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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 257 scientific papers returned from the database with the search filters currently being used below.

Mismatched single stranded antisense oligonucleotides can induce efficient dystrophin splice switching

Authors:
Fragall CT, Adams AM, Johnsen RD, Kole R, Fletcher S, Wilton SD
Citation:
BMC Med Genet. 2011 Oct 20;12(1):141. [Epub ahead of print]
Epub:
Not Epub
Abstract:
BACKGROUND: Antisense oligomer induced exon skipping aims to reduce the severity of Duchenne muscular dystrophy by redirecting...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: human myoblasts from fibroblasts
Citation Extract:
Fragall CT, Adams AM, Johnsen RD, Kole R, Fletcher S, Wilton SD. Mismatched single stranded antisense oligonucleotides can induce efficient dystrophin splice switching. BMC Med Genet. 2011 Oct 20;12(1):141. [Epub ahead of print].

Morpholino Oligomer-Mediated Exon Skipping Averts the Onset of Dystrophic Pathology in the mdx Mouse

Authors:
Fletcher S, Honeyman K, Fall AM, Harding PL, Johnsen RD, Steinhaus JP, Moulton HM, Iversen PL, Wilton SD
Citation:
Mol Ther. 2007 Sep;15(9):1587-92. Epub 2007 Jun 19.
Epub:
Not Epub
Abstract:
Duchenne and Becker muscular dystrophies are allelic disorders arising from mutations in the dystrophin gene. Duchenne muscular...
Delivery Method:
peptide-coupled
Organism or Cell Type:
MDX mice
Citation Extract:
Fletcher S, Honeyman K, Fall AM, Harding PL, Johnsen RD, Steinhaus JP, Moulton HM, Iversen PL, Wilton SD. Morpholino Oligomer-Mediated Exon Skipping Averts the Onset of Dystrophic Pathology in the mdx Mouse. Mol Ther. 2007 Sep;15(9):1587-92. Epub 2007 Jun 19..

Targeted Exon Skipping to Address \"Leaky\" Mutations in the Dystrophin Gene

Authors:
Fletcher S, Adkin CF, Meloni P, Wong B, Muntoni F, Kole R, Fragall C, Greer K, Johnsen R, Wilton SD
Citation:
Mol Ther Nucleic Acids. 2012;1:e48 doi:/10.1038/mtna.2012.40
Epub:
Not Epub
Abstract:
Protein-truncating mutations in the dystrophin gene lead to the progressive muscle wasting disorder Duchenne muscular dystrophy...
Delivery Method:
peptide-coupled in mice, elecytroporation in cell culture
Organism or Cell Type:
mice
Citation Extract:
Fletcher S, Adkin CF, Meloni P, Wong B, Muntoni F, Kole R, Fragall C, Greer K, Johnsen R, Wilton SD. Targeted Exon Skipping to Address \"Leaky\" Mutations in the Dystrophin Gene. Mol Ther Nucleic Acids. 2012;1:e48 doi:/10.1038/mtna.2012.40.

Reduction of herpes simplex virus type-2 replication in cell cultures and in rodent models with peptide-conjugated morpholino oligomers

Authors:
Eide K, Moerdyk-Schauwecker M, Stein DA, Bildfell R, Koelle DM, Jin L
Citation:
Antivir Ther. 2010;15(8):1141-1149
Epub:
Not Epub
Abstract:
BACKGROUND: Genital herpes, caused by herpes simplex virus type-2 (HSV-2), is a recurrent, lifelong disease affecting tens of...
Link:
http://www.intmedpress.com/serveFile.cfm?sUID=2c4e07a8-613a-4c97-891f-2141f142b495
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell cultures, mice, rats
Citation Extract:
Eide K, Moerdyk-Schauwecker M, Stein DA, Bildfell R, Koelle DM, Jin L. Reduction of herpes simplex virus type-2 replication in cell cultures and in rodent models with peptide-conjugated morpholino oligomers. Antivir Ther. 2010;15(8):1141-1149.

