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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 273 scientific papers returned from the database with the search filters currently being used below.

BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly

Authors:
Zhou Y, Li T, Zhang Y, Zhang N, Guo Y, Gao X, Peng W, Shu S, Zhao C, Cui D, Sun H, Sun Y, Liu J, Tang J, Zhang R, Pu J
Citation:
PLoS Pathog. 2024 Mar 18;20(3):e1012110. doi: 10.1371/journal.ppat.1012110. PMID: 38498560; PMCID: PMC10977894
Epub:
Not Epub
Abstract:
The interaction between influenza A virus (IAV) and host proteins is an important process that greatly influences viral...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10977894/
Delivery Method:
intranasal peptide-linked
Organism or Cell Type:
BALB/c mice
Citation Extract:
Zhou Y, Li T, Zhang Y, Zhang N, Guo Y, Gao X, Peng W, Shu S, Zhao C, Cui D, Sun H, Sun Y, Liu J, Tang J, Zhang R, Pu J. BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly. PLoS Pathog. 2024 Mar 18;20(3):e1012110. doi: 10.1371/journal.ppat.1012110. PMID: 38498560; PMCID: PMC10977894.

A comparative analysis of peptide-delivered antisense antibiotics employing diverse nucleotide mimics

Authors:
Ghosh C, Popella L, Dhamodharan V, Jung J, Dietzsch J, Barquist L, Höbartner C, Vogel J
Citation:
RNA. 2024 Feb 27:rna.079969.124. doi: 10.1261/rna.079969.124. Online ahead of print
Epub:
Not Epub
Abstract:
Antisense oligomer (ASO)-based antibiotics that target mRNAs of essential bacterial genes have great potential for...
Link:
https://rnajournal.cshlp.org/content/early/2024/02/27/rna.079969.124.long
Delivery Method:
peptide-linked
Organism or Cell Type:
Salmonella
Citation Extract:
Ghosh C, Popella L, Dhamodharan V, Jung J, Dietzsch J, Barquist L, Höbartner C, Vogel J. A comparative analysis of peptide-delivered antisense antibiotics employing diverse nucleotide mimics. RNA. 2024 Feb 27:rna.079969.124. doi: 10.1261/rna.079969.124. Online ahead of print.

An alternative strategy to increasing influenza virus replication for vaccine production in chicken embryo fibroblast (DF-1) cells by inhibiting interferon alpha and beta using peptide-conjugated phosphorodiamidate morpholino oligomers

Authors:
Prescott MA, Moulton H, Pastey MK
Citation:
J Med Microbiol. 2024 Feb;73(2). doi: 10.1099/jmm.0.001807
Epub:
Not Epub
Abstract:
Introduction. Influenza is a global health issue causing substantial health and economic burdens on affected populations....
Link:
https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.001807
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: DF-1 chick embryo fibroblasts
Citation Extract:
Prescott MA, Moulton H, Pastey MK. An alternative strategy to increasing influenza virus replication for vaccine production in chicken embryo fibroblast (DF-1) cells by inhibiting interferon alpha and beta using peptide-conjugated phosphorodiamidate morpholino oligomers. J Med Microbiol. 2024 Feb;73(2). doi: 10.1099/jmm.0.001807.

mCherry on Top: A Positive Read-Out Cellular Platform for Screening DMD Exon Skipping Xenopeptide-PMO Conjugates

Authors:
Lessl AL, Pöhmerer J, Lin Y, Wilk U, Höhn M, Hörterer E, Wagner E, Lächelt U
Citation:
Bioconjug Chem. 2023 Nov 22. doi: 10.1021/acs.bioconjchem.3c00408. Online ahead of print
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligomers (PMOs) are a special type of antisense oligonucleotides (ASOs) that can be used as...
Link:
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.3c00408
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: HeLa; mice
Citation Extract:
Lessl AL, Pöhmerer J, Lin Y, Wilk U, Höhn M, Hörterer E, Wagner E, Lächelt U. mCherry on Top: A Positive Read-Out Cellular Platform for Screening DMD Exon Skipping Xenopeptide-PMO Conjugates. Bioconjug Chem. 2023 Nov 22. doi: 10.1021/acs.bioconjchem.3c00408. Online ahead of print.

Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer

Authors:
Yu S, Liao R, Bai L, Guo M, Zhang Y, Zhang Y, Yang Q, Song Y, Li Z, Meng Q, Wang S, Huang X
Citation:
Drug Deliv Transl Res. 2024 May;14(5):1352-1369. doi: 10.1007/s13346-023-01469-7. Epub 2023 Nov 17. PMID: 37978163; PMCID: PMC10984892.
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (ASO) is a novel therapeutic platform for targeted cancer therapy. Previously, we have demonstrated...
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10984892/
Delivery Method:
peptide-linked, exosome
Organism or Cell Type:
cell culture: SW620, xenograft mice
Citation Extract:
Yu S, Liao R, Bai L, Guo M, Zhang Y, Zhang Y, Yang Q, Song Y, Li Z, Meng Q, Wang S, Huang X . Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer. Drug Deliv Transl Res. 2024 May;14(5):1352-1369. doi: 10.1007/s13346-023-01469-7. Epub 2023 Nov 17. PMID: 37978163; PMCID: PMC10984892..

