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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 257 scientific papers returned from the database with the search filters currently being used below.
There are 257 scientific papers returned from the database with the search filters currently being used below.
Morpholinos and Their Peptide Conjugates: Therapeutic Promise and Challenge for Duchenne Muscular Dystrophy
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Citation:
Biochim Biophys Acta. 2010;1798(12):2296-2303 Epub:
Not Epub Abstract:
Exon-skipping efficacy of phosphodiamidate morpholino oligomers (PMOs) or the conjugates of PMOs with cell-penetrating peptides... Delivery Method:
peptide-coupled versus bare oligo, injected Organism or Cell Type:
mouse, monkey, dog Citation Extract: Moulton HM, Moulton JD. Morpholinos and Their Peptide Conjugates: Therapeutic Promise and Challenge for Duchenne Muscular Dystrophy. Biochim Biophys Acta. 2010;1798(12):2296-2303 . |
Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD
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Citation:
Gene Ther. 2006 Oct;13(19):1373-81. Epub 2006 May 25 Epub:
Not Epub Abstract:
Manipulation of pre-mRNA splicing by antisense oligonucleotides (AOs) offers considerable potential for a number of genetic... Delivery Method:
Bathing primary cell culture, with and without peptide conjugates Organism or Cell Type:
cell culture: primary myoblasts, golden retreiver DMD model Citation Extract: McClorey G, Moulton HM, Iversen PL, Fletcher S, Wilton SD. Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD. Gene Ther. 2006 Oct;13(19):1373-81. Epub 2006 May 25. |
Induced dystrophin exon skipping in human muscle explants
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Citation:
Neuromuscul Disord. 2006 Oct;16(9-10):583-90. Epub 2006 Aug 21 Epub:
Not Epub Abstract:
Antisense oligonucleotide (AO) manipulation of pre-mRNA splicing of the dystrophin gene is showing promise in overcoming... Delivery Method:
peptide-coupled Organism or Cell Type:
muscle explants, mouse and human Citation Extract: McClorey G, Fall AM, Moulton HM, Iversen PL, Rasko JE, Ryan M, Fletcher S, Wilton SD. Induced dystrophin exon skipping in human muscle explants. Neuromuscul Disord. 2006 Oct;16(9-10):583-90. Epub 2006 Aug 21. |
Variations in Amino Acid Composition of Antisense Peptide-Phosphorodiamidate Morpholino Oligomer Affect Potency Against Escherichia coli in vitro and in vivo
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Citation:
Antimicrob Agents Chemother. 2009 Feb;53(2):525-30. Epub 2008 Nov 17. Epub:
Not Epub Abstract:
The potency of antisense peptide-phosphorodiamidate morpholino oligomers (PPMO) was improved by varying peptide composition. An... Delivery Method:
peptide-coupled Organism or Cell Type:
Escherichia coli Citation Extract: Mellbye BL, Puckett SE, Tilley LD, Iversen PL, Geller BL. Variations in Amino Acid Composition of Antisense Peptide-Phosphorodiamidate Morpholino Oligomer Affect Potency Against Escherichia coli in vitro and in vivo. Antimicrob Agents Chemother. 2009 Feb;53(2):525-30. Epub 2008 Nov 17.. |
Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing
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Citation:
J Immunol Methods. 2007 Aug 31;325(1-2):114-26. Epub 2007 Jul 27 Epub:
Not Epub Abstract:
Phosphorodiamidate morpholino oligomers (PMO) are synthetic antisense molecules that interfere with translation, pre-mRNA... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: mouse primary leukocytes Citation Extract: Marshall NB, Oda SK, London CA, Moulton HM, Iversen PL, Kerkvliet NI, Mourich DV. Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing. J Immunol Methods. 2007 Aug 31;325(1-2):114-26. Epub 2007 Jul 27. |
Five-Step Process for Screening Antisense Compounds for Efficacy: Gene Target IL-12Rb2
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Citation:
Methods in Molecular Biology. 2011;764:153-68 10.1007/978-1-61779-188-8_10 Epub:
Not Epub Abstract:
Antisense technologies are widely used for the inhibition of gene expression. Although traditionally the AUG start codon of the... Delivery Method:
peptide-coupled Citation Extract: Marshall NB, Hauck LL, Mourich DV. Five-Step Process for Screening Antisense Compounds for Efficacy: Gene Target IL-12Rb2. Methods in Molecular Biology. 2011;764:153-68 10.1007/978-1-61779-188-8_10. |
Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of Duchenne Muscular Dystrophy
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Citation:
Mol Ther Nucleic Acids. 2012;1:e62. doi:/10.1038/mtna.2012.54 Epub:
Not Epub Abstract:
The knockdown of myostatin, a negative regulator of skeletal muscle mass may have important implications in disease conditions... Delivery Method:
Vivo-Morpholino oligos and peptide coupled oligos Organism or Cell Type:
mice, mdx and normal Citation Extract: Malerba A, Kang JK, McClorey G, Saleh AF, Popplewell L, Gait MJ, Wood MJA, Dickson G. Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of Duchenne Muscular Dystrophy. Mol Ther Nucleic Acids. 2012;1:e62. doi:/10.1038/mtna.2012.54. |
Inhibition of influenza A H3N8 virus infections in mice by morpholino oligomers
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Citation:
Arch Virol. 2008 May;153(5):929-37. Epub 2008 Mar 28 Epub:
Not Epub Abstract:
New methods to combat influenza A virus (FLUAV) in humans and animals are needed. The H3N8 subtype virus was the cause of the... Delivery Method:
Peptide-coupled intranasal Organism or Cell Type:
mice Citation Extract: Lupfer C, Stein DA, Mourich DV, Tepper SE, Iversen PL, Pastey M. Inhibition of influenza A H3N8 virus infections in mice by morpholino oligomers. Arch Virol. 2008 May;153(5):929-37. Epub 2008 Mar 28. |
Inhibition of p53 expression by peptide-conjugated phosphorodiamidate morpholino oligomers sensitizes human cancer cells to chemotherapeutic drugs
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Citation:
Oncogene. 2011 [Epub ahead of print 18 July] doi: 10.1038/onc.2011.300 Epub:
Not Epub Abstract:
The p53 tumor suppressor gene encodes a transcription factor that is commonly mutated in cancer. Tumors arise when premalignant... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: H460 Citation Extract: Ma W, Lin Y, Xuan W, Iversen PL, Smith LJ, Benchimol S. Inhibition of p53 expression by peptide-conjugated phosphorodiamidate morpholino oligomers sensitizes human cancer cells to chemotherapeutic drugs. Oncogene. 2011 [Epub ahead of print 18 July] doi: 10.1038/onc.2011.300. |
A nanoparticle for tumor targeted delivery of oligomers
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Citation:
Methods Mol Biol. 2011;764:91-105. doi: 10.1007/978-1-61779-188-8_6 Epub:
Not Epub Abstract:
The tissue-specific delivery nanoparticle consists of an antisense oligomer, a cell-penetrating peptide, and an antitumor... Delivery Method:
Nanoparticle-peptide complex Citation Extract: Liu X, Wang Y, Hnatowich DJ. A nanoparticle for tumor targeted delivery of oligomers. Methods Mol Biol. 2011;764:91-105. doi: 10.1007/978-1-61779-188-8_6. |