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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 261 scientific papers returned from the database with the search filters currently being used below.
There are 261 scientific papers returned from the database with the search filters currently being used below.
Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity
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Citation:
Nucleic Acids Res. 2007;35(15):5182-91. Epub 2007 Aug 1 Epub:
Not Epub Abstract:
Arginine-rich cell-penetrating peptides (CPPs) are promising transporters for intracellular delivery of antisense morpholino... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: HeLa pLuc705 Antisense Test System Citation Extract: Wu RP, Youngblood DS, Hassinger JN, Lovejoy CE, Nelson MH, Iversen PL, Moulton HM. Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity. Nucleic Acids Res. 2007;35(15):5182-91. Epub 2007 Aug 1. |
Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer
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Citation:
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14814-9. doi: 10.1073/pnas.0805676105. Epub 2008 Sep 19. Epub:
Not Epub Abstract:
Antisense oligonucleotide-mediated exon skipping is able to correct out-of-frame mutations in Duchenne muscular dystrophy and... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx Citation Extract: Wu B, Moulton HM, Iversen PL, Jiang J, Li J, Li J, Spurney CF, Sali A, Guerron AD, Nagaraju K, Doran T, Lu P, Xiao X, Lu QL. Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14814-9. doi: 10.1073/pnas.0805676105. Epub 2008 Sep 19.. |
Long-Term Rescue of Dystrophin Expression and Improvement in Muscle Pathology and Function in Dystrophic mdx Mice by Peptide-Conjugated Morpholino
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Citation:
Am J Pathol. 2012 Aug;181(2):392-400. doi: 10.1016/j.ajpath.2012.04.006. Epub 2012 Jun 7. Epub:
Not Epub Abstract:
Exon skipping is capable of correcting frameshift and nonsense mutations in Duchenne muscular dystrophy (DMD). Phase 2 clinical... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx Citation Extract: Wu B, Lu P, Cloer C, Shaban M, Grewal S, Milazi S, Shah SN, Moulton HM, Lu QL. Long-Term Rescue of Dystrophin Expression and Improvement in Muscle Pathology and Function in Dystrophic mdx Mice by Peptide-Conjugated Morpholino. Am J Pathol. 2012 Aug;181(2):392-400. doi: 10.1016/j.ajpath.2012.04.006. Epub 2012 Jun 7.. |
Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes
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Citation:
PNAS. 2011;108(40):16582-7 doi:10.1073/pnas.1112561108 Epub:
Not Epub Abstract:
Basic peptides covalently linked to nucleic acids, or chemically modified nucleic acids, enable the insertion of such a... Delivery Method:
peptide-coupled Organism or Cell Type:
Bacteria, various Citation Extract: Wesolowski D, Tae HS, Gandotra N, Llopis P, Shen N, Altman S. Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes. PNAS. 2011;108(40):16582-7 doi:10.1073/pnas.1112561108. |
Combined effect of a peptide-morpholino oligonucleotide conjugate and a cell-penetrating peptide as an antibiotic
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Citation:
PNAS. 2013 May 21;110(21):8686-9. doi: 10.1073/pnas.1306911110. Epub 2013 May 6 Epub:
Not Epub Abstract:
A cell-penetrating peptide (CPP)–morpholino oligonucleotide (MO) conjugate (PMO) that has an antibiotic effect in culture had... Delivery Method:
peptide-coupled Organism or Cell Type:
Bacteria, various Citation Extract: Wesolowski D, Alonso D, Altman S. Combined effect of a peptide-morpholino oligonucleotide conjugate and a cell-penetrating peptide as an antibiotic. PNAS. 2013 May 21;110(21):8686-9. doi: 10.1073/pnas.1306911110. Epub 2013 May 6. |
In Vivo Delivery of Antisense MORF Oligomer by MORF/Carrier Streptavidin Nanoparticles
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Citation:
Cancer Biother Radiopharm. 2009 Oct;24(5):573-8. doi: 10.1089/cbr.2009.0624 Epub:
Not Epub Abstract:
Abstract Tumor targeting by oligomers is largely limited by the pharmacokinetics and cell-membrane transport obstacles. In this... Delivery Method:
Nanoparticle-peptide complex Organism or Cell Type:
mice Citation Extract: Wang Y, Liu X, Nakamura K, Chen L, Rusckowski M, Hnatowich DJ. In Vivo Delivery of Antisense MORF Oligomer by MORF/Carrier Streptavidin Nanoparticles. Cancer Biother Radiopharm. 2009 Oct;24(5):573-8. doi: 10.1089/cbr.2009.0624. |
In vitro evaluation of novel antisense oligonucleotides is predictive of in vivo exon skipping activity for Duchenne muscular dystrophy
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Citation:
J Gene Med. 2010 Mar 16. [Epub ahead of print] Epub:
Not Epub Abstract:
BACKGROUND: Targeted splice modulation of pre-mRNA transcripts by antisense oligonucleotides (AOs) can correct the function of... Delivery Method:
peptide-coupled Organism or Cell Type:
mdk mice, H2K mdx cells Citation Extract: Wang Q, Yin H, Camelliti P, Betts C, Moulton H, Lee H, Saleh AF, Gait MJ, Wood MJ. In vitro evaluation of novel antisense oligonucleotides is predictive of in vivo exon skipping activity for Duchenne muscular dystrophy. J Gene Med. 2010 Mar 16. [Epub ahead of print]. |
Antiviral activity of morpholino oligomers designed to block various aspects of Equine arteritis virus amplification in cell culture
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Citation:
J Gen Virol. 2005 Nov;86(Pt 11):3081-90 Epub:
Not Epub Abstract:
The antiviral efficacy of ten antisense phosphorodiamidate morpholino oligomers (PMOs) directed against Equine arteritis virus... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: Vero-E6 cells Citation Extract: van den Born E, Stein DA, Iversen PL, Snijder EJ. Antiviral activity of morpholino oligomers designed to block various aspects of Equine arteritis virus amplification in cell culture. J Gen Virol. 2005 Nov;86(Pt 11):3081-90. |
Inhibition of foot-and-mouth disease virus in cell cultures with antisense Morpholino oligomers
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Citation:
J Virol. 2007 Nov;81(21):11669-80. Epub 2007 Aug 29. Epub:
Not Epub Abstract:
Foot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed ungulates that can lead to severe losses in... Delivery Method:
peptide-coupled Organism or Cell Type:
Foot-and-mouth disease (FMD) virus Citation Extract: Vagnozzi A, Stein DA, Iversen PL, Rieder E. Inhibition of foot-and-mouth disease virus in cell cultures with antisense Morpholino oligomers. J Virol. 2007 Nov;81(21):11669-80. Epub 2007 Aug 29.. |
Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli
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Citation:
J Antimicrob Chemother. 2007 Jan;59(1):66-73. Epub 2006 Oct 31. Epub:
Not Epub Abstract:
OBJECTIVES: Phosphorodiamidate morpholino oligomers (PMOs) are DNA analogues that inhibit translation by an antisense mechanism... Delivery Method:
peptide-coupled Organism or Cell Type:
Escherichia coli Citation Extract: Tilley LD, Mellbye BL, Puckett SE, Iversen PL, Geller BL. Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli. J Antimicrob Chemother. 2007 Jan;59(1):66-73. Epub 2006 Oct 31.. |