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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 273 scientific papers returned from the database with the search filters currently being used below.
There are 273 scientific papers returned from the database with the search filters currently being used below.
Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity
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Citation:
J Virol. 2009 Mar;83(5):2298-309. doi: 10.1128/JVI.01245-08. Epub 2008 Dec 24. PMID: 19109397; PMCID: PMC2643707 Epub:
Not Epub Abstract:
In this study, infection of 293/ACE2 cells with SARS-CoV activated several apoptosis-associated events, namely, cleavage of... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: 293/ACE2 Citation Extract: Krähling V, Stein DA, Spiegel M, Weber F, Mühlberger E. Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity. J Virol. 2009 Mar;83(5):2298-309. doi: 10.1128/JVI.01245-08. Epub 2008 Dec 24. PMID: 19109397; PMCID: PMC2643707. |
Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers
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Citation:
J Virol. 2005 Apr;79(8):5116-28 Epub:
Not Epub Abstract:
Five dengue (DEN) virus-specific R(5)F(2)R(4) peptide-conjugated phosphorodiamidate morpholino oligomers (P4-PMOs) were... Delivery Method:
peptide-coupled Organism or Cell Type:
Dengue virus Citation Extract: Kinney RM, Huang CY, Rose BC, Kroeker AD, Dreher TW, Iversen PL, Stein DA. Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers. J Virol. 2005 Apr;79(8):5116-28. |
Long-Term Improvement in mdx Cardiomyopathy after Therapy with Peptide-conjugated Morpholino Oligomers
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Citation:
Cardiovasc Res. 2010 Feb 1;85(3):444-53. doi: 10.1093/cvr/cvp335. Epub 2009 Oct 8. Epub:
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AIMS: The cardiomyopathy found in Duchenne muscular dystrophy (DMD) is responsible for death due to heart failure in... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx Citation Extract: Jearawiriyapaisarn N, Moulton HM, Sazani P, Kole R, Willis MS. Long-Term Improvement in mdx Cardiomyopathy after Therapy with Peptide-conjugated Morpholino Oligomers. Cardiovasc Res. 2010 Feb 1;85(3):444-53. doi: 10.1093/cvr/cvp335. Epub 2009 Oct 8.. |
Sustained Dystrophin Expression Induced by Peptide-conjugated Morpholino Oligomers in the Muscles of mdx Mice
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Citation:
Mol Ther. 2008 Sep;16(9):1624-9. Epub 2008 Jun 10 Epub:
Not Epub Abstract:
Cell-penetrating peptides (CPPs), containing arginine (R), 6-aminohexanoic acid (X), and/or beta-alanine (B) conjugated to... Delivery Method:
peptide-coupled Organism or Cell Type:
MDX mice Citation Extract: Jearawiriyapaisarn N, Moulton HM, Buckley B, Roberts J, Sazani P, Fucharoen S, Iversen PL, Kole R. Sustained Dystrophin Expression Induced by Peptide-conjugated Morpholino Oligomers in the Muscles of mdx Mice. Mol Ther. 2008 Sep;16(9):1624-9. Epub 2008 Jun 10. |
Efficacy of a Phosphorodiamidate Morpholino Oligomer Antisense Compound in the Inhibition of Corneal Transplant Rejection in a Rat Cornea Transplant Model
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Citation:
J Ocul Pharmacol Ther. 2011;[Epub ahead of print] doi:10.1089/jop.2011.0135 Epub:
Not Epub Abstract:
Purpose: The cornea is one of the most commonly transplanted tissues. The morpholino-oligomer antisense compound AVI-5126... Delivery Method:
peptide-coupled Organism or Cell Type:
Rat cornea explants Citation Extract: Hosseini A, Lattanzio Jr. FA, Samudre SS, DiSandro G, Sheppard Jr. JD, Williams PB. Efficacy of a Phosphorodiamidate Morpholino Oligomer Antisense Compound in the Inhibition of Corneal Transplant Rejection in a Rat Cornea Transplant Model. J Ocul Pharmacol Ther. 2011;[Epub ahead of print] doi:10.1089/jop.2011.0135. |
Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3' stem-loop structure
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Citation:
Virology. 2006 Jan 20;344(2):439-52. Epub 2005 Oct 7. Epub:
Not Epub Abstract:
Dengue virus (DEN) is a major public health problem worldwide and causes a spectrum of diseases, for which no antiviral... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: BHK cells Citation Extract: Holden KL, Stein DA, Pierson TC, Ahmed AA, Clyde K, Iversen PL, Harris E. Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3' stem-loop structure. Virology. 2006 Jan 20;344(2):439-52. Epub 2005 Oct 7.. |
Molecular biology of flaviviruses
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Citation:
Novartis Found Symp. 2006;277:23-39; discussion 40, 71-3, 251-3 Epub:
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Flaviviruses are enveloped viruses with a single-stranded, 10.7kb positive-sense RNA genome. The genomic RNA, which has a 5... Delivery Method:
peptide-coupled Citation Extract: Harris E, Holden KL, Edgil D, Polacek C, Clyde K. Molecular biology of flaviviruses. Novartis Found Symp. 2006;277:23-39; discussion 40, 71-3, 251-3. |
Antisense Phosphorodiamidate Morpholino Oligomers Targeted to an Essential Gene Inhibit Burkholderia cepacia Complex
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Citation:
J Infect Dis. 2010 May 3. [Epub ahead of print] Epub:
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Background. Members of the Burkholderia cepacia complex (Bcc) cause considerable morbidity and mortality in patients with... Delivery Method:
peptide-coupled Organism or Cell Type:
Bacteria: Burkholderia Citation Extract: Greenberg DE, Marshall-Batty KR, Brinster LR, Zarember KA, Shaw PA, Mellbye BL, Iversen PL, Holland SM, Geller BL. Antisense Phosphorodiamidate Morpholino Oligomers Targeted to an Essential Gene Inhibit Burkholderia cepacia Complex. J Infect Dis. 2010 May 3. [Epub ahead of print]. |
Prevention of Dystrophic Pathology in Severely Affected Dystrophin/Utrophin-deficient Mice by Morpholino-oligomer-mediated Exon-skipping
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Citation:
Mol Ther. 2009 Oct 20. [Epub ahead of print] Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder caused by mutations in the dystrophin gene that result in... Delivery Method:
peptide-coupled Organism or Cell Type:
mice: dystrophin & utrophin dKO Citation Extract: Goyenvalle A, Babbs A, Powell D, Kole R, Fletcher S, Wilton SD, Davies KE. Prevention of Dystrophic Pathology in Severely Affected Dystrophin/Utrophin-deficient Mice by Morpholino-oligomer-mediated Exon-skipping. Mol Ther. 2009 Oct 20. [Epub ahead of print]. |
Antibacterial antisense
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Citation:
Curr Opin Mol Ther 2005 7(2):109-13 Epub:
Not Epub Abstract:
No abstract available. Delivery Method:
peptide-coupled Organism or Cell Type:
Escherichia coli Citation Extract: Geller BL. Antibacterial antisense. Curr Opin Mol Ther 2005 7(2):109-13. |