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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 261 scientific papers returned from the database with the search filters currently being used below.
There are 261 scientific papers returned from the database with the search filters currently being used below.
Gene-Specific Effects of Antisense Phosphorodiamidate Morpholino Oligomer-Peptide Conjugates on Escherichia coli and Salmonella enterica Serovar Typhimurium in Pure Culture and in Tissue Culture
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Citation:
Antimicrob Agents Chemother. 2006 Aug;50(8):2789-96 Epub:
Not Epub Abstract:
The objective was to improve efficacy of antisense phosphorodiamidate morpholino oligomers (PMOs) by improving their uptake... Delivery Method:
peptide-coupled Organism or Cell Type:
Escherichia coli, Salmonella enterica serovar typhimurium Citation Extract: Tilley LD, Hine OS, Kellogg JA, Hassinger JN, Weller DD, Iversen PL, Geller BL. Gene-Specific Effects of Antisense Phosphorodiamidate Morpholino Oligomer-Peptide Conjugates on Escherichia coli and Salmonella enterica Serovar Typhimurium in Pure Culture and in Tissue Culture. Antimicrob Agents Chemother. 2006 Aug;50(8):2789-96. |
A morpholino oligomer targeting highly conserved internal ribosome entry site sequence is able to inhibit multiple species of picornavirus
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Citation:
Antimicrob Agents Chemother. 2008 Jun;52(6):1970-81. Epub 2008 Mar 17. Epub:
Not Epub Abstract:
Members of the genera Enterovirus and Rhinovirus (family Picornaviridae) cause a wide range of human diseases. An established... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, cell cultures Citation Extract: Stone JK, Rijnbrand R, Stein DA, Ma Y, Yang Y, Iversen PL, Andino R. A morpholino oligomer targeting highly conserved internal ribosome entry site sequence is able to inhibit multiple species of picornavirus. Antimicrob Agents Chemother. 2008 Jun;52(6):1970-81. Epub 2008 Mar 17.. |
Inhibition of RNA virus infections with peptide-conjugated morpholino oligomers
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Citation:
Curr Pharm Des. 2008;14(25):2619-34 Epub:
Not Epub Abstract:
RNA virus infections cause immense human disease burdens globally, and few effective antiviral drugs are available for their... Delivery Method:
peptide-coupled Citation Extract: Stein DA. Inhibition of RNA virus infections with peptide-conjugated morpholino oligomers. Curr Pharm Des. 2008;14(25):2619-34. |
RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice
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Citation:
Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1205-10. Epub 2009 Jan 21 Epub:
Not Epub Abstract:
Repair of beta-globin pre-mRNA rendered defective by a thalassemia-causing splicing mutation, IVS2-654, in intron 2 of the... Delivery Method:
peptide-coupled Organism or Cell Type:
mouse: IVS2-654 Citation Extract: Svasti S, Suwanmanee T, Fucharoen S, Moulton HM, Nelson MH, Maeda N, Smithies O, Kole R. RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1205-10. Epub 2009 Jan 21. |
Inhibition of measles virus infections in cell cultures by peptide-conjugated morpholino oligomers
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Citation:
Virus Res. 2009 Mar;140(1-2):49-56. doi: 10.1016/j.virusres.2008.10.018. Epub 2009 Jan 6 Epub:
Not Epub Abstract:
Measles virus (MeV) is a highly contagious human pathogen. Despite the success of measles vaccination programs, measles is... Delivery Method:
peptide-coupled Organism or Cell Type:
Measles virus in cultured cells Citation Extract: Sleeman K, Stein DA, Tamin A, Reddish M, Iversen PL, Rota PA. Inhibition of measles virus infections in cell cultures by peptide-conjugated morpholino oligomers. Virus Res. 2009 Mar;140(1-2):49-56. doi: 10.1016/j.virusres.2008.10.018. Epub 2009 Jan 6. |
Inactivation of expression of several genes in a variety of bacterial species by EGS technology
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Citation:
Proc Natl Acad Sci U S A. 2009 Apr 30. [Epub ahead of print] Epub:
Not Epub Abstract:
The expression of gene products in bacteria can be inhibited by the use of RNA external guide sequences (EGSs) that hybridize... Delivery Method:
peptide-coupled Organism or Cell Type:
Bacteria: Escherichia, Enterococcus, Bacillus, Citation Extract: Shen N, Ko JH, Xiao G, Wesolowski D, Shan G, Geller B, Izadjoo M, Altman S. Inactivation of expression of several genes in a variety of bacterial species by EGS technology. Proc Natl Acad Sci U S A. 2009 Apr 30. [Epub ahead of print]. |
Development of a general methodology for labelling peptide-morpholino oligonucleotide conjugates using alkyne-azide click chemistry
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Citation:
Chem Commun (Camb). 2013 Nov 11;49(87):10260-2. doi: 10.1039/c3cc46067c Epub:
Not Epub Abstract:
We describe a general methodology for fluorescent labelling of peptide conjugates of phosphorodiamidate morpholino... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: mouse H2K/mdx myoblasts Citation Extract: Shabanpoor F, Gait MJ. Development of a general methodology for labelling peptide-morpholino oligonucleotide conjugates using alkyne-azide click chemistry. Chem Commun (Camb). 2013 Nov 11;49(87):10260-2. doi: 10.1039/c3cc46067c. |
Lymphocytic Choriomeningitis Virus Infection in FVB Mouse Produces Hemorrhagic Disease
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Citation:
PLoS Pathog. 2012;8(12):e1003073. doi:10.1371/journal.ppat.1003073 Epub:
Not Epub Abstract:
The viral family Arenaviridae includes a number of viruses that can cause hemorrhagic fever in humans. Arenavirus infection... Delivery Method:
peptide-coupled Organism or Cell Type:
mice Citation Extract: Schnell FJ, Sundholm S, Crumley S, Iversen PL, Mourich DV. Lymphocytic Choriomeningitis Virus Infection in FVB Mouse Produces Hemorrhagic Disease. PLoS Pathog. 2012;8(12):e1003073. doi:10.1371/journal.ppat.1003073. |
A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model
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Citation:
Int J Pharmaceutics. 2013;[Epub ahead of print] doi:10.1016/j.ijpharm.2013.05.041 Epub:
Not Epub Abstract:
Management of skin wound infections presents a serious problem in the clinic, in the community, and in both civilian and... Delivery Method:
peptide-coupled Organism or Cell Type:
Bacteria: Staphylococcus aureus in mouse Citation Extract: Sawyer AJ, Wesolowski D, Gandotra N, Stojadinovic A, Izadjoo M, Altman S, Kyriakides TR. A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model. Int J Pharmaceutics. 2013;[Epub ahead of print] doi:10.1016/j.ijpharm.2013.05.041. |
Endosomolysis by Masking of a Membrane-Active Agent (EMMA) for Cytoplasmic Release of Macromolecules
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Citation:
Bioconjug Chem. 2003 Jan-Feb;14(1):51 Epub:
Not Epub Abstract:
Endosomolysis, a critical barrier to efficient delivery of macromolecules such as nucleic acids, has been breached using a... Delivery Method:
peptide-based Organism or Cell Type:
cell culture: HeLa AntisenseTest System Citation Extract: Rozema DB, Ekena K, Lewis DL, Loomis AG, Wolff JA. Endosomolysis by Masking of a Membrane-Active Agent (EMMA) for Cytoplasmic Release of Macromolecules. Bioconjug Chem. 2003 Jan-Feb;14(1):51. |