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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 257 scientific papers returned from the database with the search filters currently being used below.
There are 257 scientific papers returned from the database with the search filters currently being used below.
Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers
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Citation:
Vet Microbiol. 2006 Oct 31;117(2-4):117-29. Epub 2006 Jul 12. Epub:
Not Epub Abstract:
Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of a contagious disease characterized by... Delivery Method:
peptide-coupled Organism or Cell Type:
Cell Culture: CRL11171 cells Citation Extract: Zhang YJ, Stein DA, Fan SM, Wang KY, Kroeker AD, Meng XJ, Iversen PL, Matson DO. Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers. Vet Microbiol. 2006 Oct 31;117(2-4):117-29. Epub 2006 Jul 12.. |
A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice
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Citation:
Hum Mol Genet. 2009 Aug 18. [Epub ahead of print] Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene that abolish the synthesis of dystrophin protein.... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx Citation Extract: Yin H, Moulton HM, Betts C, Seow Y, Boutilier J, Iverson PL, Wood MJ. A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice. Hum Mol Genet. 2009 Aug 18. [Epub ahead of print]. |
Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic muscle and cardiac dystrophin expression and function
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Citation:
Hum Mol Genet. 2008 Sep 10. [Epub ahead of print] Epub:
Not Epub Abstract:
Antisense oligonucleotides (AOs) have the potential to induce functional dystrophin protein expression via exon skipping by... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx Citation Extract: Yin H, Moulton HM, Seow Y, Boyd C, Boutilier J, Iverson P, Wood MJ. Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic muscle and cardiac dystrophin expression and function. Hum Mol Genet. 2008 Sep 10. [Epub ahead of print]. |
Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency
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Citation:
Mol Ther Nucleic Acids. 2013 Sep 24;2:e124. doi: 10.1038/mtna.2013.51 Epub:
Not Epub Abstract:
We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as B... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx Citation Extract: Yin H, Boisguerin P, Moulton HM, Betts C, Seow Y, Boutilier J, Wang Q, Walsh A, Lebleu B, Wood MJ. Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency. Mol Ther Nucleic Acids. 2013 Sep 24;2:e124. doi: 10.1038/mtna.2013.51. |
CPP-Directed Oligonucleotide Exon Skipping in Animal Models of Duchenne Muscular Dystrophy
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Citation:
Methods Mol Biol. 2011;683:321-38 Epub:
Not Epub Abstract:
Antisense oligonucleotides (AOs) are effective splice switching agents and have potential as therapeutics via the exclusion or... Delivery Method:
peptide-coupled Citation Extract: Yin H, Moulton H, Betts C, Wood M. CPP-Directed Oligonucleotide Exon Skipping in Animal Models of Duchenne Muscular Dystrophy. Methods Mol Biol. 2011;683:321-38. |
Stability of cell-penetrating Peptide-morpholino oligomer conjugates in human serum and in cells
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Citation:
Bioconjug Chem. 2007 Jan-Feb;18(1):50-60 Epub:
Not Epub Abstract:
Cell penetrating peptides (CPPs) have been shown to enhance the cellular uptake of antisense oligonucleotides (AOs). However,... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: HeLa cells Citation Extract: Youngblood DS, Hatlevig SA, Hassinger JN, Iversen PL, Moulton HM. Stability of cell-penetrating Peptide-morpholino oligomer conjugates in human serum and in cells. Bioconjug Chem. 2007 Jan-Feb;18(1):50-60. |
Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity
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Citation:
Nucleic Acids Res. 2007;35(15):5182-91. Epub 2007 Aug 1 Epub:
Not Epub Abstract:
Arginine-rich cell-penetrating peptides (CPPs) are promising transporters for intracellular delivery of antisense morpholino... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: HeLa pLuc705 Antisense Test System Citation Extract: Wu RP, Youngblood DS, Hassinger JN, Lovejoy CE, Nelson MH, Iversen PL, Moulton HM. Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity. Nucleic Acids Res. 2007;35(15):5182-91. Epub 2007 Aug 1. |
Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer
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Citation:
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14814-9. doi: 10.1073/pnas.0805676105. Epub 2008 Sep 19. Epub:
Not Epub Abstract:
Antisense oligonucleotide-mediated exon skipping is able to correct out-of-frame mutations in Duchenne muscular dystrophy and... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx Citation Extract: Wu B, Moulton HM, Iversen PL, Jiang J, Li J, Li J, Spurney CF, Sali A, Guerron AD, Nagaraju K, Doran T, Lu P, Xiao X, Lu QL. Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14814-9. doi: 10.1073/pnas.0805676105. Epub 2008 Sep 19.. |
Long-Term Rescue of Dystrophin Expression and Improvement in Muscle Pathology and Function in Dystrophic mdx Mice by Peptide-Conjugated Morpholino
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Citation:
Am J Pathol. 2012 Aug;181(2):392-400. doi: 10.1016/j.ajpath.2012.04.006. Epub 2012 Jun 7. Epub:
Not Epub Abstract:
Exon skipping is capable of correcting frameshift and nonsense mutations in Duchenne muscular dystrophy (DMD). Phase 2 clinical... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx Citation Extract: Wu B, Lu P, Cloer C, Shaban M, Grewal S, Milazi S, Shah SN, Moulton HM, Lu QL. Long-Term Rescue of Dystrophin Expression and Improvement in Muscle Pathology and Function in Dystrophic mdx Mice by Peptide-Conjugated Morpholino. Am J Pathol. 2012 Aug;181(2):392-400. doi: 10.1016/j.ajpath.2012.04.006. Epub 2012 Jun 7.. |
Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes
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Citation:
PNAS. 2011;108(40):16582-7 doi:10.1073/pnas.1112561108 Epub:
Not Epub Abstract:
Basic peptides covalently linked to nucleic acids, or chemically modified nucleic acids, enable the insertion of such a... Delivery Method:
peptide-coupled Organism or Cell Type:
Bacteria, various Citation Extract: Wesolowski D, Tae HS, Gandotra N, Llopis P, Shen N, Altman S. Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes. PNAS. 2011;108(40):16582-7 doi:10.1073/pnas.1112561108. |