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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 259 scientific papers returned from the database with the search filters currently being used below.

Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA

Authors:
Sakai A, Singh G, Khoshbakht M, Bittner S, Löhr CV, Diaz-Tapia R, Warang P, White K, Le Luo L, Tolbert B, Blanco M, Chow A, Guttman M, Li C, Bao Y, Ho J, Maurer-Stroh S, Chatterjee A, Chanda S, García-Sastre A, Schotsaert M, Teijaro JR, Moulton HM, Stein DA
Citation:
Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102331
Epub:
Not Epub
Abstract:
Further development of direct-acting antiviral agents against human SARS-CoV-2 infections remains a public health priority....
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(24)00218-X
Delivery Method:
peptide-linked; intranasal and intratracheal
Organism or Cell Type:
cell culture: Hela-ACE2; mice: K18-hACE2
Citation Extract:
Sakai A, Singh G, Khoshbakht M, Bittner S, Löhr CV, Diaz-Tapia R, Warang P, White K, Le Luo L, Tolbert B, Blanco M, Chow A, Guttman M, Li C, Bao Y, Ho J, Maurer-Stroh S, Chatterjee A, Chanda S, García-Sastre A, Schotsaert M, Teijaro JR, Moulton HM, Stein DA. Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA. Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102331.

Enhancing Peptide and PMO Delivery to Mouse Airway Epithelia by Chemical Conjugation with the Amphiphilic Peptide S10

Authors:
Auger M, Sorroza-Martinez L, Brahiti N, Huppé C-A, Faucher-Giguère L, Arbi I, Hervault M, Cheng X, Gaillet B, Couture F, Guay D, Soultan A-H
Citation:
Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102290
Epub:
Not Epub
Abstract:
Delivery of antisense oligonucleotides (ASOs) to airway epithelial cells is arduous due to the physiological barriers that...
Link:
https://www.sciencedirect.com/science/article/pii/S216225312400177X
Delivery Method:
intranasal peptide-linked
Organism or Cell Type:
cell culture: HeLa EGFP-654, mice: CAG-EGFP-654
Citation Extract:
Auger M, Sorroza-Martinez L, Brahiti N, Huppé C-A, Faucher-Giguère L, Arbi I, Hervault M, Cheng X, Gaillet B, Couture F, Guay D, Soultan A-H. Enhancing Peptide and PMO Delivery to Mouse Airway Epithelia by Chemical Conjugation with the Amphiphilic Peptide S10. Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102290.

Comparing cell penetration of biotherapeutics across human cell lines

Authors:
Batistatou N and Kritzer J
Citation:
bioRxiv [preprint] 2024.03.28.587257; doi: https://doi.org/10.1101/2024.03.28.587257
Epub:
Not Epub
Abstract:
A major obstacle in biotherapeutics development is maximizing cell penetration. Ideally, assays would allow for optimization of...
Link:
https://www.biorxiv.org/content/10.1101/2024.03.28.587257v1
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Hela, Saos-2, U2OS, MIA PaCa-2, HEK293-T, BxPC-3, HepG2
Citation Extract:
Batistatou N and Kritzer J. Comparing cell penetration of biotherapeutics across human cell lines. bioRxiv [preprint] 2024.03.28.587257; doi: https://doi.org/10.1101/2024.03.28.587257.

Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with a blood-brain barrier-penetrating ApoE-derived peptide

Authors:
Yeoh YQ, Amin A, Cuic B, Tomas D, Turner BJ, Shabanpoor F
Citation:
Biomed Pharmacother. 2024 Jun;175:116737. doi: 10.1016/j.biopha.2024.116737. Epub 2024 May 14. PMID: 38749176
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (ASO) has emerged as a promising therapeutic approach for treating central nervous system (CNS)...
Link:
https://doi.org/10.1016/j.biopha.2024.116737
Delivery Method:
BBB-penetrating peptide-linked
Organism or Cell Type:
SMA Type-I patient-derived fibroblasts, SMN2 transgenic mice
Citation Extract:
Yeoh YQ, Amin A, Cuic B, Tomas D, Turner BJ, Shabanpoor F. Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with a blood-brain barrier-penetrating ApoE-derived peptide. Biomed Pharmacother. 2024 Jun;175:116737. doi: 10.1016/j.biopha.2024.116737. Epub 2024 May 14. PMID: 38749176.

ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells

Authors:
Heindl MR, Rupp A-L, Schwerdtner M, Bestle D, Harbig A, De Rocher A, Schmacke LC, Staker B, Steinmetzer T, Stein DA, Moulton HM, Böttcher-Friebertshäuser E
Citation:
J Virol. 2024 Apr 16;98(4):e0010224. doi: 10.1128/jvi.00102-24
Epub:
Not Epub
Abstract:
The transmembrane serine protease 2 (TMPRSS2) activates the outer structural proteins of a number of respiratory viruses...
Link:
https://journals.asm.org/doi/10.1128/jvi.00102-24
Delivery Method:
(RXR)4 peptide-linked
Organism or Cell Type:
cell culture: Calu-3
Citation Extract:
Heindl MR, Rupp A-L, Schwerdtner M, Bestle D, Harbig A, De Rocher A, Schmacke LC, Staker B, Steinmetzer T, Stein DA, Moulton HM, Böttcher-Friebertshäuser E. ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells . J Virol. 2024 Apr 16;98(4):e0010224. doi: 10.1128/jvi.00102-24.

BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly

Authors:
Zhou Y, Li T, Zhang Y, Zhang N, Guo Y, Gao X, Peng W, Shu S, Zhao C, Cui D, Sun H, Sun Y, Liu J, Tang J, Zhang R, Pu J
Citation:
PLoS Pathog 20(3): e1012110. doi.org/10.1371/journal.ppat.1012110
Epub:
Not Epub
Abstract:
The interaction between influenza A virus (IAV) and host proteins is an important process that greatly influences viral...
Link:
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012110
Delivery Method:
intranasal peptide-linked
Organism or Cell Type:
BALB/c mice
Citation Extract:
Zhou Y, Li T, Zhang Y, Zhang N, Guo Y, Gao X, Peng W, Shu S, Zhao C, Cui D, Sun H, Sun Y, Liu J, Tang J, Zhang R, Pu J. BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly. PLoS Pathog 20(3): e1012110. doi.org/10.1371/journal.ppat.1012110.

A comparative analysis of peptide-delivered antisense antibiotics employing diverse nucleotide mimics

Authors:
Ghosh C, Popella L, Dhamodharan V, Jung J, Dietzsch J, Barquist L, Höbartner C, Vogel J
Citation:
RNA. 2024 Feb 27:rna.079969.124. doi: 10.1261/rna.079969.124. Online ahead of print
Epub:
Not Epub
Abstract:
Antisense oligomer (ASO)-based antibiotics that target mRNAs of essential bacterial genes have great potential for...
Link:
https://rnajournal.cshlp.org/content/early/2024/02/27/rna.079969.124.long
Delivery Method:
peptide-linked
Organism or Cell Type:
Salmonella
Citation Extract:
Ghosh C, Popella L, Dhamodharan V, Jung J, Dietzsch J, Barquist L, Höbartner C, Vogel J. A comparative analysis of peptide-delivered antisense antibiotics employing diverse nucleotide mimics. RNA. 2024 Feb 27:rna.079969.124. doi: 10.1261/rna.079969.124. Online ahead of print.

An alternative strategy to increasing influenza virus replication for vaccine production in chicken embryo fibroblast (DF-1) cells by inhibiting interferon alpha and beta using peptide-conjugated phosphorodiamidate morpholino oligomers

Authors:
Prescott MA, Moulton H, Pastey MK
Citation:
J Med Microbiol. 2024 Feb;73(2). doi: 10.1099/jmm.0.001807
Epub:
Not Epub
Abstract:
Introduction. Influenza is a global health issue causing substantial health and economic burdens on affected populations....
Link:
https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.001807
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: DF-1 chick embryo fibroblasts
Citation Extract:
Prescott MA, Moulton H, Pastey MK. An alternative strategy to increasing influenza virus replication for vaccine production in chicken embryo fibroblast (DF-1) cells by inhibiting interferon alpha and beta using peptide-conjugated phosphorodiamidate morpholino oligomers. J Med Microbiol. 2024 Feb;73(2). doi: 10.1099/jmm.0.001807.

mCherry on Top: A Positive Read-Out Cellular Platform for Screening DMD Exon Skipping Xenopeptide-PMO Conjugates

Authors:
Lessl AL, Pöhmerer J, Lin Y, Wilk U, Höhn M, Hörterer E, Wagner E, Lächelt U
Citation:
Bioconjug Chem. 2023 Nov 22. doi: 10.1021/acs.bioconjchem.3c00408. Online ahead of print
Epub:
Not Epub
Abstract:
Phosphorodiamidate morpholino oligomers (PMOs) are a special type of antisense oligonucleotides (ASOs) that can be used as...
Link:
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.3c00408
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: HeLa; mice
Citation Extract:
Lessl AL, Pöhmerer J, Lin Y, Wilk U, Höhn M, Hörterer E, Wagner E, Lächelt U. mCherry on Top: A Positive Read-Out Cellular Platform for Screening DMD Exon Skipping Xenopeptide-PMO Conjugates. Bioconjug Chem. 2023 Nov 22. doi: 10.1021/acs.bioconjchem.3c00408. Online ahead of print.

Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer

Authors:
Yu S, Liao R, Bai L, Guo M, Zhang Y, Zhang Y, Yang Q, Song Y, Li Z, Meng Q, Wang S, Huang X
Citation:
Drug Deliv Transl Res. 2024 May;14(5):1352-1369. doi: 10.1007/s13346-023-01469-7. Epub 2023 Nov 17. PMID: 37978163; PMCID: PMC10984892.
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (ASO) is a novel therapeutic platform for targeted cancer therapy. Previously, we have demonstrated...
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10984892/
Delivery Method:
peptide-linked, exosome
Organism or Cell Type:
cell culture: SW620, xenograft mice
Citation Extract:
Yu S, Liao R, Bai L, Guo M, Zhang Y, Zhang Y, Yang Q, Song Y, Li Z, Meng Q, Wang S, Huang X . Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer. Drug Deliv Transl Res. 2024 May;14(5):1352-1369. doi: 10.1007/s13346-023-01469-7. Epub 2023 Nov 17. PMID: 37978163; PMCID: PMC10984892..

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