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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 273 scientific papers returned from the database with the search filters currently being used below.

Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice

Authors:
Wang MX, Wu B, Lu P, Shah SN, Tucker JD, Bollinger LE, Lu Q
Citation:
Polymers. 2017;9(5):177. doi:10.3390/polym9050177
Epub:
Not Epub
Abstract:
A series of amphiphilic peptides modified PMO (Pt-PMO) were prepared, and their antisense effect and toxicity were evaluated...
Link:
http://www.mdpi.com/2073-4360/9/5/177
Delivery Method:
peptide linked, Endo-Porter
Organism or Cell Type:
mice mdx, cell culture C2C12E23
Citation Extract:
Wang MX, Wu B, Lu P, Shah SN, Tucker JD, Bollinger LE, Lu Q. Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice. Polymers. 2017;9(5):177. doi:10.3390/polym9050177.

Combination of valproic acid and morpholino splice-switching oligonucleotide produces improved outcomes in spinal muscular atrophy patient-derived fibroblasts

Authors:
Farrelly-Rosch A, Lau CL, Patil N, Turner BJ, Shabanpoor F
Citation:
Neurochem Int. 2017 Apr 4. pii: S0197-0186(17)30035-9. doi: 10.1016/j.neuint.2017.02.016. [Epub ahead of print]
Epub:
Yes
Abstract:
Spinal muscular atrophy (SMA), the leading genetic cause of infant mortality worldwide, is characterised by the homozygous loss...
Link:
http://www.sciencedirect.com/science/article/pii/S0197018617300359
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: primary human fibroblasts
Citation Extract:
Farrelly-Rosch A, Lau CL, Patil N, Turner BJ, Shabanpoor F. Combination of valproic acid and morpholino splice-switching oligonucleotide produces improved outcomes in spinal muscular atrophy patient-derived fibroblasts. Neurochem Int. 2017 Apr 4. pii: S0197-0186(17)30035-9. doi: 10.1016/j.neuint.2017.02.016. [Epub ahead of print].

Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy

Authors:
Echigoya Y, Nakamura A, Nagata T, Urasawa N, Lim KR, Trieu N, Panesar D, Kuraoka M, Moulton HM, Saito T, Aoki Y, Iversen P, Sazani P, Kole R, Maruyama R, Partridge T, Takeda S, Yokota T
Citation:
Proc Natl Acad Sci U S A. 2017 Apr 3. pii: 201613203. doi: 10.1073/pnas.1613203114. [Epub ahead of print]
Epub:
Yes
Abstract:
Duchenne muscular dystrophy (DMD) is a lethal genetic disorder caused by an absence of the dystrophin protein in bodywide...
Link:
http://www.pnas.org/content/early/2017/03/29/1613203114.long
Delivery Method:
peptide-linked, bare oligo injection
Organism or Cell Type:
Canis familiaris (dog)
Citation Extract:
Echigoya Y, Nakamura A, Nagata T, Urasawa N, Lim KR, Trieu N, Panesar D, Kuraoka M, Moulton HM, Saito T, Aoki Y, Iversen P, Sazani P, Kole R, Maruyama R, Partridge T, Takeda S, Yokota T. Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2017 Apr 3. pii: 201613203. doi: 10.1073/pnas.1613203114. [Epub ahead of print].

Systemic Delivery of Morpholinos to Skip Multiple Exons in a Dog Model of Duchenne Muscular Dystrophy

Authors:
Maruyama R, Echigoya Y, Caluseriu O, Aoki Y, Takeda S, Yokota T
Citation:
Methods Mol Biol. 2017;1565:201-213. doi: 10.1007/978-1-4939-6817-6_17
Epub:
Not Epub
Abstract:
Exon-skipping therapy is an emerging approach that uses synthetic DNA-like molecules called antisense oligonucleotides (AONs)...
Link:
http://www.springer.com/us/book/9781493968152
Delivery Method:
injection, peptide-linked
Organism or Cell Type:
Canis familiaris (dog)
Citation Extract:
Maruyama R, Echigoya Y, Caluseriu O, Aoki Y, Takeda S, Yokota T. Systemic Delivery of Morpholinos to Skip Multiple Exons in a Dog Model of Duchenne Muscular Dystrophy. Methods Mol Biol. 2017;1565:201-213. doi: 10.1007/978-1-4939-6817-6_17.

Intranasal Delivery of Peptide-Morpholinos to Knockdown Influenza Host Factors in Mice

Authors:
Rajsbaum R
Citation:
Methods Mol Biol. 2017;1565:191-199. doi: 10.1007/978-1-4939-6817-6_16
Epub:
Not Epub
Abstract:
Influenza viruses replicate primarily in the lung tissue of different host species. For efficient replication the virus...
Link:
http://www.springer.com/us/book/9781493968152
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Rajsbaum R. Intranasal Delivery of Peptide-Morpholinos to Knockdown Influenza Host Factors in Mice. Methods Mol Biol. 2017;1565:191-199. doi: 10.1007/978-1-4939-6817-6_16.

Inhibition of Bacterial Growth by Peptide-Conjugated Morpholino Oligomers

Authors:
Daly SM, Sturge CR, Greenberg DE
Citation:
Methods Mol Biol. 2017;1565:115-122. doi: 10.1007/978-1-4939-6817-6_10
Epub:
Not Epub
Abstract:
Morpholino oligomers (MOs) are antisense molecules designed for sequence-specific binding of target mRNA. In bacteria,...
Link:
http://www.springer.com/us/book/9781493968152
Delivery Method:
peptide-linked
Organism or Cell Type:
bacteria
Citation Extract:
Daly SM, Sturge CR, Greenberg DE. Inhibition of Bacterial Growth by Peptide-Conjugated Morpholino Oligomers. Methods Mol Biol. 2017;1565:115-122. doi: 10.1007/978-1-4939-6817-6_10.

