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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 273 scientific papers returned from the database with the search filters currently being used below.
There are 273 scientific papers returned from the database with the search filters currently being used below.
Spiroindolone That Inhibits PfATPase4 Is a Potent, Cidal Inhibitor of Toxoplasma gondii Tachyzoites In Vitro and In Vivo
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Citation:
Antimicrob Agents Chemother. 2014;58(3):1789-92. doi: 10.1128/AAC.02225-13. Epub 2013 Dec 23. PMID: 24366743 Epub:
Not Epub Abstract:
Here, we show that spiroindolone, an effective treatment for plasmodia, is also active against Toxoplasma gondii tachyzoites.... Delivery Method:
peptide-linked Organism or Cell Type:
Toxoplasma gondii Citation Extract: Zhou Y, Fomovska A, Muench S, Lai BS, Mui E, McLeod R. Spiroindolone That Inhibits PfATPase4 Is a Potent, Cidal Inhibitor of Toxoplasma gondii Tachyzoites In Vitro and In Vivo. Antimicrob Agents Chemother. 2014;58(3):1789-92. doi: 10.1128/AAC.02225-13. Epub 2013 Dec 23. PMID: 24366743 . |
Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum
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Citation:
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11935-40. doi: 10.1073/pnas.1515864112. Epub 2015 Sep 8. Epub:
Yes Abstract:
Identification and genetic validation of new targets from available genome sequences are critical steps toward the development... Delivery Method:
Vivo-Morpholino & peptide-linked Organism or Cell Type:
Plasmodium falciparum Citation Extract: Garg A, Wesolowski D, Alonso D, Deitsch KW, Ben Mamoun C, Altman S. Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum. Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11935-40. doi: 10.1073/pnas.1515864112. Epub 2015 Sep 8.. |
In Vitro Assays to Assess Exon Skipping in Duchenne Muscular Dystrophy
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Citation:
Methods Mol Biol. 2015;1324:317-29. doi: 10.1007/978-1-4939-2806-4_20 Epub:
Not Epub Abstract:
Cell-penetrating peptide (CPP)-mediated delivery of phosphorodiamidate morpholino oligomers (PMO) results in efficient exon... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: skeletal H2k cells and primary cardiomyocytes from mdx mice Citation Extract: Boisguerin P, O'Donovan L, Gait MJ, Lebleu B. In Vitro Assays to Assess Exon Skipping in Duchenne Muscular Dystrophy. Methods Mol Biol. 2015;1324:317-29. doi: 10.1007/978-1-4939-2806-4_20. |
Development and Application of an Ultrasensitive Hybridization-Based ELISA Method for the Determination of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides
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Citation:
Nucleic Acid Ther. 2015 Jul 15. [Epub ahead of print] Epub:
Yes Abstract:
Antisense oligonucleotide (AON)-induced exon skipping is one of the most promising strategies for treating Duchenne muscular... Delivery Method:
peptide-linked Citation Extract: Burki U, Keane J, Blain A, O'Donovan L, Gait MJ, Laval SH, Straub V. Development and Application of an Ultrasensitive Hybridization-Based ELISA Method for the Determination of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides. Nucleic Acid Ther. 2015 Jul 15. [Epub ahead of print]. |
Implications for Cardiac Function Following Rescue of the Dystrophic Diaphragm in a Mouse Model of Duchenne Muscular Dystrophy
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Citation:
Sci Rep. 2015;5:11632. doi:10.1038/srep11632 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is caused by absence of the integral structural protein, dystrophin, which renders muscle... Delivery Method:
peptide-linked Organism or Cell Type:
