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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 274 scientific papers returned from the database with the search filters currently being used below.
There are 274 scientific papers returned from the database with the search filters currently being used below.
Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice
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Citation:
Sci Rep. 2015 Mar 11;5:8986. doi: 10.1038/srep08986 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disorder caused by mutations in the Dmd gene. In addition to... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Betts CA, Saleh AF, Carr CA, Hammond SM, Coenen-Stass AM, Godfrey C, McClorey G, Varela MA, Roberts TC, Clarke K, Gait MJ, Wood MJ. Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice. Sci Rep. 2015 Mar 11;5:8986. doi: 10.1038/srep08986. |
High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides
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Citation:
Nucl Acids Res. 2015;[Epub ahead of print] doi:10.1093/nar/gkv060 Epub:
Yes Abstract:
The therapeutic use of antisense and siRNA oligonucleotides has been constrained by the limited ability of these membrane-... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: A375 melanoma cells Citation Extract: Yang B, Ming X, Cao C, Laing B, Yuan A, Porter MA, Hull-Ryde EA, Maddry J, Suto M, Janzen WP, Juliano RL. High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides. Nucl Acids Res. 2015;[Epub ahead of print] doi:10.1093/nar/gkv060 . |
Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides
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Citation:
Nucleic Acid Ther. 2015 Jan 16. [Epub ahead of print] Epub:
Yes Abstract:
Oligonucleotide analogs have provided novel therapeutics targeting various disorders. However, their poor cellular uptake... Delivery Method:
peptide nanoparticle Organism or Cell Type:
cell culture: U2OS cells, murine H2K mdx myotubes, human SMA type 1 fibroblasts Citation Extract: Järver P, Zaghloul EM, Arzumanov AA, Saleh AF, McClorey G, Hammond SM, Hällbrink M, Langel Ü, Smith CI, Wood MJ, Gait MJ, Andaloussi SE. Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides. Nucleic Acid Ther. 2015 Jan 16. [Epub ahead of print]. |
Bi-specific splice-switching PMO oligonucleotides conjugated via a single peptide active in a mouse model of Duchenne muscular dystrophy
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Citation:
Nucl Acids Res. 2015 Jan;43(1):29-39. doi: 10.1093/nar/gku1256. Epub 2014 Dec 2 Epub:
Not Epub Abstract:
The potential for therapeutic application of splice-switching oligonucleotides (SSOs) to modulate pre-mRNA splicing is... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: mouse H2K/mdx myotubes, mice (mdx) Citation Extract: Shabanpoor F, McClorey G, Saleh AF, Järver P, Wood MJA, Gait MJ. Bi-specific splice-switching PMO oligonucleotides conjugated via a single peptide active in a mouse model of Duchenne muscular dystrophy. Nucl Acids Res. 2015 Jan;43(1):29-39. doi: 10.1093/nar/gku1256. Epub 2014 Dec 2. |
Parallel Synthesis of Cell-Penetrating Peptide Conjugates of PMO Toward Exon Skipping Enhancement in Duchenne Muscular Dystrophy
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Citation:
Nucleic Acid Ther. 2014 Nov 20. [Epub ahead of print] Epub:
Yes Abstract:
We describe two new methods of parallel chemical synthesis of libraries of peptide conjugates of phosphorodiamidate morpholino... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: murine H2k mdx myoblast Citation Extract: O'Donovan L, Okamoto I, Arzumanov AA, Williams DL, Deuss P, Gait MJ. Parallel Synthesis of Cell-Penetrating Peptide Conjugates of PMO Toward Exon Skipping Enhancement in Duchenne Muscular Dystrophy. Nucleic Acid Ther. 2014 Nov 20. [Epub ahead of print]. |
