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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 259 scientific papers returned from the database with the search filters currently being used below.
There are 259 scientific papers returned from the database with the search filters currently being used below.
Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice
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Citation:
Mol Ther Nucleic Acids. 2016 Jun 28;5(6):e329. doi: 10.1038/mtna.2016.46 Epub:
Not Epub Abstract:
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations... Delivery Method:
injection standard oligos and peptide-linked Organism or Cell Type:
mice, mdx Citation Extract: Cao L, Han G, Lin C, Gu B, Gao X, Moulton HM, Seow Y, Yin H. Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice. Mol Ther Nucleic Acids. 2016 Jun 28;5(6):e329. doi: 10.1038/mtna.2016.46. |
Translational Inhibition of CTX-M Extended Spectrum β-Lactamase in Clinical Strains of Escherichia coli by Synthetic Antisense Oligonucleotides Partially Restores Sensitivity to Cefotaxime
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Citation:
Front Microbiol. 2016 Mar 24;7:373. eCollection 2016 Epub:
Not Epub Abstract:
Synthetic antisense oligomers are DNA mimics that can specifically inhibit gene expression at the translational level by... Delivery Method:
peptide-linked Organism or Cell Type:
Escherichia coli Citation Extract: Readman JB, Dickson G, Coldham NG. Translational Inhibition of CTX-M Extended Spectrum β-Lactamase in Clinical Strains of Escherichia coli by Synthetic Antisense Oligonucleotides Partially Restores Sensitivity to Cefotaxime. Front Microbiol. 2016 Mar 24;7:373. eCollection 2016. |
mRNA and microRNA transcriptomics analyses in a murine model of dystrophin loss and therapeutic restoration
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Citation:
Genom Data. 2015 Dec 2;7:88-9. doi: 10.1016/j.gdata.2015.11.025. eCollection 2016 Mar Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is a pediatric, X-linked, progressive muscle-wasting disorder caused by loss of function... Delivery Method:
peptide-linked Organism or Cell Type:
mice, mdx Citation Extract: Roberts TC, Blomberg KE, Smith CI, El Andaloussi S, Wood MJ. mRNA and microRNA transcriptomics analyses in a murine model of dystrophin loss and therapeutic restoration. Genom Data. 2015 Dec 2;7:88-9. doi: 10.1016/j.gdata.2015.11.025. eCollection 2016 Mar. |
Deletion of Dystrophin In-Frame Exon 5 Leads to a Severe Phenotype: Guidance for Exon Skipping Strategies
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Citation:
PLoS One. 2016 Jan 8;11(1):e0145620. doi: 10.1371/journal.pone.0145620. eCollection 2016 Epub:
Not Epub Abstract:
Duchenne and Becker muscular dystrophy severity depends upon the nature and location of the DMD gene lesion and generally... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Toh ZY, Thandar Aung-Htut M, Pinniger G, Adams AM, Krishnaswarmy S, Wong BL, Fletcher S, Wilton SD. Deletion of Dystrophin In-Frame Exon 5 Leads to a Severe Phenotype: Guidance for Exon Skipping Strategies. PLoS One. 2016 Jan 8;11(1):e0145620. doi: 10.1371/journal.pone.0145620. eCollection 2016. |
Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding
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Citation:
Cell Host & Microbe. 2015;18(6):723-35. doi:10.1016/j.chom.2015.11.002 Epub:
Not Epub Abstract:
Several systems-level datasets designed to dissect host-pathogen interactions during influenza A infection have been reported.... Delivery Method:
peptide-linked Organism or Cell Type:
BALB/c mice Citation Extract: Tripathi S, Pohl MO, Zhou Y, Rodriguez-Frandsen A, Wang G, Stein DA, Moulton HM, DeJesus P, Che J, Mulder LCF, Yángüez E, Andenmatten D, Pache L, Manicassamy B, Albrecht RA, Gonzalez MG, Nguyen Q, Brass A, Elledge S, White M, Shapira S, Hacohen N, Karlas A, Meyer TF, Shales M, Gatorano A, Johnson JR, Jang G, Johnson T, Verschueren E, Sanders D, Krogan N, Shaw M, König R, Stertz S, García-Sastre A, Chanda SK. Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding. Cell Host & Microbe. 2015;18(6):723-35. doi:10.1016/j.chom.2015.11.002. |
