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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 260 scientific papers returned from the database with the search filters currently being used below.

Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum

Authors:
Augagneur Y, Wesolowski D, Tae HS, Altman S, Mamoun CB
Citation:
PNAS. 2012;[Epub ahead of print] doi:10.1073/pnas.1203516109
Epub:
Not Epub
Abstract:
Unique peptide-morpholino oligomer (PMO) conjugates have been designed to bind and promote the cleavage of specific mRNA as a...
Link:
https://www.pnas.org/content/109/16/6235
Delivery Method:
peptide-coupled
Organism or Cell Type:
Plasmodium falciparum
Citation Extract:
Augagneur Y, Wesolowski D, Tae HS, Altman S, Mamoun CB. Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum. PNAS. 2012;[Epub ahead of print] doi:10.1073/pnas.1203516109 .

Arginine-rich cell penetrating peptides: Design, structure-activity, and applications to alter pre-mRNA splicing by steric-block oligonucleotides

Authors:
Abes R, Arzumanov A, Moulton H, Abes S, Ivanova G, Gait MJ, Iversen P, Lebleu B
Citation:
J Pept Sci. 2008 Jan 30; [Epub ahead of print]
Epub:
Not Epub
Abstract:
Rerouting the splicing machinery with steric-block oligonucleotides (ON) might lead to new therapeutic strategies in the...
Delivery Method:
peptide-coupled
Citation Extract:
Abes R, Arzumanov A, Moulton H, Abes S, Ivanova G, Gait MJ, Iversen P, Lebleu B. Arginine-rich cell penetrating peptides: Design, structure-activity, and applications to alter pre-mRNA splicing by steric-block oligonucleotides. J Pept Sci. 2008 Jan 30; [Epub ahead of print] .

Cell-penetrating-peptide-based delivery of oligonucleotides: an overview

Authors:
Abes R, Arzumanov AA, Moulton HM, Abes S, Ivanova GD, Iversen PL, Gait MJ, Lebleu B
Citation:
Biochem Soc Trans. 2007 Aug;35(Pt 4):775-9
Epub:
Not Epub
Abstract:
Cationic CPPs (cell-penetrating peptides) have been used largely for intracellular delivery of low-molecular-mass drugs,...
Delivery Method:
peptide-coupled
Citation Extract:
Abes R, Arzumanov AA, Moulton HM, Abes S, Ivanova GD, Iversen PL, Gait MJ, Lebleu B. Cell-penetrating-peptide-based delivery of oligonucleotides: an overview. Biochem Soc Trans. 2007 Aug;35(Pt 4):775-9.

Delivery of steric block morpholino oligomers by (R-X-R)4 peptides: structure-activity studies

Authors:
Abes R, Moulton HM, Clair P, Yang ST, Abes S, Melikov K, Prevot P, Youngblood DS, Iversen PL, Chernomordik LV, Lebleu B
Citation:
Nucleic Acids Res. 2008 Nov;36(20):6343-54. Epub 2008 Sep 16
Epub:
Not Epub
Abstract:
Redirecting the splicing machinery through the hybridization of high affinity, RNase H- incompetent oligonucleotide analogs...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: HeLa AntisenseTest System
Citation Extract:
Abes R, Moulton HM, Clair P, Yang ST, Abes S, Melikov K, Prevot P, Youngblood DS, Iversen PL, Chernomordik LV, Lebleu B. Delivery of steric block morpholino oligomers by (R-X-R)4 peptides: structure-activity studies. Nucleic Acids Res. 2008 Nov;36(20):6343-54. Epub 2008 Sep 16.

Inhibition of infectious haematopoietic necrosis virus in cell cultures with peptide-conjugated morpholino oligomers

Authors:
Alonso M, Stein DA, Thomann E, Moulton HM, Leong JC, Iversen P, Mourich DV
Citation:
J Fish Dis. 2005 Jul;28(7):399-410
Epub:
Not Epub
Abstract:
Delivery of phosphorodiamidate morpholino oligomers (PMO) into fish cells in vitro and tissues in vivo was examined. Uptake was...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Fish virus: infectious haematopoietic necrosis virus
Citation Extract:
Alonso M, Stein DA, Thomann E, Moulton HM, Leong JC, Iversen P, Mourich DV. Inhibition of infectious haematopoietic necrosis virus in cell cultures with peptide-conjugated morpholino oligomers. J Fish Dis. 2005 Jul;28(7):399-410.

