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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 259 scientific papers returned from the database with the search filters currently being used below.

Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers

Authors:
Paessler S, Rijnbrand R, Stein DA, Ni H, Yun NE, Dziuba N, Borisevich V, Seregin A, Ma Y, Blouch R, Iversen PL, Zacks MA
Citation:
Virology. 2008 Jul 5;376(2):357-70. Epub 2008 May 12.
Epub:
Not Epub
Abstract:
The genus Alphavirus contains members that threaten human health, both as natural pathogens and as potential biological weapons...
Link:
http://www.sciencedirect.com/science/article/pii/S0042682208002043
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice
Citation Extract:
Paessler S, Rijnbrand R, Stein DA, Ni H, Yun NE, Dziuba N, Borisevich V, Seregin A, Ma Y, Blouch R, Iversen PL, Zacks MA. Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers. Virology. 2008 Jul 5;376(2):357-70. Epub 2008 May 12..

Morpholino oligomer-mediated protection of porcine pulmonary alveolar macrophages from arterivirus-induced cell death

Authors:
Patel D, Stein DA, Zhang YJ
Citation:
Antivir Ther. 2009;14(7):899-909
Epub:
Not Epub
Abstract:
BACKGROUND: Porcine reproductive and respiratory syndrome (PRRS) causes extensive economic losses in the swine industry....
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: porcine pulmonary alveolar macrophages
Citation Extract:
Patel D, Stein DA, Zhang YJ. Morpholino oligomer-mediated protection of porcine pulmonary alveolar macrophages from arterivirus-induced cell death. Antivir Ther. 2009;14(7):899-909.

Peptide Conjugated Phosphorodiamidate Morpholino Oligomers Increase Survival of Mice Challenged with Ames Bacillus anthracis

Authors:
Panchal RG, Geller BL, Mellbye B, Lane D, Iversen PL, Bavari S
Citation:
Nucleic Acid Therapeutics. 2012;[Epub ahead of print] doi:10.1089/nat.2012.0362
Epub:
Not Epub
Abstract:
Targeting bacterial essential genes using antisense phosphorodiamidate morpholino oligomers (PMOs) represents an important...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Bacillus anthracis
Citation Extract:
Panchal RG, Geller BL, Mellbye B, Lane D, Iversen PL, Bavari S. Peptide Conjugated Phosphorodiamidate Morpholino Oligomers Increase Survival of Mice Challenged with Ames Bacillus anthracis. Nucleic Acid Therapeutics. 2012;[Epub ahead of print] doi:10.1089/nat.2012.0362.

Peptide-conjugated morpholino oligomers inhibit porcine reproductive and respiratory syndrome virus replication

Authors:
Patel D, Opriessnig T, Stein DA, Halbur PG, Meng XJ, Iversen PL, Zhang YJ
Citation:
Antiviral Res. 2008 Feb;77(2):95-107. Epub 2007 Oct 4
Epub:
Not Epub
Abstract:
Porcine reproductive and respiratory syndrome (PRRS) has been devastating the global swine industry for more than a decade, and...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Porcine reproductive and resporatory syndrome virus (PRRSV) in cell cultures
Citation Extract:
Patel D, Opriessnig T, Stein DA, Halbur PG, Meng XJ, Iversen PL, Zhang YJ. Peptide-conjugated morpholino oligomers inhibit porcine reproductive and respiratory syndrome virus replication. Antiviral Res. 2008 Feb;77(2):95-107. Epub 2007 Oct 4.

Reduced expression of CD45 protein tyrosine phosphatase provides protection against anthrax pathogenesis

Authors:
Panchal RG, Ulrich RL, Bradfute SB, Lane D, Ruthel G, Kenny TA, Iversen PL, Anderson AO, Gussio R, Raschke WC, Bavari S
Citation:
J Biol Chem. 2009 May 8;284(19):12874-85. Epub 2009 Mar 6.
Epub:
Not Epub
Abstract:
The modulation of cellular processes by small molecule inhibitors, gene inactivation or targeted knock-down strategies combined...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice and cell culture: macrophage J774A.1 cells
Citation Extract:
Panchal RG, Ulrich RL, Bradfute SB, Lane D, Ruthel G, Kenny TA, Iversen PL, Anderson AO, Gussio R, Raschke WC, Bavari S. Reduced expression of CD45 protein tyrosine phosphatase provides protection against anthrax pathogenesis. J Biol Chem. 2009 May 8;284(19):12874-85. Epub 2009 Mar 6..

