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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 259 scientific papers returned from the database with the search filters currently being used below.

Inhibition of RNA virus infections with peptide-conjugated morpholino oligomers

Authors:
Stein DA
Citation:
Curr Pharm Des. 2008;14(25):2619-34
Epub:
Not Epub
Abstract:
RNA virus infections cause immense human disease burdens globally, and few effective antiviral drugs are available for their...
Delivery Method:
peptide-coupled
Citation Extract:
Stein DA. Inhibition of RNA virus infections with peptide-conjugated morpholino oligomers. Curr Pharm Des. 2008;14(25):2619-34.

RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice

Authors:
Svasti S, Suwanmanee T, Fucharoen S, Moulton HM, Nelson MH, Maeda N, Smithies O, Kole R
Citation:
Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1205-10. Epub 2009 Jan 21
Epub:
Not Epub
Abstract:
Repair of beta-globin pre-mRNA rendered defective by a thalassemia-causing splicing mutation, IVS2-654, in intron 2 of the...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mouse: IVS2-654
Citation Extract:
Svasti S, Suwanmanee T, Fucharoen S, Moulton HM, Nelson MH, Maeda N, Smithies O, Kole R. RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1205-10. Epub 2009 Jan 21.

Inhibition of measles virus infections in cell cultures by peptide-conjugated morpholino oligomers

Authors:
Sleeman K, Stein DA, Tamin A, Reddish M, Iversen PL, Rota PA
Citation:
Virus Res. 2009 Mar;140(1-2):49-56. doi: 10.1016/j.virusres.2008.10.018. Epub 2009 Jan 6
Epub:
Not Epub
Abstract:
Measles virus (MeV) is a highly contagious human pathogen. Despite the success of measles vaccination programs, measles is...
Link:
http://www.sciencedirect.com/science/article/pii/S0168170208003894
Delivery Method:
peptide-coupled
Organism or Cell Type:
Measles virus in cultured cells
Citation Extract:
Sleeman K, Stein DA, Tamin A, Reddish M, Iversen PL, Rota PA. Inhibition of measles virus infections in cell cultures by peptide-conjugated morpholino oligomers. Virus Res. 2009 Mar;140(1-2):49-56. doi: 10.1016/j.virusres.2008.10.018. Epub 2009 Jan 6.

Inactivation of expression of several genes in a variety of bacterial species by EGS technology

Authors:
Shen N, Ko JH, Xiao G, Wesolowski D, Shan G, Geller B, Izadjoo M, Altman S
Citation:
Proc Natl Acad Sci U S A. 2009 Apr 30. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The expression of gene products in bacteria can be inhibited by the use of RNA external guide sequences (EGSs) that hybridize...
Link:
http://www.pnas.org/content/106/20/8163.long
Delivery Method:
peptide-coupled
Organism or Cell Type:
Bacteria: Escherichia, Enterococcus, Bacillus,
Citation Extract:
Shen N, Ko JH, Xiao G, Wesolowski D, Shan G, Geller B, Izadjoo M, Altman S. Inactivation of expression of several genes in a variety of bacterial species by EGS technology. Proc Natl Acad Sci U S A. 2009 Apr 30. [Epub ahead of print].

Development of a general methodology for labelling peptide-morpholino oligonucleotide conjugates using alkyne-azide click chemistry

Authors:
Shabanpoor F, Gait MJ
Citation:
Chem Commun (Camb). 2013 Nov 11;49(87):10260-2. doi: 10.1039/c3cc46067c
Epub:
Not Epub
Abstract:
We describe a general methodology for fluorescent labelling of peptide conjugates of phosphorodiamidate morpholino...
Link:
http://pubs.rsc.org/en/Content/ArticleLanding/2013/CC/C3CC46067C#!divAbstract
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: mouse H2K/mdx myoblasts
Citation Extract:
Shabanpoor F, Gait MJ. Development of a general methodology for labelling peptide-morpholino oligonucleotide conjugates using alkyne-azide click chemistry. Chem Commun (Camb). 2013 Nov 11;49(87):10260-2. doi: 10.1039/c3cc46067c.