Inhibition of Japanese encephalitis virus replication in cultured cells and mice by a peptide-conjugated morpholino oligomer

Authors:
Anantpadma M, Stein DA, Vrati S
Citation:
J Antimicrob Chemother. 2010 Mar 18. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Background Japanese encephalitis virus (JEV) has a significant impact on public health throughout Asia, and there is a pressing...
Link:
http://jac.oxfordjournals.org/content/65/5/953.long
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice and cell culture: Vero, Neuro2A and J774E cells
Citation Extract:
Anantpadma M, Stein DA, Vrati S. Inhibition of Japanese encephalitis virus replication in cultured cells and mice by a peptide-conjugated morpholino oligomer. J Antimicrob Chemother. 2010 Mar 18. [Epub ahead of print].

Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides

Authors:
Abes S, Moulton H, Turner J, Clair P, Richard JP, Iversen P, Gait MJ, Lebleu B
Citation:
Biochem Soc Trans. 2007 Feb;35(Pt 1):53-5
Epub:
Not Epub
Abstract:
CPPs (cell-penetrating peptides) have given rise to much interest for the delivery of biomolecules such as peptides, proteins...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: HeLa AntisenseTest System
Citation Extract:
Abes S, Moulton H, Turner J, Clair P, Richard JP, Iversen P, Gait MJ, Lebleu B. Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides. Biochem Soc Trans. 2007 Feb;35(Pt 1):53-5.

Pharmacokinetics, Biodistribution, Stability and Toxicity of a Cell-Penetrating Peptide-Morpholino Oligomer Conjugate

Authors:
Amantana A, Moulton HM, Cate ML, Reddy MT, Whitehead T, Hassinger JN, Youngblood DS, Iversen PL
Citation:
Bioconjug Chem. 2007 Jul-Aug;18(4):1325-31. Epub 2007 Jun 21
Epub:
Not Epub
Abstract:
Objective: Conjugation of arginine-rich cell-penetrating peptide (CPP) to phosphorodiamidate morpholino oligomers (PMO) has...
Link:
https://pubs.acs.org/doi/10.1021/bc070060v
Delivery Method:
i.v. injection, peptide conjugates vs. bare Morpholino
Organism or Cell Type:
Rat
Citation Extract:
Amantana A, Moulton HM, Cate ML, Reddy MT, Whitehead T, Hassinger JN, Youngblood DS, Iversen PL. Pharmacokinetics, Biodistribution, Stability and Toxicity of a Cell-Penetrating Peptide-Morpholino Oligomer Conjugate. Bioconjug Chem. 2007 Jul-Aug;18(4):1325-31. Epub 2007 Jun 21.

Splice Redirection as a Convenient Assay to Monitor CPP-ON Efficiency and Mechanism

Authors:
Abes R, Arzumanov AA, Saleh AF, Said Hassane F, Gait MJ, Lebleu B
Citation:
Methods Mol Biol. 2011;683:307-20
Epub:
Not Epub
Abstract:
Several strategies based on synthetic oligonucleotides (ON) have been proposed to control gene expression. As for most...
Delivery Method:
peptide-coupled
Citation Extract:
Abes R, Arzumanov AA, Saleh AF, Said Hassane F, Gait MJ, Lebleu B. Splice Redirection as a Convenient Assay to Monitor CPP-ON Efficiency and Mechanism. Methods Mol Biol. 2011;683:307-20.

Vectorization of morpholino oligomers by the (R-Ahx-R)(4) peptide allows efficient splicing correction in the absence of endosomolytic agents

Authors:
Abes S, Moulton HM, Clair P, Prevot P, Youngblood DS, Wu RP, Iversen PL, Lebleu B
Citation:
J Control Release. 2006 Dec 1;116(3):304-13. Epub 2006 Sep 30.
Epub:
Not Epub
Abstract:
The efficient and non-toxic nuclear delivery of steric-block oligonucleotides (ON) is a prerequisite for therapeutic strategies...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0168365906004603
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: HeLa AntisenseTest System
Citation Extract:
Abes S, Moulton HM, Clair P, Prevot P, Youngblood DS, Wu RP, Iversen PL, Lebleu B. Vectorization of morpholino oligomers by the (R-Ahx-R)(4) peptide allows efficient splicing correction in the absence of endosomolytic agents. J Control Release. 2006 Dec 1;116(3):304-13. Epub 2006 Sep 30..

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