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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Perturbation of astroglial Slc38 glutamine transporters by NH4+ contributes to neurophysiologic manifestations in acute liver failure

Authors:
Hamdani EH, Popek M, Frontczak-Baniewicz M, Utheim TP, Albrecht J, Zielińska M, Chaudhry FA
Citation:
FASEB J. 2021;35:e21588. doi:10.1096/fj.202001712RR
Epub:
Not Epub
Abstract:
Ammonia is considered the main pathogenic toxin in hepatic encephalopathy (HE). However, the molecular mechanisms involved have...
Delivery Method:
Vivo-Morpholino osmotic pump to frontal cortex
Organism or Cell Type:
C57Bl6 mice
Citation Extract:
Hamdani EH, Popek M, Frontczak-Baniewicz M, Utheim TP, Albrecht J, Zielińska M, Chaudhry FA. Perturbation of astroglial Slc38 glutamine transporters by NH4+ contributes to neurophysiologic manifestations in acute liver failure. FASEB J. 2021;35:e21588. doi:10.1096/fj.202001712RR.

Defects of cohesin loader lead to bone dysplasia associated with transcriptional disturbance

Authors:
Gu W, Wang, Gu R,Ouyang H, Bao B, Zheng L, Xu B
Citation:
J Cell Physiol. 2021;[Epub] doi:doi.org/10.1002/jcp.30491
Epub:
Not Epub
Abstract:
Cohesin loader nipped-B-like protein (Nipbl) is increasingly recognized for its important role in development and cancer....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gu W, Wang, Gu R,Ouyang H, Bao B, Zheng L, Xu B. Defects of cohesin loader lead to bone dysplasia associated with transcriptional disturbance. J Cell Physiol. 2021;[Epub] doi:doi.org/10.1002/jcp.30491.

Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code

Authors:
Saha K, Fernandez MM, Biswas T, Joseph S, Ghosh G
Citation:
Nucl Acids Res. 2021;gkab533[Epub] doi:10.1093/nar/gkab533
Epub:
Yes
Abstract:
The specific recognition of splice signals at or near exon-intron junctions is not explained by their weak conservation and...
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Saha K, Fernandez MM, Biswas T, Joseph S, Ghosh G. Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code. Nucl Acids Res. 2021;gkab533[Epub] doi:10.1093/nar/gkab533.

The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression

Authors:
Gentile A, Bensimon-Brito A, Priya R, Maischein HM, Piesker J, Guenther S, Gunawan F, Stainier DY
Citation:
Elife. 2021 Jun 21;10:e66143. doi: 10.7554/eLife.66143
Epub:
Not Epub
Abstract:
The transcription factor Snai1, a well-known regulator of epithelial-to-mesenchymal transition, has been implicated in early...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gentile A, Bensimon-Brito A, Priya R, Maischein HM, Piesker J, Guenther S, Gunawan F, Stainier DY. The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression. Elife. 2021 Jun 21;10:e66143. doi: 10.7554/eLife.66143.

Genetic compensation for cilia defects in cep290/NPHP6 mutants by upregulation of cilia-associated small GTPases

Authors:
Cardenas-Rodriguez M, Austin-Tse C, Bergboer JGM, Molinari E, Sugano Y, Bachmann-Gagescu R, Sayer JA, Drummond IA
Citation:
J Cell Sci. 2021 Jun 22:jcs.258568. doi: 10.1242/jcs.258568. Online ahead of print
Epub:
Yes
Abstract:
Mutations in CEP290, a large multidomain coiled coil protein, are associated with multiple cilia-associated syndromes. Over 130...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cardenas-Rodriguez M, Austin-Tse C, Bergboer JGM, Molinari E, Sugano Y, Bachmann-Gagescu R, Sayer JA, Drummond IA. Genetic compensation for cilia defects in cep290/NPHP6 mutants by upregulation of cilia-associated small GTPases. J Cell Sci. 2021 Jun 22:jcs.258568. doi: 10.1242/jcs.258568. Online ahead of print.

