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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 273 scientific papers returned from the database with the search filters currently being used below.
There are 273 scientific papers returned from the database with the search filters currently being used below.
Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy
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Citation:
Nucleic Acid Ther. 2017 Jan 24. doi: 10.1089/nat.2016.0652. [Epub ahead of print] Epub:
Yes Abstract:
Splice-switching antisense oligonucleotides are emerging treatments for neuromuscular diseases, with several splice-switching... Delivery Method:
peptide-linked Organism or Cell Type:
mouse Citation Extract: Shabanpoor F, Hammond SM, Abendroth F, Hazell G, Wood MJ, Gait MJ. Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy. Nucleic Acid Ther. 2017 Jan 24. doi: 10.1089/nat.2016.0652. [Epub ahead of print]. |
Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo
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Citation:
J Antimicrob Chemother. 2016 Dec 20. pii: dkw476. doi: 10.1093/jac/dkw476. [Epub ahead of print] Epub:
Yes Abstract:
OBJECTIVES: The objective of this study was to test the efficacy of an inhibitor of the New Delhi metallo-β- lactamase (NDM-1... Delivery Method:
peptide-linked Organism or Cell Type:
Escherichia coli Citation Extract: Sully EK, Geller BL, Li L, Moody CM, Bailey SM, Moore AL, Wong M, Nordmann P, Daly SM, Sturge CR, Greenberg DE. Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo. J Antimicrob Chemother. 2016 Dec 20. pii: dkw476. doi: 10.1093/jac/dkw476. [Epub ahead of print]. |
Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy
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Citation:
PLoS Biol. 2016 Sep 15;14(9):e1002552. doi: 10.1371/journal.pbio.1002552. eCollection 2016 Sep Epub:
Not Epub Abstract:
The lack of effective and well-tolerated therapies against antibiotic-resistant bacteria is a global public health problem... Delivery Method:
Peptide-linked Organism or Cell Type:
cell culture: Escherichia coli, Klebsiella pneumoniae, Salmonella enterica, Acinetobacter baumannii, Pseudomonas aeruginosa, Burkholderia cenocepacia Citation Extract: Ayhan DH, Tamer YT, Akbar M, Bailey SM, Wong M, Daly SM, Greenberg DE, Toprak E. Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy. PLoS Biol. 2016 Sep 15;14(9):e1002552. doi: 10.1371/journal.pbio.1002552. eCollection 2016 Sep. |
Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy
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Citation:
Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10962-7. doi: 10.1073/pnas.1605731113. Epub 2016 Sep 12 Epub:
Yes Abstract:
The development of antisense oligonucleotide therapy is an important advance in the identification of corrective therapy for... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Hammond SM, Hazell G, Shabanpoor F, Saleh AF, Bowerman M, Sleigh JN, Meijboom KE, Zhou H, Muntoni F, Talbot K, Gait MJ, Wood MJ. Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10962-7. doi: 10.1073/pnas.1605731113. Epub 2016 Sep 12. |
Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice
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Citation:
Mol Ther Nucleic Acids. 2016 Jun 28;5(6):e329. doi: 10.1038/mtna.2016.46 Epub:
Not Epub Abstract:
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations... Delivery Method:
injection standard oligos and peptide-linked Organism or Cell Type:
mice, mdx Citation Extract: Cao L, Han G, Lin C, Gu B, Gao X, Moulton HM, Seow Y, Yin H. Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice. Mol Ther Nucleic Acids. 2016 Jun 28;5(6):e329. doi: 10.1038/mtna.2016.46. |
Translational Inhibition of CTX-M Extended Spectrum β-Lactamase in Clinical Strains of Escherichia coli by Synthetic Antisense Oligonucleotides Partially Restores Sensitivity to Cefotaxime
