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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12353 scientific papers returned from the database with the search filters currently being used below.

Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

Authors:
Scaffidi P, Misteli T
Citation:
Nat Med. 2005 Apr;11(4):440-5. Epub 2005 Mar 6
Epub:
Not Epub
Abstract:
Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in...
Link:
http://www.nature.com/nm/journal/v11/n4/full/nm1204.html
Delivery Method:
Electroporation
Organism or Cell Type:
cell culture: primary human fibroblast, lymphoblastoid lines
Citation Extract:
Scaffidi P, Misteli T. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med. 2005 Apr;11(4):440-5. Epub 2005 Mar 6.

Safety Pharmacology and Genotoxicity Evaluation of AVI-4658

Authors:
Sazani P, Weller DL, Shrewsbury SB
Citation:
Int J Toxicol. 2010 Jan 28. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is caused by dystrophin gene mutations. Restoration of dystrophin by exon skipping was...
Link:
http://journals.sagepub.com/doi/abs/10.1177/1091581809359206
Organism or Cell Type:
Mouse, cynomolgus monkey
Citation Extract:
Sazani P, Weller DL, Shrewsbury SB. Safety Pharmacology and Genotoxicity Evaluation of AVI-4658. Int J Toxicol. 2010 Jan 28. [Epub ahead of print].

Site-1 protease is required for cartilage development in zebrafish

Authors:
Schlombs K, Wagner T, Scheel J
Citation:
Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24): 14024-9. Epub 2003 Nov 11.
Epub:
Not Epub
Abstract:
gonzo (goz) is a zebrafish mutant with defects in cartilage formation. The goz phenotype comprises cartilage matrix defects and...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Schlombs K, Wagner T, Scheel J. Site-1 protease is required for cartilage development in zebrafish. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24): 14024-9. Epub 2003 Nov 11..

SKY1 is involved in cisplatin-induced cell kill in Saccharomyces cerevisiae, and inactivation of its human homologue, SRPK1, induces cisplatin resistance in a human ovarian carcinoma cell line.

Authors:
Schenk PW, Boersma AW, Brandsma JA, den Dulk H, Burger H, Stoter G, Brouwer J, Nooter K.
Citation:
Cancer Res. 2001 Oct 1;61(19):6982-6
Epub:
Not Epub
Abstract:
The therapeutic potential of cisplatin, one of the most active and widely used anticancer drugs, is severely limited by the...
Delivery Method:
Special Delivery
Organism or Cell Type:
cell culture: human ovarian carcinoma A2780 cell line
Citation Extract:
Schenk PW, Boersma AW, Brandsma JA, den Dulk H, Burger H, Stoter G, Brouwer J, Nooter K.. SKY1 is involved in cisplatin-induced cell kill in Saccharomyces cerevisiae, and inactivation of its human homologue, SRPK1, induces cisplatin resistance in a human ovarian carcinoma cell line.. Cancer Res. 2001 Oct 1;61(19):6982-6.

Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish

Authors:
Saxena A, Peng BN, Bronner ME
Citation:
eLife. 2013;2:e00336 doi:10.7554/eLife.00336
Epub:
Not Epub
Abstract:
The sense of smell in vertebrates is detected by specialized sensory neurons derived from the peripheral nervous system....
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Saxena A, Peng BN, Bronner ME. Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish. eLife. 2013;2:e00336 doi:10.7554/eLife.00336.

STAT5 acts as a repressor to regulate early embryonic erythropoiesis

Authors:
Schmerer M, Torregroza I, Pascal A, Umbhauer M, Evans T
Citation:
Blood. 2006 Nov 1;108(9):2989-97. Epub 2006 Jul 11.
Epub:
Not Epub
Abstract:
STAT5 regulates definitive (adult stage) erythropoiesis through its ability to transduce signals from the erythropoietin...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Schmerer M, Torregroza I, Pascal A, Umbhauer M, Evans T. STAT5 acts as a repressor to regulate early embryonic erythropoiesis. Blood. 2006 Nov 1;108(9):2989-97. Epub 2006 Jul 11..