mice, mdx Citation Extract: Betts CA, Saleh AF, Carr CA, Muses S, Wells KE, Hammond SM, Godfrey C, McClorey G, Woffindale C, Clarke K, Wells DJ, Gait MJ, Wood MJA. Implications for Cardiac Function Following Rescue of the Dystrophic Diaphragm in a Mouse Model of Duchenne Muscular Dystrophy. Sci Rep. 2015;5:11632. doi:10.1038/srep11632. |
Combination Antisense Treatment for Destructive Exon Skipping of Myostatin and Open Reading Frame Rescue of Dystrophin in Neonatal mdx Mice
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Citation:
Mol Ther. 2015;[Epub ahead of print] doi:10.1038/mt.2015.88 Epub:
Yes Abstract:
The fatal X-linked Duchenne muscular dystrophy (DMD), characterized by progressive muscle wasting and muscle weakness, is... Delivery Method:
peptide-linked Organism or Cell Type:
mice, mdx Citation Extract: Lu-Nguyen NB, Jarmin SA, Saleh AF, Popplewell L, Gait MJ, Dickson G. Combination Antisense Treatment for Destructive Exon Skipping of Myostatin and Open Reading Frame Rescue of Dystrophin in Neonatal mdx Mice. Mol Ther. 2015;[Epub ahead of print] doi:10.1038/mt.2015.88. |
Inhibition of hepatitis E virus replication by peptide-conjugated morpholino oligomers
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Citation:
Antiviral Res. 2015 Aug;120:134-9. doi: 10.1016/j.antiviral.2015.06.006. Epub 2015 Jun 15. PMID: 26086884; PMCID: PMC4502978 Epub:
Yes Abstract:
Hepatitis E virus (HEV) infection is a cause of hepatitis in humans worldwide and has been associated with a mortality rate of... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: liver cells Citation Extract: Nan Y, Ma Z, Kannan H, Stein DA, Iversen PI, Meng XJ, Zhang YJ. Inhibition of hepatitis E virus replication by peptide-conjugated morpholino oligomers. Antiviral Res. 2015 Aug;120:134-9. doi: 10.1016/j.antiviral.2015.06.006. Epub 2015 Jun 15. PMID: 26086884; PMCID: PMC4502978. |
Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides
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Citation:
Nano Lett. 2015;[Epub ahead of print] doi:10.1021/acs.nanolett.5b00490 Epub:
Yes Abstract:
Antisense oligonucleotides (ASOs) have the potential of revolutionizing medicine due to their ability to manipulate gene... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture, mice Citation Extract: Ahmed K, Aoki Y, Koo T, McClorey G, Benner L, Coenen-Stass A, O'Donovan L, Lehto T, Garciaguerra A, Nordin JZ, Saleh AF, Behlke MA, Morris , Goyenvalle A, Dugovic B, Leumann CJ, Gordon S, Gait MJ, El-Andaloussi S, Wood MJA. Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides. Nano Lett. 2015;[Epub ahead of print] doi:10.1021/acs.nanolett.5b00490. |
Combination antisense treatment for destructive exon skipping of myostatin and open reading frame rescue of dystrophin in neonatal mdx mice
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Citation:
Mol Ther. 2015 May 11. doi: 10.1038/mt.2015.88. [Epub ahead of print] Epub:
Yes Abstract:
The fatal X-linked Duchenne muscular dystrophy (DMD), characterized by progressive muscle wasting and muscle weakness, is... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx Citation Extract: Lu-Nguyen NB, Jarmin SA, Saleh AF, Popplewell L, Gait MJ, Dickson G. Combination antisense treatment for destructive exon skipping of myostatin and open reading frame rescue of dystrophin in neonatal mdx mice. Mol Ther. 2015 May 11. doi: 10.1038/mt.2015.88. [Epub ahead of print]. |
Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice
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Citation:
Sci Rep. 2015 Mar 11;5:8986. doi: 10.1038/srep08986 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disorder caused by mutations in the Dmd gene. In addition to... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Betts CA, Saleh AF, Carr CA, Hammond SM, Coenen-Stass AM, Godfrey C, McClorey G, Varela MA, Roberts TC, Clarke K, Gait MJ, Wood MJ. Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice. Sci Rep. 2015 Mar 11;5:8986. doi: 10.1038/srep08986. |