You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 30 scientific papers returned from the database with the search filters currently being used below.

Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli

Authors:
Tilley LD, Mellbye BL, Puckett SE, Iversen PL, Geller BL
Citation:
J Antimicrob Chemother. 2007 Jan;59(1):66-73. Epub 2006 Oct 31.
Epub:
Not Epub
Abstract:
OBJECTIVES: Phosphorodiamidate morpholino oligomers (PMOs) are DNA analogues that inhibit translation by an antisense mechanism...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Escherichia coli
Citation Extract:
Tilley LD, Mellbye BL, Puckett SE, Iversen PL, Geller BL. Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli. J Antimicrob Chemother. 2007 Jan;59(1):66-73. Epub 2006 Oct 31..

Gene-Specific Effects of Antisense Phosphorodiamidate Morpholino Oligomer-Peptide Conjugates on Escherichia coli and Salmonella enterica Serovar Typhimurium in Pure Culture and in Tissue Culture

Authors:
Tilley LD, Hine OS, Kellogg JA, Hassinger JN, Weller DD, Iversen PL, Geller BL
Citation:
Antimicrob Agents Chemother. 2006 Aug;50(8):2789-96
Epub:
Not Epub
Abstract:
The objective was to improve efficacy of antisense phosphorodiamidate morpholino oligomers (PMOs) by improving their uptake...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Escherichia coli, Salmonella enterica serovar typhimurium
Citation Extract:
Tilley LD, Hine OS, Kellogg JA, Hassinger JN, Weller DD, Iversen PL, Geller BL. Gene-Specific Effects of Antisense Phosphorodiamidate Morpholino Oligomer-Peptide Conjugates on Escherichia coli and Salmonella enterica Serovar Typhimurium in Pure Culture and in Tissue Culture. Antimicrob Agents Chemother. 2006 Aug;50(8):2789-96.

Inactivation of expression of several genes in a variety of bacterial species by EGS technology

Authors:
Shen N, Ko JH, Xiao G, Wesolowski D, Shan G, Geller B, Izadjoo M, Altman S
Citation:
Proc Natl Acad Sci U S A. 2009 Apr 30. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The expression of gene products in bacteria can be inhibited by the use of RNA external guide sequences (EGSs) that hybridize...
Link:
http://www.pnas.org/content/106/20/8163.long
Delivery Method:
peptide-coupled
Organism or Cell Type:
Bacteria: Escherichia, Enterococcus, Bacillus,
Citation Extract:
Shen N, Ko JH, Xiao G, Wesolowski D, Shan G, Geller B, Izadjoo M, Altman S. Inactivation of expression of several genes in a variety of bacterial species by EGS technology. Proc Natl Acad Sci U S A. 2009 Apr 30. [Epub ahead of print].

A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model

Authors:
Sawyer AJ, Wesolowski D, Gandotra N, Stojadinovic A, Izadjoo M, Altman S, Kyriakides TR
Citation:
Int J Pharmaceutics. 2013;[Epub ahead of print] doi:10.1016/j.ijpharm.2013.05.041
Epub:
Not Epub
Abstract:
Management of skin wound infections presents a serious problem in the clinic, in the community, and in both civilian and...
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756894/
Delivery Method:
peptide-coupled
Organism or Cell Type:
Bacteria: Staphylococcus aureus in mouse
Citation Extract:
Sawyer AJ, Wesolowski D, Gandotra N, Stojadinovic A, Izadjoo M, Altman S, Kyriakides TR. A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model. Int J Pharmaceutics. 2013;[Epub ahead of print] doi:10.1016/j.ijpharm.2013.05.041.

Bacterial Resistance to Antisense Peptide-Phosphorodiamidate Morpholino Oligomers

Authors:
Puckett SE, Reese KA, Mitev GM, Mullen V, Johnson RC, Pomraning KR, Mellbye BL, Tilley LD, Iversen PL, Freitag M, Geller BL
Citation:
Antimicrob Agents Chemother. 2012 Sep 17. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Peptide phosphorodiamidate morpholino oligomers (PPMO) are synthetic DNA mimics that bind complementary RNA and inhibit...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Escherichia coli
Citation Extract:
Puckett SE, Reese KA, Mitev GM, Mullen V, Johnson RC, Pomraning KR, Mellbye BL, Tilley LD, Iversen PL, Freitag M, Geller BL. Bacterial Resistance to Antisense Peptide-Phosphorodiamidate Morpholino Oligomers. Antimicrob Agents Chemother. 2012 Sep 17. [Epub ahead of print].

