You are here
Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 259 scientific papers returned from the database with the search filters currently being used below.
There are 259 scientific papers returned from the database with the search filters currently being used below.
Wild-type mouse models to screen antisense oligonucleotides for exon-skipping efficacy in duchenne muscular dystrophy
|
Citation:
PLoS One. 2014 Nov 3;9(11):e111079. doi: 10.1371/journal.pone.0111079. eCollection 2014 Epub:
Not Epub Abstract:
A readily available animal model is essential for rapidly identifying effective treatments for Duchenne muscular dystrophy (DMD... Delivery Method:
injection and peptide-coupled Organism or Cell Type:
mice Citation Extract: Cao L, Han G, Gu B, Yin H. Wild-type mouse models to screen antisense oligonucleotides for exon-skipping efficacy in duchenne muscular dystrophy. PLoS One. 2014 Nov 3;9(11):e111079. doi: 10.1371/journal.pone.0111079. eCollection 2014. |
Antisense Oligonucleotide-mediated Suppression of Muscle Glycogen Synthase 1 Synthesis as an Approach for Substrate Reduction Therapy of Pompe Disease
|
Citation:
Mol Ther Nucleic Acids. 2014 Oct 28;3:e206. doi: 10.1038/mtna.2014.57 Epub:
Not Epub Abstract:
Pompe disease is an autosomal recessive disorder caused by a deficiency of acid α-glucosidase (GAA; EC 3.2.1.20) and the... Delivery Method:
injection & electroporation or peptide-linked Organism or Cell Type:
mice Citation Extract: Clayton NP, Nelson CA, Weeden T, Taylor KM, Moreland RJ, Scheule RK, Phillips L, Leger AJ, Cheng SH, Wentworth BM. Antisense Oligonucleotide-mediated Suppression of Muscle Glycogen Synthase 1 Synthesis as an Approach for Substrate Reduction Therapy of Pompe Disease. Mol Ther Nucleic Acids. 2014 Oct 28;3:e206. doi: 10.1038/mtna.2014.57. |
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model
|
Citation:
J Clin Invest. 2014 Aug 8. pii: 76175. doi: 10.1172/JCI76175. [Epub ahead of print] Epub:
Yes Abstract:
X-linked agammaglobulinemia (XLA) is an inherited immunodeficiency that results from mutations within the gene encoding Bruton... Delivery Method:
Peptide-linked or bare oligo Organism or Cell Type:
mice, cell culture: U2OS reporter cell line Citation Extract: Bestas B, Moreno PM, Blomberg KE, Mohammad DK, Saleh AF, Sutlu T, Nordin JZ, Guterstam P, Gustafsson MO, Kharazi S, Piątosa B, Roberts TC, Behlke MA, Wood MJ, Gait MJ, Lundin KE, El Andaloussi S, Månsson R, Berglöf A, Wengel J, Smith CI. Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model. J Clin Invest. 2014 Aug 8. pii: 76175. doi: 10.1172/JCI76175. [Epub ahead of print]. |
Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum
|
Citation:
J Biol Chem. 2013 Jul 12;288(28):20558-67. doi: 10.1074/jbc.M113.482992. Epub 2013 May 31 Epub:
Not Epub Abstract:
The human malaria parasite Plasmodium falciparum is absolutely dependent on the acquisition of host pantothenate for its... Delivery Method:
peptide-coupled Organism or Cell Type:
Plasmodium falciparum Citation Extract: Augagneur Y, Jaubert L, Schiavoni M, Pachikara N, Garg A, Usmani-Brown S, Wesolowski D, Zeller S, Ghosal A, Cornillot E, Said HM, Kumar P, Altman S, Ben Mamoun C. Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum. J Biol Chem. 2013 Jul 12;288(28):20558-67. doi: 10.1074/jbc.M113.482992. Epub 2013 May 31. |
Induced IL-10 Splice Altering Approach to Antiviral Drug Discovery
|
Citation:
Nucleic Acid Ther. 2014;24(3):179-185. doi:10.1089/nat.2013.0457 Epub:
Not Epub Abstract:
