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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 259 scientific papers returned from the database with the search filters currently being used below.
There are 259 scientific papers returned from the database with the search filters currently being used below.
In-Cell Penetration Selection-Mass Spectrometry Produces Noncanonical Peptides for Antisense Delivery
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Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.04.13.488231 Epub:
Not Epub Abstract:
Peptide-mediated delivery of macromolecules in cells has significant potential therapeutic benefits, but no therapy employing... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: HeLa 654 Citation Extract: Schissel CK, Farquhar CE, Loas A, Malmberg AB, Pentelute BL. In-Cell Penetration Selection-Mass Spectrometry Produces Noncanonical Peptides for Antisense Delivery. bioRxiv. 2022;[preprint] doi:10.1101/2022.04.13.488231. |
The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity
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Citation:
Cell Rep. 2022 Mar 8;38(10):110434. doi: 10.1016/j.celrep.2022.110434 Epub:
Not Epub Abstract:
Type I interferons (IFN-I) are essential to establish antiviral innate immunity. Unanchored (or free) polyubiquitin (poly-Ub)... Delivery Method:
intranasal peptide-linked Organism or Cell Type:
C57BL/6 or BALB/c mice Citation Extract: Hage A, Bharaj P, van Tol S, Giraldo MI, Gonzalez-Orozco M, Valerdi KM, Warren AN, Aguilera-Aguirre L, Xie X, Widen SG, Moulton HM, Lee B, Johnson JR, Krogan NJ, García-Sastre A, Shi PY, Freiberg AN, Rajsbaum R. The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity. Cell Rep. 2022 Mar 8;38(10):110434. doi: 10.1016/j.celrep.2022.110434. |
Proof of concept of peptide-linked blockmiR-induced MBNL functional rescue in myotonic dystrophy type 1 mouse model
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Citation:
Mol Ther Nucleic Acids. 2022:[Epub ahead of print] doi:10.1016/j.omtn.2022.02.003 Epub:
Yes Abstract:
Myotonic dystrophy type 1 is a debilitating neuromuscular disease causing muscle weakness, myotonia, and cardiac dysfunction.... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Overby SJ, Cerro-Herreros E, González-Martínez I, Varela MA, Seoane-Miraz D, Jad Y, Raz R, Møller T, Pérez-Alonso M, Wood MJ, Llamusí B, Artero R. Proof of concept of peptide-linked blockmiR-induced MBNL functional rescue in myotonic dystrophy type 1 mouse model. Mol Ther Nucleic Acids. 2022:[Epub ahead of print] doi:10.1016/j.omtn.2022.02.003. |
Cell-Penetrating d-Peptides Retain Antisense Morpholino Oligomer Delivery Activity
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Citation:
ACS Bio Med Chem Au. 2022:[Epub ahead of print] doi:10.1021/acsbiomedchemau.1c00053 Epub:
Yes Abstract:
Cell-penetrating peptides (CPPs) can cross the cell membrane to enter the cytosol and deliver otherwise nonpenetrant... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: HeLa 654 Citation Extract: Schissel CK, Farquhar CE, Malmberg AB, Loas A, Pentelute BL. Cell-Penetrating d-Peptides Retain Antisense Morpholino Oligomer Delivery Activity. ACS Bio Med Chem Au. 2022:[Epub ahead of print] doi:10.1021/acsbiomedchemau.1c00053. |
Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen
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Citation:
Methods Mol Biol. 2022;2434:129-141. Humana, New York, NY. doi:10.1007/978-1-0716-2010-6_8 Epub:
Not Epub Abstract:
Phosphorodiamidate morpholino oligomers (PMOs) offer great promise as therapeutic agents for translation blocking or splice... Delivery Method:
peptide-linked Citation Extract: Palacio-Castañeda V, Brock R, Verdurmen WPR. Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen. Methods Mol Biol. 2022;2434:129-141. Humana, New York, NY. doi:10.1007/978-1-0716-2010-6_8. |