Electrical impedance myography detects dystrophin-related muscle changes in mdx mice

Authors:
Hiyoshi T, Zhao F, Baba R, Hirakawa T, Kuboki R, Suzuki K, Tomimatsu Y, O'Donnell P, Han S, Zach N, Nakashima M
Citation:
Skelet Muscle. 2023 Nov 18;13(1):19. doi: 10.1186/s13395-023-00331-1
Epub:
Not Epub
Abstract:
Background: The lack of functional dystrophin protein in Duchenne muscular dystrophy (DMD) causes chronic skeletal muscle...
Link:
https://skeletalmusclejournal.biomedcentral.com/articles/10.1186/s13395-023-00331-1
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Hiyoshi T, Zhao F, Baba R, Hirakawa T, Kuboki R, Suzuki K, Tomimatsu Y, O'Donnell P, Han S, Zach N, Nakashima M. Electrical impedance myography detects dystrophin-related muscle changes in mdx mice. Skelet Muscle. 2023 Nov 18;13(1):19. doi: 10.1186/s13395-023-00331-1.

Targeting the Expanded TCF4/Fuchs’ Endothelial Corneal Dystrophy CUG Repeat with Morpholino Peptide Conjugates

Authors:
Hu J, Shen X, Kheirabadi M, Streeter MD, Qian Z, Mootha VV, Corey DR
Citation:
ACS Omega. 2023;[Epub] doi:10.1021/acsomega.3c05634
Epub:
Yes
Abstract:
Fuchs’ corneal endothelial dystrophy (FECD) is a major cause of vision loss. Corneal transplantation is the only effective...
Link:
https://pubs.acs.org/doi/10.1021/acsomega.3c05634
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: FECD patient-derived F35T corneal endothelial cells
Citation Extract:
Hu J, Shen X, Kheirabadi M, Streeter MD, Qian Z, Mootha VV, Corey DR. Targeting the Expanded TCF4/Fuchs’ Endothelial Corneal Dystrophy CUG Repeat with Morpholino Peptide Conjugates. ACS Omega. 2023;[Epub] doi:10.1021/acsomega.3c05634.

An Induced Pluripotent Stem Cell-Derived Human Blood-Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides

Authors:
Selvakumaran J, Ursu S, Bowerman M, Lu-Nguyen N, Wood MJ, Malerba A, Yáñez-Muñoz RJ
Citation:
Biomedicines. 2023 Oct 4;11(10):2700. doi: 10.3390/biomedicines11102700
Epub:
Not Epub
Abstract:
The blood-brain barrier (BBB) is the specialised microvasculature system that shields the central nervous system (CNS) from...
Link:
https://www.mdpi.com/2227-9059/11/10/2700
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: induced brain microvascular endothelial cells (BMECs)
Citation Extract:
Selvakumaran J, Ursu S, Bowerman M, Lu-Nguyen N, Wood MJ, Malerba A, Yáñez-Muñoz RJ. An Induced Pluripotent Stem Cell-Derived Human Blood-Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides. Biomedicines. 2023 Oct 4;11(10):2700. doi: 10.3390/biomedicines11102700.

P23 Evaluation of safety parameters and dystrophin expression by sequential administration of exon-skipping and gene therapy in a DMDmdx mouse model

Authors:
Potter R, Cooper Olson GC, Smith L, Greve J, Haile A, Wier C, Snedeker J, Burch P, Hunter B, Malmberg A, Rodino-Klapac L
Citation:
Neuromuscul Disord. 2023;33(Supp 1):S102-3. doi:10.1016/j.nmd.2023.07.150
Epub:
Not Epub
Abstract:
There are promising treatment approaches emerging for Duchenne muscular dystrophy (DMD): exon skipping with peptide-conjugated...
Link:
https://www.nmd-journal.com/article/S0960-8966(23)00330-9/pdf
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Potter R, Cooper Olson GC, Smith L, Greve J, Haile A, Wier C, Snedeker J, Burch P, Hunter B, Malmberg A, Rodino-Klapac L. P23 Evaluation of safety parameters and dystrophin expression by sequential administration of exon-skipping and gene therapy in a DMDmdx mouse model. Neuromuscul Disord. 2023;33(Supp 1):S102-3. doi:10.1016/j.nmd.2023.07.150.

Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression

Authors:
González-Martínez I, Cerro-Herreros E, Moreno N, García-Rey A, Espinosa-Espinosa J, Carrascosa-Sàez M, Piqueras-Losilla D, Arzumanov A, Seoane-Miraz D, Jad Y, Raz R, Wood MJ, Varela MA, Llamusí B, Artero R
Citation:
Mol Ther Nucleic Acids. 2023 Sep 5;34:102024. doi: 10.1016/j.omtn.2023.09.001. eCollection 2023 Dec 12
Epub:
Not Epub
Abstract:
Myotonic dystrophy type 1 (DM1) is a rare neuromuscular disease caused by a CTG repeat expansion in the DMPK gene that...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00237-8
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: DM1, mice
Citation Extract:
González-Martínez I, Cerro-Herreros E, Moreno N, García-Rey A, Espinosa-Espinosa J, Carrascosa-Sàez M, Piqueras-Losilla D, Arzumanov A, Seoane-Miraz D, Jad Y, Raz R, Wood MJ, Varela MA, Llamusí B, Artero R. Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression. Mol Ther Nucleic Acids. 2023 Sep 5;34:102024. doi: 10.1016/j.omtn.2023.09.001. eCollection 2023 Dec 12.

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