Structural and functional characterization of the zebrafish lamin B receptor

Authors:
Schild-Prufert K, Giegerich M, Schafer M, Winkler C, Krohne G
Citation:
Eur J Cell Biol. 2006 Aug;85(8):813-24. Epub 2006 Jun 6.
Epub:
Not Epub
Abstract:
The lamin B receptor (LBR) is an integral membrane protein of the inner nuclear membrane that is interacting with B-type lamins...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Schild-Prufert K, Giegerich M, Schafer M, Winkler C, Krohne G. Structural and functional characterization of the zebrafish lamin B receptor. Eur J Cell Biol. 2006 Aug;85(8):813-24. Epub 2006 Jun 6..

Systemically delivered antisense oligomers upregulate gene expression in mouse tissues

Authors:
Sazani P, Gemignani F, Kang SH, Maier MA, Manoharan M, Persmark M, Bortner D, Kole R
Citation:
Nat Biotechnol. 2002 Dec;20(12):1228-33
Epub:
Not Epub
Abstract:
Systemically injected 2'-O-methoxyethyl (2'-O-MOE)-phosphorothioate and PNA-4K oligomers (peptide nucleic acid with...
Delivery Method:
in vivo: injection
Organism or Cell Type:
Mice: EGFP transgenic
Citation Extract:
Sazani P, Gemignani F, Kang SH, Maier MA, Manoharan M, Persmark M, Bortner D, Kole R. Systemically delivered antisense oligomers upregulate gene expression in mouse tissues. Nat Biotechnol. 2002 Dec;20(12):1228-33.

The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4

Authors:
Sayer JA, Otto EA, O'toole JF, Nurnberg G, Kennedy MA, Becker C, Hennies HC, Helou J, Attanasio M, Fausett BV, Utsch B, Khanna H, Liu Y, Drummond I, Kawakami I, Kusakabe T, Tsuda M, Ma L, Lee H, Larson RG, Allen SJ, Wilkinson CJ, Nigg EA, Shou C, Lillo C, Williams DS, Hoppe B, Kemper MJ, Neuhaus T, Parisi MA, Glass IA, Petry M, Kispert A, Gloy J, Ganner A, Walz G, Zhu X, Goldman D, Nurnberg P, Swaroop A, Leroux MR, Hildebrandt F
Citation:
Nat Genet. 2006 Jun;38(6):674-81. Epub 2006 May 7
Epub:
Not Epub
Abstract:
The molecular basis of nephronophthisis, the most frequent genetic cause of renal failure in children and young adults, and its...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sayer JA, Otto EA, O'toole JF, Nurnberg G, Kennedy MA, Becker C, Hennies HC, Helou J, Attanasio M, Fausett BV, Utsch B, Khanna H, Liu Y, Drummond I, Kawakami I, Kusakabe T, Tsuda M, Ma L, Lee H, Larson RG, Allen SJ, Wilkinson CJ, Nigg EA, Shou C, Lillo C, Williams DS, Hoppe B, Kemper MJ, Neuhaus T, Parisi MA, Glass IA, Petry M, Kispert A, Gloy J, Ganner A, Walz G, Zhu X, Goldman D, Nurnberg P, Swaroop A, Leroux MR, Hildebrandt F. The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet. 2006 Jun;38(6):674-81. Epub 2006 May 7.

The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development

Authors:
Schenck A, Goto-Silva L, Collinet C, Rhinn M, Giner A, Habermann B, Brand M, Zerial M
Citation:
Cell. 2008 May 2;133(3):486-97
Epub:
Not Epub
Abstract:
During development of multicellular organisms, cells respond to extracellular cues through nonlinear signal transduction...
Organism or Cell Type:
zebrafish
Citation Extract:
Schenck A, Goto-Silva L, Collinet C, Rhinn M, Giner A, Habermann B, Brand M, Zerial M. The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell. 2008 May 2;133(3):486-97.

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