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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12371 scientific papers returned from the database with the search filters currently being used below.

Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis

Authors:
Okuda K, Keyser M, Gurevich DB, Sturtzel C, Paterson S, Chen H, Scott M, Condon N, Martin PB, Distel M, Hogan BM
Citation:
bioRxiv 2020;[preprint] doi:10.1101/2020.08.17.254912
Epub:
Not Epub
Abstract:
The formation of new blood vessel networks occurs via angiogenesis during development, tissue repair and disease. Angiogenesis...
Link:
https://www.biorxiv.org/content/10.1101/2020.08.17.254912v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Okuda K, Keyser M, Gurevich DB, Sturtzel C, Paterson S, Chen H, Scott M, Condon N, Martin PB, Distel M, Hogan BM. Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis. bioRxiv 2020;[preprint] doi:10.1101/2020.08.17.254912.

Production of common carp donor-derived offspring from goldfish surrogate broodstock

Authors:
Franěk R, Kašpar V, Gela D, Pšenička M
Citation:
Research Square. 2020:[preprint] doi:10.21203/rs.3.rs-57467/v1+
Epub:
Not Epub
Abstract:
Background: Common carp is the fourth most-produced species in worldwide aquaculture. Significant efforts are invested in...
Link:
https://www.researchsquare.com/article/rs-57467/v1
Delivery Method:
microinjection
Organism or Cell Type:
Carassius auratus (goldfish)
Citation Extract:
Franěk R, Kašpar V, Gela D, Pšenička M. Production of common carp donor-derived offspring from goldfish surrogate broodstock. Research Square. 2020:[preprint] doi:10.21203/rs.3.rs-57467/v1+.

Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome

Authors:
Miao Y, Tian L, Martin M, Paige SL, Galdos FX, Li J, Klein A, Zhang H, Ma N, Wei Y, Stewart M, Lee S, Moonen J-R, Zhang B, Grossfeld P, Mital S, Chitayat D, Wu JC, Rabinovitch M, Nelson TJ, Nie S, Wu SM, Gu M
Citation:
Cell Stem Cell. 2020;[Epub ahead of print] doi:10.1016/j.stem.2020.07.015
Epub:
Not Epub
Abstract:
Hypoplastic left heart syndrome (HLHS) is a complex congenital heart disease characterized by abnormalities in the left...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1934590920303532
Delivery Method:
injection
Organism or Cell Type:
Xenopus
Citation Extract:
Miao Y, Tian L, Martin M, Paige SL, Galdos FX, Li J, Klein A, Zhang H, Ma N, Wei Y, Stewart M, Lee S, Moonen J-R, Zhang B, Grossfeld P, Mital S, Chitayat D, Wu JC, Rabinovitch M, Nelson TJ, Nie S, Wu SM, Gu M. Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome. Cell Stem Cell. 2020;[Epub ahead of print] doi:10.1016/j.stem.2020.07.015.

Proteolytic Restriction of Chordin Range Underlies BMP Gradient Formation

Authors:
Tuazon FB, Wang X, Andrade JL, Umulis D, Mullins MC
Citation:
Cell Rep. 2020;32(7):108039. doi:10.1016/j.celrep.2020.108039
Epub:
Not Epub
Abstract:
A fundamental question in developmental biology is how morphogens, such as bone morphogenetic protein (BMP), form precise...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31024-X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tuazon FB, Wang X, Andrade JL, Umulis D, Mullins MC. Proteolytic Restriction of Chordin Range Underlies BMP Gradient Formation. Cell Rep. 2020;32(7):108039. doi:10.1016/j.celrep.2020.108039.

In-depth analysis reveals complex molecular etiology of idiopathic cerebral palsy

Authors:
Li N, Zhou P, Tang H, He L, Fang X, Zhao J, Wang X, Qi Y, Sun C, Lin Y, Qin F, Yang M, Zhang Z, Liao C, Zheng S, Peng X, Xue T, Zhu Q, Li Y, Liu L, Huang J, Liu L, Peng C, Han D, Liu D, Xu K, Hu H(C)
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.08.17.255158
Epub:
Not Epub
Abstract:
Cerebral palsy (CP), the most prevalent physical disability in children, has long been ignored with regard to its inherent...
Link:
https://www.biorxiv.org/content/10.1101/2020.08.17.255158v1.full.pdf
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li N, Zhou P, Tang H, He L, Fang X, Zhao J, Wang X, Qi Y, Sun C, Lin Y, Qin F, Yang M, Zhang Z, Liao C, Zheng S, Peng X, Xue T, Zhu Q, Li Y, Liu L, Huang J, Liu L, Peng C, Han D, Liu D, Xu K, Hu H(C). In-depth analysis reveals complex molecular etiology of idiopathic cerebral palsy. bioRxiv. 2020;[preprint] doi:10.1101/2020.08.17.255158.

Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy

Authors:
Ding Y, Yang J, Chen P, Lu T, Jiao K, Tester DJ, Giudicessi JR, Jiang K, Ackerman MJ, Li Y, Wang DW, Lee HC, Wang DW, Xu X
Citation:
J Am Heart Assoc. 2020 Aug 18:e017055. doi:10.1161/JAHA.119.017055. Online ahead of print
Epub:
Yes
Abstract:
Background Sorbs2b (sorbin and SH3 domain-containing 2b) was recently identified as a cardiomyopathy gene from a zebrafish...
Link:
https://www.ahajournals.org/doi/10.1161/JAHA.119.017055
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ding Y, Yang J, Chen P, Lu T, Jiao K, Tester DJ, Giudicessi JR, Jiang K, Ackerman MJ, Li Y, Wang DW, Lee HC, Wang DW, Xu X. Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy. J Am Heart Assoc. 2020 Aug 18:e017055. doi:10.1161/JAHA.119.017055. Online ahead of print.

The tolerance to hypoxia is defined by a time-sensitive response of the gene regulatory network in sea urchin embryos

Authors:
Layous M, Khalaily L, Gildor T, de-Leon SB-T
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.08.09.242933
Epub:
Not Epub
Abstract:
Deoxygenation, the reduction of oxygen level in the oceans induced by global warming and anthropogenic disturbances, is a major...
Link:
https://www.biorxiv.org/content/10.1101/2020.08.09.242933v2
Delivery Method:
microinjection
Organism or Cell Type:
Paracentrotus lividus (sea urchin)
Citation Extract:
Layous M, Khalaily L, Gildor T, de-Leon SB-T. The tolerance to hypoxia is defined by a time-sensitive response of the gene regulatory network in sea urchin embryos. bioRxiv. 2020;[preprint] doi:10.1101/2020.08.09.242933 .

Rab7 mediates Wnt-dependent mesoderm patterning and gastrulation in Xenopus

Authors:
Kreis J, Wielath FM, Vick P
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.08.14.251298
Epub:
Not Epub
Abstract:
Early embryogenesis requires tightly controlled temporal and spatial activity of growth factors. Modulation is achieved at...
Link:
https://www.biorxiv.org/content/10.1101/2020.08.14.251298v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kreis J, Wielath FM, Vick P. Rab7 mediates Wnt-dependent mesoderm patterning and gastrulation in Xenopus. bioRxiv. 2020;[preprint] doi:10.1101/2020.08.14.251298 .

A Nodal/Eph signalling relay drives the transition from apical constriction to apico-basal shortening in ascidian endoderm invagination

Authors:
Fiuza UM, Negishi T, Rouan A, Yasuo H, Lemaire P
Citation:
Development. 2020;[Epub ahead of print]. doi: 10.1242/dev.186965
Epub:
Yes
Abstract:
Gastrulation is the first major morphogenetic event during animal embryogenesis. Ascidian gastrulation starts with the...
Link:
https://dev.biologists.org/content/147/15/dev186965
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis (ascidian)
Citation Extract:
Fiuza UM, Negishi T, Rouan A, Yasuo H, Lemaire P. A Nodal/Eph signalling relay drives the transition from apical constriction to apico-basal shortening in ascidian endoderm invagination. Development. 2020;[Epub ahead of print]. doi: 10.1242/dev.186965.

Abortive Intussusceptive Angiogenesis Causes Multi-Cavernous Vascular Malformations

Authors:
Li W, Tran V, Shaked I, Xue B, Moore T, Lightle R, Kleinfeld D, Awad IA, Ginsberg MH
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.08.14.251744
Epub:
Not Epub
Abstract:
Mosaic inactivation of CCM2 in humans causes cerebral cavernous malformations (CCMs) containing adjacent dilated blood-filled...
Link:
https://www.biorxiv.org/content/10.1101/2020.08.14.251744v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li W, Tran V, Shaked I, Xue B, Moore T, Lightle R, Kleinfeld D, Awad IA, Ginsberg MH. Abortive Intussusceptive Angiogenesis Causes Multi-Cavernous Vascular Malformations. bioRxiv. 2020;[preprint] doi:10.1101/2020.08.14.251744.

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