Development of DG9 peptide-conjugated single- and multi-exon skipping therapies for the treatment of Duchenne muscular dystrophy
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Citation:
Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2112546119. doi: 10.1073/pnas.2112546119 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is primarily caused by out-of-frame deletions in the dystrophin gene. Exon skipping using... Delivery Method:
peptide-linked Organism or Cell Type:
mice hDMDdel52;mdx Citation Extract: Lim KRQ, Woo S, Melo D, Huang Y, Dzierlega K, Shah MNA, Aslesh T, Roshmi RR, Echigoya Y, Maruyama R, Moulton HM, Yokota T. Development of DG9 peptide-conjugated single- and multi-exon skipping therapies for the treatment of Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2112546119. doi: 10.1073/pnas.2112546119. |
A Dystrophin Exon-52 Deleted Miniature Pig Model of Duchenne Muscular Dystrophy and Evaluation of Exon Skipping
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Citation:
Int J Mol Sci. 2021;22(23):13065. doi:10.3390/ijms222313065 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a lethal X-linked recessive disorder caused by mutations in the DMD gene and the... Delivery Method:
peptide-linked, Endo-Porter Organism or Cell Type:
Sus scrofa domestica (pig) Citation Extract: Echigoya Y, Trieu N, Duddy W, Moulton HM, Yin H, Partridge TA, Hoffman EP, Kornegay JN, Rohret FA, Rogers CS, Yokota T. A Dystrophin Exon-52 Deleted Miniature Pig Model of Duchenne Muscular Dystrophy and Evaluation of Exon Skipping. Int J Mol Sci. 2021;22(23):13065. doi:10.3390/ijms222313065 . |
Targeting IgE polyadenylation signal with antisense oligonucleotides decreases IgE secretion and plasma cell viability
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Citation:
J Allergy Clin Immunol. 2021 Nov 2;S0091-6749(21)01680-8. doi: 10.1016/j.jaci.2021.09.039. Epub:
Not Epub Abstract:
Background: Allergy regroups numerous complex and various diseases classified as IgE-dependent or non-dependent... Delivery Method:
Vivo-Morpholino, peptide-linked Organism or Cell Type:
cell culture: B cells, myeloma cells; InEps mice Citation Extract: Marchalot A, Horiot C, Lambert J-M, Carrion C, Oblet C, Pollet J, Cogné M, Moreau J, Laffleur B, Delpy L. Targeting IgE polyadenylation signal with antisense oligonucleotides decreases IgE secretion and plasma cell viability. J Allergy Clin Immunol. 2021 Nov 2;S0091-6749(21)01680-8. doi: 10.1016/j.jaci.2021.09.039.. |
Deep Learning Enables Discovery of a Short Nuclear Targeting Peptide for Efficient Delivery of Antisense Oligomers
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Citation:
JACS Au. 2021;[Epub] doi:10.1021/jacsau.1c00327 Epub:
Not Epub Abstract:
Therapeutic macromolecules such as proteins and oligonucleotides can be highly efficacious but are often limited to... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: HeLa, mice Citation Extract: López-Vidal EM, Schissel CK, Mohapatra S, Bellovoda K, Wu C-L, Wood JA, Malmberg AB, Loas A, Gómez-Bombarelli R, Pentelute BL. Deep Learning Enables Discovery of a Short Nuclear Targeting Peptide for Efficient Delivery of Antisense Oligomers. JACS Au. 2021;[Epub] doi:10.1021/jacsau.1c00327. |
Cell-Penetrating D-Peptides Retain Antisense Morpholino Oligomer Delivery Activity
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Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.09.30.462617 Epub:
Not Epub Abstract:
Cell-penetrating peptides (CPPs) can cross the cell membrane to enter the cytosol and deliver otherwise non-penetrant... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: HeLa 654 Citation Extract: Schissel CK, Farquhar CE, Malmberg AB, Loas A, Pentelute BL. Cell-Penetrating D-Peptides Retain Antisense Morpholino Oligomer Delivery Activity. bioRxiv. 2021;[preprint] doi:10.1101/2021.09.30.462617. |