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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 259 scientific papers returned from the database with the search filters currently being used below.
There are 259 scientific papers returned from the database with the search filters currently being used below.
In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus
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Citation:
Antimicrob Agents Chemother. 2007 Jul;51(7):2470-82. Epub 2007 May 7 Epub:
Not Epub Abstract:
We characterize the in vitro resistance and demonstrate the in vivo efficacy of two antisense phosphorodiamidate-morpholino-... Delivery Method:
peptide-coupled Organism or Cell Type:
Flavivirus in cell culture and mice Citation Extract: Deas TS, Bennett CJ, Jones SA, Tilgner M, Ren P, Behr MJ, Stein DA, Iversen PL, Kramer LD, Bernard KA, Shi PY. In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus. Antimicrob Agents Chemother. 2007 Jul;51(7):2470-82. Epub 2007 May 7. |
Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication
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Citation:
J Virol. 2005 Apr;79(8):4599-609 Epub:
Not Epub Abstract:
RNA elements within flavivirus genomes are potential targets for antiviral therapy. A panel of phosphorodiamidate morpholino... Delivery Method:
peptide-coupled Organism or Cell Type:
West Nile Virus Citation Extract: Deas TS, Binduga-Gajewska I, Tilgner M, Ren P, Stein DA, Moulton HM, Iversen PL, Kauffman EB, Kramer LD, Shi PY. Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication. J Virol. 2005 Apr;79(8):4599-609. |
Diaphragm Rescue Alone Prevents Heart Dysfunction in Dystrophic Mice
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Citation:
Hum. Mol. Genet. 2010; [Epub Nov. 9] doi:10.1093/hmg/ddq477 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is an X-linked recessive disease caused, in most cases, by the complete absence of the 427 kD... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx Citation Extract: Crisp A, Yin HF, Goyenvalle A, Betts C, Moulton HM, Seow Y, Babbs A, Merritt T, Saleh AF, Gait MJ, Stuckey DJ, Clarke K, Davies KE, Wood MJA. Diaphragm Rescue Alone Prevents Heart Dysfunction in Dystrophic Mice. Hum. Mol. Genet. 2010; [Epub Nov. 9] doi:10.1093/hmg/ddq477. |
Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models
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Citation:
J. Virol. 2007 Jun;81(11):5637-48. Epub 2007 Mar 7. Epub:
Not Epub Abstract:
The recent emergence of novel pathogenic human and animal coronaviruses has highlighted the need for antiviral therapies that... Delivery Method:
peptide-coupled Organism or Cell Type:
Mice, C57B16 Citation Extract: Burrer R, Neuman BW, Ting JPC, Stein DA, Moulton HM, Iversen PL, Kuhn P, Buchmeier MJ. Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models. J. Virol. 2007 Jun;81(11):5637-48. Epub 2007 Mar 7.. |
Cell Penetrating Peptide Delivery of Splice Directing Oligonucleotides as a Treatment for Duchenne Muscular Dystrophy
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Citation:
Curr Pharm Des. 2012 Nov 2. [Epub ahead of print] Epub:
Not Epub Abstract:
Duchenne muscular dystrophy is a severe, X-linked muscle wasting disorder caused by the absence of an integral structural... Delivery Method:
peptide-coupled Citation Extract: Betts CA, Wood MJ. Cell Penetrating Peptide Delivery of Splice Directing Oligonucleotides as a Treatment for Duchenne Muscular Dystrophy. Curr Pharm Des. 2012 Nov 2. [Epub ahead of print]. |
Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin activating protease TMPRSS2
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Citation:
J Virol. 2010 Dec 1. [Epub ahead of print] Epub:
Not Epub Abstract:
Influenza A viruses constitute a major and ongoing global public health concern. Current antiviral strategies target viral gene... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: human Calu-3 airway epithelial cells Citation Extract: Böttcher-Friebertshäuser E, Stein DA, Klenk HD, Garten W. Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin activating protease TMPRSS2. J Virol. 2010 Dec 1. [Epub ahead of print]. |
Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome
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Citation:
Virology. 2008 Oct 25;380(2):328-37. doi: 10.1016/j.virol.2008.08.007. Epub 2008 Sep 9. Epub:
Not Epub Abstract:
Noroviruses are an important cause of non-bacterial epidemic gastroenteritis, but no specific antiviral therapies are available... Delivery Method:
peptide-coupled Organism or Cell Type:
virus: norovirus Citation Extract: Bok K, Cavanaugh VJ, Matson DO, González-Molleda L, Chang KO, Zintz C, Smith AW, Iversen P, Green KY, Campbell AE. Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome. Virology. 2008 Oct 25;380(2):328-37. doi: 10.1016/j.virol.2008.08.007. Epub 2008 Sep 9. . |
Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment
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Citation:
Mol Ther Nucleic Acids. 2012;[Epub ahead of print] http://dx.doi.org/10.1038/mtna.2012.30 Epub:
Not Epub Abstract:
Antisense oligonucleotides (AOs) are currently the most promising therapeutic intervention for Duchenne muscular dystrophy (DMD... Delivery Method:
peptide-coupled Organism or Cell Type:
mice (mdx), cultured mdx myotubes Citation Extract: Betts C, Saleh A, Arzumanov A, Hammond S, Godfrey C, Coursindel T, Gait M, Wood M. Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment. Mol Ther Nucleic Acids. 2012;[Epub ahead of print] http://dx.doi.org/10.1038/mtna.2012.30. |
Reverse genetics technology for Rift Valley fever virus: current and future applications for the development of therapeutics and vaccines
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Citation:
Antiviral Res. 2009 Nov;84(2):101-18. Epub 2009 Aug 12. Review Epub:
Not Epub Abstract:
The advent of reverse genetics technology has revolutionized the study of RNA viruses, making it possible to manipulate their... Delivery Method:
peptide-coupled Citation Extract: Bouloy M, Flick R. Reverse genetics technology for Rift Valley fever virus: current and future applications for the development of therapeutics and vaccines. Antiviral Res. 2009 Nov;84(2):101-18. Epub 2009 Aug 12. Review. |
Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum
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Citation:
PNAS. 2012;[Epub ahead of print] doi:10.1073/pnas.1203516109 Epub:
Not Epub Abstract:
Unique peptide-morpholino oligomer (PMO) conjugates have been designed to bind and promote the cleavage of specific mRNA as a... Delivery Method:
peptide-coupled Organism or Cell Type:
Plasmodium falciparum Citation Extract: Augagneur Y, Wesolowski D, Tae HS, Altman S, Mamoun CB. Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum. PNAS. 2012;[Epub ahead of print] doi:10.1073/pnas.1203516109 . |