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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 273 scientific papers returned from the database with the search filters currently being used below.
There are 273 scientific papers returned from the database with the search filters currently being used below.
Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing
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Citation:
J Immunol Methods. 2007 Aug 31;325(1-2):114-26. Epub 2007 Jul 27 Epub:
Not Epub Abstract:
Phosphorodiamidate morpholino oligomers (PMO) are synthetic antisense molecules that interfere with translation, pre-mRNA... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: mouse primary leukocytes Citation Extract: Marshall NB, Oda SK, London CA, Moulton HM, Iversen PL, Kerkvliet NI, Mourich DV. Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing. J Immunol Methods. 2007 Aug 31;325(1-2):114-26. Epub 2007 Jul 27. |
Five-Step Process for Screening Antisense Compounds for Efficacy: Gene Target IL-12Rb2
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Citation:
Methods in Molecular Biology. 2011;764:153-68 10.1007/978-1-61779-188-8_10 Epub:
Not Epub Abstract:
Antisense technologies are widely used for the inhibition of gene expression. Although traditionally the AUG start codon of the... Delivery Method:
peptide-coupled Citation Extract: Marshall NB, Hauck LL, Mourich DV. Five-Step Process for Screening Antisense Compounds for Efficacy: Gene Target IL-12Rb2. Methods in Molecular Biology. 2011;764:153-68 10.1007/978-1-61779-188-8_10. |
Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of Duchenne Muscular Dystrophy
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Citation:
Mol Ther Nucleic Acids. 2012;1:e62. doi:/10.1038/mtna.2012.54 Epub:
Not Epub Abstract:
The knockdown of myostatin, a negative regulator of skeletal muscle mass may have important implications in disease conditions... Delivery Method:
Vivo-Morpholino oligos and peptide coupled oligos Organism or Cell Type:
mice, mdx and normal Citation Extract: Malerba A, Kang JK, McClorey G, Saleh AF, Popplewell L, Gait MJ, Wood MJA, Dickson G. Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of Duchenne Muscular Dystrophy. Mol Ther Nucleic Acids. 2012;1:e62. doi:/10.1038/mtna.2012.54. |
Inhibition of influenza A H3N8 virus infections in mice by morpholino oligomers
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Citation:
Arch Virol. 2008 May;153(5):929-37. Epub 2008 Mar 28 Epub:
Not Epub Abstract:
New methods to combat influenza A virus (FLUAV) in humans and animals are needed. The H3N8 subtype virus was the cause of the... Delivery Method:
Peptide-coupled intranasal Organism or Cell Type:
mice Citation Extract: Lupfer C, Stein DA, Mourich DV, Tepper SE, Iversen PL, Pastey M. Inhibition of influenza A H3N8 virus infections in mice by morpholino oligomers. Arch Virol. 2008 May;153(5):929-37. Epub 2008 Mar 28. |
Inhibition of p53 expression by peptide-conjugated phosphorodiamidate morpholino oligomers sensitizes human cancer cells to chemotherapeutic drugs
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Citation:
Oncogene. 2011 [Epub ahead of print 18 July] doi: 10.1038/onc.2011.300 Epub:
Not Epub Abstract:
The p53 tumor suppressor gene encodes a transcription factor that is commonly mutated in cancer. Tumors arise when premalignant... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: H460 Citation Extract: Ma W, Lin Y, Xuan W, Iversen PL, Smith LJ, Benchimol S. Inhibition of p53 expression by peptide-conjugated phosphorodiamidate morpholino oligomers sensitizes human cancer cells to chemotherapeutic drugs. Oncogene. 2011 [Epub ahead of print 18 July] doi: 10.1038/onc.2011.300. |
