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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Antagonistic Activities of Vegfr3/Flt4 and Notch1b Fine-tune Mechanosensitive Signaling during Zebrafish Cardiac Valvulogenesis

Authors:
Fontana F, Haack T, Reichenbach M, Knaus P, Puceat M, Abdelilah-Seyfried SA
Citation:
Cell Rep. 2020;32(2):107833. doi:10.1016/j.celrep.2020.107883
Epub:
Not Epub
Abstract:
The formation of cardiac valves depends on mechanical forces exerted by blood flow. Endocardial cells lining the interior of...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30864-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fontana F, Haack T, Reichenbach M, Knaus P, Puceat M, Abdelilah-Seyfried SA. Antagonistic Activities of Vegfr3/Flt4 and Notch1b Fine-tune Mechanosensitive Signaling during Zebrafish Cardiac Valvulogenesis. Cell Rep. 2020;32(2):107833. doi:10.1016/j.celrep.2020.107883.

PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation

Authors:
Johansson JA, Marie KL, Lu Y, Brombin A, Santoriello C, Zeng Z, Zich J, Gautier P, von Kriegsheim A, Brunsdon H, Wheeler AP, Dreger M, Houston DR, Dooley CM, Sims AH, Busch-Nentwich EM, Zon LI, Illingworth RS, Patton EE
Citation:
Dev Cell. 2020 Jul 8:S1534-5807(20)30463-9. doi: 10.1016/j.devcel.2020.06.013. Online ahead of print
Epub:
Yes
Abstract:
Melanocytes, replenished throughout life by melanocyte stem cells (MSCs), play a critical role in pigmentation and melanoma....
Link:
https://www.sciencedirect.com/science/article/pii/S1534580720304639
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Johansson JA, Marie KL, Lu Y, Brombin A, Santoriello C, Zeng Z, Zich J, Gautier P, von Kriegsheim A, Brunsdon H, Wheeler AP, Dreger M, Houston DR, Dooley CM, Sims AH, Busch-Nentwich EM, Zon LI, Illingworth RS, Patton EE. PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation. Dev Cell. 2020 Jul 8:S1534-5807(20)30463-9. doi: 10.1016/j.devcel.2020.06.013. Online ahead of print.

Fast, In Vivo Model for Drug-Response Prediction in Patients with B-Cell Precursor Acute Lymphoblastic Leukemia

Authors:
Gauert A, Olk N, Pimentel-Gutiérrez H, Astrahantseff K, Jensen LD, Cao Yihai, Eggert A, Eckert C, Hagemann AIH
Citation:
Cancers. 2020;12(7):[Epub] doi:10.3390/cancers12071883
Epub:
Not Epub
Abstract:
Only half of patients with relapsed B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) currently survive with standard...
Link:
https://www.mdpi.com/2072-6694/12/7/1883
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gauert A, Olk N, Pimentel-Gutiérrez H, Astrahantseff K, Jensen LD, Cao Yihai, Eggert A, Eckert C, Hagemann AIH. Fast, In Vivo Model for Drug-Response Prediction in Patients with B-Cell Precursor Acute Lymphoblastic Leukemia. Cancers. 2020;12(7):[Epub] doi:10.3390/cancers12071883.

Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins

Authors:
Trnka D, Engelke AD, Gellert M, Moseler D, Hossain MdF, Lindenberg TT, Pedroletti L, Odermatt B, de Souza JV, Bronowska AK, Dick TP, Mühlenhoff U, Meyer AJ, Berndt, Lillig CH
Citation:
Nat Commun. 2020;11:3445. doi:10.1038/s41467-020-17323-0
Epub:
Not Epub
Abstract:
Despite their very close structural similarity, CxxC/S-type (class I) glutaredoxins (Grxs) act as oxidoreductases, while CGFS-...
Link:
https://www.nature.com/articles/s41467-020-17323-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Trnka D, Engelke AD, Gellert M, Moseler D, Hossain MdF, Lindenberg TT, Pedroletti L, Odermatt B, de Souza JV, Bronowska AK, Dick TP, Mühlenhoff U, Meyer AJ, Berndt, Lillig CH. Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins. Nat Commun. 2020;11:3445. doi:10.1038/s41467-020-17323-0.

Cardiac Na+-Ca2+ exchanger 1 (ncx1h) is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish

Authors:
Chu L, Yin H, Gao L, Gao L, Xia Y, Zhang C, Chen Y, Liu T, Huang J, Boheler KR, Zhou Y, Yang HT
Citation:
Sci China Life Sci. 2020 Jul 7. doi:10.1007/s11427-019-1706-1. Online ahead of print
Epub:
Yes
Abstract:
Ca2+ signaling is critical for heart development; however, the precise roles and regulatory pathways of Ca2+ transport proteins...
Link:
https://link.springer.com/article/10.1007%2Fs11427-019-1706-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chu L, Yin H, Gao L, Gao L, Xia Y, Zhang C, Chen Y, Liu T, Huang J, Boheler KR, Zhou Y, Yang HT. Cardiac Na+-Ca2+ exchanger 1 (ncx1h) is critical for the ventricular cardiomyocyte formation via regulating the expression levels of gata4 and hand2 in zebrafish. Sci China Life Sci. 2020 Jul 7. doi:10.1007/s11427-019-1706-1. Online ahead of print.