Identification of novel, therapy-responsive protein biomarkers in a mouse model of Duchenne muscular dystrophy by aptamer-based serum proteomics
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Citation:
Sci Rep. 2015;5:17104 doi:10.1038/srep17014 Epub:
Not Epub Abstract:
There is currently an urgent need for biomarkers that can be used to monitor the efficacy of experimental therapies for... Delivery Method:
peptide-linked Organism or Cell Type:
mice, mdx Citation Extract: Coenen-Stass AML, McClorey G, Manzano R, Betts CA, Blain A, Saleh AF, Gait MJ, Lochmüller H, Wood MJA, Roberts TC. Identification of novel, therapy-responsive protein biomarkers in a mouse model of Duchenne muscular dystrophy by aptamer-based serum proteomics. Sci Rep. 2015;5:17104 doi:10.1038/srep17014. |
Spiroindolone That Inhibits PfATPase4 Is a Potent, Cidal Inhibitor of Toxoplasma gondii Tachyzoites In Vitro and In Vivo
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Citation:
Antimicrob Agents Chemother. 2014;58(3):1789-92. doi: 10.1128/AAC.02225-13. Epub 2013 Dec 23. PMID: 24366743 Epub:
Not Epub Abstract:
Here, we show that spiroindolone, an effective treatment for plasmodia, is also active against Toxoplasma gondii tachyzoites.... Delivery Method:
peptide-linked Organism or Cell Type:
Toxoplasma gondii Citation Extract: Zhou Y, Fomovska A, Muench S, Lai BS, Mui E, McLeod R. Spiroindolone That Inhibits PfATPase4 Is a Potent, Cidal Inhibitor of Toxoplasma gondii Tachyzoites In Vitro and In Vivo. Antimicrob Agents Chemother. 2014;58(3):1789-92. doi: 10.1128/AAC.02225-13. Epub 2013 Dec 23. PMID: 24366743 . |
Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum
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Citation:
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11935-40. doi: 10.1073/pnas.1515864112. Epub 2015 Sep 8. Epub:
Yes Abstract:
Identification and genetic validation of new targets from available genome sequences are critical steps toward the development... Delivery Method:
Vivo-Morpholino & peptide-linked Organism or Cell Type:
Plasmodium falciparum Citation Extract: Garg A, Wesolowski D, Alonso D, Deitsch KW, Ben Mamoun C, Altman S. Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum. Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11935-40. doi: 10.1073/pnas.1515864112. Epub 2015 Sep 8.. |
In Vitro Assays to Assess Exon Skipping in Duchenne Muscular Dystrophy
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Citation:
Methods Mol Biol. 2015;1324:317-29. doi: 10.1007/978-1-4939-2806-4_20 Epub:
Not Epub Abstract:
Cell-penetrating peptide (CPP)-mediated delivery of phosphorodiamidate morpholino oligomers (PMO) results in efficient exon... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: skeletal H2k cells and primary cardiomyocytes from mdx mice Citation Extract: Boisguerin P, O'Donovan L, Gait MJ, Lebleu B. In Vitro Assays to Assess Exon Skipping in Duchenne Muscular Dystrophy. Methods Mol Biol. 2015;1324:317-29. doi: 10.1007/978-1-4939-2806-4_20. |
Development and Application of an Ultrasensitive Hybridization-Based ELISA Method for the Determination of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides
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Citation:
Nucleic Acid Ther. 2015 Jul 15. [Epub ahead of print] Epub:
Yes Abstract:
Antisense oligonucleotide (AON)-induced exon skipping is one of the most promising strategies for treating Duchenne muscular... Delivery Method:
peptide-linked Citation Extract: Burki U, Keane J, Blain A, O'Donovan L, Gait MJ, Laval SH, Straub V. Development and Application of an Ultrasensitive Hybridization-Based ELISA Method for the Determination of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides. Nucleic Acid Ther. 2015 Jul 15. [Epub ahead of print]. |