Ebola virus causes an acute hemorrhagic fever lethal in primates and rodents. The contribution of host immune factors to... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Panchal RG, Mourich DV, Bradfute S, Hauck LL, Warfield KL, Iversen PL, Bavari S. Induced IL-10 Splice Altering Approach to Antiviral Drug Discovery. Nucleic Acid Ther. 2014;24(3):179-185. doi:10.1089/nat.2013.0457. |
Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response
|
Citation:
Immunity. 2014;[Epub ahead of print] doi:10.1016/j.immuni.2014.04.018 Epub:
Yes Abstract:
Type I interferons (IFN-I) are essential antiviral cytokines produced upon microbial infection. IFN-I elicits this activity... Delivery Method:
peptide-linked Organism or Cell Type:
BALB/c mice Citation Extract: Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva A, Martínez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L, Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever BR, García-Sastre A. Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response. Immunity. 2014;[Epub ahead of print] doi:10.1016/j.immuni.2014.04.018. |
Silencing of GRA10 protein expression inhibits Toxoplasma gondii intracellular growth and development
|
Citation:
Parasitol Int. 2014 May 13. pii: S1383-5769(14)00059-2. doi: 10.1016/j.parint.2014.05.001. [Epub ahead of print] Epub:
Yes Abstract:
Toxoplasma gondii dense granule proteins (GRAs) are secreted abundantly in both the tachyzoite and bradyzoite stages of the... Delivery Method:
peptide-linked Organism or Cell Type:
Toxoplasma gondii Citation Extract: Witola WH, Bauman B, McHugh M, Matthews K. Silencing of GRA10 protein expression inhibits Toxoplasma gondii intracellular growth and development. Parasitol Int. 2014 May 13. pii: S1383-5769(14)00059-2. doi: 10.1016/j.parint.2014.05.001. [Epub ahead of print]. |
Effective dystrophin restoration by a novel muscle-homing peptide-morpholino conjugate in dystrophin-deficient mdx mice
|
Citation:
Mol Ther. 2014 Apr 15. doi: 10.1038/mt.2014.63. [Epub ahead of print] Epub:
Yes Abstract:
Antisense oligonucleotide (AO) - mediated splice correction therapy for Duchenne muscular dystrophy (DMD) has shown huge... Delivery Method:
peptide-linked Organism or Cell Type:
mdx mice Citation Extract: Gao X, Zhao J, Han G, Zhang Y, Dong X, Cao L, Wang Q, Moulton HM, Yin H. Effective dystrophin restoration by a novel muscle-homing peptide-morpholino conjugate in dystrophin-deficient mdx mice. Mol Ther. 2014 Apr 15. doi: 10.1038/mt.2014.63. [Epub ahead of print]. |
Targeted Exon Skipping to Correct Exon Duplications in the Dystrophin Gene
|
Citation:
Molec Ther Nucleic Acids. 2014;3,e155. doi:10.1038/mtna.2014.8 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy is a severe muscle-wasting disease caused by mutations in the dystrophin gene that ablate... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: primary fibroblasts induced myogenic Citation Extract: Greer KL, Lochmüller H, Flanigan K, Fletcher S, Wilton SD. Targeted Exon Skipping to Correct Exon Duplications in the Dystrophin Gene. Molec Ther Nucleic Acids. 2014;3,e155. doi:10.1038/mtna.2014.8. |
Multicellular Tumor Spheroids as a Model for Assessing Delivery of Oligonucleotides in Three Dimensions
|
Citation:
Mol Ther Nucleic Acids. 2014;3:e153. doi:10.1038/mtna.2014.5 Epub:
Not Epub Abstract:
Oligonucleotides have shown promise in selectively manipulating gene expression in vitro, but that success has not translated... Delivery Method:
peptide-linked Organism or Cell Type:
culture: multicellular tumor spheroid Citation Extract: Carver K, Ming X, Juliano RL. Multicellular Tumor Spheroids as a Model for Assessing Delivery of Oligonucleotides in Three Dimensions. Mol Ther Nucleic Acids. 2014;3:e153. doi:10.1038/mtna.2014.5. |