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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 259 scientific papers returned from the database with the search filters currently being used below.
There are 259 scientific papers returned from the database with the search filters currently being used below.
Morpholino oligomers tested in vitro, in biofilm and in vivo against multidrug-resistant Klebsiella pneumoniae
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Citation:
J Antimicrob Chemother. 2018;[Epub ahead of print] doi:10.1093/jac/dky058 Epub:
Yes Abstract:
Background: Klebsiella pneumoniae is an opportunistic pathogen and many strains are multidrug resistant. KPC is one of the most... Delivery Method:
peptide-linked Organism or Cell Type:
Klebsiella pneumoniae Citation Extract: Geller BL, Li L, Martinez F, Sully E, Sturge CR, Daly SM, Pybus C, Greenberg DE. Morpholino oligomers tested in vitro, in biofilm and in vivo against multidrug-resistant Klebsiella pneumoniae. J Antimicrob Chemother. 2018;[Epub ahead of print] doi:10.1093/jac/dky058. |
Perfluoroaryl Bicyclic Cell-Penetrating Peptides for Delivery of Antisense Oligonucleotides
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Citation:
Angew Chem Int Ed. 2018;[Epub ahead of print] doi:10.1002/anie.201801167 Epub:
Yes Abstract:
Exon-skipping antisense oligonucleotides are effective treatments for genetic diseases, yet exon-skipping activity requires... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: HeLa-654 Citation Extract: Wolfe JM, Fadzen CM, Holden RL, Yao M, Hanson GJ, Pentelute B. Perfluoroaryl Bicyclic Cell-Penetrating Peptides for Delivery of Antisense Oligonucleotides. Angew Chem Int Ed. 2018;[Epub ahead of print] doi:10.1002/anie.201801167. |
Antisense inhibitors retain activity in pulmonary models of Burkholderia infection
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Citation:
ACS Infect Dis. 2018 Feb 20. doi: 10.1021/acsinfecdis.7b00235. [Epub ahead of print] Epub:
Yes Abstract:
The Burkholderia cepacia complex is a group of gram-negative bacteria that are opportunistic pathogens in immunocompromised... Delivery Method:
peptide-linked Organism or Cell Type:
Burkholderia cepacia, Pseudomonas Citation Extract: Daly SM, Sturge CR, Marshall-Batty KR, Felder-Scott CF, Jain R, Geller B, Greenberg D. Antisense inhibitors retain activity in pulmonary models of Burkholderia infection. ACS Infect Dis. 2018 Feb 20. doi: 10.1021/acsinfecdis.7b00235. [Epub ahead of print]. |
MCR-1 Inhibition with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Sensitivity to Polymyxin in Escherichia coli
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Citation:
mBio. 2017;8:e01315-17. doi:10.1128/mBio.01315-17 Epub:
Not Epub Abstract:
In late 2015, the first example of a transferrable polymyxin resistance mechanism in Gram-negative pathogens, MCR-1, was... Delivery Method:
peptide-linked Organism or Cell Type:
mice, Escherichia coli Citation Extract: Daly SM, Sturge CR, Felder-Scott CF, Geller BL, Greenberg DE. MCR-1 Inhibition with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Sensitivity to Polymyxin in Escherichia coli. mBio. 2017;8:e01315-17. doi:10.1128/mBio.01315-17. |
Amphiphilic lipopeptide significantly enhances uptake of charge-neutral splice switching morpholino oligonucleotide in spinal muscular atrophy patient-derived fibroblasts
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Citation:
Int J Pharmaceutics. 2017;[Epub ahead of print] doi:10.1016/j.ijpharm.2017.08.116 Epub:
Yes Abstract:
Splice-switching antisense oligonucleotides (SSOs) are emerging therapeutics with two SSOs recently approved by the FDA for... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: patient-derived SMA fibroblasts Citation Extract: Tajik-Ahmadabad B, Polyzos A, Separovic F, Shabanpoor F. Amphiphilic lipopeptide significantly enhances uptake of charge-neutral splice switching morpholino oligonucleotide in spinal muscular atrophy patient-derived fibroblasts. Int J Pharmaceutics. 2017;[Epub ahead of print] doi:10.1016/j.ijpharm.2017.08.116. |