A nanoparticle for tumor targeted delivery of oligomers
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Citation:
Methods Mol Biol. 2011;764:91-105. doi: 10.1007/978-1-61779-188-8_6 Epub:
Not Epub Abstract:
The tissue-specific delivery nanoparticle consists of an antisense oligomer, a cell-penetrating peptide, and an antitumor... Delivery Method:
Nanoparticle-peptide complex Citation Extract: Liu X, Wang Y, Hnatowich DJ. A nanoparticle for tumor targeted delivery of oligomers. Methods Mol Biol. 2011;764:91-105. doi: 10.1007/978-1-61779-188-8_6. |
Systemic Delivery of a Peptide-Linked Morpholino Oligonucleotide Neutralizes Mutant RNA Toxicity in a Mouse Model of Myotonic Dystrophy
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Citation:
Nucleic Acid Ther. 2013 Jan 11. [Epub ahead of print] Epub:
Not Epub Abstract:
Expansions of CUG trinucleotide sequences in RNA transcripts provide the basis for toxic RNA gain-of-function that leads to... Delivery Method:
peptide-coupled Organism or Cell Type:
mouse HSA(LR) Citation Extract: Leger AJ, Mosquea LM, Clayton NP, Wu IH, Weeden T, Nelson CA, Phillips L, Roberts E, Piepenhagen PA, Cheng SH, Wentworth BM. Systemic Delivery of a Peptide-Linked Morpholino Oligonucleotide Neutralizes Mutant RNA Toxicity in a Mouse Model of Myotonic Dystrophy. Nucleic Acid Ther. 2013 Jan 11. [Epub ahead of print]. |
Cell penetrating peptide conjugates of steric block oligonucleotides
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Citation:
Adv Drug Deliv Rev. 2008 Mar 1;60(4-5):517-29. Epub 2007 Oct 22. Epub:
Not Epub Abstract:
Charge neutral steric block oligonucleotide analogues, such as peptide nucleic acids (PNA) or phosphorodiamidate morpholino... Delivery Method:
peptide-coupled Organism or Cell Type:
various Citation Extract: Lebleu B, Moulton HM, Abes R, Ivanova GD, Abes S, Stein DA, Iversen PL, Arzumanov AA, Gait MJ. Cell penetrating peptide conjugates of steric block oligonucleotides. Adv Drug Deliv Rev. 2008 Mar 1;60(4-5):517-29. Epub 2007 Oct 22.. |
Inhibition of Respiratory Syncytial Virus Infections With Morpholino Oligomers in Cell Cultures and in Mice
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Citation:
Mol Ther. 2008 Jun;16(6):1120-8. doi: 10.1038/mt.2008.81. Epub 2008 Apr 29. PMID: 18443602; PMCID: PMC2782410 Epub:
Not Epub Abstract:
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in infants, young children, and high-... Delivery Method:
Peptide-coupled intranasal Organism or Cell Type:
mice and cell culture Citation Extract: Lai SH, Stein DA, Guerrero-Plata A, Liao SL, Ivanciuc T, Hong C, Iversen PL, Casola A, Garofalo RP. Inhibition of Respiratory Syncytial Virus Infections With Morpholino Oligomers in Cell Cultures and in Mice. Mol Ther. 2008 Jun;16(6):1120-8. doi: 10.1038/mt.2008.81. Epub 2008 Apr 29. PMID: 18443602; PMCID: PMC2782410. |
Molecular target validation, antimicrobial delivery, and potential treatment of Toxoplasma gondii infections
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Citation:
PNAS. 2012;[Epub ahead of print] doi:10.1073/pnas.1208775109 Epub:
Not Epub Abstract:
Toxoplasma gondii persistently infects over two billion people worldwide. It can cause substantial morbidity and mortality.... Delivery Method:
peptide-coupled and Vivo-Morpholino Organism or Cell Type:
Toxoplasma gondii Citation Extract: Lai BS, Witola WH, El Bissati KE, Zhou Y, Mui E, Fomovska A, McLeod R. Molecular target validation, antimicrobial delivery, and potential treatment of Toxoplasma gondii infections. PNAS. 2012;[Epub ahead of print] doi:10.1073/pnas.1208775109. |