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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 257 scientific papers returned from the database with the search filters currently being used below.
There are 257 scientific papers returned from the database with the search filters currently being used below.
Comparing cell penetration of biotherapeutics across human cell lines
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Citation:
bioRxiv [preprint] 2024.03.28.587257; doi: https://doi.org/10.1101/2024.03.28.587257 Epub:
Not Epub Abstract:
A major obstacle in biotherapeutics development is maximizing cell penetration. Ideally, assays would allow for optimization of... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: Hela, Saos-2, U2OS,MIA PcCa-2 HEK293-T, BxPC-3, HepG2 Citation Extract: Batistatou N and Kritzer J. Comparing cell penetration of biotherapeutics across human cell lines. bioRxiv [preprint] 2024.03.28.587257; doi: https://doi.org/10.1101/2024.03.28.587257. |
Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with a blood-brain barrier-penetrating ApoE-derived peptide
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Citation:
Biomed Pharmacother. 2024 Jun;175:116737. doi: 10.1016/j.biopha.2024.116737. Epub 2024 May 14. PMID: 38749176 Epub:
Not Epub Abstract:
Antisense oligonucleotide (ASO) has emerged as a promising therapeutic approach for treating central nervous system (CNS)... Delivery Method:
BBB-penetrating peptide-linked Organism or Cell Type:
SMA Type-I patient-derived fibroblasts, SMN2 transgenic mice Citation Extract: Yeoh YQ, Amin A, Cuic B, Tomas D, Turner BJ, Shabanpoor F. Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with a blood-brain barrier-penetrating ApoE-derived peptide. Biomed Pharmacother. 2024 Jun;175:116737. doi: 10.1016/j.biopha.2024.116737. Epub 2024 May 14. PMID: 38749176. |
ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells
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Citation:
J Virol. 2024 Apr 16;98(4):e0010224. doi: 10.1128/jvi.00102-24 Epub:
Not Epub Abstract:
The transmembrane serine protease 2 (TMPRSS2) activates the outer structural proteins of a number of respiratory viruses... Delivery Method:
(RXR)4 peptide-linked Organism or Cell Type:
cell culture: Calu-3 Citation Extract: Heindl MR, Rupp A-L, Schwerdtner M, Bestle D, Harbig A, De Rocher A, Schmacke LC, Staker B, Steinmetzer T, Stein DA, Moulton HM, Böttcher-Friebertshäuser E. ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells . J Virol. 2024 Apr 16;98(4):e0010224. doi: 10.1128/jvi.00102-24. |
BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly
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Citation:
PLoS Pathog 20(3): e1012110. doi.org/10.1371/journal.ppat.1012110 Epub:
Not Epub Abstract:
The interaction between influenza A virus (IAV) and host proteins is an important process that greatly influences viral... Delivery Method:
intranasal peptide-linked Organism or Cell Type:
BALB/c mice Citation Extract: Zhou Y, Li T, Zhang Y, Zhang N, Guo Y, Gao X, Peng W, Shu S, Zhao C, Cui D, Sun H, Sun Y, Liu J, Tang J, Zhang R, Pu J. BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly. PLoS Pathog 20(3): e1012110. doi.org/10.1371/journal.ppat.1012110. |
A comparative analysis of peptide-delivered antisense antibiotics employing diverse nucleotide mimics
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Citation:
RNA. 2024 Feb 27:rna.079969.124. doi: 10.1261/rna.079969.124. Online ahead of print Epub:
Not Epub Abstract:
Antisense oligomer (ASO)-based antibiotics that target mRNAs of essential bacterial genes have great potential for... Delivery Method:
peptide-linked Organism or Cell Type:
Salmonella Citation Extract: Ghosh C, Popella L, Dhamodharan V, Jung J, Dietzsch J, Barquist L, Höbartner C, Vogel J. A comparative analysis of peptide-delivered antisense antibiotics employing diverse nucleotide mimics. RNA. 2024 Feb 27:rna.079969.124. doi: 10.1261/rna.079969.124. Online ahead of print. |
