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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 273 scientific papers returned from the database with the search filters currently being used below.

Inhibition of gene expression in Escherichia coli by antisense phosphorodiamidate morpholino oligomers.

Authors:
Geller BL, Deere JD, Stein DA, Kroeker AD, Moulton HM, Iversen PL.
Citation:
Antimicrob Agents Chemother. 2003 Oct;47(10):3233-9.
Epub:
Not Epub
Abstract:
Antisense phosphorodiamidate morpholino oligomers (PMOs) were tested for the ability to inhibit gene expression in Escherichia...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Escherichia coli
Citation Extract:
Geller BL, Deere JD, Stein DA, Kroeker AD, Moulton HM, Iversen PL.. Inhibition of gene expression in Escherichia coli by antisense phosphorodiamidate morpholino oligomers.. Antimicrob Agents Chemother. 2003 Oct;47(10):3233-9..

Inhibition of Multiple Subtypes of Influenza A Virus in Cell Cultures with Morpholino Oligomers

Authors:
Ge Q, Pastey M, Kobasa D, Puthavathana P, Lupfer C, Bestwick RK, Iversen PL, Chen J, Stein DA
Citation:
Antimicrob Agents Chemother. 2006 Nov;50(11):3724-33. Epub 2006 Sep 11
Epub:
Not Epub
Abstract:
Peptide conjugated phosphorodiamidate morpholino oligomers (P-PMO) are single-stranded-nucleic-acid-like antisense agents that...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture
Citation Extract:
Ge Q, Pastey M, Kobasa D, Puthavathana P, Lupfer C, Bestwick RK, Iversen PL, Chen J, Stein DA. Inhibition of Multiple Subtypes of Influenza A Virus in Cell Cultures with Morpholino Oligomers. Antimicrob Agents Chemother. 2006 Nov;50(11):3724-33. Epub 2006 Sep 11.

Morpholino oligomers targeting the PB1 and NP genes enhance the survival of mice infected with highly pathogenic influenza A H7N7 virus

Authors:
Gabriel G, Nordmann A, Stein DA, Iversen PL, Klenk HD
Citation:
J Gen Virol. 2008 Apr;89(Pt 4):939-48
Epub:
Not Epub
Abstract:
Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMO) are single-stranded nucleic acid-analogue antisense agents...
Link:
http://jgv.sgmjournals.org/content/journal/jgv/10.1099/vir.0.83449-0
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice and cell cultures: MDCK
Citation Extract:
Gabriel G, Nordmann A, Stein DA, Iversen PL, Klenk HD. Morpholino oligomers targeting the PB1 and NP genes enhance the survival of mice infected with highly pathogenic influenza A H7N7 virus. J Gen Virol. 2008 Apr;89(Pt 4):939-48.

Antisense suppression of donor splice site mutations in the dystrophin gene transcript

Authors:
Fletcher S, Meloni PL, Johnsen RD, Wong BL, Muntoni F, Wilton SD
Citation:
Mol Genet Genomic Med. 2013 Sep;1(3):162-73. doi: 10.1002/mgg3.19. Epub 2013 Jun 13. PMID: 24498612; PMCID: PMC3865583
Epub:
Not Epub
Abstract:
We describe two donor splice site mutations, affecting dystrophin exons 16 and 45 that led to Duchenne muscular dystrophy (DMD...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3865583/
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: human primary fibroblasts and myogenic cells (subsequently differentiated)
Citation Extract:
Fletcher S, Meloni PL, Johnsen RD, Wong BL, Muntoni F, Wilton SD. Antisense suppression of donor splice site mutations in the dystrophin gene transcript. Mol Genet Genomic Med. 2013 Sep;1(3):162-73. doi: 10.1002/mgg3.19. Epub 2013 Jun 13. PMID: 24498612; PMCID: PMC3865583.

Dystrophin expression in the mdx mouse after localised and systemic administration of a morpholino antisense oligonucleotide

Authors:
Fletcher S, Honeyman K, Fall AM, Harding PL, Johnsen RD, Wilton SD
Citation:
J Gene Med. 2006 Feb;8(2):207-16.
Epub:
Not Epub
Abstract:
BACKGROUND: Duchenne and Becker muscular dystrophies are allelic disorders arising from mutations in the dystrophin gene....
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice
Citation Extract:
Fletcher S, Honeyman K, Fall AM, Harding PL, Johnsen RD, Wilton SD. Dystrophin expression in the mdx mouse after localised and systemic administration of a morpholino antisense oligonucleotide. J Gene Med. 2006 Feb;8(2):207-16..

