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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 273 scientific papers returned from the database with the search filters currently being used below.

Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides

Authors:
Moulton HM, Nelson MH, Hatlevig SA, Reddy MT, Iversen PL
Citation:
Bioconjug Chem. 2004 Mar-Apr;15(2):290-9
Epub:
Not Epub
Abstract:
Although the sequence specificity, biostability, and low toxicity of PMO (phosphorodiamidate morpholino oligomers) make them...
Link:
https://pubs.acs.org/doi/abs/10.1021/bc034221g
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: HeLa pLuc705 and NIH-3T3 cells
Citation Extract:
Moulton HM, Nelson MH, Hatlevig SA, Reddy MT, Iversen PL. Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides. Bioconjug Chem. 2004 Mar-Apr;15(2):290-9.

Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function

Authors:
Morse MA, Hobeika A, Serra D, Aird K, McKinney M, Aldrich A, Clay T, Mourich D, Lyerly HK, Iversen PL, Devi GR
Citation:
Cancer Gene Ther. 2011 Oct 14. doi: 10.1038/cgt.2011.63. [Epub ahead of print]
Epub:
Not Epub
Abstract:
CD4+CD25+regulatory T cells (T(reg)) impair anti-tumor and anti-viral immunity. As there are higher T(reg) levels in cancer...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: CD4+CD25+regulatory T cells (Treg)
Citation Extract:
Morse MA, Hobeika A, Serra D, Aird K, McKinney M, Aldrich A, Clay T, Mourich D, Lyerly HK, Iversen PL, Devi GR. Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function. Cancer Gene Ther. 2011 Oct 14. doi: 10.1038/cgt.2011.63. [Epub ahead of print].

HIV Tat peptide enhances cellular delivery of antisense morpholino oligomers

Authors:
Moulton HM, Hase MC, Smith KM, Iversen PL
Citation:
Antisense Nucleic Acid Drug Dev. 2003 Feb;13(1):31-43
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligomers (PMO) are uncharged antisense molecules that bind complementary sequences of RNA,...
Link:
http://online.liebertpub.com/doi/abs/10.1089/108729003764097322
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: various Hela
Citation Extract:
Moulton HM, Hase MC, Smith KM, Iversen PL. HIV Tat peptide enhances cellular delivery of antisense morpholino oligomers. Antisense Nucleic Acid Drug Dev. 2003 Feb;13(1):31-43.

In Vivo Delivery of Morpholino Oligos by Cell-Penetrating Peptides

Authors:
Moulton HM
Citation:
Curr Pharm Des. 2013;19(16):2963-9
Epub:
Not Epub
Abstract:
Morpholino oligos (Morpholinos) are widely used tools for knocking down gene expression and are currently in a clinical trial...
Link:
http://www.ingentaconnect.com/content/ben/cpd/2013/00000019/00000016/art00010
Delivery Method:
peptide-coupled
Citation Extract:
Moulton HM. In Vivo Delivery of Morpholino Oligos by Cell-Penetrating Peptides. Curr Pharm Des. 2013;19(16):2963-9.

Inhibition of HSV-1 ocular infection with morpholino oligomers targeting ICP0 and ICP27

Authors:
Moerdyk-Schauwecker M, Stein DA, Eide K, Blouch RE, Bildfell R, Iversen P, Jin L
Citation:
Antiviral Res. 2009 Nov;84(2):131-41. Epub 2009 Aug 7.
Epub:
Not Epub
Abstract:
Alternative therapies are needed for HSV-1 infections in patients refractory to treatment with Acyclovir (ACV) and its...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: Rabbit skin (RS) cells, Vero cells
Citation Extract:
Moerdyk-Schauwecker M, Stein DA, Eide K, Blouch RE, Bildfell R, Iversen P, Jin L. Inhibition of HSV-1 ocular infection with morpholino oligomers targeting ICP0 and ICP27. Antiviral Res. 2009 Nov;84(2):131-41. Epub 2009 Aug 7..

