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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 260 scientific papers returned from the database with the search filters currently being used below.

Cell-Penetrating D-Peptides Retain Antisense Morpholino Oligomer Delivery Activity

Authors:
Schissel CK, Farquhar CE, Malmberg AB, Loas A, Pentelute BL
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.09.30.462617
Epub:
Not Epub
Abstract:
Cell-penetrating peptides (CPPs) can cross the cell membrane to enter the cytosol and deliver otherwise non-penetrant...
Link:
https://www.biorxiv.org/content/10.1101/2021.09.30.462617v1
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: HeLa 654
Citation Extract:
Schissel CK, Farquhar CE, Malmberg AB, Loas A, Pentelute BL. Cell-Penetrating D-Peptides Retain Antisense Morpholino Oligomer Delivery Activity. bioRxiv. 2021;[preprint] doi:10.1101/2021.09.30.462617.

Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy

Authors:
Martin-Sancho L, Tripathi S, Rodriguez-Frandsen A, Pache L, Sanchez-Aparicio M, McGregor MJ, Haas KM, Swaney DL, Nguyen TT, Mamede JI, Churas C, Pratt D, Rosenthal SB, Riva L, Nguyen C, Beltran-Raygoza N, Soonthornvacharin S, Wang G, Jimenez-Morales D, De Jesus PD, Moulton HM, Stein DA, Chang MW, Benner C, Ideker T, Albrecht RA, Hultquist JF, Krogan NJ, García-Sastre A, Chanda SK
Citation:
Nat Microbiol. 2021;[Epub] doi:10.1038/s41564-021-00964-2
Epub:
Yes
Abstract:
The fate of influenza A virus (IAV) infection in the host cell depends on the balance between cellular defence mechanisms and...
Link:
https://www.nature.com/articles/s41564-021-00964-2
Delivery Method:
intranasal peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Martin-Sancho L, Tripathi S, Rodriguez-Frandsen A, Pache L, Sanchez-Aparicio M, McGregor MJ, Haas KM, Swaney DL, Nguyen TT, Mamede JI, Churas C, Pratt D, Rosenthal SB, Riva L, Nguyen C, Beltran-Raygoza N, Soonthornvacharin S, Wang G, Jimenez-Morales D, De Jesus PD, Moulton HM, Stein DA, Chang MW, Benner C, Ideker T, Albrecht RA, Hultquist JF, Krogan NJ, García-Sastre A, Chanda SK. Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy. Nat Microbiol. 2021;[Epub] doi:10.1038/s41564-021-00964-2.

Hemagglutinins of avian influenza viruses are proteolytically activated by TMPRSS2 in human and murine airway cells

Authors:
Bestle D, Limburg H, Kruhl D, Harbig A, Stein DA, Moulton H, Matrosovich M, Abdelwhab EM, Stech J, Böttcher-Friebertshäuser E
Citation:
J Virol. 2021 Jul 28:JVI0090621. doi: 10.1128/JVI.00906-21. Online ahead of print
Epub:
Not Epub
Abstract:
Cleavage of the influenza A virus (IAV) hemagglutinin (HA) by host proteases is indispensable for virus replication. Most IAVs...
Link:
https://journals.asm.org/doi/10.1128/JVI.00906-21
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: human and mouse airway cells
Citation Extract:
Bestle D, Limburg H, Kruhl D, Harbig A, Stein DA, Moulton H, Matrosovich M, Abdelwhab EM, Stech J, Böttcher-Friebertshäuser E. Hemagglutinins of avian influenza viruses are proteolytically activated by TMPRSS2 in human and murine airway cells. J Virol. 2021 Jul 28:JVI0090621. doi: 10.1128/JVI.00906-21. Online ahead of print.

Chapter Six - Emerging RNA Suppression Technologies to Protect Citrus Trees From Citrus Greening Disease Bacteria

Authors:
Hunter WB, Sinisterra-Hunter SH
Citation:
Adv In Insect Physiol. 2018;55:163-197. doi:10.1016/bs.aiip.2018.08.001
Epub:
Not Epub
Abstract:
Research on the development of RNA-suppressing technologies, which include RNA interference, (RNAi), and the application of RNA...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0065280618300171
Delivery Method:
peptide-linked
Organism or Cell Type:
Candidatus Liberibacter asiaticus
Citation Extract:
Hunter WB, Sinisterra-Hunter SH. Chapter Six - Emerging RNA Suppression Technologies to Protect Citrus Trees From Citrus Greening Disease Bacteria. Adv In Insect Physiol. 2018;55:163-197. doi:10.1016/bs.aiip.2018.08.001.

Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung

Authors:
Dang Y, van Heusden C, Nickerson V, Chung F, Wang Y, Quinney NL, Gentzsch M, Randell SH, Moulton HM, Kole R, Ni A, Juliano RL, Kreda SM
Citation:
Nucleic Acids Res. 2021;49(11):6100–13. doi: 10.1093/nar/gkab488. Online ahead of print
Epub:
Not Epub
Abstract:
Pulmonary diseases offer many targets for oligonucleotide therapeutics. However, effective delivery of oligonucleotides to the...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab488/6295539
Delivery Method:
peptide-linked plus endosome escape reagent (OEC)
Organism or Cell Type:
cell culture: HeLa EGFP654, Human Bronchial Epithelial, UNCCF8T, EGFP654 Mouse Tracheal Epithelial, mouse
Citation Extract:
Dang Y, van Heusden C, Nickerson V, Chung F, Wang Y, Quinney NL, Gentzsch M, Randell SH, Moulton HM, Kole R, Ni A, Juliano RL, Kreda SM. Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung. Nucleic Acids Res. 2021;49(11):6100–13. doi: 10.1093/nar/gkab488. Online ahead of print.

