You are here
Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 261 scientific papers returned from the database with the search filters currently being used below.
There are 261 scientific papers returned from the database with the search filters currently being used below.
In Vitro Assays to Assess Exon Skipping in Duchenne Muscular Dystrophy
|
Citation:
Methods Mol Biol. 2015;1324:317-29. doi: 10.1007/978-1-4939-2806-4_20 Epub:
Not Epub Abstract:
Cell-penetrating peptide (CPP)-mediated delivery of phosphorodiamidate morpholino oligomers (PMO) results in efficient exon... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: skeletal H2k cells and primary cardiomyocytes from mdx mice Citation Extract: Boisguerin P, O'Donovan L, Gait MJ, Lebleu B. In Vitro Assays to Assess Exon Skipping in Duchenne Muscular Dystrophy. Methods Mol Biol. 2015;1324:317-29. doi: 10.1007/978-1-4939-2806-4_20. |
Development and Application of an Ultrasensitive Hybridization-Based ELISA Method for the Determination of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides
|
Citation:
Nucleic Acid Ther. 2015 Jul 15. [Epub ahead of print] Epub:
Yes Abstract:
Antisense oligonucleotide (AON)-induced exon skipping is one of the most promising strategies for treating Duchenne muscular... Delivery Method:
peptide-linked Citation Extract: Burki U, Keane J, Blain A, O'Donovan L, Gait MJ, Laval SH, Straub V. Development and Application of an Ultrasensitive Hybridization-Based ELISA Method for the Determination of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides. Nucleic Acid Ther. 2015 Jul 15. [Epub ahead of print]. |
Implications for Cardiac Function Following Rescue of the Dystrophic Diaphragm in a Mouse Model of Duchenne Muscular Dystrophy
|
Citation:
Sci Rep. 2015;5:11632. doi:10.1038/srep11632 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is caused by absence of the integral structural protein, dystrophin, which renders muscle... Delivery Method:
peptide-linked Organism or Cell Type:
mice, mdx Citation Extract: Betts CA, Saleh AF, Carr CA, Muses S, Wells KE, Hammond SM, Godfrey C, McClorey G, Woffindale C, Clarke K, Wells DJ, Gait MJ, Wood MJA. Implications for Cardiac Function Following Rescue of the Dystrophic Diaphragm in a Mouse Model of Duchenne Muscular Dystrophy. Sci Rep. 2015;5:11632. doi:10.1038/srep11632. |
Combination Antisense Treatment for Destructive Exon Skipping of Myostatin and Open Reading Frame Rescue of Dystrophin in Neonatal mdx Mice
|
Citation:
Mol Ther. 2015;[Epub ahead of print] doi:10.1038/mt.2015.88 Epub:
Yes Abstract:
The fatal X-linked Duchenne muscular dystrophy (DMD), characterized by progressive muscle wasting and muscle weakness, is... Delivery Method:
peptide-linked Organism or Cell Type:
mice, mdx Citation Extract: Lu-Nguyen NB, Jarmin SA, Saleh AF, Popplewell L, Gait MJ, Dickson G. Combination Antisense Treatment for Destructive Exon Skipping of Myostatin and Open Reading Frame Rescue of Dystrophin in Neonatal mdx Mice. Mol Ther. 2015;[Epub ahead of print] doi:10.1038/mt.2015.88. |
Inhibition of hepatitis E virus replication by peptide-conjugated morpholino oligomers
|
Citation:
Antiviral Res. 2015;[Epub ahead of print] doi:10.1016/j.antiviral.2015.06.006 Epub:
Yes Abstract:
Hepatitis E virus (HEV) infection is a cause of hepatitis in humans worldwide and has been associated with a mortality rate of... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: liver cells Citation Extract: Nan Y, Ma Z, Kannan H, Stein DA, Iversen PI, Meng X-J, Zhang Y-J. Inhibition of hepatitis E virus replication by peptide-conjugated morpholino oligomers. Antiviral Res. 2015;[Epub ahead of print] doi:10.1016/j.antiviral.2015.06.006. |
Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides
|
Citation:
Nano Lett. 2015;[Epub ahead of print] doi:10.1021/acs.nanolett.5b00490 Epub:
Yes Abstract:
Antisense oligonucleotides (ASOs) have the potential of revolutionizing medicine due to their ability to manipulate gene... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture, mice Citation Extract: Ahmed K, Aoki Y, Koo T, McClorey G, Benner L, Coenen-Stass A, O'Donovan L, Lehto T, Garciaguerra A, Nordin JZ, Saleh AF, Behlke MA, Morris , Goyenvalle A, Dugovic B, Leumann CJ, Gordon S, Gait MJ, El-Andaloussi S, Wood MJA. Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides. Nano Lett. 2015;[Epub ahead of print] doi:10.1021/acs.nanolett.5b00490. |
Combination antisense treatment for destructive exon skipping of myostatin and open reading frame rescue of dystrophin in neonatal mdx mice
|
Citation:
Mol Ther. 2015 May 11. doi: 10.1038/mt.2015.88. [Epub ahead of print] Epub:
Yes Abstract:
The fatal X-linked Duchenne muscular dystrophy (DMD), characterized by progressive muscle wasting and muscle weakness, is... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx Citation Extract: Lu-Nguyen NB, Jarmin SA, Saleh AF, Popplewell L, Gait MJ, Dickson G. Combination antisense treatment for destructive exon skipping of myostatin and open reading frame rescue of dystrophin in neonatal mdx mice. Mol Ther. 2015 May 11. doi: 10.1038/mt.2015.88. [Epub ahead of print]. |
Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice
|
Citation:
Sci Rep. 2015 Mar 11;5:8986. doi: 10.1038/srep08986 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disorder caused by mutations in the Dmd gene. In addition to... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Betts CA, Saleh AF, Carr CA, Hammond SM, Coenen-Stass AM, Godfrey C, McClorey G, Varela MA, Roberts TC, Clarke K, Gait MJ, Wood MJ. Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice. Sci Rep. 2015 Mar 11;5:8986. doi: 10.1038/srep08986. |
High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides
|
Citation:
Nucl Acids Res. 2015;[Epub ahead of print] doi:10.1093/nar/gkv060 Epub:
Yes Abstract:
The therapeutic use of antisense and siRNA oligonucleotides has been constrained by the limited ability of these membrane-... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: A375 melanoma cells Citation Extract: Yang B, Ming X, Cao C, Laing B, Yuan A, Porter MA, Hull-Ryde EA, Maddry J, Suto M, Janzen WP, Juliano RL. High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides. Nucl Acids Res. 2015;[Epub ahead of print] doi:10.1093/nar/gkv060 . |
Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides
|
Citation:
Nucleic Acid Ther. 2015 Jan 16. [Epub ahead of print] Epub:
Yes Abstract:
Oligonucleotide analogs have provided novel therapeutics targeting various disorders. However, their poor cellular uptake... Delivery Method:
peptide nanoparticle Organism or Cell Type:
cell culture: U2OS cells, murine H2K mdx myotubes, human SMA type 1 fibroblasts Citation Extract: Järver P, Zaghloul EM, Arzumanov AA, Saleh AF, McClorey G, Hammond SM, Hällbrink M, Langel Ü, Smith CI, Wood MJ, Gait MJ, Andaloussi SE. Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides. Nucleic Acid Ther. 2015 Jan 16. [Epub ahead of print]. |