VP35 Knockdown Inhibits Ebola Virus Amplification and Protects against Lethal Infection in Mice

Authors:
Enterlein S, Warfield KL, Swenson DL, Stein DA, Smith JL, Gamble CS, Kroeker AD, Iversen PL, Bavari S, Muhlberger E
Citation:
Antimicrob Agents Chemother. 2006 Mar;50(3):984-93
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligomers (PMO) are a class of uncharged single-stranded DNA analogs modified such that each...
Link:
http://aac.asm.org/content/50/3/984.abstract
Delivery Method:
Peptide-coupled and oligo bathing
Organism or Cell Type:
mice and cell culture
Citation Extract:
Enterlein S, Warfield KL, Swenson DL, Stein DA, Smith JL, Gamble CS, Kroeker AD, Iversen PL, Bavari S, Muhlberger E. VP35 Knockdown Inhibits Ebola Virus Amplification and Protects against Lethal Infection in Mice. Antimicrob Agents Chemother. 2006 Mar;50(3):984-93.

Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum

Authors:
Du L, Kayali R, Bertoni C, Fike F, Hu H, Iversen PL, Gatti RA
Citation:
Hum Mol Genet. 2011 May 16. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Antisense morpholino oligonucleotides (AMOs) can reprogram pre-mRNA splicing by complementarily binding to a target site and...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice
Citation Extract:
Du L, Kayali R, Bertoni C, Fike F, Hu H, Iversen PL, Gatti RA. Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum. Hum Mol Genet. 2011 May 16. [Epub ahead of print].

Proteomic profiling of antisense-induced exon skipping reveals reversal of pathobiochemical abnormalities in dystrophic mdx diaphragm

Authors:
Doran P, Wilton SD, Fletcher S, Ohlendieck K
Citation:
Proteomics. 2009 Jan 8. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The disintegration of the dystrophin-glycoprotein complex represents the initial pathobiochemical insult in Duchenne muscular...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice, mdx
Citation Extract:
Doran P, Wilton SD, Fletcher S, Ohlendieck K. Proteomic profiling of antisense-induced exon skipping reveals reversal of pathobiochemical abnormalities in dystrophic mdx diaphragm. Proteomics. 2009 Jan 8. [Epub ahead of print].

Cell-Penetrating Peptides for Antiviral Drug Development

Authors:
Delcroix M, Riley LW
Citation:
Pharmaceuticals. 2010;3:448-70
Epub:
Not Epub
Abstract:
Viral diseases affect hundreds of millions of people worldwide, and the few available drugs to treat these diseases often come...
Delivery Method:
peptide-coupled
Citation Extract:
Delcroix M, Riley LW. Cell-Penetrating Peptides for Antiviral Drug Development. Pharmaceuticals. 2010;3:448-70.

In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus

Authors:
Deas TS, Bennett CJ, Jones SA, Tilgner M, Ren P, Behr MJ, Stein DA, Iversen PL, Kramer LD, Bernard KA, Shi PY
Citation:
Antimicrob Agents Chemother. 2007 Jul;51(7):2470-82. Epub 2007 May 7
Epub:
Not Epub
Abstract:
We characterize the in vitro resistance and demonstrate the in vivo efficacy of two antisense phosphorodiamidate-morpholino-...
Link:
http://aac.asm.org/content/51/7/2470.long
Delivery Method:
peptide-coupled
Organism or Cell Type:
Flavivirus in cell culture and mice
Citation Extract:
Deas TS, Bennett CJ, Jones SA, Tilgner M, Ren P, Behr MJ, Stein DA, Iversen PL, Kramer LD, Bernard KA, Shi PY. In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus. Antimicrob Agents Chemother. 2007 Jul;51(7):2470-82. Epub 2007 May 7.

Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication

Authors:
Deas TS, Binduga-Gajewska I, Tilgner M, Ren P, Stein DA, Moulton HM, Iversen PL, Kauffman EB, Kramer LD, Shi PY
Citation:
J Virol. 2005 Apr;79(8):4599-609
Epub:
Not Epub
Abstract:
RNA elements within flavivirus genomes are potential targets for antiviral therapy. A panel of phosphorodiamidate morpholino...
Link:
http://jvi.asm.org/content/79/8/4599.long
Delivery Method:
peptide-coupled
Organism or Cell Type:
West Nile Virus
Citation Extract:
Deas TS, Binduga-Gajewska I, Tilgner M, Ren P, Stein DA, Moulton HM, Iversen PL, Kauffman EB, Kramer LD, Shi PY. Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication. J Virol. 2005 Apr;79(8):4599-609.

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