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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 259 scientific papers returned from the database with the search filters currently being used below.
There are 259 scientific papers returned from the database with the search filters currently being used below.
Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics
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Citation:
bioRxiv. 2019;[preprint] doi:10.1101/791780 Epub:
Not Epub Abstract:
Dystrophin plays a vital role in maintaining muscle health, yet low mRNA expression, lengthy transcription time and the... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Hildyard JCW, Rawson F, Wells DJ, Piercy RJ. Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics. bioRxiv. 2019;[preprint] doi:10.1101/791780 . |
Hexose potentiates peptide-conjugated morpholino oligomer efficacy in cardiac muscles of dystrophic mice in an age-dependent manner
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Citation:
Mol Ther Nucl Acids. 2019 Sep 23;18:341-350. doi: 10.1016/j.omtn.2019.09.012. [Epub ahead of print] Epub:
Not Epub Abstract:
Insufficient delivery of oligonucleotides to muscle and heart remains a barrier for clinical implementation of antisense... Delivery Method:
peptide-linked Organism or Cell Type:
mice mdx Citation Extract: Han G, Gu B, Lin C, Ning H, Song J, Gao X, Moulton HM, Yin HF. Hexose potentiates peptide-conjugated morpholino oligomer efficacy in cardiac muscles of dystrophic mice in an age-dependent manner. Mol Ther Nucl Acids. 2019 Sep 23;18:341-350. doi: 10.1016/j.omtn.2019.09.012. [Epub ahead of print]. |
Reduction of integrin alpha 4 activity through splice modulating antisense oligonucleotides
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Citation:
Sci Rep. 2019;9(1):12994. doi:10.1038/s41598-019-49385-6 Epub:
Not Epub Abstract:
With recent approvals of antisense oligonucleotides as therapeutics, there is an increasing interest in expanding the... Delivery Method:
in vitro lipofectamine (fibroblasts) electroporation (Jurkat) , in vivo peptide-linked Organism or Cell Type:
cell culture: primary dermal fibroblasts, Jurkat; autoimmune encephalomyelitis mouse model of multiple sclerosis Citation Extract: Aung-Htut MT, Comerford I, Johnsen R, Foyle K, Fletcher S, Wilton SD. Reduction of integrin alpha 4 activity through splice modulating antisense oligonucleotides. Sci Rep. 2019;9(1):12994. doi:10.1038/s41598-019-49385-6. |
Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice
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Citation:
J Clin Invest. 2019 Nov 1;129(11):4739-4744. doi: 10.1172/JCI128205 Epub:
Not Epub Abstract:
Antisense oligonucleotides (ASOs) targeting pathologic RNAs have shown promising therapeutic corrections for many genetic... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: patient-derived muscle DM1 mice Citation Extract: Klein AF, Varela MA, Arandel L, Holland A, Naouar N, Arzumanov A, Seoane D, Revillod L, Bassez G, Ferry A, Jauvin D, Gourdon G, Puymirat J, Gait MJ, Furling D, Wood MJA. Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice. J Clin Invest. 2019 Nov 1;129(11):4739-4744. doi: 10.1172/JCI128205. |
Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy
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Citation:
Biochemistry. 2019;[Epub ahead of print] doi:10.1021/acs.biochem.9b00413 Epub:
Yes Abstract:
Phosphorodiamidate morpholino oligonucleotides (PMOs) are a promising class of therapeutics for genetic disease. PMOs designed... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: HeLa-654 Citation Extract: Fadzen CM, Holden R, Wolfe JM, Choo Z-N, Schissel CK, Yao M, Hanson GJ, Pentelute BL. Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy. Biochemistry. 2019;[Epub ahead of print] doi:10.1021/acs.biochem.9b00413. |
TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes
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Citation:
J Virol. 2019;[Epub ahead of print] doi:10.1128/JVI.00649-19 Epub:
Yes Abstract:
Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is essential for virus infectivity and spread. We... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: primary human bronchial epithelial cells (HBEC), primary type II alveolar epithelial cells (AECII) and Calu-3 cells Citation Extract: Limburg H, Harbig A, Bestle D, Stein DA, Moulton HM, Jaeger J, Janga H, Hardes K, Koepke J, Schulte L, Koczulla AR, Schmeck B, Klenk H-D, Böttcher-Friebertshäuser E. TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes. J Virol. 2019;[Epub ahead of print] doi:10.1128/JVI.00649-19. |
Global analysis of polysome-associated mRNA in vesicular stomatitis virus infected cells
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Citation:
PLoS Pathog. 2019;15(6):e1007875. doi:10.1371/journal.ppat.1007875 Epub:
Not Epub Abstract:
Infection of mammalian cells with vesicular stomatitis virus (VSV) results in the inhibition of cellular translation while... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: HeLa Citation Extract: Neidermyer WJ Jr, Whelan SPJ. Global analysis of polysome-associated mRNA in vesicular stomatitis virus infected cells. PLoS Pathog. 2019;15(6):e1007875. doi:10.1371/journal.ppat.1007875. |
AcrAB-TolC Inhibition by Peptide-conjugated Phosphorodiamidate Morpholino Oligomers Restores Antibiotic Activity in vitro and in vivo
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Citation:
ACS Infect Dis. 2019 May 23. doi: 10.1021/acsinfecdis.9b00123. [Epub ahead of print] Epub:
Yes Abstract:
Overexpression of bacterial efflux pumps are a driver of increasing antibiotic resistance in gram-negative pathogens. The AcrAB... Delivery Method:
peptide-linked Organism or Cell Type:
Enterobacteriaceae strains, Klebsiella pneumoniae, Pseudomonas aeruginosa Citation Extract: Sturge CR, Felder-Scott CF, Pifer R, Pybus C, Jain R, Geller B, Greenberg D. AcrAB-TolC Inhibition by Peptide-conjugated Phosphorodiamidate Morpholino Oligomers Restores Antibiotic Activity in vitro and in vivo. ACS Infect Dis. 2019 May 23. doi: 10.1021/acsinfecdis.9b00123. [Epub ahead of print]. |
Scavenger receptor class A1 mediates uptake of morpholino antisense oligonucleotide into dystrophic skeletal muscle
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Citation:
Mol Ther Nucl Acids. 2019 Jan 25;14:520-535. doi: 10.1016/j.omtn.2019.01.008. Epub:
Not Epub Abstract:
Exon-skipping using phosphorodiamidate morpholino oligomers (PMOs) is a promising treatment strategy for Duchenne muscular... Delivery Method:
peptide-linked, cell bathing Organism or Cell Type:
mice mdx62, cell culture: H2K-mdx 52 myoblasts Citation Extract: Miyatake S, Mizobe Y, Tsoumpra M, Lim KRQ, Hara Y, Shabanpoor F, Yokota T, Takeda S, Aoki Y. Scavenger receptor class A1 mediates uptake of morpholino antisense oligonucleotide into dystrophic skeletal muscle. Mol Ther Nucl Acids. 2019 Jan 25;14:520-535. doi: 10.1016/j.omtn.2019.01.008. . |
Comprehensive RNA-Sequencing Analysis in Serum and Muscle Reveals Novel Small RNA Signatures with Biomarker Potential for DMD
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Citation:
Mol Ther Nucleic Acids. 2018 Dec 7;13:1-15. doi: 10.1016/j.omtn.2018.08.005. Epub 2018 Aug 17 Epub:
Not Epub Abstract:
Extracellular small RNAs (sRNAs), including microRNAs (miRNAs), are promising biomarkers for diseases such as Duchenne muscular... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Coenen-Stass AML, Sork H, Gatto S, Godfrey C, Bhomra A, Krjutškov K, Hart JR, Westholm JO, O'Donovan L, Roos A, Lochmüller H, Puri PL, El Andaloussi S, Wood MJA, Roberts TC. Comprehensive RNA-Sequencing Analysis in Serum and Muscle Reveals Novel Small RNA Signatures with Biomarker Potential for DMD. Mol Ther Nucleic Acids. 2018 Dec 7;13:1-15. doi: 10.1016/j.omtn.2018.08.005. Epub 2018 Aug 17. |