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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 273 scientific papers returned from the database with the search filters currently being used below.
There are 273 scientific papers returned from the database with the search filters currently being used below.
A platform for discovery of functional cell-penetrating peptides for efficient multi-cargo intracellular delivery
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Citation:
Sci Rep. 2018;8:12538 doi:10.1038/s41598-018-30790-2 Epub:
Not Epub Abstract:
Cell penetrating peptides (CPPs) offer great potential to deliver therapeutic molecules to previously inaccessible... Delivery Method:
peptide-linked Organism or Cell Type:
mice mdx Citation Extract: Hoffmann K, Milech N, Juraja SM, Cunningham PT, Stone SR, Francis RW, Anastasas M, Hall CM, Heinrich T, Bogdawa HM, Winslow S, Scobie MN, Dewhurst RE, Florez L, Ong F, Kerfoot M, Champain D, Adams AM, Fletcher S, Viola HM, Hool LC, Connor T, Longville BAC, Tan Y-F, Kroeger K, Morath V, Weiss GA, Skerra A, Hopkins RM, Watt PM. A platform for discovery of functional cell-penetrating peptides for efficient multi-cargo intracellular delivery. Sci Rep. 2018;8:12538 doi:10.1038/s41598-018-30790-2. |
Inhibiting neutral amino acid transport for the treatment of phenylketonuria
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Citation:
JCI Insight. 2018 Jul 26;3(14). pii: 121762. doi: 10.1172/jci.insight.121762. [Epub ahead of print] Epub:
Not Epub Abstract:
The neuropathological effects of phenylketonuria (PKU) stem from the inability of the body to metabolize excess phenylalanine (... Delivery Method:
Endo-Porter in culture, peptide-linked in mice Organism or Cell Type:
cell culture: primary mouse renal tubular epithelial cells, mice Citation Extract: Belanger AM, Przybylska M, Gefteas E, Furgerson M, Geller S, Kloss A, Cheng SH, Zhu Y, Yew NS. Inhibiting neutral amino acid transport for the treatment of phenylketonuria. JCI Insight. 2018 Jul 26;3(14). pii: 121762. doi: 10.1172/jci.insight.121762. [Epub ahead of print]. |
Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy
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Citation:
PLoS One. 2018 Jun 18;13(6):e0198897. doi: 10.1371/journal.pone.0198897. eCollection 2018 Epub:
Not Epub Abstract:
Blain AM, Greally E, McClorey G, Manzano R, Betts CA, Godfrey C, O'Donovan L, Coursindel T, Gait MJ, Wood MJ, MacGowan GA... Delivery Method:
peptide-linked Organism or Cell Type:
mice mdx Citation Extract: Blain AM, Greally E, McClorey G, Manzano R, Betts CA, Godfrey C, O'Donovan L, Coursindel T, Gait MJ, Wood MJ, MacGowan GA, Straub VW. Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy. PLoS One. 2018 Jun 18;13(6):e0198897. doi: 10.1371/journal.pone.0198897. eCollection 2018. |
Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery
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Citation:
ACS Cent Sci. 2018;[Epub] doi:10.1021/acscentsci.8b00098 Epub:
Yes Abstract:
Cell-penetrating peptides (CPPs) can facilitate the intracellular delivery of large therapeutically relevant molecules,... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: HeLa 654 Citation Extract: Wolfe JM, Fadzen CM, Choo Z-N, Rebecca L. Holden RL, Yao M, Hanson GJ, Pentelute BL. Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery. ACS Cent Sci. 2018;[Epub] doi:10.1021/acscentsci.8b00098. |
Morpholino oligomers tested in vitro, in biofilm and in vivo against multidrug-resistant Klebsiella pneumoniae
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Citation:
J Antimicrob Chemother. 2018;[Epub ahead of print] doi:10.1093/jac/dky058 Epub:
Yes Abstract:
Background: Klebsiella pneumoniae is an opportunistic pathogen and many strains are multidrug resistant. KPC is one of the most... Delivery Method:
peptide-linked Organism or Cell Type:
