intraperitoneal (i.p.) Organism or Cell Type:
cell culture: murine H2K mdx myogenic cells; mice: mdx & C57BL/10ScSn Citation Extract: Li D, Adams AM, Johnsen RD, Fletcher S, Wilton SD. Morpholino Oligomer-Induced Dystrophin Isoforms to Map the Functional Domains in the Dystrophin Protein. Molec Ther. 2020 Aug 21;22:263-272. doi:10.1016/j.omtn.2020.08.019. |
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
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Citation:
Life Sci Alliance. 2020;3(9):e202000786 doi:10.26508/lsa.202000786 Epub:
Not Epub Abstract:
The novel emerged SARS-CoV-2 has rapidly spread around the world causing acute infection of the respiratory tract (COVID-19)... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: Calu-3 human airway epithelial cells Citation Extract: Bestle D, Heindl MR, Limburg H, Lam van TV, Pilgram O, Moulton H, Stein DA, Hardes K, Eickmann M, Dolnik O, Rohde C, Klenk H-D, Garten W, Steinmetzer T, Böttcher-Friebertshäuser E. TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells. Life Sci Alliance. 2020;3(9):e202000786 doi:10.26508/lsa.202000786. |