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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 259 scientific papers returned from the database with the search filters currently being used below.

Efficacy of a Phosphorodiamidate Morpholino Oligomer Antisense Compound in the Inhibition of Corneal Transplant Rejection in a Rat Cornea Transplant Model

Authors:
Hosseini A, Lattanzio Jr. FA, Samudre SS, DiSandro G, Sheppard Jr. JD, Williams PB
Citation:
J Ocul Pharmacol Ther. 2011;[Epub ahead of print] doi:10.1089/jop.2011.0135
Epub:
Not Epub
Abstract:
Purpose: The cornea is one of the most commonly transplanted tissues. The morpholino-oligomer antisense compound AVI-5126...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Rat cornea explants
Citation Extract:
Hosseini A, Lattanzio Jr. FA, Samudre SS, DiSandro G, Sheppard Jr. JD, Williams PB. Efficacy of a Phosphorodiamidate Morpholino Oligomer Antisense Compound in the Inhibition of Corneal Transplant Rejection in a Rat Cornea Transplant Model. J Ocul Pharmacol Ther. 2011;[Epub ahead of print] doi:10.1089/jop.2011.0135.

Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3' stem-loop structure

Authors:
Holden KL, Stein DA, Pierson TC, Ahmed AA, Clyde K, Iversen PL, Harris E
Citation:
Virology. 2006 Jan 20;344(2):439-52. Epub 2005 Oct 7.
Epub:
Not Epub
Abstract:
Dengue virus (DEN) is a major public health problem worldwide and causes a spectrum of diseases, for which no antiviral...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: BHK cells
Citation Extract:
Holden KL, Stein DA, Pierson TC, Ahmed AA, Clyde K, Iversen PL, Harris E. Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3' stem-loop structure. Virology. 2006 Jan 20;344(2):439-52. Epub 2005 Oct 7..

Molecular biology of flaviviruses

Authors:
Harris E, Holden KL, Edgil D, Polacek C, Clyde K
Citation:
Novartis Found Symp. 2006;277:23-39; discussion 40, 71-3, 251-3
Epub:
Not Epub
Abstract:
Flaviviruses are enveloped viruses with a single-stranded, 10.7kb positive-sense RNA genome. The genomic RNA, which has a 5...
Delivery Method:
peptide-coupled
Citation Extract:
Harris E, Holden KL, Edgil D, Polacek C, Clyde K. Molecular biology of flaviviruses. Novartis Found Symp. 2006;277:23-39; discussion 40, 71-3, 251-3.

Antisense Phosphorodiamidate Morpholino Oligomers Targeted to an Essential Gene Inhibit Burkholderia cepacia Complex

Authors:
Greenberg DE, Marshall-Batty KR, Brinster LR, Zarember KA, Shaw PA, Mellbye BL, Iversen PL, Holland SM, Geller BL
Citation:
J Infect Dis. 2010 May 3. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Background. Members of the Burkholderia cepacia complex (Bcc) cause considerable morbidity and mortality in patients with...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Bacteria: Burkholderia
Citation Extract:
Greenberg DE, Marshall-Batty KR, Brinster LR, Zarember KA, Shaw PA, Mellbye BL, Iversen PL, Holland SM, Geller BL. Antisense Phosphorodiamidate Morpholino Oligomers Targeted to an Essential Gene Inhibit Burkholderia cepacia Complex. J Infect Dis. 2010 May 3. [Epub ahead of print].

Prevention of Dystrophic Pathology in Severely Affected Dystrophin/Utrophin-deficient Mice by Morpholino-oligomer-mediated Exon-skipping

Authors:
Goyenvalle A, Babbs A, Powell D, Kole R, Fletcher S, Wilton SD, Davies KE
Citation:
Mol Ther. 2009 Oct 20. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder caused by mutations in the dystrophin gene that result in...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice: dystrophin & utrophin dKO
Citation Extract:
Goyenvalle A, Babbs A, Powell D, Kole R, Fletcher S, Wilton SD, Davies KE. Prevention of Dystrophic Pathology in Severely Affected Dystrophin/Utrophin-deficient Mice by Morpholino-oligomer-mediated Exon-skipping. Mol Ther. 2009 Oct 20. [Epub ahead of print].