Prmt5 promotes vascular morphogenesis in zebrafish independently of its methyltransferase activity

Authors:
Quillien A, Boulet M, Ethuin S, Vandel L
Citation:
PLoS Genet. 2021;17(6):e1009641 doi:10.1371/journal.pgen.1009641
Epub:
Not Epub
Abstract:
During development, the vertebrate vasculature undergoes major growth and remodeling. While the transcriptional cascade...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Quillien A, Boulet M, Ethuin S, Vandel L. Prmt5 promotes vascular morphogenesis in zebrafish independently of its methyltransferase activity. PLoS Genet. 2021;17(6):e1009641 doi:10.1371/journal.pgen.1009641.

Tfap2b specifies an embryonic melanocyte stem cell population that retains adult multi-fate potential

Authors:
Brombin A, Simpson DJ, Travnickova J, Brunsdon HR, Zeng Z, Lu Y, Chandra T, Patton EE
Citation:
bioRxiv. 2021;[preprint] doi: https://doi.org/10.1101/2021.06.18.448859
Epub:
Not Epub
Abstract:
Melanocytes, our pigment producing cells, originate from neural crest-derived progenitors during embryogenesis and from...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Brombin A, Simpson DJ, Travnickova J, Brunsdon HR, Zeng Z, Lu Y, Chandra T, Patton EE. Tfap2b specifies an embryonic melanocyte stem cell population that retains adult multi-fate potential. bioRxiv. 2021;[preprint] doi: https://doi.org/10.1101/2021.06.18.448859 .

Light-induced, spatiotemporal control of protein in the developing embryo of the sea urchin

Authors:
Wavreil FDM, Poon J, Wessel GM, Yajima M
Citation:
Dev Biol. 2021 Jun 17:S0012-1606(21)00148-2. doi: 10.1016/j.ydbio.2021.06.006. Online ahead of print
Epub:
Not Epub
Abstract:
Differential protein regulation is a critical biological process that regulates cellular activity and controls cell fate...
Delivery Method:
microinjection
Organism or Cell Type:
sea urchin
Citation Extract:
Wavreil FDM, Poon J, Wessel GM, Yajima M. Light-induced, spatiotemporal control of protein in the developing embryo of the sea urchin. Dev Biol. 2021 Jun 17:S0012-1606(21)00148-2. doi: 10.1016/j.ydbio.2021.06.006. Online ahead of print.

The dual-specificity protein kinase Clk3 is essential for Xenopus neural development

Authors:
Virgirinia RP, Nakamura M, Takebayashi-Suzuki K, Fatchiyah F, Suzuki A
Citation:
Biochem Biophys Res Commun. 2021 Jun 16;567:99-105. doi: 10.1016/j.bbrc.2021.06.005. Online ahead of print
Epub:
Not Epub
Abstract:
During vertebrate development, the formation of the central nervous system (CNS) is initiated by neural induction and...
Organism or Cell Type:
Xenopus
Citation Extract:
Virgirinia RP, Nakamura M, Takebayashi-Suzuki K, Fatchiyah F, Suzuki A. The dual-specificity protein kinase Clk3 is essential for Xenopus neural development. Biochem Biophys Res Commun. 2021 Jun 16;567:99-105. doi: 10.1016/j.bbrc.2021.06.005. Online ahead of print.

Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2

Authors:
Soto RA, Najia MAT, Hachimi M, Frame JM, Yette GA, da Rocha EL, Stankunas K, Daley GQ, North TE
Citation:
Stem Cell Rep. 2021;[Epub] doi:10.1016/j.stemcr.2021.05.014
Epub:
Not Epub
Abstract:
Across species, hematopoietic stem and progenitor cells (HSPCs) arise during embryogenesis from a specialized arterial...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Soto RA, Najia MAT, Hachimi M, Frame JM, Yette GA, da Rocha EL, Stankunas K, Daley GQ, North TE. Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2. Stem Cell Rep. 2021;[Epub] doi:10.1016/j.stemcr.2021.05.014.

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