Peptide Conjugated Phosphorodiamidate Morpholino Oligomers Increase Survival of Mice Challenged with Ames Bacillus anthracis

Authors:
Panchal RG, Geller BL, Mellbye B, Lane D, Iversen PL, Bavari S
Citation:
Nucleic Acid Therapeutics. 2012;[Epub ahead of print] doi:10.1089/nat.2012.0362
Epub:
Not Epub
Abstract:
Targeting bacterial essential genes using antisense phosphorodiamidate morpholino oligomers (PMOs) represents an important...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Bacillus anthracis
Citation Extract:
Panchal RG, Geller BL, Mellbye B, Lane D, Iversen PL, Bavari S. Peptide Conjugated Phosphorodiamidate Morpholino Oligomers Increase Survival of Mice Challenged with Ames Bacillus anthracis. Nucleic Acid Therapeutics. 2012;[Epub ahead of print] doi:10.1089/nat.2012.0362.

In Vivo Delivery of Morpholino Oligos by Cell-Penetrating Peptides

Authors:
Moulton HM
Citation:
Curr Pharm Des. 2013;19(16):2963-9
Epub:
Not Epub
Abstract:
Morpholino oligos (Morpholinos) are widely used tools for knocking down gene expression and are currently in a clinical trial...
Link:
http://www.ingentaconnect.com/content/ben/cpd/2013/00000019/00000016/art00010
Delivery Method:
peptide-coupled
Citation Extract:
Moulton HM. In Vivo Delivery of Morpholino Oligos by Cell-Penetrating Peptides. Curr Pharm Des. 2013;19(16):2963-9.

Inhibition of Intracellular Growth of Salmonella enterica serovar typhimurium in Tissue Culture by Antisense Peptide-Phosphorodiamidate Morpholino Oligomer

Authors:
Mitev GM, Mellbye BL, Iversen PL, Geller BL
Citation:
Antimicrob Agents Chemother. 2009 Jul 6. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Two types of phosphorodiamidate morpholino oligomers (PMOs) were tested for inhibition of growth of Salmonella enterica serovar...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Salmonella enterica serovar typhimurium & infected macrophages
Citation Extract:
Mitev GM, Mellbye BL, Iversen PL, Geller BL. Inhibition of Intracellular Growth of Salmonella enterica serovar typhimurium in Tissue Culture by Antisense Peptide-Phosphorodiamidate Morpholino Oligomer. Antimicrob Agents Chemother. 2009 Jul 6. [Epub ahead of print].

Variations in Amino Acid Composition of Antisense Peptide-Phosphorodiamidate Morpholino Oligomer Affect Potency Against Escherichia coli in vitro and in vivo

Authors:
Mellbye BL, Puckett SE, Tilley LD, Iversen PL, Geller BL
Citation:
Antimicrob Agents Chemother. 2009 Feb;53(2):525-30. Epub 2008 Nov 17.
Epub:
Not Epub
Abstract:
The potency of antisense peptide-phosphorodiamidate morpholino oligomers (PPMO) was improved by varying peptide composition. An...
Delivery Method:
peptide-coupled
Organism or Cell Type:
Escherichia coli
Citation Extract:
Mellbye BL, Puckett SE, Tilley LD, Iversen PL, Geller BL. Variations in Amino Acid Composition of Antisense Peptide-Phosphorodiamidate Morpholino Oligomer Affect Potency Against Escherichia coli in vitro and in vivo. Antimicrob Agents Chemother. 2009 Feb;53(2):525-30. Epub 2008 Nov 17..

Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome

Authors:
Bok K, Cavanaugh VJ, Matson DO, González-Molleda L, Chang KO, Zintz C, Smith AW, Iversen P, Green KY, Campbell AE
Citation:
Virology. 2008 Oct 25;380(2):328-37. doi: 10.1016/j.virol.2008.08.007. Epub 2008 Sep 9.
Epub:
Not Epub
Abstract:
Noroviruses are an important cause of non-bacterial epidemic gastroenteritis, but no specific antiviral therapies are available...
Link:
http://www.sciencedirect.com/science/article/pii/S0042682208005199
Delivery Method:
peptide-coupled
Organism or Cell Type:
virus: norovirus
Citation Extract:
Bok K, Cavanaugh VJ, Matson DO, González-Molleda L, Chang KO, Zintz C, Smith AW, Iversen P, Green KY, Campbell AE. Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome. Virology. 2008 Oct 25;380(2):328-37. doi: 10.1016/j.virol.2008.08.007. Epub 2008 Sep 9. .

Pages