Lymphocytic Choriomeningitis Virus Infection in FVB Mouse Produces Hemorrhagic Disease

Authors:
Schnell FJ, Sundholm S, Crumley S, Iversen PL, Mourich DV
Citation:
PLoS Pathog. 2012;8(12):e1003073. doi:10.1371/journal.ppat.1003073
Epub:
Not Epub
Abstract:
The viral family Arenaviridae includes a number of viruses that can cause hemorrhagic fever in humans. Arenavirus infection...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice
Citation Extract:
Schnell FJ, Sundholm S, Crumley S, Iversen PL, Mourich DV. Lymphocytic Choriomeningitis Virus Infection in FVB Mouse Produces Hemorrhagic Disease. PLoS Pathog. 2012;8(12):e1003073. doi:10.1371/journal.ppat.1003073.

A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model

Authors:
Sawyer AJ, Wesolowski D, Gandotra N, Stojadinovic A, Izadjoo M, Altman S, Kyriakides TR
Citation:
Int J Pharmaceutics. 2013;[Epub ahead of print] doi:10.1016/j.ijpharm.2013.05.041
Epub:
Not Epub
Abstract:
Management of skin wound infections presents a serious problem in the clinic, in the community, and in both civilian and...
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756894/
Delivery Method:
peptide-coupled
Organism or Cell Type:
Bacteria: Staphylococcus aureus in mouse
Citation Extract:
Sawyer AJ, Wesolowski D, Gandotra N, Stojadinovic A, Izadjoo M, Altman S, Kyriakides TR. A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model. Int J Pharmaceutics. 2013;[Epub ahead of print] doi:10.1016/j.ijpharm.2013.05.041.

Endosomolysis by Masking of a Membrane-Active Agent (EMMA) for Cytoplasmic Release of Macromolecules

Authors:
Rozema DB, Ekena K, Lewis DL, Loomis AG, Wolff JA
Citation:
Bioconjug Chem. 2003 Jan-Feb;14(1):51
Epub:
Not Epub
Abstract:
Endosomolysis, a critical barrier to efficient delivery of macromolecules such as nucleic acids, has been breached using a...
Delivery Method:
peptide-based
Organism or Cell Type:
cell culture: HeLa AntisenseTest System
Citation Extract:
Rozema DB, Ekena K, Lewis DL, Loomis AG, Wolff JA. Endosomolysis by Masking of a Membrane-Active Agent (EMMA) for Cytoplasmic Release of Macromolecules. Bioconjug Chem. 2003 Jan-Feb;14(1):51.

Expression Analysis in Multiple Muscle Groups and Serum Reveals Complexity in the MicroRNA Transcriptome of the mdx Mouse with Implications for Therapy

Authors:
Roberts TC, Blomberg KEM, McClorey G, Andaloussi SEL, Godfrey C, Betts C, Coursindel T, Gait MJ, Edvard S, Wood MJA
Citation:
Mol Ther Nucleic Acids. 2012;[Epub ahead of print] doi:/10.1038/mtna.2012.26
Epub:
Not Epub
Abstract:
MicroRNAs (miRNAs) are a class of small RNAs that regulate gene expression and are implicated in wide-ranging cellular...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice, mdx
Citation Extract:
Roberts TC, Blomberg KEM, McClorey G, Andaloussi SEL, Godfrey C, Betts C, Coursindel T, Gait MJ, Edvard S, Wood MJA. Expression Analysis in Multiple Muscle Groups and Serum Reveals Complexity in the MicroRNA Transcriptome of the mdx Mouse with Implications for Therapy. Mol Ther Nucleic Acids. 2012;[Epub ahead of print] doi:/10.1038/mtna.2012.26.

Bacterial Resistance to Antisense Peptide-Phosphorodiamidate Morpholino Oligomers

Authors:
Puckett SE, Reese KA, Mitev GM, Mullen V, Johnson RC, Pomraning KR, Mellbye BL, Tilley LD, Iversen PL, Freitag M, Geller BL
Citation:
Antimicrob Agents Chemother. 2012 Sep 17. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Peptide phosphorodiamidate morpholino oligomers (PPMO) are synthetic DNA mimics that bind complementary RNA and inhibit...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Escherichia coli
Citation Extract:
Puckett SE, Reese KA, Mitev GM, Mullen V, Johnson RC, Pomraning KR, Mellbye BL, Tilley LD, Iversen PL, Freitag M, Geller BL. Bacterial Resistance to Antisense Peptide-Phosphorodiamidate Morpholino Oligomers. Antimicrob Agents Chemother. 2012 Sep 17. [Epub ahead of print].

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