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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 273 scientific papers returned from the database with the search filters currently being used below.

CPP-Directed Oligonucleotide Exon Skipping in Animal Models of Duchenne Muscular Dystrophy

Authors:
Yin H, Moulton H, Betts C, Wood M
Citation:
Methods Mol Biol. 2011;683:321-38
Epub:
Not Epub
Abstract:
Antisense oligonucleotides (AOs) are effective splice switching agents and have potential as therapeutics via the exclusion or...
Delivery Method:
peptide-coupled
Citation Extract:
Yin H, Moulton H, Betts C, Wood M. CPP-Directed Oligonucleotide Exon Skipping in Animal Models of Duchenne Muscular Dystrophy. Methods Mol Biol. 2011;683:321-38.

Stability of cell-penetrating Peptide-morpholino oligomer conjugates in human serum and in cells

Authors:
Youngblood DS, Hatlevig SA, Hassinger JN, Iversen PL, Moulton HM
Citation:
Bioconjug Chem. 2007 Jan-Feb;18(1):50-60
Epub:
Not Epub
Abstract:
Cell penetrating peptides (CPPs) have been shown to enhance the cellular uptake of antisense oligonucleotides (AOs). However,...
Link:
http://pubs.acs.org/doi/abs/10.1021/bc060138s
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: HeLa cells
Citation Extract:
Youngblood DS, Hatlevig SA, Hassinger JN, Iversen PL, Moulton HM. Stability of cell-penetrating Peptide-morpholino oligomer conjugates in human serum and in cells. Bioconjug Chem. 2007 Jan-Feb;18(1):50-60.

Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity

Authors:
Wu RP, Youngblood DS, Hassinger JN, Lovejoy CE, Nelson MH, Iversen PL, Moulton HM
Citation:
Nucleic Acids Res. 2007;35(15):5182-91. Epub 2007 Aug 1
Epub:
Not Epub
Abstract:
Arginine-rich cell-penetrating peptides (CPPs) are promising transporters for intracellular delivery of antisense morpholino...
Link:
https://academic.oup.com/nar/article/35/15/5182/1074443
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: HeLa pLuc705 Antisense Test System
Citation Extract:
Wu RP, Youngblood DS, Hassinger JN, Lovejoy CE, Nelson MH, Iversen PL, Moulton HM. Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity. Nucleic Acids Res. 2007;35(15):5182-91. Epub 2007 Aug 1.

Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer

Authors:
Wu B, Moulton HM, Iversen PL, Jiang J, Li J, Li J, Spurney CF, Sali A, Guerron AD, Nagaraju K, Doran T, Lu P, Xiao X, Lu QL
Citation:
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14814-9. doi: 10.1073/pnas.0805676105. Epub 2008 Sep 19.
Epub:
Not Epub
Abstract:
Antisense oligonucleotide-mediated exon skipping is able to correct out-of-frame mutations in Duchenne muscular dystrophy and...
Link:
http://www.pnas.org/content/105/39/14814.long
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice, mdx
Citation Extract:
Wu B, Moulton HM, Iversen PL, Jiang J, Li J, Li J, Spurney CF, Sali A, Guerron AD, Nagaraju K, Doran T, Lu P, Xiao X, Lu QL. Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14814-9. doi: 10.1073/pnas.0805676105. Epub 2008 Sep 19..

Long-Term Rescue of Dystrophin Expression and Improvement in Muscle Pathology and Function in Dystrophic mdx Mice by Peptide-Conjugated Morpholino

Authors:
Wu B, Lu P, Cloer C, Shaban M, Grewal S, Milazi S, Shah SN, Moulton HM, Lu QL
Citation:
Am J Pathol. 2012 Aug;181(2):392-400. doi: 10.1016/j.ajpath.2012.04.006. Epub 2012 Jun 7.
Epub:
Not Epub
Abstract:
Exon skipping is capable of correcting frameshift and nonsense mutations in Duchenne muscular dystrophy (DMD). Phase 2 clinical...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice, mdx
Citation Extract:
Wu B, Lu P, Cloer C, Shaban M, Grewal S, Milazi S, Shah SN, Moulton HM, Lu QL. Long-Term Rescue of Dystrophin Expression and Improvement in Muscle Pathology and Function in Dystrophic mdx Mice by Peptide-Conjugated Morpholino. Am J Pathol. 2012 Aug;181(2):392-400. doi: 10.1016/j.ajpath.2012.04.006. Epub 2012 Jun 7..

Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes

Authors:
Wesolowski D, Tae HS, Gandotra N, Llopis P, Shen N, Altman S
Citation:
PNAS. 2011;108(40):16582-7 doi:10.1073/pnas.1112561108
Epub:
Not Epub
Abstract:
Basic peptides covalently linked to nucleic acids, or chemically modified nucleic acids, enable the insertion of such a...
Link:
http://www.pnas.org/content/108/40/16582.long
Delivery Method:
peptide-coupled
Organism or Cell Type:
Bacteria, various
Citation Extract:
Wesolowski D, Tae HS, Gandotra N, Llopis P, Shen N, Altman S. Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes. PNAS. 2011;108(40):16582-7 doi:10.1073/pnas.1112561108.

Combined effect of a peptide-morpholino oligonucleotide conjugate and a cell-penetrating peptide as an antibiotic

Authors:
Wesolowski D, Alonso D, Altman S
Citation:
PNAS. 2013 May 21;110(21):8686-9. doi: 10.1073/pnas.1306911110. Epub 2013 May 6
Epub:
Not Epub
Abstract:
A cell-penetrating peptide (CPP)–morpholino oligonucleotide (MO) conjugate (PMO) that has an antibiotic effect in culture had...
Link:
https://www.pnas.org/content/110/21/8686.long
Delivery Method:
peptide-coupled
Organism or Cell Type:
Bacteria, various
Citation Extract:
Wesolowski D, Alonso D, Altman S. Combined effect of a peptide-morpholino oligonucleotide conjugate and a cell-penetrating peptide as an antibiotic. PNAS. 2013 May 21;110(21):8686-9. doi: 10.1073/pnas.1306911110. Epub 2013 May 6.

In Vivo Delivery of Antisense MORF Oligomer by MORF/Carrier Streptavidin Nanoparticles

Authors:
Wang Y, Liu X, Nakamura K, Chen L, Rusckowski M, Hnatowich DJ
Citation:
Cancer Biother Radiopharm. 2009 Oct;24(5):573-8. doi: 10.1089/cbr.2009.0624
Epub:
Not Epub
Abstract:
Abstract Tumor targeting by oligomers is largely limited by the pharmacokinetics and cell-membrane transport obstacles. In this...
Link:
http://online.liebertpub.com/doi/abs/10.1089/cbr.2009.0624
Delivery Method:
Nanoparticle-peptide complex
Organism or Cell Type:
mice
Citation Extract:
Wang Y, Liu X, Nakamura K, Chen L, Rusckowski M, Hnatowich DJ. In Vivo Delivery of Antisense MORF Oligomer by MORF/Carrier Streptavidin Nanoparticles. Cancer Biother Radiopharm. 2009 Oct;24(5):573-8. doi: 10.1089/cbr.2009.0624.

In vitro evaluation of novel antisense oligonucleotides is predictive of in vivo exon skipping activity for Duchenne muscular dystrophy

Authors:
Wang Q, Yin H, Camelliti P, Betts C, Moulton H, Lee H, Saleh AF, Gait MJ, Wood MJ
Citation:
J Gene Med. 2010 Mar 16. [Epub ahead of print]
Epub:
Not Epub
Abstract:
BACKGROUND: Targeted splice modulation of pre-mRNA transcripts by antisense oligonucleotides (AOs) can correct the function of...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mdk mice, H2K mdx cells
Citation Extract:
Wang Q, Yin H, Camelliti P, Betts C, Moulton H, Lee H, Saleh AF, Gait MJ, Wood MJ. In vitro evaluation of novel antisense oligonucleotides is predictive of in vivo exon skipping activity for Duchenne muscular dystrophy. J Gene Med. 2010 Mar 16. [Epub ahead of print].

Antiviral activity of morpholino oligomers designed to block various aspects of Equine arteritis virus amplification in cell culture

Authors:
van den Born E, Stein DA, Iversen PL, Snijder EJ
Citation:
J Gen Virol. 2005 Nov;86(Pt 11):3081-90
Epub:
Not Epub
Abstract:
The antiviral efficacy of ten antisense phosphorodiamidate morpholino oligomers (PMOs) directed against Equine arteritis virus...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: Vero-E6 cells
Citation Extract:
van den Born E, Stein DA, Iversen PL, Snijder EJ. Antiviral activity of morpholino oligomers designed to block various aspects of Equine arteritis virus amplification in cell culture. J Gen Virol. 2005 Nov;86(Pt 11):3081-90.

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