Systemic Antisense Therapeutics for Dystrophin and Myostatin Exon Splice Modulation Improve Muscle Pathology of Adult mdx Mice

Authors:
Lu-Nguyen N, Malerba A, Popplewell L, Schnell F, Hanson G, Dickson G
Citation:
Mol Ther Nucleic Acids. 2017 Mar 17;6:15-28. doi: 10.1016/j.omtn.2016.11.009
Epub:
Not Epub
Abstract:
Antisense-mediated exon skipping is a promising approach for the treatment of Duchenne muscular dystrophy (DMD), a rare life-...
Link:
http://www.cell.com/molecular-therapy-family/nucleic-acids/abstract/S2162-2531(16)30367-5
Delivery Method:
peptide-linked
Organism or Cell Type:
mouse mdx
Citation Extract:
Lu-Nguyen N, Malerba A, Popplewell L, Schnell F, Hanson G, Dickson G. Systemic Antisense Therapeutics for Dystrophin and Myostatin Exon Splice Modulation Improve Muscle Pathology of Adult mdx Mice. Mol Ther Nucleic Acids. 2017 Mar 17;6:15-28. doi: 10.1016/j.omtn.2016.11.009.

How much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse

Authors:
Godfrey C, Muses S, McClorey G, Wells KE, Coursindel T, Terry RL, Betts C, Hammond S, O'Donovan L, Hildyard J, El Andaloussi S, Gait MJ, Wood MJ, Wells DJ
Citation:
Hum Mol Genet. 2015 Aug 1;24(15):4225-37. doi: 10.1093/hmg/ddv155
Epub:
Not Epub
Abstract:
Splice modulation therapy has shown great clinical promise in Duchenne muscular dystrophy, resulting in the production of...
Link:
https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/ddv155
Delivery Method:
peptide-linked
Organism or Cell Type:
mouse mdx
Citation Extract:
Godfrey C, Muses S, McClorey G, Wells KE, Coursindel T, Terry RL, Betts C, Hammond S, O'Donovan L, Hildyard J, El Andaloussi S, Gait MJ, Wood MJ, Wells DJ. How much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse. Hum Mol Genet. 2015 Aug 1;24(15):4225-37. doi: 10.1093/hmg/ddv155.

Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation

Authors:
Soonthornvacharin S, Rodriguez-Frandsen A, Zhou Y, Galvez F, Huffmaster NJ, Tripathi S, Balasubramaniam VRMT, Inoue A, de Castro E, Moulton H, Stein DA, Sánchez-Aparicio MT, De Jesus PD, Nguyen Q, König R, Krogan NJ, García-Sastre A, Yoh SM, Chanda SK
Citation:
Nat Microbio. 2017;2:17022. doi:10.1038/nmicrobiol.2017.22
Epub:
Not Epub
Abstract:
Retinoic acid-inducible gene I (RIG-I) receptor recognizes 5′-triphosphorylated RNA and triggers a signalling cascade that...
Link:
http://www.nature.com/articles/nmicrobiol201722
Delivery Method:
peptide-linked
Organism or Cell Type:
mice C57BL/6
Citation Extract:
Soonthornvacharin S, Rodriguez-Frandsen A, Zhou Y, Galvez F, Huffmaster NJ, Tripathi S, Balasubramaniam VRMT, Inoue A, de Castro E, Moulton H, Stein DA, Sánchez-Aparicio MT, De Jesus PD, Nguyen Q, König R, Krogan NJ, García-Sastre A, Yoh SM, Chanda SK. Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation. Nat Microbio. 2017;2:17022. doi:10.1038/nmicrobiol.2017.22.

Inhibition of Pseudomonas aeruginosa by Peptide-conjugated Phosphorodiamidate Morpholino Oligomers

Authors:
Howard JJ, Sturge CR, Moustafa DA, Daly SM, Marshall-Batty KR, Felder CF, Zamora D, Yabe-Gill M, Labandeira-Rey M, Bailey SM, Wong M, Goldberg JB, Geller BL, Greenberg DE
Citation:
Antimicrob Agents Chemother. 2017 Jan 30. pii: AAC.01938-16. doi: 10.1128/AAC.01938-16. [Epub ahead of print]
Epub:
Yes
Abstract:
Pseudomonas aeruginosa is a highly virulent, multidrug-resistant pathogen that causes significant morbidity and mortality in...
Link:
http://aac.asm.org/content/early/2017/01/24/AAC.01938-16.abstract
Delivery Method:
peptide-linked
Organism or Cell Type:
Pseudomonas aeruginosa
Citation Extract:
Howard JJ, Sturge CR, Moustafa DA, Daly SM, Marshall-Batty KR, Felder CF, Zamora D, Yabe-Gill M, Labandeira-Rey M, Bailey SM, Wong M, Goldberg JB, Geller BL, Greenberg DE. Inhibition of Pseudomonas aeruginosa by Peptide-conjugated Phosphorodiamidate Morpholino Oligomers. Antimicrob Agents Chemother. 2017 Jan 30. pii: AAC.01938-16. doi: 10.1128/AAC.01938-16. [Epub ahead of print].

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