Emerging drugs for respiratory syncytial virus infection

Authors:
Olszewska W, Openshaw P
Citation:
Expert Opin Emerg Drugs. 2009 Jun;14(2):207-17
Epub:
Not Epub
Abstract:
Although respiratory syncytial virus (RSV) was discovered > 40 years ago, treatment remains largely supportive. There are no...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice and cell culture
Citation Extract:
Olszewska W, Openshaw P. Emerging drugs for respiratory syncytial virus infection. Expert Opin Emerg Drugs. 2009 Jun;14(2):207-17.

Inhibition of porcine reproductive and respiratory syndrome virus infection in piglets by a peptide-conjugated morpholino oligomer

Authors:
Opriessnig T, Patel D, Wang R, Halbur PG, Meng XJ, Stein DA, Zhang YJ
Citation:
Antiviral Res. 2011 Apr 30. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Porcine reproductive and respiratory syndrome (PRRS) causes substantial economic losses to the swine industry in many countries...
Delivery Method:
Peptide-coupled intranasal
Organism or Cell Type:
pig
Citation Extract:
Opriessnig T, Patel D, Wang R, Halbur PG, Meng XJ, Stein DA, Zhang YJ. Inhibition of porcine reproductive and respiratory syndrome virus infection in piglets by a peptide-conjugated morpholino oligomer. Antiviral Res. 2011 Apr 30. [Epub ahead of print].

Antisense Morpholino-Oligomers Directed against the 5' End of the Genome Inhibit Coronavirus Proliferation and Growth

Authors:
Neuman BW, Stein DA, Kroeker AD, Paulino AD, Moulton HM, Iversen PL, Buchmeier MJ
Citation:
J Virol. 2004 Jun;78(11):5891-5899
Epub:
Not Epub
Abstract:
Conjugation of a peptide related to the human immunodeficiency virus type 1 Tat represents a novel method for delivery of...
Link:
https://jvi.asm.org/content/78/11/5891
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: mouse astrocytoma DBT
Citation Extract:
Neuman BW, Stein DA, Kroeker AD, Paulino AD, Moulton HM, Iversen PL, Buchmeier MJ. Antisense Morpholino-Oligomers Directed against the 5' End of the Genome Inhibit Coronavirus Proliferation and Growth. J Virol. 2004 Jun;78(11):5891-5899.

Antisense Targeting of cFLIP Sensitizes Activated T Cells to Undergo Apoptosis and Desensitizes Responses to Contact Dermatitis

Authors:
Mourich DV, Jendrzejewski JL, Marshall NB, Hinrichs DJ, Iversen PL, Brand RM
Citation:
J Invest Dermatol. 2009 Feb 19. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Contact dermatitis is the result of inflammatory responses mediated by hapten-specific activated CD8+ and CD4+ T cells....
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice and cell culture: T cells
Citation Extract:
Mourich DV, Jendrzejewski JL, Marshall NB, Hinrichs DJ, Iversen PL, Brand RM. Antisense Targeting of cFLIP Sensitizes Activated T Cells to Undergo Apoptosis and Desensitizes Responses to Contact Dermatitis. J Invest Dermatol. 2009 Feb 19. [Epub ahead of print].

Arginine-rich Peptide conjugation to morpholino oligomers: effects on antisense activity and specificity

Authors:
Nelson MH, Stein DA, Kroeker AD, Hatlevig SA, Iversen PL, Moulton HM
Citation:
Bioconjug Chem. 2005 Jul-Aug;16(4):959-66
Epub:
Not Epub
Abstract:
Noncharged antisense compounds, such as phosphorodiamidate morpholino oligomers (PMOs), do not readily enter mammalian cells in...
Link:
https://pubs.acs.org/doi/abs/10.1021/bc0501045
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: HeLa Antisense Test System, others
Citation Extract:
Nelson MH, Stein DA, Kroeker AD, Hatlevig SA, Iversen PL, Moulton HM. Arginine-rich Peptide conjugation to morpholino oligomers: effects on antisense activity and specificity. Bioconjug Chem. 2005 Jul-Aug;16(4):959-66.

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