Induction of a local muscular dystrophy using electroporation in vivo: an easy tool for screening therapeutics

Authors:
Derenne A, Tassin A, Nguyen TH, De Roeck E, Jenart V, Ansseau E, Belayew A, Coppée F, Declèves A-E, Legrand A
Citation:
Sci Rep. 2020;10(1):11301. doi:10.1038/s41598-020-68135-7
Epub:
Not Epub
Abstract:
Intramuscular injection and electroporation of naked plasmid DNA (IMEP) has emerged as a potential alternative to viral vector...
Link:
https://www.nature.com/articles/s41598-020-68135-7
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Derenne A, Tassin A, Nguyen TH, De Roeck E, Jenart V, Ansseau E, Belayew A, Coppée F, Declèves A-E, Legrand A. Induction of a local muscular dystrophy using electroporation in vivo: an easy tool for screening therapeutics. Sci Rep. 2020;10(1):11301. doi:10.1038/s41598-020-68135-7.

Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression

Authors:
Lim KH, Han Z, Jeon HY, Kach J, Jing E, Weyn-Vanhentenryck S, Downs M, Corrionero A, Oh R, Scharner J, Venkatesh A, Ji S, Liau G, Ticho B, Nash H, Aznarez I
Citation:
Nat Commun. 2020;11(1):3501. doi:10.1038/s41467-020-17093-9
Epub:
Not Epub
Abstract:
While most monogenic diseases are caused by loss or reduction of protein function, the need for technologies that can...
Link:
https://www.nature.com/articles/s41467-020-17093-9
Organism or Cell Type:
cell culture
Citation Extract:
Lim KH, Han Z, Jeon HY, Kach J, Jing E, Weyn-Vanhentenryck S, Downs M, Corrionero A, Oh R, Scharner J, Venkatesh A, Ji S, Liau G, Ticho B, Nash H, Aznarez I. Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression. Nat Commun. 2020;11(1):3501. doi:10.1038/s41467-020-17093-9.

Fgf/Ets signalling in Xenopus ectoderm initiates neural induction and patterning in an autonomous and paracrine manners

Authors:
Hongo I, Okamoto H
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.07.07.191288
Epub:
Not Epub
Abstract:
Fibroblast growth factor (Fgf) and anti-bone morphogenetic protein (Bmp) signals are derived from the organiser of mesoderm...
Link:
https://www.biorxiv.org/content/10.1101/2020.07.07.191288v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Hongo I, Okamoto H. Fgf/Ets signalling in Xenopus ectoderm initiates neural induction and patterning in an autonomous and paracrine manners. bioRxiv. 2020;[preprint] doi:10.1101/2020.07.07.191288.

Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia

Authors:
Crispin A, Guo C, Chen C, Campagna DR, Schmidt PJ, Lichtenstein DA, Cao C, Sendamarai AK, Hildick-Smith GJ, Huston NC, Boudreaux J, Bottomley SS, Heeney MM, Paw BH, Fleming MD, Ducamp S
Citation:
J Clin Invest. 2020 Jul 7:135479. doi:10.1172/JCI135479. Online ahead of print
Epub:
Yes
Abstract:
The congenital sideroblastic anemias (CSAs) can be caused by primary defects in mitochondrial iron-sulfur cluster (Fe-S)...
Link:
https://www.jci.org/articles/view/135479
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Crispin A, Guo C, Chen C, Campagna DR, Schmidt PJ, Lichtenstein DA, Cao C, Sendamarai AK, Hildick-Smith GJ, Huston NC, Boudreaux J, Bottomley SS, Heeney MM, Paw BH, Fleming MD, Ducamp S. Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia. J Clin Invest. 2020 Jul 7:135479. doi:10.1172/JCI135479. Online ahead of print.

DLG5 variants are associated with multiple congenital anomalies including ciliopathy phenotypes

Authors:
Marquez J, Mann N, Arana K, Deniz E, Ji W, Konstantino M, Mis EK, Deshpande C, Jeffries L, McGlynn J, Hugo H, Widmeier E, Konrad M, Tasic V, Morotti R, Baptista J, Ellard S, Lakhani SA, Hildebrandt F, Khokha MK
Citation:
J Med Genet. 2020 Jul 6:jmedgenet-2019-106805. doi:10.1136/jmedgenet-2019-106805. Online ahead of print
Epub:
Yes
Abstract:
Background: Cilia are dynamic cellular extensions that generate and sense signals to orchestrate proper development and tissue...
Link:
https://jmg.bmj.com/content/early/2020/07/05/jmedgenet-2019-106805
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Marquez J, Mann N, Arana K, Deniz E, Ji W, Konstantino M, Mis EK, Deshpande C, Jeffries L, McGlynn J, Hugo H, Widmeier E, Konrad M, Tasic V, Morotti R, Baptista J, Ellard S, Lakhani SA, Hildebrandt F, Khokha MK. DLG5 variants are associated with multiple congenital anomalies including ciliopathy phenotypes. J Med Genet. 2020 Jul 6:jmedgenet-2019-106805. doi:10.1136/jmedgenet-2019-106805. Online ahead of print.

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