Targeted Delivery of FLT-Morpholino Using Cyclic RGD Peptide
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Citation:
Transl Vis Sci Technol. 2017 May 24;6(3):9. doi: 10.1167/tvst.6.3.9. eCollection 2017 May Epub:
Not Epub Abstract:
PURPOSE: We previously showed that intravitreal injection of the sFLT morpholino-oligomer (FLT-MO) suppresses laser-induced... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: primary mouse aortic endothelial cells (MAECs), mice Citation Extract: Uehara H, Muddana SK, Zhang X, Das SK, Bhuvanagiri S, Liu J, Wu Y, Choi S, Carroll LS, Archer B, Ambati BK. Targeted Delivery of FLT-Morpholino Using Cyclic RGD Peptide. Transl Vis Sci Technol. 2017 May 24;6(3):9. doi: 10.1167/tvst.6.3.9. eCollection 2017 May. |
Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice
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Citation:
Polymers. 2017;9(5):177. doi:10.3390/polym9050177 Epub:
Not Epub Abstract:
A series of amphiphilic peptides modified PMO (Pt-PMO) were prepared, and their antisense effect and toxicity were evaluated... Delivery Method:
peptide linked, Endo-Porter Organism or Cell Type:
mice mdx, cell culture C2C12E23 Citation Extract: Wang MX, Wu B, Lu P, Shah SN, Tucker JD, Bollinger LE, Lu Q. Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice. Polymers. 2017;9(5):177. doi:10.3390/polym9050177. |
Combination of valproic acid and morpholino splice-switching oligonucleotide produces improved outcomes in spinal muscular atrophy patient-derived fibroblasts
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Citation:
Neurochem Int. 2017 Apr 4. pii: S0197-0186(17)30035-9. doi: 10.1016/j.neuint.2017.02.016. [Epub ahead of print] Epub:
Yes Abstract:
Spinal muscular atrophy (SMA), the leading genetic cause of infant mortality worldwide, is characterised by the homozygous loss... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: primary human fibroblasts Citation Extract: Farrelly-Rosch A, Lau CL, Patil N, Turner BJ, Shabanpoor F. Combination of valproic acid and morpholino splice-switching oligonucleotide produces improved outcomes in spinal muscular atrophy patient-derived fibroblasts. Neurochem Int. 2017 Apr 4. pii: S0197-0186(17)30035-9. doi: 10.1016/j.neuint.2017.02.016. [Epub ahead of print]. |
Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy
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Citation:
Proc Natl Acad Sci U S A. 2017 Apr 3. pii: 201613203. doi: 10.1073/pnas.1613203114. [Epub ahead of print] Epub:
Yes Abstract:
Duchenne muscular dystrophy (DMD) is a lethal genetic disorder caused by an absence of the dystrophin protein in bodywide... Delivery Method:
peptide-linked, bare oligo injection Organism or Cell Type:
Canis familiaris (dog) Citation Extract: Echigoya Y, Nakamura A, Nagata T, Urasawa N, Lim KR, Trieu N, Panesar D, Kuraoka M, Moulton HM, Saito T, Aoki Y, Iversen P, Sazani P, Kole R, Maruyama R, Partridge T, Takeda S, Yokota T. Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2017 Apr 3. pii: 201613203. doi: 10.1073/pnas.1613203114. [Epub ahead of print]. |
Systemic Delivery of Morpholinos to Skip Multiple Exons in a Dog Model of Duchenne Muscular Dystrophy
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Citation:
Methods Mol Biol. 2017;1565:201-213. doi: 10.1007/978-1-4939-6817-6_17 Epub:
Not Epub Abstract:
Exon-skipping therapy is an emerging approach that uses synthetic DNA-like molecules called antisense oligonucleotides (AONs)... Delivery Method:
injection, peptide-linked Organism or Cell Type:
Canis familiaris (dog) Citation Extract: Maruyama R, Echigoya Y, Caluseriu O, Aoki Y, Takeda S, Yokota T. Systemic Delivery of Morpholinos to Skip Multiple Exons in a Dog Model of Duchenne Muscular Dystrophy. Methods Mol Biol. 2017;1565:201-213. doi: 10.1007/978-1-4939-6817-6_17. |