CX3CR1 is a Receptor for Human Respiratory Syncytial Virus in Cotton Rats

Authors:
Green G, Johnson SM, Costello H, Brakel K, Harder O, Oomens AG, Peeples ME, Moulton HM, Niewiesk S
Citation:
J Virol. 2021 May 26:JVI0001021. doi: 10.1128/JVI.00010-21. Online ahead of print
Epub:
Not Epub
Abstract:
Respiratory syncytial virus (RSV) has been reported to use CX3CR1 in vitro as a receptor on cultured primary human airway...
Link:
https://journals.asm.org/doi/10.1128/JVI.00010-21
Delivery Method:
peptide-linked
Organism or Cell Type:
Sigmodon sp. (Cotton rat)
Citation Extract:
Green G, Johnson SM, Costello H, Brakel K, Harder O, Oomens AG, Peeples ME, Moulton HM, Niewiesk S. CX3CR1 is a Receptor for Human Respiratory Syncytial Virus in Cotton Rats. J Virol. 2021 May 26:JVI0001021. doi: 10.1128/JVI.00010-21. Online ahead of print.

A targeted antisense therapeutic approach for Hutchinson–Gilford progeria syndrome

Authors:
Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS
Citation:
Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038/s41591-021-01274-0. Epub 2021 Mar 11.
Epub:
Not Epub
Abstract:
Hutchinson–Gilford progeria syndrome (HGPS) is a rare accelerated aging disorder characterized by premature death from...
Link:
https://www.nature.com/articles/s41591-021-01274-0
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: human progeric fibroblasts, mice
Citation Extract:
Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS. A targeted antisense therapeutic approach for Hutchinson–Gilford progeria syndrome. Nat Med. 2021 Mar;27(3):536-545. doi: 10.1038/s41591-021-01274-0. Epub 2021 Mar 11..

Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation

Authors:
Dastpeyman M, Karas JA, Amin A, Turner BJ, Shabanpoor F
Citation:
Front Chem. 2021;9:9. doi:10.3389/fchem.2021.627329
Epub:
Not Epub
Abstract:
Cell penetrating peptides (CPPs) are being increasingly used as efficient vectors for intracellular delivery of biologically...
Link:
https://www.frontiersin.org/articles/10.3389/fchem.2021.627329/full
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: spinal muscular atrophy (SMA) patient fibroblasts
Citation Extract:
Dastpeyman M, Karas JA, Amin A, Turner BJ, Shabanpoor F. Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation. Front Chem. 2021;9:9. doi:10.3389/fchem.2021.627329.

Endosomal escape cell-penetrating peptides significantly enhance pharmacological effectiveness and CNS activity of systemically administered antisense oligonucleotides

Authors:
Dastpeyman M, Sharifi R, Amin A, Karas JA, Cuic B, Pan Y, Nicolazzo JA, Turner BJ, Shabanpoor F
Citation:
Int J Pharm. 2021 Feb 25:120398. doi: 10.1016/j.ijpharm.2021.120398. Online ahead of print
Epub:
Yes
Abstract:
Antisense oligonucleotides (ASOs) are an emerging class of gene-specific therapeutics for diseases associated with the central...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0378517321002027
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Dastpeyman M, Sharifi R, Amin A, Karas JA, Cuic B, Pan Y, Nicolazzo JA, Turner BJ, Shabanpoor F. Endosomal escape cell-penetrating peptides significantly enhance pharmacological effectiveness and CNS activity of systemically administered antisense oligonucleotides. Int J Pharm. 2021 Feb 25:120398. doi: 10.1016/j.ijpharm.2021.120398. Online ahead of print.

Targeting the 5' untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy

Authors:
Winkelsas AM, Grunseich C, Harmison GG, Chwalenia K, Rinaldi C, Hammond SM, Johnson K, Bowerman M, Arya S, Talbot K, Wood MJ, Fischbeck KH
Citation:
Mol Ther Nucleic Acids. 2021 Jan 5;23:731-742. doi: 10.1016/j.omtn.2020.12.027. eCollection 2021 Mar 5
Epub:
Not Epub
Abstract:
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by mutations in the survival motor neuron 1 (SMN1) gene. All...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(20)30408-X
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: iPSC
Citation Extract:
Winkelsas AM, Grunseich C, Harmison GG, Chwalenia K, Rinaldi C, Hammond SM, Johnson K, Bowerman M, Arya S, Talbot K, Wood MJ, Fischbeck KH. Targeting the 5' untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophy. Mol Ther Nucleic Acids. 2021 Jan 5;23:731-742. doi: 10.1016/j.omtn.2020.12.027. eCollection 2021 Mar 5.

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