Wild-type mouse models to screen antisense oligonucleotides for exon-skipping efficacy in duchenne muscular dystrophy
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Citation:
PLoS One. 2014 Nov 3;9(11):e111079. doi: 10.1371/journal.pone.0111079. eCollection 2014 Epub:
Not Epub Abstract:
A readily available animal model is essential for rapidly identifying effective treatments for Duchenne muscular dystrophy (DMD... Delivery Method:
injection and peptide-coupled Organism or Cell Type:
mice Citation Extract: Cao L, Han G, Gu B, Yin H. Wild-type mouse models to screen antisense oligonucleotides for exon-skipping efficacy in duchenne muscular dystrophy. PLoS One. 2014 Nov 3;9(11):e111079. doi: 10.1371/journal.pone.0111079. eCollection 2014. |
Antisense Oligonucleotide-mediated Suppression of Muscle Glycogen Synthase 1 Synthesis as an Approach for Substrate Reduction Therapy of Pompe Disease
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Citation:
Mol Ther Nucleic Acids. 2014 Oct 28;3:e206. doi: 10.1038/mtna.2014.57 Epub:
Not Epub Abstract:
Pompe disease is an autosomal recessive disorder caused by a deficiency of acid α-glucosidase (GAA; EC 3.2.1.20) and the... Delivery Method:
injection & electroporation or peptide-linked Organism or Cell Type:
mice Citation Extract: Clayton NP, Nelson CA, Weeden T, Taylor KM, Moreland RJ, Scheule RK, Phillips L, Leger AJ, Cheng SH, Wentworth BM. Antisense Oligonucleotide-mediated Suppression of Muscle Glycogen Synthase 1 Synthesis as an Approach for Substrate Reduction Therapy of Pompe Disease. Mol Ther Nucleic Acids. 2014 Oct 28;3:e206. doi: 10.1038/mtna.2014.57. |
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model
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Citation:
J Clin Invest. 2014 Aug 8. pii: 76175. doi: 10.1172/JCI76175. [Epub ahead of print] Epub:
Yes Abstract:
X-linked agammaglobulinemia (XLA) is an inherited immunodeficiency that results from mutations within the gene encoding Bruton... Delivery Method:
Peptide-linked or bare oligo Organism or Cell Type:
mice, cell culture: U2OS reporter cell line Citation Extract: Bestas B, Moreno PM, Blomberg KE, Mohammad DK, Saleh AF, Sutlu T, Nordin JZ, Guterstam P, Gustafsson MO, Kharazi S, Piątosa B, Roberts TC, Behlke MA, Wood MJ, Gait MJ, Lundin KE, El Andaloussi S, Månsson R, Berglöf A, Wengel J, Smith CI. Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model. J Clin Invest. 2014 Aug 8. pii: 76175. doi: 10.1172/JCI76175. [Epub ahead of print]. |
Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum
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Citation:
J Biol Chem. 2013 Jul 12;288(28):20558-67. doi: 10.1074/jbc.M113.482992. Epub 2013 May 31 Epub:
Not Epub Abstract:
The human malaria parasite Plasmodium falciparum is absolutely dependent on the acquisition of host pantothenate for its... Delivery Method:
peptide-coupled Organism or Cell Type:
Plasmodium falciparum Citation Extract: Augagneur Y, Jaubert L, Schiavoni M, Pachikara N, Garg A, Usmani-Brown S, Wesolowski D, Zeller S, Ghosal A, Cornillot E, Said HM, Kumar P, Altman S, Ben Mamoun C. Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum. J Biol Chem. 2013 Jul 12;288(28):20558-67. doi: 10.1074/jbc.M113.482992. Epub 2013 May 31. |
Induced IL-10 Splice Altering Approach to Antiviral Drug Discovery
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Citation:
Nucleic Acid Ther. 2014;24(3):179-185. doi:10.1089/nat.2013.0457 Epub:
Not Epub Abstract:
Ebola virus causes an acute hemorrhagic fever lethal in primates and rodents. The contribution of host immune factors to... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Panchal RG, Mourich DV, Bradfute S, Hauck LL, Warfield KL, Iversen PL, Bavari S. Induced IL-10 Splice Altering Approach to Antiviral Drug Discovery. Nucleic Acid Ther. 2014;24(3):179-185. doi:10.1089/nat.2013.0457. |