An alternative strategy to increasing influenza virus replication for vaccine production in chicken embryo fibroblast (DF-1) cells by inhibiting interferon alpha and beta using peptide-conjugated phosphorodiamidate morpholino oligomers
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Citation:
J Med Microbiol. 2024 Feb;73(2). doi: 10.1099/jmm.0.001807 Epub:
Not Epub Abstract:
Introduction. Influenza is a global health issue causing substantial health and economic burdens on affected populations.... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: DF-1 chick embryo fibroblasts Citation Extract: Prescott MA, Moulton H, Pastey MK. An alternative strategy to increasing influenza virus replication for vaccine production in chicken embryo fibroblast (DF-1) cells by inhibiting interferon alpha and beta using peptide-conjugated phosphorodiamidate morpholino oligomers. J Med Microbiol. 2024 Feb;73(2). doi: 10.1099/jmm.0.001807. |
mCherry on Top: A Positive Read-Out Cellular Platform for Screening DMD Exon Skipping Xenopeptide-PMO Conjugates
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Citation:
Bioconjug Chem. 2023 Nov 22. doi: 10.1021/acs.bioconjchem.3c00408. Online ahead of print Epub:
Not Epub Abstract:
Phosphorodiamidate morpholino oligomers (PMOs) are a special type of antisense oligonucleotides (ASOs) that can be used as... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: HeLa; mice Citation Extract: Lessl AL, Pöhmerer J, Lin Y, Wilk U, Höhn M, Hörterer E, Wagner E, Lächelt U. mCherry on Top: A Positive Read-Out Cellular Platform for Screening DMD Exon Skipping Xenopeptide-PMO Conjugates. Bioconjug Chem. 2023 Nov 22. doi: 10.1021/acs.bioconjchem.3c00408. Online ahead of print. |
Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer
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Citation:
Drug Deliv Transl Res. 2024 May;14(5):1352-1369. doi: 10.1007/s13346-023-01469-7. Epub 2023 Nov 17. PMID: 37978163; PMCID: PMC10984892. Epub:
Not Epub Abstract:
Antisense oligonucleotide (ASO) is a novel therapeutic platform for targeted cancer therapy. Previously, we have demonstrated... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: SW620, xenograft mice Citation Extract: Yu S, Liao R, Bai L, Guo M, Zhang Y, Zhang Y, Yang Q, Song Y, Li Z, Meng Q, Wang S, Huang X
. Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer. Drug Deliv Transl Res. 2024 May;14(5):1352-1369. doi: 10.1007/s13346-023-01469-7. Epub 2023 Nov 17. PMID: 37978163; PMCID: PMC10984892.. |
Electrical impedance myography detects dystrophin-related muscle changes in mdx mice
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Citation:
Skelet Muscle. 2023 Nov 18;13(1):19. doi: 10.1186/s13395-023-00331-1 Epub:
Not Epub Abstract:
Background: The lack of functional dystrophin protein in Duchenne muscular dystrophy (DMD) causes chronic skeletal muscle... Delivery Method:
peptide-linked Organism or Cell Type:
mice Citation Extract: Hiyoshi T, Zhao F, Baba R, Hirakawa T, Kuboki R, Suzuki K, Tomimatsu Y, O'Donnell P, Han S, Zach N, Nakashima M. Electrical impedance myography detects dystrophin-related muscle changes in mdx mice. Skelet Muscle. 2023 Nov 18;13(1):19. doi: 10.1186/s13395-023-00331-1. |
Targeting the Expanded TCF4/Fuchs’ Endothelial Corneal Dystrophy CUG Repeat with Morpholino Peptide Conjugates
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Citation:
ACS Omega. 2023;[Epub] doi:10.1021/acsomega.3c05634 Epub:
Yes Abstract:
Fuchs’ corneal endothelial dystrophy (FECD) is a major cause of vision loss. Corneal transplantation is the only effective... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: FECD patient-derived F35T corneal endothelial cells Citation Extract: Hu J, Shen X, Kheirabadi M, Streeter MD, Qian Z, Mootha VV, Corey DR. Targeting the Expanded TCF4/Fuchs’ Endothelial Corneal Dystrophy CUG Repeat with Morpholino Peptide Conjugates. ACS Omega. 2023;[Epub] doi:10.1021/acsomega.3c05634. |