Dystrophin Isoform Induction In Vivo by Antisense-mediated Alternative Splicing

Authors:
Fletcher S, Adams AM, Johnsen RD, Greer K, Moulton HM, Wilton SD
Citation:
Mol Ther. 2010 Mar 23. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Antisense oligomer-induced manipulation of dystrophin pre-mRNA processing can remove exons carrying mutations, or exclude...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice
Citation Extract:
Fletcher S, Adams AM, Johnsen RD, Greer K, Moulton HM, Wilton SD. Dystrophin Isoform Induction In Vivo by Antisense-mediated Alternative Splicing. Mol Ther. 2010 Mar 23. [Epub ahead of print].

Mismatched single stranded antisense oligonucleotides can induce efficient dystrophin splice switching

Authors:
Fragall CT, Adams AM, Johnsen RD, Kole R, Fletcher S, Wilton SD
Citation:
BMC Med Genet. 2011 Oct 20;12(1):141. [Epub ahead of print]
Epub:
Not Epub
Abstract:
BACKGROUND: Antisense oligomer induced exon skipping aims to reduce the severity of Duchenne muscular dystrophy by redirecting...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: human myoblasts from fibroblasts
Citation Extract:
Fragall CT, Adams AM, Johnsen RD, Kole R, Fletcher S, Wilton SD. Mismatched single stranded antisense oligonucleotides can induce efficient dystrophin splice switching. BMC Med Genet. 2011 Oct 20;12(1):141. [Epub ahead of print].

Morpholino Oligomer-Mediated Exon Skipping Averts the Onset of Dystrophic Pathology in the mdx Mouse

Authors:
Fletcher S, Honeyman K, Fall AM, Harding PL, Johnsen RD, Steinhaus JP, Moulton HM, Iversen PL, Wilton SD
Citation:
Mol Ther. 2007 Sep;15(9):1587-92. Epub 2007 Jun 19.
Epub:
Not Epub
Abstract:
Duchenne and Becker muscular dystrophies are allelic disorders arising from mutations in the dystrophin gene. Duchenne muscular...
Delivery Method:
peptide-coupled
Organism or Cell Type:
MDX mice
Citation Extract:
Fletcher S, Honeyman K, Fall AM, Harding PL, Johnsen RD, Steinhaus JP, Moulton HM, Iversen PL, Wilton SD. Morpholino Oligomer-Mediated Exon Skipping Averts the Onset of Dystrophic Pathology in the mdx Mouse. Mol Ther. 2007 Sep;15(9):1587-92. Epub 2007 Jun 19..

Targeted Exon Skipping to Address \"Leaky\" Mutations in the Dystrophin Gene

Authors:
Fletcher S, Adkin CF, Meloni P, Wong B, Muntoni F, Kole R, Fragall C, Greer K, Johnsen R, Wilton SD
Citation:
Mol Ther Nucleic Acids. 2012;1:e48 doi:/10.1038/mtna.2012.40
Epub:
Not Epub
Abstract:
Protein-truncating mutations in the dystrophin gene lead to the progressive muscle wasting disorder Duchenne muscular dystrophy...
Delivery Method:
peptide-coupled in mice, elecytroporation in cell culture
Organism or Cell Type:
mice
Citation Extract:
Fletcher S, Adkin CF, Meloni P, Wong B, Muntoni F, Kole R, Fragall C, Greer K, Johnsen R, Wilton SD. Targeted Exon Skipping to Address \"Leaky\" Mutations in the Dystrophin Gene. Mol Ther Nucleic Acids. 2012;1:e48 doi:/10.1038/mtna.2012.40.

Reduction of herpes simplex virus type-2 replication in cell cultures and in rodent models with peptide-conjugated morpholino oligomers

Authors:
Eide K, Moerdyk-Schauwecker M, Stein DA, Bildfell R, Koelle DM, Jin L
Citation:
Antivir Ther. 2010;15(8):1141-1149
Epub:
Not Epub
Abstract:
BACKGROUND: Genital herpes, caused by herpes simplex virus type-2 (HSV-2), is a recurrent, lifelong disease affecting tens of...
Link:
http://www.intmedpress.com/serveFile.cfm?sUID=2c4e07a8-613a-4c97-891f-2141f142b495
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell cultures, mice, rats
Citation Extract:
Eide K, Moerdyk-Schauwecker M, Stein DA, Bildfell R, Koelle DM, Jin L. Reduction of herpes simplex virus type-2 replication in cell cultures and in rodent models with peptide-conjugated morpholino oligomers. Antivir Ther. 2010;15(8):1141-1149.

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