Antibacterial antisense

Authors:
Geller BL
Citation:
Curr Opin Mol Ther 2005 7(2):109-13
Epub:
Not Epub
Abstract:
No abstract available.
Delivery Method:
peptide-coupled
Organism or Cell Type:
Escherichia coli
Citation Extract:
Geller BL. Antibacterial antisense. Curr Opin Mol Ther 2005 7(2):109-13.

Inhibition of gene expression in Escherichia coli by antisense phosphorodiamidate morpholino oligomers.

Authors:
Geller BL, Deere JD, Stein DA, Kroeker AD, Moulton HM, Iversen PL.
Citation:
Antimicrob Agents Chemother. 2003 Oct;47(10):3233-9.
Epub:
Not Epub
Abstract:
Antisense phosphorodiamidate morpholino oligomers (PMOs) were tested for the ability to inhibit gene expression in Escherichia...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Escherichia coli
Citation Extract:
Geller BL, Deere JD, Stein DA, Kroeker AD, Moulton HM, Iversen PL.. Inhibition of gene expression in Escherichia coli by antisense phosphorodiamidate morpholino oligomers.. Antimicrob Agents Chemother. 2003 Oct;47(10):3233-9..

Inhibition of Multiple Subtypes of Influenza A Virus in Cell Cultures with Morpholino Oligomers

Authors:
Ge Q, Pastey M, Kobasa D, Puthavathana P, Lupfer C, Bestwick RK, Iversen PL, Chen J, Stein DA
Citation:
Antimicrob Agents Chemother. 2006 Nov;50(11):3724-33. Epub 2006 Sep 11
Epub:
Not Epub
Abstract:
Peptide conjugated phosphorodiamidate morpholino oligomers (P-PMO) are single-stranded-nucleic-acid-like antisense agents that...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture
Citation Extract:
Ge Q, Pastey M, Kobasa D, Puthavathana P, Lupfer C, Bestwick RK, Iversen PL, Chen J, Stein DA. Inhibition of Multiple Subtypes of Influenza A Virus in Cell Cultures with Morpholino Oligomers. Antimicrob Agents Chemother. 2006 Nov;50(11):3724-33. Epub 2006 Sep 11.

Morpholino oligomers targeting the PB1 and NP genes enhance the survival of mice infected with highly pathogenic influenza A H7N7 virus

Authors:
Gabriel G, Nordmann A, Stein DA, Iversen PL, Klenk HD
Citation:
J Gen Virol. 2008 Apr;89(Pt 4):939-48
Epub:
Not Epub
Abstract:
Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMO) are single-stranded nucleic acid-analogue antisense agents...
Link:
http://jgv.sgmjournals.org/content/journal/jgv/10.1099/vir.0.83449-0
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice and cell cultures: MDCK
Citation Extract:
Gabriel G, Nordmann A, Stein DA, Iversen PL, Klenk HD. Morpholino oligomers targeting the PB1 and NP genes enhance the survival of mice infected with highly pathogenic influenza A H7N7 virus. J Gen Virol. 2008 Apr;89(Pt 4):939-48.

Antisense suppression of donor splice site mutations in the dystrophin gene transcript

Authors:
Fletcher S, Meloni PL, Johnsen RD, Wong BL, Muntoni F, Wilton SD
Citation:
Mol Genet Genomic Med. 2013;[Epub ahead of print] doi:10.1002/mgg3.19
Epub:
Not Epub
Abstract:
We describe two donor splice site mutations, affecting dystrophin exons 16 and 45 that led to Duchenne muscular dystrophy (DMD...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: human primary fibroblasts and myogenic cells (subsequently differentiated)
Citation Extract:
Fletcher S, Meloni PL, Johnsen RD, Wong BL, Muntoni F, Wilton SD. Antisense suppression of donor splice site mutations in the dystrophin gene transcript. Mol Genet Genomic Med. 2013;[Epub ahead of print] doi:10.1002/mgg3.19.

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