Klebsiella pneumoniae Citation Extract: Geller BL, Li L, Martinez F, Sully E, Sturge CR, Daly SM, Pybus C, Greenberg DE. Morpholino oligomers tested in vitro, in biofilm and in vivo against multidrug-resistant Klebsiella pneumoniae. J Antimicrob Chemother. 2018;[Epub ahead of print] doi:10.1093/jac/dky058. |
Perfluoroaryl Bicyclic Cell-Penetrating Peptides for Delivery of Antisense Oligonucleotides
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Citation:
Angew Chem Int Ed. 2018;[Epub ahead of print] doi:10.1002/anie.201801167 Epub:
Yes Abstract:
Exon-skipping antisense oligonucleotides are effective treatments for genetic diseases, yet exon-skipping activity requires... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: HeLa-654 Citation Extract: Wolfe JM, Fadzen CM, Holden RL, Yao M, Hanson GJ, Pentelute B. Perfluoroaryl Bicyclic Cell-Penetrating Peptides for Delivery of Antisense Oligonucleotides. Angew Chem Int Ed. 2018;[Epub ahead of print] doi:10.1002/anie.201801167. |
Antisense inhibitors retain activity in pulmonary models of Burkholderia infection
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Citation:
ACS Infect Dis. 2018 Feb 20. doi: 10.1021/acsinfecdis.7b00235. [Epub ahead of print] Epub:
Yes Abstract:
The Burkholderia cepacia complex is a group of gram-negative bacteria that are opportunistic pathogens in immunocompromised... Delivery Method:
peptide-linked Organism or Cell Type:
Burkholderia cepacia, Pseudomonas Citation Extract: Daly SM, Sturge CR, Marshall-Batty KR, Felder-Scott CF, Jain R, Geller B, Greenberg D. Antisense inhibitors retain activity in pulmonary models of Burkholderia infection. ACS Infect Dis. 2018 Feb 20. doi: 10.1021/acsinfecdis.7b00235. [Epub ahead of print]. |
MCR-1 Inhibition with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Sensitivity to Polymyxin in Escherichia coli
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Citation:
mBio. 2017;8:e01315-17. doi:10.1128/mBio.01315-17 Epub:
Not Epub Abstract:
In late 2015, the first example of a transferrable polymyxin resistance mechanism in Gram-negative pathogens, MCR-1, was... Delivery Method:
peptide-linked Organism or Cell Type:
mice, Escherichia coli Citation Extract: Daly SM, Sturge CR, Felder-Scott CF, Geller BL, Greenberg DE. MCR-1 Inhibition with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Sensitivity to Polymyxin in Escherichia coli. mBio. 2017;8:e01315-17. doi:10.1128/mBio.01315-17. |
Amphiphilic lipopeptide significantly enhances uptake of charge-neutral splice switching morpholino oligonucleotide in spinal muscular atrophy patient-derived fibroblasts
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Citation:
Int J Pharmaceutics. 2017;[Epub ahead of print] doi:10.1016/j.ijpharm.2017.08.116 Epub:
Yes Abstract:
Splice-switching antisense oligonucleotides (SSOs) are emerging therapeutics with two SSOs recently approved by the FDA for... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: patient-derived SMA fibroblasts Citation Extract: Tajik-Ahmadabad B, Polyzos A, Separovic F, Shabanpoor F. Amphiphilic lipopeptide significantly enhances uptake of charge-neutral splice switching morpholino oligonucleotide in spinal muscular atrophy patient-derived fibroblasts. Int J Pharmaceutics. 2017;[Epub ahead of print] doi:10.1016/j.ijpharm.2017.08.116. |
Targeted Delivery of FLT-Morpholino Using Cyclic RGD Peptide
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Citation:
Transl Vis Sci Technol. 2017 May 24;6(3):9. doi: 10.1167/tvst.6.3.9. eCollection 2017 May Epub:
Not Epub Abstract:
PURPOSE: We previously showed that intravitreal injection of the sFLT morpholino-oligomer (FLT-MO) suppresses laser-induced... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: primary mouse aortic endothelial cells (MAECs), mice Citation Extract: Uehara H, Muddana SK, Zhang X, Das SK, Bhuvanagiri S, Liu J, Wu Y, Choi S, Carroll LS, Archer B, Ambati BK. Targeted Delivery of FLT-Morpholino Using Cyclic RGD Peptide. Transl Vis Sci Technol. 2017 May 24;6(3):9. doi: 10.1167/tvst.6.3.9. eCollection 2017 May. |