Inhibition of Intracellular Growth of Salmonella enterica serovar typhimurium in Tissue Culture by Antisense Peptide-Phosphorodiamidate Morpholino Oligomer

Authors:
Mitev GM, Mellbye BL, Iversen PL, Geller BL
Citation:
Antimicrob Agents Chemother. 2009 Jul 6. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Two types of phosphorodiamidate morpholino oligomers (PMOs) were tested for inhibition of growth of Salmonella enterica serovar...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Salmonella enterica serovar typhimurium & infected macrophages
Citation Extract:
Mitev GM, Mellbye BL, Iversen PL, Geller BL. Inhibition of Intracellular Growth of Salmonella enterica serovar typhimurium in Tissue Culture by Antisense Peptide-Phosphorodiamidate Morpholino Oligomer. Antimicrob Agents Chemother. 2009 Jul 6. [Epub ahead of print].

Morpholinos and Their Peptide Conjugates: Therapeutic Promise and Challenge for Duchenne Muscular Dystrophy

Authors:
Moulton HM, Moulton JD
Citation:
Biochim Biophys Acta. 2010;1798(12):2296-2303
Epub:
Not Epub
Abstract:
Exon-skipping efficacy of phosphodiamidate morpholino oligomers (PMOs) or the conjugates of PMOs with cell-penetrating peptides...
Link:
http://www.sciencedirect.com/science/article/pii/S0005273610000520
Delivery Method:
peptide-coupled versus bare oligo, injected
Organism or Cell Type:
mouse, monkey, dog
Citation Extract:
Moulton HM, Moulton JD. Morpholinos and Their Peptide Conjugates: Therapeutic Promise and Challenge for Duchenne Muscular Dystrophy. Biochim Biophys Acta. 2010;1798(12):2296-2303 .

Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD

Authors:
McClorey G, Moulton HM, Iversen PL, Fletcher S, Wilton SD
Citation:
Gene Ther. 2006 Oct;13(19):1373-81. Epub 2006 May 25
Epub:
Not Epub
Abstract:
Manipulation of pre-mRNA splicing by antisense oligonucleotides (AOs) offers considerable potential for a number of genetic...
Delivery Method:
Bathing primary cell culture, with and without peptide conjugates
Organism or Cell Type:
cell culture: primary myoblasts, golden retreiver DMD model
Citation Extract:
McClorey G, Moulton HM, Iversen PL, Fletcher S, Wilton SD. Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD. Gene Ther. 2006 Oct;13(19):1373-81. Epub 2006 May 25.

Induced dystrophin exon skipping in human muscle explants

Authors:
McClorey G, Fall AM, Moulton HM, Iversen PL, Rasko JE, Ryan M, Fletcher S, Wilton SD
Citation:
Neuromuscul Disord. 2006 Oct;16(9-10):583-90. Epub 2006 Aug 21
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (AO) manipulation of pre-mRNA splicing of the dystrophin gene is showing promise in overcoming...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S096089660600174X
Delivery Method:
peptide-coupled
Organism or Cell Type:
muscle explants, mouse and human
Citation Extract:
McClorey G, Fall AM, Moulton HM, Iversen PL, Rasko JE, Ryan M, Fletcher S, Wilton SD. Induced dystrophin exon skipping in human muscle explants. Neuromuscul Disord. 2006 Oct;16(9-10):583-90. Epub 2006 Aug 21.

Variations in Amino Acid Composition of Antisense Peptide-Phosphorodiamidate Morpholino Oligomer Affect Potency Against Escherichia coli in vitro and in vivo

Authors:
Mellbye BL, Puckett SE, Tilley LD, Iversen PL, Geller BL
Citation:
Antimicrob Agents Chemother. 2009 Feb;53(2):525-30. Epub 2008 Nov 17.
Epub:
Not Epub
Abstract:
The potency of antisense peptide-phosphorodiamidate morpholino oligomers (PPMO) was improved by varying peptide composition. An...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Escherichia coli
Citation Extract:
Mellbye BL, Puckett SE, Tilley LD, Iversen PL, Geller BL. Variations in Amino Acid Composition of Antisense Peptide-Phosphorodiamidate Morpholino Oligomer Affect Potency Against Escherichia coli in vitro and in vivo. Antimicrob Agents Chemother. 2009 Feb;53(2):525-30. Epub 2008 Nov 17..

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