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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 273 scientific papers returned from the database with the search filters currently being used below.

Inhibition of foot-and-mouth disease virus in cell cultures with antisense Morpholino oligomers

Authors:
Vagnozzi A, Stein DA, Iversen PL, Rieder E
Citation:
J Virol. 2007 Nov;81(21):11669-80. Epub 2007 Aug 29.
Epub:
Not Epub
Abstract:
Foot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed ungulates that can lead to severe losses in...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Foot-and-mouth disease (FMD) virus
Citation Extract:
Vagnozzi A, Stein DA, Iversen PL, Rieder E. Inhibition of foot-and-mouth disease virus in cell cultures with antisense Morpholino oligomers. J Virol. 2007 Nov;81(21):11669-80. Epub 2007 Aug 29..

Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli

Authors:
Tilley LD, Mellbye BL, Puckett SE, Iversen PL, Geller BL
Citation:
J Antimicrob Chemother. 2007 Jan;59(1):66-73. Epub 2006 Oct 31.
Epub:
Not Epub
Abstract:
OBJECTIVES: Phosphorodiamidate morpholino oligomers (PMOs) are DNA analogues that inhibit translation by an antisense mechanism...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Escherichia coli
Citation Extract:
Tilley LD, Mellbye BL, Puckett SE, Iversen PL, Geller BL. Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli. J Antimicrob Chemother. 2007 Jan;59(1):66-73. Epub 2006 Oct 31..

Gene-Specific Effects of Antisense Phosphorodiamidate Morpholino Oligomer-Peptide Conjugates on Escherichia coli and Salmonella enterica Serovar Typhimurium in Pure Culture and in Tissue Culture

Authors:
Tilley LD, Hine OS, Kellogg JA, Hassinger JN, Weller DD, Iversen PL, Geller BL
Citation:
Antimicrob Agents Chemother. 2006 Aug;50(8):2789-96
Epub:
Not Epub
Abstract:
The objective was to improve efficacy of antisense phosphorodiamidate morpholino oligomers (PMOs) by improving their uptake...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Escherichia coli, Salmonella enterica serovar typhimurium
Citation Extract:
Tilley LD, Hine OS, Kellogg JA, Hassinger JN, Weller DD, Iversen PL, Geller BL. Gene-Specific Effects of Antisense Phosphorodiamidate Morpholino Oligomer-Peptide Conjugates on Escherichia coli and Salmonella enterica Serovar Typhimurium in Pure Culture and in Tissue Culture. Antimicrob Agents Chemother. 2006 Aug;50(8):2789-96.

A morpholino oligomer targeting highly conserved internal ribosome entry site sequence is able to inhibit multiple species of picornavirus

Authors:
Stone JK, Rijnbrand R, Stein DA, Ma Y, Yang Y, Iversen PL, Andino R
Citation:
Antimicrob Agents Chemother. 2008 Jun;52(6):1970-81. Epub 2008 Mar 17.
Epub:
Not Epub
Abstract:
Members of the genera Enterovirus and Rhinovirus (family Picornaviridae) cause a wide range of human diseases. An established...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice, cell cultures
Citation Extract:
Stone JK, Rijnbrand R, Stein DA, Ma Y, Yang Y, Iversen PL, Andino R. A morpholino oligomer targeting highly conserved internal ribosome entry site sequence is able to inhibit multiple species of picornavirus. Antimicrob Agents Chemother. 2008 Jun;52(6):1970-81. Epub 2008 Mar 17..

Inhibition of RNA virus infections with peptide-conjugated morpholino oligomers

Authors:
Stein DA
Citation:
Curr Pharm Des. 2008;14(25):2619-34
Epub:
Not Epub
Abstract:
RNA virus infections cause immense human disease burdens globally, and few effective antiviral drugs are available for their...
Delivery Method:
peptide-coupled
Citation Extract:
Stein DA. Inhibition of RNA virus infections with peptide-conjugated morpholino oligomers. Curr Pharm Des. 2008;14(25):2619-34.

RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice

Authors:
Svasti S, Suwanmanee T, Fucharoen S, Moulton HM, Nelson MH, Maeda N, Smithies O, Kole R
Citation:
Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1205-10. Epub 2009 Jan 21
Epub:
Not Epub
Abstract:
Repair of beta-globin pre-mRNA rendered defective by a thalassemia-causing splicing mutation, IVS2-654, in intron 2 of the...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mouse: IVS2-654
Citation Extract:
Svasti S, Suwanmanee T, Fucharoen S, Moulton HM, Nelson MH, Maeda N, Smithies O, Kole R. RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1205-10. Epub 2009 Jan 21.

Inhibition of measles virus infections in cell cultures by peptide-conjugated morpholino oligomers

Authors:
Sleeman K, Stein DA, Tamin A, Reddish M, Iversen PL, Rota PA
Citation:
Virus Res. 2009 Mar;140(1-2):49-56. doi: 10.1016/j.virusres.2008.10.018. Epub 2009 Jan 6
Epub:
Not Epub
Abstract:
Measles virus (MeV) is a highly contagious human pathogen. Despite the success of measles vaccination programs, measles is...
Link:
http://www.sciencedirect.com/science/article/pii/S0168170208003894
Delivery Method:
peptide-coupled
Organism or Cell Type:
Measles virus in cultured cells
Citation Extract:
Sleeman K, Stein DA, Tamin A, Reddish M, Iversen PL, Rota PA. Inhibition of measles virus infections in cell cultures by peptide-conjugated morpholino oligomers. Virus Res. 2009 Mar;140(1-2):49-56. doi: 10.1016/j.virusres.2008.10.018. Epub 2009 Jan 6.

Inactivation of expression of several genes in a variety of bacterial species by EGS technology

Authors:
Shen N, Ko JH, Xiao G, Wesolowski D, Shan G, Geller B, Izadjoo M, Altman S
Citation:
Proc Natl Acad Sci U S A. 2009 Apr 30. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The expression of gene products in bacteria can be inhibited by the use of RNA external guide sequences (EGSs) that hybridize...
Link:
http://www.pnas.org/content/106/20/8163.long
Delivery Method:
peptide-coupled
Organism or Cell Type:
Bacteria: Escherichia, Enterococcus, Bacillus,
Citation Extract:
Shen N, Ko JH, Xiao G, Wesolowski D, Shan G, Geller B, Izadjoo M, Altman S. Inactivation of expression of several genes in a variety of bacterial species by EGS technology. Proc Natl Acad Sci U S A. 2009 Apr 30. [Epub ahead of print].

Development of a general methodology for labelling peptide-morpholino oligonucleotide conjugates using alkyne-azide click chemistry

Authors:
Shabanpoor F, Gait MJ
Citation:
Chem Commun (Camb). 2013 Nov 11;49(87):10260-2. doi: 10.1039/c3cc46067c
Epub:
Not Epub
Abstract:
We describe a general methodology for fluorescent labelling of peptide conjugates of phosphorodiamidate morpholino...
Link:
http://pubs.rsc.org/en/Content/ArticleLanding/2013/CC/C3CC46067C#!divAbstract
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: mouse H2K/mdx myoblasts
Citation Extract:
Shabanpoor F, Gait MJ. Development of a general methodology for labelling peptide-morpholino oligonucleotide conjugates using alkyne-azide click chemistry. Chem Commun (Camb). 2013 Nov 11;49(87):10260-2. doi: 10.1039/c3cc46067c.

Lymphocytic Choriomeningitis Virus Infection in FVB Mouse Produces Hemorrhagic Disease

Authors:
Schnell FJ, Sundholm S, Crumley S, Iversen PL, Mourich DV
Citation:
PLoS Pathog. 2012;8(12):e1003073. doi:10.1371/journal.ppat.1003073
Epub:
Not Epub
Abstract:
The viral family Arenaviridae includes a number of viruses that can cause hemorrhagic fever in humans. Arenavirus infection...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice
Citation Extract:
Schnell FJ, Sundholm S, Crumley S, Iversen PL, Mourich DV. Lymphocytic Choriomeningitis Virus Infection in FVB Mouse Produces Hemorrhagic Disease. PLoS Pathog. 2012;8(12):e1003073. doi:10.1371/journal.ppat.1003073.

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