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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 260 scientific papers returned from the database with the search filters currently being used below.

Multicellular Tumor Spheroids as a Model for Assessing Delivery of Oligonucleotides in Three Dimensions

Authors:
Carver K, Ming X, Juliano RL
Citation:
Mol Ther Nucleic Acids. 2014;3:e153. doi:10.1038/mtna.2014.5
Epub:
Not Epub
Abstract:
Oligonucleotides have shown promise in selectively manipulating gene expression in vitro, but that success has not translated...
Delivery Method:
peptide-linked
Organism or Cell Type:
culture: multicellular tumor spheroid
Citation Extract:
Carver K, Ming X, Juliano RL. Multicellular Tumor Spheroids as a Model for Assessing Delivery of Oligonucleotides in Three Dimensions. Mol Ther Nucleic Acids. 2014;3:e153. doi:10.1038/mtna.2014.5.

Assessment of RT-qPCR Normalization Strategies for Accurate Quantification of Extracellular microRNAs in Murine Serum

Authors:
Roberts TC, Coenen-Stass AML, Wood MJA
Citation:
PLoS ONE. 2014;9(2):e89237. doi:10.1371/journal.pone.0089237
Epub:
Not Epub
Abstract:
Extracellular microRNAs (miRNAs) are under investigation as minimally-invasive biomarkers for a wide range of disease...
Delivery Method:
peptide-linked
Organism or Cell Type:
mouse
Citation Extract:
Roberts TC, Coenen-Stass AML, Wood MJA. Assessment of RT-qPCR Normalization Strategies for Accurate Quantification of Extracellular microRNAs in Murine Serum. PLoS ONE. 2014;9(2):e89237. doi:10.1371/journal.pone.0089237.

Antisense suppression of donor splice site mutations in the dystrophin gene transcript

Authors:
Fletcher S, Meloni PL, Johnsen RD, Wong BL, Muntoni F, Wilton SD
Citation:
Mol Genet Genomic Med. 2013 Sep;1(3):162-73. doi: 10.1002/mgg3.19. Epub 2013 Jun 13
Epub:
Not Epub
Abstract:
We describe two donor splice site mutations, affecting dystrophin exons 16 and 45 that led to Duchenne muscular dystrophy (DMD...
Delivery Method:
peptide-linked
Organism or Cell Type:
Primary DMD human cells underwent forced myogenesis
Citation Extract:
Fletcher S, Meloni PL, Johnsen RD, Wong BL, Muntoni F, Wilton SD. Antisense suppression of donor splice site mutations in the dystrophin gene transcript. Mol Genet Genomic Med. 2013 Sep;1(3):162-73. doi: 10.1002/mgg3.19. Epub 2013 Jun 13.

Antibiotics Present and Future

Authors:
Altman S
Citation:
FEBS Letters. 2013;[Epub ahead of print] doi:10.1016/j.febslet.2013.10.048
Epub:
Not Epub
Abstract:
Here we make a brief survey of the present state of antibiotic research and use. We also describe a novel antibiotic that...
Delivery Method:
peptide-linked
Organism or Cell Type:
Plasmodium falciparum, bacteria
Citation Extract:
Altman S. Antibiotics Present and Future. FEBS Letters. 2013;[Epub ahead of print] doi:10.1016/j.febslet.2013.10.048.

Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy

Authors:
Lehto T, Abes R, Oskolkov N, Suhorutsenko J, Copolovici DM, Mäger I, Viola JR, Simonson OE, Ezzat K, Guterstam P, Eriste E, Smith CI, Lebleu B, Samir El Andaloussi, Langel U
Citation:
J Control Release. 2010 Jan 4;141(1):42-51. doi: 10.1016/j.jconrel.2009.08.028. Epub 2009 Sep 8
Epub:
Not Epub
Abstract:
In recent years, oligonucleotide-based molecules have been intensely used to modulate gene expression. All these molecules...
Delivery Method:
peptide
Organism or Cell Type:
cell culture
Citation Extract:
Lehto T, Abes R, Oskolkov N, Suhorutsenko J, Copolovici DM, Mäger I, Viola JR, Simonson OE, Ezzat K, Guterstam P, Eriste E, Smith CI, Lebleu B, Samir El Andaloussi, Langel U. Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy. J Control Release. 2010 Jan 4;141(1):42-51. doi: 10.1016/j.jconrel.2009.08.028. Epub 2009 Sep 8.