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Citation:
Front Microbiol. 2016 Mar 24;7:373. eCollection 2016 Epub:
Not Epub Abstract:
Synthetic antisense oligomers are DNA mimics that can specifically inhibit gene expression at the translational level by... Delivery Method:
peptide-linked Organism or Cell Type:
Escherichia coli Citation Extract: Readman JB, Dickson G, Coldham NG. Translational Inhibition of CTX-M Extended Spectrum β-Lactamase in Clinical Strains of Escherichia coli by Synthetic Antisense Oligonucleotides Partially Restores Sensitivity to Cefotaxime. Front Microbiol. 2016 Mar 24;7:373. eCollection 2016. |
mRNA and microRNA transcriptomics analyses in a murine model of dystrophin loss and therapeutic restoration
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Citation:
Genom Data. 2015 Dec 2;7:88-9. doi: 10.1016/j.gdata.2015.11.025. eCollection 2016 Mar Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a pediatric, X-linked, progressive muscle-wasting disorder caused by loss of function... Delivery Method:
peptide-linked Organism or Cell Type:
mice, mdx Citation Extract: Roberts TC, Blomberg KE, Smith CI, El Andaloussi S, Wood MJ. mRNA and microRNA transcriptomics analyses in a murine model of dystrophin loss and therapeutic restoration. Genom Data. 2015 Dec 2;7:88-9. doi: 10.1016/j.gdata.2015.11.025. eCollection 2016 Mar. |
Deletion of Dystrophin In-Frame Exon 5 Leads to a Severe Phenotype: Guidance for Exon Skipping Strategies
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Citation:
PLoS One. 2016 Jan 8;11(1):e0145620. doi: 10.1371/journal.pone.0145620. eCollection 2016 Epub:
Not Epub Abstract:
Duchenne and Becker muscular dystrophy severity depends upon the nature and location of the DMD gene lesion and generally... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Toh ZY, Thandar Aung-Htut M, Pinniger G, Adams AM, Krishnaswarmy S, Wong BL, Fletcher S, Wilton SD. Deletion of Dystrophin In-Frame Exon 5 Leads to a Severe Phenotype: Guidance for Exon Skipping Strategies. PLoS One. 2016 Jan 8;11(1):e0145620. doi: 10.1371/journal.pone.0145620. eCollection 2016. |
Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding
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Citation:
Cell Host & Microbe. 2015;18(6):723-35. doi:10.1016/j.chom.2015.11.002 Epub:
Not Epub Abstract:
Several systems-level datasets designed to dissect host-pathogen interactions during influenza A infection have been reported.... Delivery Method:
peptide-linked Organism or Cell Type:
BALB/c mice Citation Extract: Tripathi S, Pohl MO, Zhou Y, Rodriguez-Frandsen A, Wang G, Stein DA, Moulton HM, DeJesus P, Che J, Mulder LCF, Yángüez E, Andenmatten D, Pache L, Manicassamy B, Albrecht RA, Gonzalez MG, Nguyen Q, Brass A, Elledge S, White M, Shapira S, Hacohen N, Karlas A, Meyer TF, Shales M, Gatorano A, Johnson JR, Jang G, Johnson T, Verschueren E, Sanders D, Krogan N, Shaw M, König R, Stertz S, García-Sastre A, Chanda SK. Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding. Cell Host & Microbe. 2015;18(6):723-35. doi:10.1016/j.chom.2015.11.002. |
Identification of novel, therapy-responsive protein biomarkers in a mouse model of Duchenne muscular dystrophy by aptamer-based serum proteomics
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Citation:
Sci Rep. 2015;5:17104 doi:10.1038/srep17014 Epub:
Not Epub Abstract:
There is currently an urgent need for biomarkers that can be used to monitor the efficacy of experimental therapies for... Delivery Method:
peptide-linked Organism or Cell Type:
mice, mdx Citation Extract: Coenen-Stass AML, McClorey G, Manzano R, Betts CA, Blain A, Saleh AF, Gait MJ, Lochmüller H, Wood MJA, Roberts TC. Identification of novel, therapy-responsive protein biomarkers in a mouse model of Duchenne muscular dystrophy by aptamer-based serum proteomics. Sci Rep. 2015;5:17104 doi:10.1038/srep17014. |