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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 261 scientific papers returned from the database with the search filters currently being used below.

Proteomic profiling of antisense-induced exon skipping reveals reversal of pathobiochemical abnormalities in dystrophic mdx diaphragm

Authors:
Doran P, Wilton SD, Fletcher S, Ohlendieck K
Citation:
Proteomics. 2009 Jan 8. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The disintegration of the dystrophin-glycoprotein complex represents the initial pathobiochemical insult in Duchenne muscular...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice, mdx
Citation Extract:
Doran P, Wilton SD, Fletcher S, Ohlendieck K. Proteomic profiling of antisense-induced exon skipping reveals reversal of pathobiochemical abnormalities in dystrophic mdx diaphragm. Proteomics. 2009 Jan 8. [Epub ahead of print].

Cell-Penetrating Peptides for Antiviral Drug Development

Authors:
Delcroix M, Riley LW
Citation:
Pharmaceuticals. 2010;3:448-70
Epub:
Not Epub
Abstract:
Viral diseases affect hundreds of millions of people worldwide, and the few available drugs to treat these diseases often come...
Delivery Method:
peptide-coupled
Citation Extract:
Delcroix M, Riley LW. Cell-Penetrating Peptides for Antiviral Drug Development. Pharmaceuticals. 2010;3:448-70.

In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus

Authors:
Deas TS, Bennett CJ, Jones SA, Tilgner M, Ren P, Behr MJ, Stein DA, Iversen PL, Kramer LD, Bernard KA, Shi PY
Citation:
Antimicrob Agents Chemother. 2007 Jul;51(7):2470-82. Epub 2007 May 7
Epub:
Not Epub
Abstract:
We characterize the in vitro resistance and demonstrate the in vivo efficacy of two antisense phosphorodiamidate-morpholino-...
Link:
http://aac.asm.org/content/51/7/2470.long
Delivery Method:
peptide-coupled
Organism or Cell Type:
Flavivirus in cell culture and mice
Citation Extract:
Deas TS, Bennett CJ, Jones SA, Tilgner M, Ren P, Behr MJ, Stein DA, Iversen PL, Kramer LD, Bernard KA, Shi PY. In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus. Antimicrob Agents Chemother. 2007 Jul;51(7):2470-82. Epub 2007 May 7.

Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication

Authors:
Deas TS, Binduga-Gajewska I, Tilgner M, Ren P, Stein DA, Moulton HM, Iversen PL, Kauffman EB, Kramer LD, Shi PY
Citation:
J Virol. 2005 Apr;79(8):4599-609
Epub:
Not Epub
Abstract:
RNA elements within flavivirus genomes are potential targets for antiviral therapy. A panel of phosphorodiamidate morpholino...
Link:
http://jvi.asm.org/content/79/8/4599.long
Delivery Method:
peptide-coupled
Organism or Cell Type:
West Nile Virus
Citation Extract:
Deas TS, Binduga-Gajewska I, Tilgner M, Ren P, Stein DA, Moulton HM, Iversen PL, Kauffman EB, Kramer LD, Shi PY. Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication. J Virol. 2005 Apr;79(8):4599-609.

Diaphragm Rescue Alone Prevents Heart Dysfunction in Dystrophic Mice

Authors:
Crisp A, Yin HF, Goyenvalle A, Betts C, Moulton HM, Seow Y, Babbs A, Merritt T, Saleh AF, Gait MJ, Stuckey DJ, Clarke K, Davies KE, Wood MJA
Citation:
Hum. Mol. Genet. 2010; [Epub Nov. 9] doi:10.1093/hmg/ddq477
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is an X-linked recessive disease caused, in most cases, by the complete absence of the 427 kD...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice, mdx
Citation Extract:
Crisp A, Yin HF, Goyenvalle A, Betts C, Moulton HM, Seow Y, Babbs A, Merritt T, Saleh AF, Gait MJ, Stuckey DJ, Clarke K, Davies KE, Wood MJA. Diaphragm Rescue Alone Prevents Heart Dysfunction in Dystrophic Mice. Hum. Mol. Genet. 2010; [Epub Nov. 9] doi:10.1093/hmg/ddq477.

Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models

Authors:
Burrer R, Neuman BW, Ting JPC, Stein DA, Moulton HM, Iversen PL, Kuhn P, Buchmeier MJ
Citation:
J. Virol. 2007 Jun;81(11):5637-48. Epub 2007 Mar 7.
Epub:
Not Epub
Abstract:
The recent emergence of novel pathogenic human and animal coronaviruses has highlighted the need for antiviral therapies that...
Link:
https://jvi.asm.org/content/81/11/5637
Delivery Method:
peptide-coupled
Organism or Cell Type:
Mice, C57B16
Citation Extract:
Burrer R, Neuman BW, Ting JPC, Stein DA, Moulton HM, Iversen PL, Kuhn P, Buchmeier MJ. Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models. J. Virol. 2007 Jun;81(11):5637-48. Epub 2007 Mar 7..

Cell Penetrating Peptide Delivery of Splice Directing Oligonucleotides as a Treatment for Duchenne Muscular Dystrophy

Authors:
Betts CA, Wood MJ
Citation:
Curr Pharm Des. 2012 Nov 2. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy is a severe, X-linked muscle wasting disorder caused by the absence of an integral structural...
Delivery Method:
peptide-coupled
Citation Extract:
Betts CA, Wood MJ. Cell Penetrating Peptide Delivery of Splice Directing Oligonucleotides as a Treatment for Duchenne Muscular Dystrophy. Curr Pharm Des. 2012 Nov 2. [Epub ahead of print].

Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin activating protease TMPRSS2

Authors:
Böttcher-Friebertshäuser E, Stein DA, Klenk HD, Garten W
Citation:
J Virol. 2010 Dec 1. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Influenza A viruses constitute a major and ongoing global public health concern. Current antiviral strategies target viral gene...
Link:
http://jvi.asm.org/content/85/4/1554.long
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: human Calu-3 airway epithelial cells
Citation Extract:
Böttcher-Friebertshäuser E, Stein DA, Klenk HD, Garten W. Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin activating protease TMPRSS2. J Virol. 2010 Dec 1. [Epub ahead of print].

Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome

Authors:
Bok K, Cavanaugh VJ, Matson DO, González-Molleda L, Chang KO, Zintz C, Smith AW, Iversen P, Green KY, Campbell AE
Citation:
Virology. 2008 Oct 25;380(2):328-37. doi: 10.1016/j.virol.2008.08.007. Epub 2008 Sep 9.
Epub:
Not Epub
Abstract:
Noroviruses are an important cause of non-bacterial epidemic gastroenteritis, but no specific antiviral therapies are available...
Link:
http://www.sciencedirect.com/science/article/pii/S0042682208005199
Delivery Method:
peptide-coupled
Organism or Cell Type:
virus: norovirus
Citation Extract:
Bok K, Cavanaugh VJ, Matson DO, González-Molleda L, Chang KO, Zintz C, Smith AW, Iversen P, Green KY, Campbell AE. Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome. Virology. 2008 Oct 25;380(2):328-37. doi: 10.1016/j.virol.2008.08.007. Epub 2008 Sep 9. .

Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment

Authors:
Betts C, Saleh A, Arzumanov A, Hammond S, Godfrey C, Coursindel T, Gait M, Wood M
Citation:
Mol Ther Nucleic Acids. 2012;[Epub ahead of print] http://dx.doi.org/10.1038/mtna.2012.30
Epub:
Not Epub
Abstract:
Antisense oligonucleotides (AOs) are currently the most promising therapeutic intervention for Duchenne muscular dystrophy (DMD...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice (mdx), cultured mdx myotubes
Citation Extract:
Betts C, Saleh A, Arzumanov A, Hammond S, Godfrey C, Coursindel T, Gait M, Wood M. Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment. Mol Ther Nucleic Acids. 2012;[Epub ahead of print] http://dx.doi.org/10.1038/mtna.2012.30.

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