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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 259 scientific papers returned from the database with the search filters currently being used below.

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo

Authors:
Moustafa DA, Wu AW, Zamora D, Daly SM, Sturge CR, Pybus C, Geller BL, Goldberg JB, Greenberg DE
Citation:
mBio. 2021;12(1):e02411-20. doi:10.1128/mBio.02411-20
Epub:
Not Epub
Abstract:
Most antimicrobials currently in the clinical pipeline are modifications of existing classes of antibiotics and are considered...
Link:
https://mbio.asm.org/content/12/1/e02411-20
Delivery Method:
peptide-linked
Organism or Cell Type:
Pseudomonas aeruginosa as biofilm or murine pneumonial infection
Citation Extract:
Moustafa DA, Wu AW, Zamora D, Daly SM, Sturge CR, Pybus C, Geller BL, Goldberg JB, Greenberg DE. Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo. mBio. 2021;12(1):e02411-20. doi:10.1128/mBio.02411-20.

Discovery and mechanistic characterization of a novel AhR receptor ligand that induces apoptosis in cancer cells

Authors:
O'Donnell E, Jang HS, Liefwalker D, Kerkvliet N, Kolluri SK
Citation:
Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-131951/v1
Epub:
Not Epub
Abstract:
Background: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and a member of the bHLH/PAS (basic...
Link:
https://www.researchsquare.com/article/rs-131951/v1
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Hepa 1
Citation Extract:
O'Donnell E, Jang HS, Liefwalker D, Kerkvliet N, Kolluri SK. Discovery and mechanistic characterization of a novel AhR receptor ligand that induces apoptosis in cancer cells. Research Square. 2020;[preprint] doi:10.21203/rs.3.rs-131951/v1.

MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice

Authors:
Ran N, Lin C, Leng L, Han G, Geng M, Wu Y, Bittner S, Moulton H, Yin H
Citation:
EMBO Mol Med. 2020;13:e12993 doi:10.15252/emmm.202012993
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (AO)‐mediated exon‐skipping therapies show promise in Duchenne muscular dystrophy (DMD), a...
Link:
https://www.embopress.org/doi/full/10.15252/emmm.202012993
Delivery Method:
unlinked MOTS‐c peptide
Organism or Cell Type:
mouse mdx
Citation Extract:
Ran N, Lin C, Leng L, Han G, Geng M, Wu Y, Bittner S, Moulton H, Yin H. MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice. EMBO Mol Med. 2020;13:e12993 doi:10.15252/emmm.202012993.

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers for In Situ Live-Cell Molecular Imaging of Dengue Virus Replication

Authors:
Victorio CB, Novera W, Tham JY, Watanabe S, Vasudevan SG, Chacko A-M
Citation:
Int J Molec Sci. 2020;21(23):1422-0067 doi:10.3390/ijms21239260
Epub:
Not Epub
Abstract:
Current methods to detect and monitor pathogens in biological systems are largely limited by the tradeoffs between spatial...
Link:
https://www.mdpi.com/1422-0067/21/23/9260
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Vero, BHK-21
Citation Extract:
Victorio CB, Novera W, Tham JY, Watanabe S, Vasudevan SG, Chacko A-M. Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers for In Situ Live-Cell Molecular Imaging of Dengue Virus Replication. Int J Molec Sci. 2020;21(23):1422-0067 doi:10.3390/ijms21239260.

Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers

Authors:
Rosenke K, Leventhal S, Moulton H, Hatlevig S, Hawman D, Feldmann H, Stein DA
Citation:
J Antimicrob Chemother. 2020;[Epub ahead of print]:dkaa460 doi:10.1093/jac/dkaa460
Epub:
Yes
Abstract:
Background: As the causative agent of COVID-19, SARS-CoV-2 is a pathogen of immense importance to global public health....
Link:
https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkaa460/5961620
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Vero-E6 and SARS-CoV-2
Citation Extract:
Rosenke K, Leventhal S, Moulton H, Hatlevig S, Hawman D, Feldmann H, Stein DA. Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers. J Antimicrob Chemother. 2020;[Epub ahead of print]:dkaa460 doi:10.1093/jac/dkaa460.

Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers

Authors:
Rosenke K, Leventhal S, Moulton H, Hatlevig S, Hawman D, Feldmann H, Stein DA
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.09.29.319731
Epub:
Not Epub
Abstract:
Background: SARS-CoV-2 is the causative agent of COVID-19 and a pathogen of immense global public health importance....
Link:
https://www.biorxiv.org/content/10.1101/2020.09.29.319731v1
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Vero-E6 and SARS-CoV-2
Citation Extract:
Rosenke K, Leventhal S, Moulton H, Hatlevig S, Hawman D, Feldmann H, Stein DA. Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers. bioRxiv. 2020;[preprint] doi:10.1101/2020.09.29.319731.

Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics

Authors:
Hildyard JCW, Rawson F, Wells DJ, Piercy RJ
Citation:
PLoS ONE. 2020;15(9):e0239467. doi:10.1371/journal.pone.0239467
Epub:
Not Epub
Abstract:
Dystrophin plays a vital role in maintaining muscle health, yet low mRNA expression, lengthy transcription time and the...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239467
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Hildyard JCW, Rawson F, Wells DJ, Piercy RJ. Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics. PLoS ONE. 2020;15(9):e0239467. doi:10.1371/journal.pone.0239467.

In vivo Pharmacokinetic and Biodistribution profile of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides

Authors:
Burki U, Blain A, Greally E, O’Donovan L, Gait M, Laval S, Straub V
Citation:
Poster at 2015 Oligonucleotide Therapeutics Society meeting
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (AON) induced exon skipping is one of the most promising strategies for treating Duchene muscular...
Link:
https://www.researchgate.net/publication/283047310_In_vivo_Pharmacokinetic_and_Biodistribution_profile_of_Peptide-Conjugated_Phosphorodiamidate_Morpholino_Oligonucleotides [accessed Sep 17 2020]
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Burki U, Blain A, Greally E, O’Donovan L, Gait M, Laval S, Straub V. In vivo Pharmacokinetic and Biodistribution profile of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides. Poster at 2015 Oligonucleotide Therapeutics Society meeting.

Morpholino Oligomer-Induced Dystrophin Isoforms to Map the Functional Domains in the Dystrophin Protein

Authors:
Li D, Adams AM, Johnsen RD, Fletcher S, Wilton SD
Citation:
Molec Ther. 2020 Aug 21;22:263-272. doi:10.1016/j.omtn.2020.08.019
Epub:
Not Epub
Abstract:
Dystrophin plays a crucial role in maintaining sarcolemma stability during muscle contractions, and mutations that prevent the...
Link:
https://www.sciencedirect.com/science/article/pii/S2162253120302481
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: murine H2K mdx myogenic cells, mice
Citation Extract:
Li D, Adams AM, Johnsen RD, Fletcher S, Wilton SD. Morpholino Oligomer-Induced Dystrophin Isoforms to Map the Functional Domains in the Dystrophin Protein. Molec Ther. 2020 Aug 21;22:263-272. doi:10.1016/j.omtn.2020.08.019.

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

Authors:
Bestle D, Heindl MR, Limburg H, Lam van TV, Pilgram O, Moulton H, Stein DA, Hardes K, Eickmann M, Dolnik O, Rohde C, Klenk H-D, Garten W, Steinmetzer T, Böttcher-Friebertshäuser E
Citation:
Life Sci Alliance. 2020;3(9):e202000786 doi:10.26508/lsa.202000786
Epub:
Not Epub
Abstract:
The novel emerged SARS-CoV-2 has rapidly spread around the world causing acute infection of the respiratory tract (COVID-19)...
Link:
https://www.life-science-alliance.org/content/3/9/e202000786
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Calu-3 human airway epithelial cells
Citation Extract:
Bestle D, Heindl MR, Limburg H, Lam van TV, Pilgram O, Moulton H, Stein DA, Hardes K, Eickmann M, Dolnik O, Rohde C, Klenk H-D, Garten W, Steinmetzer T, Böttcher-Friebertshäuser E. TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells. Life Sci Alliance. 2020;3(9):e202000786 doi:10.26508/lsa.202000786.

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