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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 261 scientific papers returned from the database with the search filters currently being used below.

Targeting the 5' untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy

Authors:
Winkelsas AM, Grunseich C, Harmison GG, Chwalenia K, Rinaldi C, Hammond SM, Johnson K, Bowerman M, Arya S, Talbot K, Wood MJ, Fischbeck KH
Citation:
Mol Ther Nucleic Acids. 2021 Jan 5;23:731-742. doi: 10.1016/j.omtn.2020.12.027. eCollection 2021 Mar 5
Epub:
Not Epub
Abstract:
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by mutations in the survival motor neuron 1 (SMN1) gene. All...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(20)30408-X
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: iPSC
Citation Extract:
Winkelsas AM, Grunseich C, Harmison GG, Chwalenia K, Rinaldi C, Hammond SM, Johnson K, Bowerman M, Arya S, Talbot K, Wood MJ, Fischbeck KH. Targeting the 5' untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy. Mol Ther Nucleic Acids. 2021 Jan 5;23:731-742. doi: 10.1016/j.omtn.2020.12.027. eCollection 2021 Mar 5.

Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides

Authors:
Tone Y, Mamchaoui K, Tsoumpra MK, Hashimoto Y, Terada R, Maruyama R, Gait MJ, Arzumanov AA, McClorey G, Imamura M, Takeda S, Yokota T, Wood MJA, Mouly V, Aoki Y
Citation:
Nucleic Acid Ther. 2021 Feb 9. doi: 10.1089/nat.2020.0907. Online ahead of print
Epub:
Yes
Abstract:
Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disease caused by frameshift or nonsense mutations in the DMD gene...
Link:
https://www.liebertpub.com/doi/10.1089/nat.2020.0907
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture:CXMDJ immortalized myoblasts
Citation Extract:
Tone Y, Mamchaoui K, Tsoumpra MK, Hashimoto Y, Terada R, Maruyama R, Gait MJ, Arzumanov AA, McClorey G, Imamura M, Takeda S, Yokota T, Wood MJA, Mouly V, Aoki Y. Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides. Nucleic Acid Ther. 2021 Feb 9. doi: 10.1089/nat.2020.0907. Online ahead of print.

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo

Authors:
Moustafa DA, Wu AW, Zamora D, Daly SM, Sturge CR, Pybus C, Geller BL, Goldberg JB, Greenberg DE
Citation:
mBio. 2021;12(1):e02411-20. doi:10.1128/mBio.02411-20
Epub:
Not Epub
Abstract:
Most antimicrobials currently in the clinical pipeline are modifications of existing classes of antibiotics and are considered...
Link:
https://mbio.asm.org/content/12/1/e02411-20
Delivery Method:
peptide-linked
Organism or Cell Type:
Pseudomonas aeruginosa as biofilm or murine pneumonial infection
Citation Extract:
Moustafa DA, Wu AW, Zamora D, Daly SM, Sturge CR, Pybus C, Geller BL, Goldberg JB, Greenberg DE. Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo. mBio. 2021;12(1):e02411-20. doi:10.1128/mBio.02411-20.

Discovery and mechanistic characterization of a novel AhR receptor ligand that induces apoptosis in cancer cells

Authors:
O'Donnell E, Jang HS, Liefwalker D, Kerkvliet N, Kolluri SK
Citation:
Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-131951/v1
Epub:
Not Epub
Abstract:
Background: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and a member of the bHLH/PAS (basic...
Link:
https://www.researchsquare.com/article/rs-131951/v1
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Hepa 1
Citation Extract:
O'Donnell E, Jang HS, Liefwalker D, Kerkvliet N, Kolluri SK. Discovery and mechanistic characterization of a novel AhR receptor ligand that induces apoptosis in cancer cells. Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-131951/v1.

MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice

Authors:
Ran N, Lin C, Leng L, Han G, Geng M, Wu Y, Bittner S, Moulton H, Yin H
Citation:
EMBO Mol Med. 2020;13:e12993 doi:10.15252/emmm.202012993
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (AO)‐mediated exon‐skipping therapies show promise in Duchenne muscular dystrophy (DMD), a...
Link:
https://www.embopress.org/doi/full/10.15252/emmm.202012993
Delivery Method:
unlinked MOTS‐c peptide
Organism or Cell Type:
mouse mdx
Citation Extract:
Ran N, Lin C, Leng L, Han G, Geng M, Wu Y, Bittner S, Moulton H, Yin H. MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice. EMBO Mol Med. 2020;13:e12993 doi:10.15252/emmm.202012993.

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers for In Situ Live-Cell Molecular Imaging of Dengue Virus Replication

Authors:
Victorio CB, Novera W, Tham JY, Watanabe S, Vasudevan SG, Chacko A-M
Citation:
Int J Molec Sci. 2020;21(23):1422-0067 doi:10.3390/ijms21239260
Epub:
Not Epub
Abstract:
Current methods to detect and monitor pathogens in biological systems are largely limited by the tradeoffs between spatial...
Link:
https://www.mdpi.com/1422-0067/21/23/9260
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Vero, BHK-21
Citation Extract:
Victorio CB, Novera W, Tham JY, Watanabe S, Vasudevan SG, Chacko A-M. Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers for In Situ Live-Cell Molecular Imaging of Dengue Virus Replication. Int J Molec Sci. 2020;21(23):1422-0067 doi:10.3390/ijms21239260.

Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers

Authors:
Rosenke K, Leventhal S, Moulton H, Hatlevig S, Hawman D, Feldmann H, Stein DA
Citation:
J Antimicrob Chemother. 2020;[Epub ahead of print]:dkaa460 doi:10.1093/jac/dkaa460
Epub:
Yes
Abstract:
Background: As the causative agent of COVID-19, SARS-CoV-2 is a pathogen of immense importance to global public health....
Link:
https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkaa460/5961620
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Vero-E6 and SARS-CoV-2
Citation Extract:
Rosenke K, Leventhal S, Moulton H, Hatlevig S, Hawman D, Feldmann H, Stein DA. Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers. J Antimicrob Chemother. 2020;[Epub ahead of print]:dkaa460 doi:10.1093/jac/dkaa460.

Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers

Authors:
Rosenke K, Leventhal S, Moulton H, Hatlevig S, Hawman D, Feldmann H, Stein DA
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.09.29.319731
Epub:
Not Epub
Abstract:
Background: SARS-CoV-2 is the causative agent of COVID-19 and a pathogen of immense global public health importance....
Link:
https://www.biorxiv.org/content/10.1101/2020.09.29.319731v1
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Vero-E6 and SARS-CoV-2
Citation Extract:
Rosenke K, Leventhal S, Moulton H, Hatlevig S, Hawman D, Feldmann H, Stein DA. Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers. bioRxiv. 2020;[preprint] doi:10.1101/2020.09.29.319731.

Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics

Authors:
Hildyard JCW, Rawson F, Wells DJ, Piercy RJ
Citation:
PLoS ONE. 2020;15(9):e0239467. doi:10.1371/journal.pone.0239467
Epub:
Not Epub
Abstract:
Dystrophin plays a vital role in maintaining muscle health, yet low mRNA expression, lengthy transcription time and the...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239467
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Hildyard JCW, Rawson F, Wells DJ, Piercy RJ. Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics. PLoS ONE. 2020;15(9):e0239467. doi:10.1371/journal.pone.0239467.

In vivo Pharmacokinetic and Biodistribution profile of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides

Authors:
Burki U, Blain A, Greally E, O’Donovan L, Gait M, Laval S, Straub V
Citation:
Poster at 2015 Oligonucleotide Therapeutics Society meeting
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (AON) induced exon skipping is one of the most promising strategies for treating Duchene muscular...
Link:
https://www.researchgate.net/publication/283047310_In_vivo_Pharmacokinetic_and_Biodistribution_profile_of_Peptide-Conjugated_Phosphorodiamidate_Morpholino_Oligonucleotides [accessed Sep 17 2020]
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Burki U, Blain A, Greally E, O’Donovan L, Gait M, Laval S, Straub V. In vivo Pharmacokinetic and Biodistribution profile of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides. Poster at 2015 Oligonucleotide Therapeutics Society meeting.

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