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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 261 scientific papers returned from the database with the search filters currently being used below.

Curing of HeLa Cells Persistently Infected with Equine Arteritis Virus by a Peptide-conjugated Morpholino Oligomer

Authors:
Zhang J, Stein DA, Timoney PJ, Balasuriya UB
Citation:
Virus Res. 2010 Mar 2. [Epub ahead of print]
Epub:
Not Epub
Abstract:
A significant consequence of equine arteritis virus (EAV) infection of horses is persistence of the virus in a variable...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: HeLa with equine arteritis viral infection
Citation Extract:
Zhang J, Stein DA, Timoney PJ, Balasuriya UB. Curing of HeLa Cells Persistently Infected with Equine Arteritis Virus by a Peptide-conjugated Morpholino Oligomer. Virus Res. 2010 Mar 2. [Epub ahead of print].

Inhibition of coxsackievirus B3 in cell cultures and in mice by peptide-conjugated morpholino oligomers targeting the internal ribosome entry site.

Authors:
Yuan J, Stein DA, Lim T, Qiu D, Coughlin S, Liu Z, Wang Y, Bouch R, Moulton HM, Iversen PL, Yang D
Citation:
J Virol. 2006 Dec;80(23):11510-9. Epub 2006 Sep 20.
Epub:
Not Epub
Abstract:
Coxsackievirus B3 (CVB3) is a primary cause of viral myocarditis, yet no effective therapeutic against CVB3 is available....
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice - A/J [H-2a] (Jackson Laboratory)
Citation Extract:
Yuan J, Stein DA, Lim T, Qiu D, Coughlin S, Liu Z, Wang Y, Bouch R, Moulton HM, Iversen PL, Yang D. Inhibition of coxsackievirus B3 in cell cultures and in mice by peptide-conjugated morpholino oligomers targeting the internal ribosome entry site.. J Virol. 2006 Dec;80(23):11510-9. Epub 2006 Sep 20..

Inhibition of primary effusion lymphoma engraftment in SCID mice by morpholino oligomers against early lytic genes of Kaposi's sarcoma-associated herpesvirus

Authors:
Zhang YJ, Patel D, Nan Y, Fan S
Citation:
Antivir Ther. 2011;16(5):657-66
Epub:
Not Epub
Abstract:
BACKGROUND: Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with several malignant diseases, including Kaposi...
Link:
http://www.intmedpress.com/serveFile.cfm?sUID=66e4edb7-dfdf-4cc1-97ff-4072d9ea4f58
Delivery Method:
peptide-coupled
Organism or Cell Type:
virus: Kaposi's sarcoma-associated herpesvirus in SCID mice
Citation Extract:
Zhang YJ, Patel D, Nan Y, Fan S. Inhibition of primary effusion lymphoma engraftment in SCID mice by morpholino oligomers against early lytic genes of Kaposi's sarcoma-associated herpesvirus. Antivir Ther. 2011;16(5):657-66.

Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers

Authors:
Zhang YJ, Wang KY, Stein DA, Patel D, Watkins R, Moulton HM, Iversen PL, Matson DO
Citation:
Antiviral Res. 2007 Jan;73(1):12-23. Epub 2006 Jun 14.
Epub:
Not Epub
Abstract:
Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with Kaposi's sarcoma and primary effusion lymphoma (PEL...
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390898/
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: PEL cells
Citation Extract:
Zhang YJ, Wang KY, Stein DA, Patel D, Watkins R, Moulton HM, Iversen PL, Matson DO. Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers. Antiviral Res. 2007 Jan;73(1):12-23. Epub 2006 Jun 14..

Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers

Authors:
Zhang YJ, Stein DA, Fan SM, Wang KY, Kroeker AD, Meng XJ, Iversen PL, Matson DO
Citation:
Vet Microbiol. 2006 Oct 31;117(2-4):117-29. Epub 2006 Jul 12.
Epub:
Not Epub
Abstract:
Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of a contagious disease characterized by...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Cell Culture: CRL11171 cells
Citation Extract:
Zhang YJ, Stein DA, Fan SM, Wang KY, Kroeker AD, Meng XJ, Iversen PL, Matson DO. Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers. Vet Microbiol. 2006 Oct 31;117(2-4):117-29. Epub 2006 Jul 12..

A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice

Authors:
Yin H, Moulton HM, Betts C, Seow Y, Boutilier J, Iverson PL, Wood MJ
Citation:
Hum Mol Genet. 2009 Aug 18. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene that abolish the synthesis of dystrophin protein....
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice, mdx
Citation Extract:
Yin H, Moulton HM, Betts C, Seow Y, Boutilier J, Iverson PL, Wood MJ. A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice. Hum Mol Genet. 2009 Aug 18. [Epub ahead of print].

Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic muscle and cardiac dystrophin expression and function

Authors:
Yin H, Moulton HM, Seow Y, Boyd C, Boutilier J, Iverson P, Wood MJ
Citation:
Hum Mol Genet. 2008 Sep 10. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Antisense oligonucleotides (AOs) have the potential to induce functional dystrophin protein expression via exon skipping by...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice, mdx
Citation Extract:
Yin H, Moulton HM, Seow Y, Boyd C, Boutilier J, Iverson P, Wood MJ. Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic muscle and cardiac dystrophin expression and function. Hum Mol Genet. 2008 Sep 10. [Epub ahead of print].

Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency

Authors:
Yin H, Boisguerin P, Moulton HM, Betts C, Seow Y, Boutilier J, Wang Q, Walsh A, Lebleu B, Wood MJ
Citation:
Mol Ther Nucleic Acids. 2013 Sep 24;2:e124. doi: 10.1038/mtna.2013.51
Epub:
Not Epub
Abstract:
We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as B...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice, mdx
Citation Extract:
Yin H, Boisguerin P, Moulton HM, Betts C, Seow Y, Boutilier J, Wang Q, Walsh A, Lebleu B, Wood MJ. Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency. Mol Ther Nucleic Acids. 2013 Sep 24;2:e124. doi: 10.1038/mtna.2013.51.

CPP-Directed Oligonucleotide Exon Skipping in Animal Models of Duchenne Muscular Dystrophy

Authors:
Yin H, Moulton H, Betts C, Wood M
Citation:
Methods Mol Biol. 2011;683:321-38
Epub:
Not Epub
Abstract:
Antisense oligonucleotides (AOs) are effective splice switching agents and have potential as therapeutics via the exclusion or...
Delivery Method:
peptide-coupled
Citation Extract:
Yin H, Moulton H, Betts C, Wood M. CPP-Directed Oligonucleotide Exon Skipping in Animal Models of Duchenne Muscular Dystrophy. Methods Mol Biol. 2011;683:321-38.

Stability of cell-penetrating Peptide-morpholino oligomer conjugates in human serum and in cells

Authors:
Youngblood DS, Hatlevig SA, Hassinger JN, Iversen PL, Moulton HM
Citation:
Bioconjug Chem. 2007 Jan-Feb;18(1):50-60
Epub:
Not Epub
Abstract:
Cell penetrating peptides (CPPs) have been shown to enhance the cellular uptake of antisense oligonucleotides (AOs). However,...
Link:
http://pubs.acs.org/doi/abs/10.1021/bc060138s
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: HeLa cells
Citation Extract:
Youngblood DS, Hatlevig SA, Hassinger JN, Iversen PL, Moulton HM. Stability of cell-penetrating Peptide-morpholino oligomer conjugates in human serum and in cells. Bioconjug Chem. 2007 Jan-Feb;18(1):50-60.

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