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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 273 scientific papers returned from the database with the search filters currently being used below.
There are 273 scientific papers returned from the database with the search filters currently being used below.
VP35 Knockdown Inhibits Ebola Virus Amplification and Protects against Lethal Infection in Mice
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Citation:
Antimicrob Agents Chemother. 2006 Mar;50(3):984-93 Epub:
Not Epub Abstract:
Phosphorodiamidate morpholino oligomers (PMO) are a class of uncharged single-stranded DNA analogs modified such that each... Delivery Method:
Peptide-coupled and oligo bathing Organism or Cell Type:
mice and cell culture Citation Extract: Enterlein S, Warfield KL, Swenson DL, Stein DA, Smith JL, Gamble CS, Kroeker AD, Iversen PL, Bavari S, Muhlberger E. VP35 Knockdown Inhibits Ebola Virus Amplification and Protects against Lethal Infection in Mice. Antimicrob Agents Chemother. 2006 Mar;50(3):984-93. |
Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum
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Citation:
Hum Mol Genet. 2011 May 16. [Epub ahead of print] Epub:
Not Epub Abstract:
Antisense morpholino oligonucleotides (AMOs) can reprogram pre-mRNA splicing by complementarily binding to a target site and... Delivery Method:
peptide-coupled Organism or Cell Type:
mice Citation Extract: Du L, Kayali R, Bertoni C, Fike F, Hu H, Iversen PL, Gatti RA. Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum. Hum Mol Genet. 2011 May 16. [Epub ahead of print]. |
Proteomic profiling of antisense-induced exon skipping reveals reversal of pathobiochemical abnormalities in dystrophic mdx diaphragm
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Citation:
Proteomics. 2009 Jan 8. [Epub ahead of print] Epub:
Not Epub Abstract:
The disintegration of the dystrophin-glycoprotein complex represents the initial pathobiochemical insult in Duchenne muscular... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx Citation Extract: Doran P, Wilton SD, Fletcher S, Ohlendieck K. Proteomic profiling of antisense-induced exon skipping reveals reversal of pathobiochemical abnormalities in dystrophic mdx diaphragm. Proteomics. 2009 Jan 8. [Epub ahead of print]. |
Cell-Penetrating Peptides for Antiviral Drug Development
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Citation:
Pharmaceuticals. 2010;3:448-70 Epub:
Not Epub Abstract:
Viral diseases affect hundreds of millions of people worldwide, and the few available drugs to treat these diseases often come... Delivery Method:
peptide-coupled Citation Extract: Delcroix M, Riley LW. Cell-Penetrating Peptides for Antiviral Drug Development. Pharmaceuticals. 2010;3:448-70. |
In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus
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Citation:
Antimicrob Agents Chemother. 2007 Jul;51(7):2470-82. Epub 2007 May 7 Epub:
Not Epub Abstract:
We characterize the in vitro resistance and demonstrate the in vivo efficacy of two antisense phosphorodiamidate-morpholino-... Delivery Method:
peptide-coupled Organism or Cell Type:
Flavivirus in cell culture and mice Citation Extract: Deas TS, Bennett CJ, Jones SA, Tilgner M, Ren P, Behr MJ, Stein DA, Iversen PL, Kramer LD, Bernard KA, Shi PY. In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus. Antimicrob Agents Chemother. 2007 Jul;51(7):2470-82. Epub 2007 May 7. |
Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication
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Citation:
J Virol. 2005 Apr;79(8):4599-609 Epub:
Not Epub Abstract:
RNA elements within flavivirus genomes are potential targets for antiviral therapy. A panel of phosphorodiamidate morpholino... Delivery Method:
peptide-coupled Organism or Cell Type:
West Nile Virus Citation Extract: Deas TS, Binduga-Gajewska I, Tilgner M, Ren P, Stein DA, Moulton HM, Iversen PL, Kauffman EB, Kramer LD, Shi PY. Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication. J Virol. 2005 Apr;79(8):4599-609. |
Diaphragm Rescue Alone Prevents Heart Dysfunction in Dystrophic Mice
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Citation:
Hum. Mol. Genet. 2010; [Epub Nov. 9] doi:10.1093/hmg/ddq477 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is an X-linked recessive disease caused, in most cases, by the complete absence of the 427 kD... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx Citation Extract: Crisp A, Yin HF, Goyenvalle A, Betts C, Moulton HM, Seow Y, Babbs A, Merritt T, Saleh AF, Gait MJ, Stuckey DJ, Clarke K, Davies KE, Wood MJA. Diaphragm Rescue Alone Prevents Heart Dysfunction in Dystrophic Mice. Hum. Mol. Genet. 2010; [Epub Nov. 9] doi:10.1093/hmg/ddq477. |
Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models
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Citation:
J. Virol. 2007 Jun;81(11):5637-48. Epub 2007 Mar 7. Epub:
Not Epub Abstract:
The recent emergence of novel pathogenic human and animal coronaviruses has highlighted the need for antiviral therapies that... Delivery Method:
peptide-coupled Organism or Cell Type:
Mice, C57B16 Citation Extract: Burrer R, Neuman BW, Ting JPC, Stein DA, Moulton HM, Iversen PL, Kuhn P, Buchmeier MJ. Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models. J. Virol. 2007 Jun;81(11):5637-48. Epub 2007 Mar 7.. |
Cell Penetrating Peptide Delivery of Splice Directing Oligonucleotides as a Treatment for Duchenne Muscular Dystrophy
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Citation:
Curr Pharm Des. 2013;19(16):2948-62. doi: 10.2174/1381612811319160009. PMID: 23140454 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy is a severe, X-linked muscle wasting disorder caused by the absence of an integral structural... Delivery Method:
peptide-coupled Citation Extract: Betts CA, Wood MJ. Cell Penetrating Peptide Delivery of Splice Directing Oligonucleotides as a Treatment for Duchenne Muscular Dystrophy. Curr Pharm Des. 2013;19(16):2948-62. doi: 10.2174/1381612811319160009. PMID: 23140454. |
Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2
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Citation:
J Virol. 2011 Feb;85(4):1554-62. doi: 10.1128/JVI.01294-10. Epub 2010 Dec 1. PMID: 21123387; PMCID: PMC3028871 Epub:
Not Epub Abstract:
Influenza A viruses constitute a major and ongoing global public health concern. Current antiviral strategies target viral gene... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: human Calu-3 airway epithelial cells Citation Extract: Böttcher-Friebertshäuser E, Stein DA, Klenk HD, Garten W. Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2. J Virol. 2011 Feb;85(4):1554-62. doi: 10.1128/JVI.01294-10. Epub 2010 Dec 1. PMID: 21123387; PMCID: PMC3028871. |