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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 259 scientific papers returned from the database with the search filters currently being used below.

Inhibition of p53 expression by peptide-conjugated phosphorodiamidate morpholino oligomers sensitizes human cancer cells to chemotherapeutic drugs

Authors:
Ma W, Lin Y, Xuan W, Iversen PL, Smith LJ, Benchimol S
Citation:
Oncogene. 2011 [Epub ahead of print 18 July] doi: 10.1038/onc.2011.300
Epub:
Not Epub
Abstract:
The p53 tumor suppressor gene encodes a transcription factor that is commonly mutated in cancer. Tumors arise when premalignant...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: H460
Citation Extract:
Ma W, Lin Y, Xuan W, Iversen PL, Smith LJ, Benchimol S. Inhibition of p53 expression by peptide-conjugated phosphorodiamidate morpholino oligomers sensitizes human cancer cells to chemotherapeutic drugs. Oncogene. 2011 [Epub ahead of print 18 July] doi: 10.1038/onc.2011.300.

A nanoparticle for tumor targeted delivery of oligomers

Authors:
Liu X, Wang Y, Hnatowich DJ
Citation:
Methods Mol Biol. 2011;764:91-105. doi: 10.1007/978-1-61779-188-8_6
Epub:
Not Epub
Abstract:
The tissue-specific delivery nanoparticle consists of an antisense oligomer, a cell-penetrating peptide, and an antitumor...
Link:
http://link.springer.com/protocol/10.1007%2F978-1-61779-188-8_6
Delivery Method:
Nanoparticle-peptide complex
Citation Extract:
Liu X, Wang Y, Hnatowich DJ. A nanoparticle for tumor targeted delivery of oligomers. Methods Mol Biol. 2011;764:91-105. doi: 10.1007/978-1-61779-188-8_6.

Systemic Delivery of a Peptide-Linked Morpholino Oligonucleotide Neutralizes Mutant RNA Toxicity in a Mouse Model of Myotonic Dystrophy

Authors:
Leger AJ, Mosquea LM, Clayton NP, Wu IH, Weeden T, Nelson CA, Phillips L, Roberts E, Piepenhagen PA, Cheng SH, Wentworth BM
Citation:
Nucleic Acid Ther. 2013 Jan 11. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Expansions of CUG trinucleotide sequences in RNA transcripts provide the basis for toxic RNA gain-of-function that leads to...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mouse HSA(LR)
Citation Extract:
Leger AJ, Mosquea LM, Clayton NP, Wu IH, Weeden T, Nelson CA, Phillips L, Roberts E, Piepenhagen PA, Cheng SH, Wentworth BM. Systemic Delivery of a Peptide-Linked Morpholino Oligonucleotide Neutralizes Mutant RNA Toxicity in a Mouse Model of Myotonic Dystrophy. Nucleic Acid Ther. 2013 Jan 11. [Epub ahead of print].

Cell penetrating peptide conjugates of steric block oligonucleotides

Authors:
Lebleu B, Moulton HM, Abes R, Ivanova GD, Abes S, Stein DA, Iversen PL, Arzumanov AA, Gait MJ
Citation:
Adv Drug Deliv Rev. 2008 Mar 1;60(4-5):517-29. Epub 2007 Oct 22.
Epub:
Not Epub
Abstract:
Charge neutral steric block oligonucleotide analogues, such as peptide nucleic acids (PNA) or phosphorodiamidate morpholino...
Delivery Method:
peptide-coupled
Organism or Cell Type:
various
Citation Extract:
Lebleu B, Moulton HM, Abes R, Ivanova GD, Abes S, Stein DA, Iversen PL, Arzumanov AA, Gait MJ. Cell penetrating peptide conjugates of steric block oligonucleotides. Adv Drug Deliv Rev. 2008 Mar 1;60(4-5):517-29. Epub 2007 Oct 22..

Inhibition of Respiratory Syncytial Virus Infections With Morpholino Oligomers in Cell Cultures and in Mice

Authors:
Lai SH, Stein DA, Guerrero-Plata A, Liao SL, Ivanciuc T, Hong C, Iversen PL, Casola A, Garofalo RP
Citation:
Mol Ther. 2008 Apr 29; [Epub ahead of print]
Epub:
Not Epub
Abstract:
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection in infants, young children, and high-...
Delivery Method:
Peptide-coupled intranasal
Organism or Cell Type:
mice and cell culture
Citation Extract:
Lai SH, Stein DA, Guerrero-Plata A, Liao SL, Ivanciuc T, Hong C, Iversen PL, Casola A, Garofalo RP. Inhibition of Respiratory Syncytial Virus Infections With Morpholino Oligomers in Cell Cultures and in Mice. Mol Ther. 2008 Apr 29; [Epub ahead of print] .