Gene-Silencing Antisense Oligomers Inhibit Acinetobacter Growth In Vitro and In Vivo

Authors:
Geller BL, Marshall-Batty K, Schnell FJ, McKnight MM, Iversen PL, Greenberg DE
Citation:
J Infect Dis. 2013;[Epub ahead of print] doi:10.1093/infdis/jit460
Epub:
Not Epub
Abstract:
Background. Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) are synthetic DNA/RNA analogues that silence...
Delivery Method:
Peptide-coupled
Organism or Cell Type:
Mice
Citation Extract:
Geller BL, Marshall-Batty K, Schnell FJ, McKnight MM, Iversen PL, Greenberg DE. Gene-Silencing Antisense Oligomers Inhibit Acinetobacter Growth In Vitro and In Vivo. J Infect Dis. 2013;[Epub ahead of print] doi:10.1093/infdis/jit460 .

Blockade of viral interleukin-6 expression of Kaposi's sarcoma-associated herpesvirus

Authors:
Zhang YJ, Bonaparte RS, Patel D, Stein DA, Iversen PL
Citation:
Mol Cancer Ther. 2008 Mar;7(3):712-20
Epub:
Not Epub
Abstract:
Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8, is associated with several malignant...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: PEL
Citation Extract:
Zhang YJ, Bonaparte RS, Patel D, Stein DA, Iversen PL. Blockade of viral interleukin-6 expression of Kaposi's sarcoma-associated herpesvirus. Mol Cancer Ther. 2008 Mar;7(3):712-20.

Co-selection of West Nile virus nucleotides that confer resistance to an antisense oligomer while maintaining long-distance RNA/RNA base pairings

Authors:
Zhang B, Dong H, Stein DA, Shi PY
Citation:
Virology. 2008 Dec 5;382(1):98-106. Epub 2008 Oct 7.
Epub:
Not Epub
Abstract:
West Nile virus (WNV) genome cyclization is mediated by two pairs of long-distance RNA/RNA interactions: the 5'CS/3'...
Delivery Method:
peptide-coupled
Organism or Cell Type:
West Nile Virus
Citation Extract:
Zhang B, Dong H, Stein DA, Shi PY. Co-selection of West Nile virus nucleotides that confer resistance to an antisense oligomer while maintaining long-distance RNA/RNA base pairings. Virology. 2008 Dec 5;382(1):98-106. Epub 2008 Oct 7..

Construction of a novel chimera consisting of a chelator-containing Tat peptide conjugated to a morpholino antisense oligomer for technetium-99m labeling and accelerating cellular kinetics

Authors:
Zhang YM, Tung CH, He J, Liu N, Yanachkov I, Liu G, Rusckowski M, Vanderheyden JL
Citation:
Nucl Med Biol. 2006 Feb;33(2):263-9
Epub:
Not Epub
Abstract:
The attempt to target the limited copies of messenger RNA (mRNA) in vivo with radiolabeled nucleobase oligomers as antisense...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture
Citation Extract:
Zhang YM, Tung CH, He J, Liu N, Yanachkov I, Liu G, Rusckowski M, Vanderheyden JL. Construction of a novel chimera consisting of a chelator-containing Tat peptide conjugated to a morpholino antisense oligomer for technetium-99m labeling and accelerating cellular kinetics. Nucl Med Biol. 2006 Feb;33(2):263-9.

Curing of HeLa Cells Persistently Infected with Equine Arteritis Virus by a Peptide-conjugated Morpholino Oligomer

Authors:
Zhang J, Stein DA, Timoney PJ, Balasuriya UB
Citation:
Virus Res. 2010 Mar 2. [Epub ahead of print]
Epub:
Not Epub
Abstract:
A significant consequence of equine arteritis virus (EAV) infection of horses is persistence of the virus in a variable...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: HeLa with equine arteritis viral infection
Citation Extract:
Zhang J, Stein DA, Timoney PJ, Balasuriya UB. Curing of HeLa Cells Persistently Infected with Equine Arteritis Virus by a Peptide-conjugated Morpholino Oligomer. Virus Res. 2010 Mar 2. [Epub ahead of print].

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