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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 257 scientific papers returned from the database with the search filters currently being used below.

Systemic Antisense Therapeutics for Dystrophin and Myostatin Exon Splice Modulation Improve Muscle Pathology of Adult mdx Mice

Authors:
Lu-Nguyen N, Malerba A, Popplewell L, Schnell F, Hanson G, Dickson G
Citation:
Mol Ther Nucleic Acids. 2017 Mar 17;6:15-28. doi: 10.1016/j.omtn.2016.11.009
Epub:
Not Epub
Abstract:
Antisense-mediated exon skipping is a promising approach for the treatment of Duchenne muscular dystrophy (DMD), a rare life-...
Link:
http://www.cell.com/molecular-therapy-family/nucleic-acids/abstract/S2162-2531(16)30367-5
Delivery Method:
peptide-linked
Organism or Cell Type:
mouse mdx
Citation Extract:
Lu-Nguyen N, Malerba A, Popplewell L, Schnell F, Hanson G, Dickson G. Systemic Antisense Therapeutics for Dystrophin and Myostatin Exon Splice Modulation Improve Muscle Pathology of Adult mdx Mice. Mol Ther Nucleic Acids. 2017 Mar 17;6:15-28. doi: 10.1016/j.omtn.2016.11.009.

How much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse

Authors:
Godfrey C, Muses S, McClorey G, Wells KE, Coursindel T, Terry RL, Betts C, Hammond S, O'Donovan L, Hildyard J, El Andaloussi S, Gait MJ, Wood MJ, Wells DJ
Citation:
Hum Mol Genet. 2015 Aug 1;24(15):4225-37. doi: 10.1093/hmg/ddv155
Epub:
Not Epub
Abstract:
Splice modulation therapy has shown great clinical promise in Duchenne muscular dystrophy, resulting in the production of...
Link:
https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/ddv155
Delivery Method:
peptide-linked
Organism or Cell Type:
mouse mdx
Citation Extract:
Godfrey C, Muses S, McClorey G, Wells KE, Coursindel T, Terry RL, Betts C, Hammond S, O'Donovan L, Hildyard J, El Andaloussi S, Gait MJ, Wood MJ, Wells DJ. How much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse. Hum Mol Genet. 2015 Aug 1;24(15):4225-37. doi: 10.1093/hmg/ddv155.

Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation

Authors:
Soonthornvacharin S, Rodriguez-Frandsen A, Zhou Y, Galvez F, Huffmaster NJ, Tripathi S, Balasubramaniam VRMT, Inoue A, de Castro E, Moulton H, Stein DA, Sánchez-Aparicio MT, De Jesus PD, Nguyen Q, König R, Krogan NJ, García-Sastre A, Yoh SM, Chanda SK
Citation:
Nat Microbio. 2017;2:17022. doi:10.1038/nmicrobiol.2017.22
Epub:
Not Epub
Abstract:
Retinoic acid-inducible gene I (RIG-I) receptor recognizes 5′-triphosphorylated RNA and triggers a signalling cascade that...
Link:
http://www.nature.com/articles/nmicrobiol201722
Delivery Method:
peptide-linked
Organism or Cell Type:
mice C57BL/6
Citation Extract:
Soonthornvacharin S, Rodriguez-Frandsen A, Zhou Y, Galvez F, Huffmaster NJ, Tripathi S, Balasubramaniam VRMT, Inoue A, de Castro E, Moulton H, Stein DA, Sánchez-Aparicio MT, De Jesus PD, Nguyen Q, König R, Krogan NJ, García-Sastre A, Yoh SM, Chanda SK. Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation. Nat Microbio. 2017;2:17022. doi:10.1038/nmicrobiol.2017.22.

Inhibition of Pseudomonas aeruginosa by Peptide-conjugated Phosphorodiamidate Morpholino Oligomers

Authors:
Howard JJ, Sturge CR, Moustafa DA, Daly SM, Marshall-Batty KR, Felder CF, Zamora D, Yabe-Gill M, Labandeira-Rey M, Bailey SM, Wong M, Goldberg JB, Geller BL, Greenberg DE
Citation:
Antimicrob Agents Chemother. 2017 Jan 30. pii: AAC.01938-16. doi: 10.1128/AAC.01938-16. [Epub ahead of print]
Epub:
Yes
Abstract:
Pseudomonas aeruginosa is a highly virulent, multidrug-resistant pathogen that causes significant morbidity and mortality in...
Link:
http://aac.asm.org/content/early/2017/01/24/AAC.01938-16.abstract
Delivery Method:
peptide-linked
Organism or Cell Type:
Pseudomonas aeruginosa
Citation Extract:
Howard JJ, Sturge CR, Moustafa DA, Daly SM, Marshall-Batty KR, Felder CF, Zamora D, Yabe-Gill M, Labandeira-Rey M, Bailey SM, Wong M, Goldberg JB, Geller BL, Greenberg DE. Inhibition of Pseudomonas aeruginosa by Peptide-conjugated Phosphorodiamidate Morpholino Oligomers. Antimicrob Agents Chemother. 2017 Jan 30. pii: AAC.01938-16. doi: 10.1128/AAC.01938-16. [Epub ahead of print].

Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy

Authors:
Shabanpoor F, Hammond SM, Abendroth F, Hazell G, Wood MJ, Gait MJ
Citation:
Nucleic Acid Ther. 2017 Jan 24. doi: 10.1089/nat.2016.0652. [Epub ahead of print]
Epub:
Yes
Abstract:
Splice-switching antisense oligonucleotides are emerging treatments for neuromuscular diseases, with several splice-switching...
Link:
http://online.liebertpub.com/doi/abs/10.1089/nat.2016.0652
Delivery Method:
peptide-linked
Organism or Cell Type:
mouse
Citation Extract:
Shabanpoor F, Hammond SM, Abendroth F, Hazell G, Wood MJ, Gait MJ. Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy. Nucleic Acid Ther. 2017 Jan 24. doi: 10.1089/nat.2016.0652. [Epub ahead of print].

Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo

Authors:
Sully EK, Geller BL, Li L, Moody CM, Bailey SM, Moore AL, Wong M, Nordmann P, Daly SM, Sturge CR, Greenberg DE
Citation:
J Antimicrob Chemother. 2016 Dec 20. pii: dkw476. doi: 10.1093/jac/dkw476. [Epub ahead of print]
Epub:
Yes
Abstract:
OBJECTIVES: The objective of this study was to test the efficacy of an inhibitor of the New Delhi metallo-β- lactamase (NDM-1...
Link:
http://jac.oxfordjournals.org/content/early/2016/12/02/jac.dkw476.abstract
Delivery Method:
peptide-linked
Organism or Cell Type:
Escherichia coli
Citation Extract:
Sully EK, Geller BL, Li L, Moody CM, Bailey SM, Moore AL, Wong M, Nordmann P, Daly SM, Sturge CR, Greenberg DE. Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo. J Antimicrob Chemother. 2016 Dec 20. pii: dkw476. doi: 10.1093/jac/dkw476. [Epub ahead of print].

Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy

Authors:
Ayhan DH, Tamer YT, Akbar M, Bailey SM, Wong M, Daly SM, Greenberg DE, Toprak E
Citation:
PLoS Biol. 2016 Sep 15;14(9):e1002552. doi: 10.1371/journal.pbio.1002552. eCollection 2016 Sep
Epub:
Not Epub
Abstract:
The lack of effective and well-tolerated therapies against antibiotic-resistant bacteria is a global public health problem...
Link:
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002552
Delivery Method:
Peptide-linked
Organism or Cell Type:
cell culture: Escherichia coli, Klebsiella pneumoniae, Salmonella enterica, Acinetobacter baumannii, Pseudomonas aeruginosa, Burkholderia cenocepacia
Citation Extract:
Ayhan DH, Tamer YT, Akbar M, Bailey SM, Wong M, Daly SM, Greenberg DE, Toprak E. Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy. PLoS Biol. 2016 Sep 15;14(9):e1002552. doi: 10.1371/journal.pbio.1002552. eCollection 2016 Sep.

Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy

Authors:
Hammond SM, Hazell G, Shabanpoor F, Saleh AF, Bowerman M, Sleigh JN, Meijboom KE, Zhou H, Muntoni F, Talbot K, Gait MJ, Wood MJ
Citation:
Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10962-7. doi: 10.1073/pnas.1605731113. Epub 2016 Sep 12
Epub:
Yes
Abstract:
The development of antisense oligonucleotide therapy is an important advance in the identification of corrective therapy for...
Link:
http://www.pnas.org/content/early/2016/09/07/1605731113.long
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Hammond SM, Hazell G, Shabanpoor F, Saleh AF, Bowerman M, Sleigh JN, Meijboom KE, Zhou H, Muntoni F, Talbot K, Gait MJ, Wood MJ. Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10962-7. doi: 10.1073/pnas.1605731113. Epub 2016 Sep 12.

Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice

Authors:
Cao L, Han G, Lin C, Gu B, Gao X, Moulton HM, Seow Y, Yin H
Citation:
Mol Ther Nucleic Acids. 2016 Jun 28;5(6):e329. doi: 10.1038/mtna.2016.46
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations...
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022132/
Delivery Method:
injection standard oligos and peptide-linked
Organism or Cell Type:
mice, mdx
Citation Extract:
Cao L, Han G, Lin C, Gu B, Gao X, Moulton HM, Seow Y, Yin H. Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice. Mol Ther Nucleic Acids. 2016 Jun 28;5(6):e329. doi: 10.1038/mtna.2016.46.

Translational Inhibition of CTX-M Extended Spectrum β-Lactamase in Clinical Strains of Escherichia coli by Synthetic Antisense Oligonucleotides Partially Restores Sensitivity to Cefotaxime

Authors:
Readman JB, Dickson G, Coldham NG
Citation:
Front Microbiol. 2016 Mar 24;7:373. eCollection 2016
Epub:
Not Epub
Abstract:
Synthetic antisense oligomers are DNA mimics that can specifically inhibit gene expression at the translational level by...
Link:
http://journal.frontiersin.org/article/10.3389/fmicb.2016.00373/full
Delivery Method:
peptide-linked
Organism or Cell Type:
Escherichia coli
Citation Extract:
Readman JB, Dickson G, Coldham NG. Translational Inhibition of CTX-M Extended Spectrum β-Lactamase in Clinical Strains of Escherichia coli by Synthetic Antisense Oligonucleotides Partially Restores Sensitivity to Cefotaxime. Front Microbiol. 2016 Mar 24;7:373. eCollection 2016.

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