Molecular target validation, antimicrobial delivery, and potential treatment of Toxoplasma gondii infections

Authors:
Lai BS, Witola WH, El Bissati KE, Zhou Y, Mui E, Fomovska A, McLeod R
Citation:
PNAS. 2012;[Epub ahead of print] doi:10.1073/pnas.1208775109
Epub:
Not Epub
Abstract:
Toxoplasma gondii persistently infects over two billion people worldwide. It can cause substantial morbidity and mortality....
Delivery Method:
peptide-coupled and Vivo-Morpholino
Organism or Cell Type:
Toxoplasma gondii
Citation Extract:
Lai BS, Witola WH, El Bissati KE, Zhou Y, Mui E, Fomovska A, McLeod R. Molecular target validation, antimicrobial delivery, and potential treatment of Toxoplasma gondii infections. PNAS. 2012;[Epub ahead of print] doi:10.1073/pnas.1208775109.

SARS-Coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity

Authors:
Krähling V, Stein DA, Spiegel M, Weber F, Mühlberger E
Citation:
J Virol. 2008 Dec 24. [Epub ahead of print]
Epub:
Not Epub
Abstract:
In this study, infection of 293/ACE2 cells with SARS-CoV activated several apoptosis-associated events, namely, cleavage of...
Link:
https://jvi.asm.org/content/83/5/2298
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: 293/ACE2
Citation Extract:
Krähling V, Stein DA, Spiegel M, Weber F, Mühlberger E. SARS-Coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity. J Virol. 2008 Dec 24. [Epub ahead of print].

Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers

Authors:
Kinney RM, Huang CY, Rose BC, Kroeker AD, Dreher TW, Iversen PL, Stein DA
Citation:
J Virol. 2005 Apr;79(8):5116-28
Epub:
Not Epub
Abstract:
Five dengue (DEN) virus-specific R(5)F(2)R(4) peptide-conjugated phosphorodiamidate morpholino oligomers (P4-PMOs) were...
Link:
http://jvi.asm.org/content/79/8/5116.long
Delivery Method:
peptide-coupled
Organism or Cell Type:
Dengue virus
Citation Extract:
Kinney RM, Huang CY, Rose BC, Kroeker AD, Dreher TW, Iversen PL, Stein DA. Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers. J Virol. 2005 Apr;79(8):5116-28.

Long-Term Improvement in mdx Cardiomyopathy after Therapy with Peptide-conjugated Morpholino Oligomers

Authors:
Jearawiriyapaisarn N, Moulton HM, Sazani P, Kole R, Willis MS
Citation:
Cardiovasc Res. 2010 Feb 1;85(3):444-53. doi: 10.1093/cvr/cvp335. Epub 2009 Oct 8.
Epub:
Not Epub
Abstract:
AIMS: The cardiomyopathy found in Duchenne muscular dystrophy (DMD) is responsible for death due to heart failure in...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice, mdx
Citation Extract:
Jearawiriyapaisarn N, Moulton HM, Sazani P, Kole R, Willis MS. Long-Term Improvement in mdx Cardiomyopathy after Therapy with Peptide-conjugated Morpholino Oligomers. Cardiovasc Res. 2010 Feb 1;85(3):444-53. doi: 10.1093/cvr/cvp335. Epub 2009 Oct 8..

Sustained Dystrophin Expression Induced by Peptide-conjugated Morpholino Oligomers in the Muscles of mdx Mice

Authors:
Jearawiriyapaisarn N, Moulton HM, Buckley B, Roberts J, Sazani P, Fucharoen S, Iversen PL, Kole R
Citation:
Mol Ther. 2008 Sep;16(9):1624-9. Epub 2008 Jun 10
Epub:
Not Epub
Abstract:
Cell-penetrating peptides (CPPs), containing arginine (R), 6-aminohexanoic acid (X), and/or beta-alanine (B) conjugated to...
Delivery Method:
peptide-coupled
Organism or Cell Type:
MDX mice
Citation Extract:
Jearawiriyapaisarn N, Moulton HM, Buckley B, Roberts J, Sazani P, Fucharoen S, Iversen PL, Kole R. Sustained Dystrophin Expression Induced by Peptide-conjugated Morpholino Oligomers in the Muscles of mdx Mice. Mol Ther. 2008 Sep;16(9):1624-9. Epub 2008 Jun 10.

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