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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 268 scientific papers returned from the database with the search filters currently being used below.
There are 268 scientific papers returned from the database with the search filters currently being used below.
Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication
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Citation:
J Virol. 2005 Apr;79(8):4599-609 Epub:
Not Epub Abstract:
RNA elements within flavivirus genomes are potential targets for antiviral therapy. A panel of phosphorodiamidate morpholino... Delivery Method:
peptide-coupled Organism or Cell Type:
West Nile Virus Citation Extract: Deas TS, Binduga-Gajewska I, Tilgner M, Ren P, Stein DA, Moulton HM, Iversen PL, Kauffman EB, Kramer LD, Shi PY. Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication. J Virol. 2005 Apr;79(8):4599-609. |
Diaphragm Rescue Alone Prevents Heart Dysfunction in Dystrophic Mice
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Citation:
Hum. Mol. Genet. 2010; [Epub Nov. 9] doi:10.1093/hmg/ddq477 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is an X-linked recessive disease caused, in most cases, by the complete absence of the 427 kD... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx Citation Extract: Crisp A, Yin HF, Goyenvalle A, Betts C, Moulton HM, Seow Y, Babbs A, Merritt T, Saleh AF, Gait MJ, Stuckey DJ, Clarke K, Davies KE, Wood MJA. Diaphragm Rescue Alone Prevents Heart Dysfunction in Dystrophic Mice. Hum. Mol. Genet. 2010; [Epub Nov. 9] doi:10.1093/hmg/ddq477. |
Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models
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Citation:
J. Virol. 2007 Jun;81(11):5637-48. Epub 2007 Mar 7. Epub:
Not Epub Abstract:
The recent emergence of novel pathogenic human and animal coronaviruses has highlighted the need for antiviral therapies that... Delivery Method:
peptide-coupled Organism or Cell Type:
Mice, C57B16 Citation Extract: Burrer R, Neuman BW, Ting JPC, Stein DA, Moulton HM, Iversen PL, Kuhn P, Buchmeier MJ. Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models. J. Virol. 2007 Jun;81(11):5637-48. Epub 2007 Mar 7.. |
Cell Penetrating Peptide Delivery of Splice Directing Oligonucleotides as a Treatment for Duchenne Muscular Dystrophy
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Citation:
Curr Pharm Des. 2013;19(16):2948-62. doi: 10.2174/1381612811319160009. PMID: 23140454 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy is a severe, X-linked muscle wasting disorder caused by the absence of an integral structural... Delivery Method:
peptide-coupled Citation Extract: Betts CA, Wood MJ. Cell Penetrating Peptide Delivery of Splice Directing Oligonucleotides as a Treatment for Duchenne Muscular Dystrophy. Curr Pharm Des. 2013;19(16):2948-62. doi: 10.2174/1381612811319160009. PMID: 23140454. |
Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2
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Citation:
J Virol. 2011 Feb;85(4):1554-62. doi: 10.1128/JVI.01294-10. Epub 2010 Dec 1. PMID: 21123387; PMCID: PMC3028871 Epub:
Not Epub Abstract:
Influenza A viruses constitute a major and ongoing global public health concern. Current antiviral strategies target viral gene... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: human Calu-3 airway epithelial cells Citation Extract: Böttcher-Friebertshäuser E, Stein DA, Klenk HD, Garten W. Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2. J Virol. 2011 Feb;85(4):1554-62. doi: 10.1128/JVI.01294-10. Epub 2010 Dec 1. PMID: 21123387; PMCID: PMC3028871. |
Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome
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Citation:
Virology. 2008 Oct 25;380(2):328-37. doi: 10.1016/j.virol.2008.08.007. Epub 2008 Sep 9. Epub:
Not Epub Abstract:
Noroviruses are an important cause of non-bacterial epidemic gastroenteritis, but no specific antiviral therapies are available... Delivery Method:
peptide-coupled Organism or Cell Type:
virus: norovirus Citation Extract: Bok K, Cavanaugh VJ, Matson DO, González-Molleda L, Chang KO, Zintz C, Smith AW, Iversen P, Green KY, Campbell AE. Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome. Virology. 2008 Oct 25;380(2):328-37. doi: 10.1016/j.virol.2008.08.007. Epub 2008 Sep 9. . |
Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment
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Citation:
Mol Ther Nucleic Acids. 2012;[Epub ahead of print] http://dx.doi.org/10.1038/mtna.2012.30 Epub:
Not Epub Abstract:
Antisense oligonucleotides (AOs) are currently the most promising therapeutic intervention for Duchenne muscular dystrophy (DMD... Delivery Method:
peptide-coupled Organism or Cell Type:
mice (mdx), cultured mdx myotubes Citation Extract: Betts C, Saleh A, Arzumanov A, Hammond S, Godfrey C, Coursindel T, Gait M, Wood M. Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment. Mol Ther Nucleic Acids. 2012;[Epub ahead of print] http://dx.doi.org/10.1038/mtna.2012.30. |
Reverse genetics technology for Rift Valley fever virus: current and future applications for the development of therapeutics and vaccines
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Citation:
Antiviral Res. 2009 Nov;84(2):101-18. Epub 2009 Aug 12. Review Epub:
Not Epub Abstract:
The advent of reverse genetics technology has revolutionized the study of RNA viruses, making it possible to manipulate their... Delivery Method:
peptide-coupled Citation Extract: Bouloy M, Flick R. Reverse genetics technology for Rift Valley fever virus: current and future applications for the development of therapeutics and vaccines. Antiviral Res. 2009 Nov;84(2):101-18. Epub 2009 Aug 12. Review. |
Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum
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Citation:
PNAS. 2012;[Epub ahead of print] doi:10.1073/pnas.1203516109 Epub:
Not Epub Abstract:
Unique peptide-morpholino oligomer (PMO) conjugates have been designed to bind and promote the cleavage of specific mRNA as a... Delivery Method:
peptide-coupled Organism or Cell Type:
Plasmodium falciparum Citation Extract: Augagneur Y, Wesolowski D, Tae HS, Altman S, Mamoun CB. Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum. PNAS. 2012;[Epub ahead of print] doi:10.1073/pnas.1203516109 . |
Arginine-rich cell penetrating peptides: Design, structure-activity, and applications to alter pre-mRNA splicing by steric-block oligonucleotides
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Citation:
J Pept Sci. 2008 Jan 30; [Epub ahead of print] Epub:
Not Epub Abstract:
Rerouting the splicing machinery with steric-block oligonucleotides (ON) might lead to new therapeutic strategies in the... Delivery Method:
peptide-coupled Citation Extract: Abes R, Arzumanov A, Moulton H, Abes S, Ivanova G, Gait MJ, Iversen P, Lebleu B. Arginine-rich cell penetrating peptides: Design, structure-activity, and applications to alter pre-mRNA splicing by steric-block oligonucleotides. J Pept Sci. 2008 Jan 30; [Epub ahead of print] . |