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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 273 scientific papers returned from the database with the search filters currently being used below.

Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen

Authors:
Palacio-Castañeda V, Brock R, Verdurmen WPR
Citation:
Methods Mol Biol. 2022;2434:129-141. Humana, New York, NY. doi:10.1007/978-1-0716-2010-6_8
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligomers (PMOs) offer great promise as therapeutic agents for translation blocking or splice...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-2010-6_8
Delivery Method:
peptide-linked
Citation Extract:
Palacio-Castañeda V, Brock R, Verdurmen WPR. Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen. Methods Mol Biol. 2022;2434:129-141. Humana, New York, NY. doi:10.1007/978-1-0716-2010-6_8.

Development of DG9 peptide-conjugated single- and multi-exon skipping therapies for the treatment of Duchenne muscular dystrophy

Authors:
Lim KRQ, Woo S, Melo D, Huang Y, Dzierlega K, Shah MNA, Aslesh T, Roshmi RR, Echigoya Y, Maruyama R, Moulton HM, Yokota T
Citation:
Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2112546119. doi: 10.1073/pnas.2112546119
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is primarily caused by out-of-frame deletions in the dystrophin gene. Exon skipping using...
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892351/
Delivery Method:
peptide-linked
Organism or Cell Type:
mice hDMDdel52;mdx
Citation Extract:
Lim KRQ, Woo S, Melo D, Huang Y, Dzierlega K, Shah MNA, Aslesh T, Roshmi RR, Echigoya Y, Maruyama R, Moulton HM, Yokota T. Development of DG9 peptide-conjugated single- and multi-exon skipping therapies for the treatment of Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2112546119. doi: 10.1073/pnas.2112546119.

A Dystrophin Exon-52 Deleted Miniature Pig Model of Duchenne Muscular Dystrophy and Evaluation of Exon Skipping

Authors:
Echigoya Y, Trieu N, Duddy W, Moulton HM, Yin H, Partridge TA, Hoffman EP, Kornegay JN, Rohret FA, Rogers CS, Yokota T
Citation:
Int J Mol Sci. 2021;22(23):13065. doi:10.3390/ijms222313065
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a lethal X-linked recessive disorder caused by mutations in the DMD gene and the...
Link:
https://www.mdpi.com/1422-0067/22/23/13065
Delivery Method:
peptide-linked, Endo-Porter
Organism or Cell Type:
Sus scrofa domestica (pig)
Citation Extract:
Echigoya Y, Trieu N, Duddy W, Moulton HM, Yin H, Partridge TA, Hoffman EP, Kornegay JN, Rohret FA, Rogers CS, Yokota T. A Dystrophin Exon-52 Deleted Miniature Pig Model of Duchenne Muscular Dystrophy and Evaluation of Exon Skipping. Int J Mol Sci. 2021;22(23):13065. doi:10.3390/ijms222313065 .

Targeting IgE polyadenylation signal with antisense oligonucleotides decreases IgE secretion and plasma cell viability

Authors:
Marchalot A, Horiot C, Lambert J-M, Carrion C, Oblet C, Pollet J, Cogné M, Moreau J, Laffleur B, Delpy L
Citation:
J Allergy Clin Immunol. 2021 Nov 2;S0091-6749(21)01680-8. doi: 10.1016/j.jaci.2021.09.039.
Epub:
Not Epub
Abstract:
Background: Allergy regroups numerous complex and various diseases classified as IgE-dependent or non-dependent...
Link:
https://www.jacionline.org/article/S0091-6749(21)01680-8/fulltext
Delivery Method:
Vivo-Morpholino, peptide-linked
Organism or Cell Type:
cell culture: B cells, myeloma cells; InEps mice
Citation Extract:
Marchalot A, Horiot C, Lambert J-M, Carrion C, Oblet C, Pollet J, Cogné M, Moreau J, Laffleur B, Delpy L. Targeting IgE polyadenylation signal with antisense oligonucleotides decreases IgE secretion and plasma cell viability. J Allergy Clin Immunol. 2021 Nov 2;S0091-6749(21)01680-8. doi: 10.1016/j.jaci.2021.09.039..

Deep Learning Enables Discovery of a Short Nuclear Targeting Peptide for Efficient Delivery of Antisense Oligomers

Authors:
López-Vidal EM, Schissel CK, Mohapatra S, Bellovoda K, Wu C-L, Wood JA, Malmberg AB, Loas A, Gómez-Bombarelli R, Pentelute BL
Citation:
JACS Au. 2021;[Epub] doi:10.1021/jacsau.1c00327
Epub:
Not Epub
Abstract:
Therapeutic macromolecules such as proteins and oligonucleotides can be highly efficacious but are often limited to...
Link:
https://pubs.acs.org/doi/full/10.1021/jacsau.1c00327
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: HeLa, mice
Citation Extract:
López-Vidal EM, Schissel CK, Mohapatra S, Bellovoda K, Wu C-L, Wood JA, Malmberg AB, Loas A, Gómez-Bombarelli R, Pentelute BL. Deep Learning Enables Discovery of a Short Nuclear Targeting Peptide for Efficient Delivery of Antisense Oligomers. JACS Au. 2021;[Epub] doi:10.1021/jacsau.1c00327.

Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy

Authors:
Martin-Sancho L, Tripathi S, Rodriguez-Frandsen A, Pache L, Sanchez-Aparicio M, McGregor MJ, Haas KM, Swaney DL, Nguyen TT, Mamede JI, Churas C, Pratt D, Rosenthal SB, Riva L, Nguyen C, Beltran-Raygoza N, Soonthornvacharin S, Wang G, Jimenez-Morales D, De Jesus PD, Moulton HM, Stein DA, Chang MW, Benner C, Ideker T, Albrecht RA, Hultquist JF, Krogan NJ, García-Sastre A, Chanda SK
Citation:
Nat Microbiol. 2021;[Epub] doi:10.1038/s41564-021-00964-2
Epub:
Yes
Abstract:
The fate of influenza A virus (IAV) infection in the host cell depends on the balance between cellular defence mechanisms and...
Link:
https://www.nature.com/articles/s41564-021-00964-2
Delivery Method:
intranasal peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Martin-Sancho L, Tripathi S, Rodriguez-Frandsen A, Pache L, Sanchez-Aparicio M, McGregor MJ, Haas KM, Swaney DL, Nguyen TT, Mamede JI, Churas C, Pratt D, Rosenthal SB, Riva L, Nguyen C, Beltran-Raygoza N, Soonthornvacharin S, Wang G, Jimenez-Morales D, De Jesus PD, Moulton HM, Stein DA, Chang MW, Benner C, Ideker T, Albrecht RA, Hultquist JF, Krogan NJ, García-Sastre A, Chanda SK. Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy. Nat Microbiol. 2021;[Epub] doi:10.1038/s41564-021-00964-2.

Hemagglutinins of Avian Influenza Viruses Are Proteolytically Activated by TMPRSS2 in Human and Murine Airway Cells

Authors:
Bestle D, Limburg H, Kruhl D, Harbig A, Stein DA, Moulton H, Matrosovich M, Abdelwhab EM, Stech J, Böttcher-Friebertshäuser E
Citation:
J Virol. 2021 Sep 27;95(20):e0090621. doi: 10.1128/JVI.00906-21. Epub 2021 Jul 28. PMID: 34319155; PMCID: PMC8475512
Epub:
Not Epub
Abstract:
Cleavage of the influenza A virus (IAV) hemagglutinin (HA) by host proteases is indispensable for virus replication. Most IAVs...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8475512/
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: human and mouse airway cells
Citation Extract:
Bestle D, Limburg H, Kruhl D, Harbig A, Stein DA, Moulton H, Matrosovich M, Abdelwhab EM, Stech J, Böttcher-Friebertshäuser E. Hemagglutinins of Avian Influenza Viruses Are Proteolytically Activated by TMPRSS2 in Human and Murine Airway Cells. J Virol. 2021 Sep 27;95(20):e0090621. doi: 10.1128/JVI.00906-21. Epub 2021 Jul 28. PMID: 34319155; PMCID: PMC8475512.

Chapter Six - Emerging RNA Suppression Technologies to Protect Citrus Trees From Citrus Greening Disease Bacteria

Authors:
Hunter WB, Sinisterra-Hunter SH
Citation:
Adv In Insect Physiol. 2018;55:163-197. doi:10.1016/bs.aiip.2018.08.001
Epub:
Not Epub
Abstract:
Research on the development of RNA-suppressing technologies, which include RNA interference, (RNAi), and the application of RNA...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0065280618300171
Delivery Method:
peptide-linked
Organism or Cell Type:
Candidatus Liberibacter asiaticus
Citation Extract:
Hunter WB, Sinisterra-Hunter SH. Chapter Six - Emerging RNA Suppression Technologies to Protect Citrus Trees From Citrus Greening Disease Bacteria. Adv In Insect Physiol. 2018;55:163-197. doi:10.1016/bs.aiip.2018.08.001.

Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung

Authors:
Dang Y, van Heusden C, Nickerson V, Chung F, Wang Y, Quinney NL, Gentzsch M, Randell SH, Moulton HM, Kole R, Ni A, Juliano RL, Kreda SM
Citation:
Nucleic Acids Res. 2021;49(11):6100–13. doi: 10.1093/nar/gkab488. Online ahead of print
Epub:
Not Epub
Abstract:
Pulmonary diseases offer many targets for oligonucleotide therapeutics. However, effective delivery of oligonucleotides to the...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab488/6295539
Delivery Method:
peptide-linked plus endosome escape reagent (OEC)
Organism or Cell Type:
cell culture: HeLa EGFP654, Human Bronchial Epithelial, UNCCF8T, EGFP654 Mouse Tracheal Epithelial, mouse
Citation Extract:
Dang Y, van Heusden C, Nickerson V, Chung F, Wang Y, Quinney NL, Gentzsch M, Randell SH, Moulton HM, Kole R, Ni A, Juliano RL, Kreda SM. Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung. Nucleic Acids Res. 2021;49(11):6100–13. doi: 10.1093/nar/gkab488. Online ahead of print.

CX3CR1 is a Receptor for Human Respiratory Syncytial Virus in Cotton Rats

Authors:
Green G, Johnson SM, Costello H, Brakel K, Harder O, Oomens AG, Peeples ME, Moulton HM, Niewiesk S
Citation:
J Virol. 2021 Jul 26;95(16):e0001021. doi: 10.1128/JVI.00010-21. Epub 2021 Jul 26. PMID: 34037420; PMCID: PMC8312862
Epub:
Not Epub
Abstract:
Respiratory syncytial virus (RSV) has been reported to use CX3CR1 in vitro as a receptor on cultured primary human airway...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8312862/
Delivery Method:
peptide-linked
Organism or Cell Type:
Sigmodon sp. (Cotton rat)
Citation Extract:
Green G, Johnson SM, Costello H, Brakel K, Harder O, Oomens AG, Peeples ME, Moulton HM, Niewiesk S. CX3CR1 is a Receptor for Human Respiratory Syncytial Virus in Cotton Rats. J Virol. 2021 Jul 26;95(16):e0001021. doi: 10.1128/JVI.00010-21. Epub 2021 Jul 26. PMID: 34037420; PMCID: PMC8312862.

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