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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 30 scientific papers returned from the database with the search filters currently being used below.
There are 30 scientific papers returned from the database with the search filters currently being used below.
Morpholino oligomers tested in vitro, in biofilm and in vivo against multidrug-resistant Klebsiella pneumoniae
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Citation:
J Antimicrob Chemother. 2018;[Epub ahead of print] doi:10.1093/jac/dky058 Epub:
Yes Abstract:
Background: Klebsiella pneumoniae is an opportunistic pathogen and many strains are multidrug resistant. KPC is one of the most... Delivery Method:
peptide-linked Organism or Cell Type:
Klebsiella pneumoniae Citation Extract: Geller BL, Li L, Martinez F, Sully E, Sturge CR, Daly SM, Pybus C, Greenberg DE. Morpholino oligomers tested in vitro, in biofilm and in vivo against multidrug-resistant Klebsiella pneumoniae. J Antimicrob Chemother. 2018;[Epub ahead of print] doi:10.1093/jac/dky058. |
Antisense inhibitors retain activity in pulmonary models of Burkholderia infection
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Citation:
ACS Infect Dis. 2018 Feb 20. doi: 10.1021/acsinfecdis.7b00235. [Epub ahead of print] Epub:
Yes Abstract:
The Burkholderia cepacia complex is a group of gram-negative bacteria that are opportunistic pathogens in immunocompromised... Delivery Method:
peptide-linked Organism or Cell Type:
Burkholderia cepacia, Pseudomonas Citation Extract: Daly SM, Sturge CR, Marshall-Batty KR, Felder-Scott CF, Jain R, Geller B, Greenberg D. Antisense inhibitors retain activity in pulmonary models of Burkholderia infection. ACS Infect Dis. 2018 Feb 20. doi: 10.1021/acsinfecdis.7b00235. [Epub ahead of print]. |
MCR-1 Inhibition with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Sensitivity to Polymyxin in Escherichia coli
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Citation:
mBio. 2017;8:e01315-17. doi:10.1128/mBio.01315-17 Epub:
Not Epub Abstract:
In late 2015, the first example of a transferrable polymyxin resistance mechanism in Gram-negative pathogens, MCR-1, was... Delivery Method:
peptide-linked Organism or Cell Type:
mice, Escherichia coli Citation Extract: Daly SM, Sturge CR, Felder-Scott CF, Geller BL, Greenberg DE. MCR-1 Inhibition with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Sensitivity to Polymyxin in Escherichia coli. mBio. 2017;8:e01315-17. doi:10.1128/mBio.01315-17. |
Inhibition of Bacterial Growth by Peptide-Conjugated Morpholino Oligomers
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Citation:
Methods Mol Biol. 2017;1565:115-122. doi: 10.1007/978-1-4939-6817-6_10 Epub:
Not Epub Abstract:
Morpholino oligomers (MOs) are antisense molecules designed for sequence-specific binding of target mRNA. In bacteria,... Delivery Method:
peptide-linked Organism or Cell Type:
bacteria Citation Extract: Daly SM, Sturge CR, Greenberg DE. Inhibition of Bacterial Growth by Peptide-Conjugated Morpholino Oligomers. Methods Mol Biol. 2017;1565:115-122. doi: 10.1007/978-1-4939-6817-6_10. |
Inhibition of Pseudomonas aeruginosa by Peptide-conjugated Phosphorodiamidate Morpholino Oligomers
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Citation:
Antimicrob Agents Chemother. 2017 Jan 30. pii: AAC.01938-16. doi: 10.1128/AAC.01938-16. [Epub ahead of print] Epub:
Yes Abstract:
Pseudomonas aeruginosa is a highly virulent, multidrug-resistant pathogen that causes significant morbidity and mortality in... Delivery Method:
peptide-linked Organism or Cell Type:
Pseudomonas aeruginosa Citation Extract: Howard JJ, Sturge CR, Moustafa DA, Daly SM, Marshall-Batty KR, Felder CF, Zamora D, Yabe-Gill M, Labandeira-Rey M, Bailey SM, Wong M, Goldberg JB, Geller BL, Greenberg DE. Inhibition of Pseudomonas aeruginosa by Peptide-conjugated Phosphorodiamidate Morpholino Oligomers. Antimicrob Agents Chemother. 2017 Jan 30. pii: AAC.01938-16. doi: 10.1128/AAC.01938-16. [Epub ahead of print]. |
Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo
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Citation:
J Antimicrob Chemother. 2016 Dec 20. pii: dkw476. doi: 10.1093/jac/dkw476. [Epub ahead of print] Epub:
Yes Abstract:
OBJECTIVES: The objective of this study was to test the efficacy of an inhibitor of the New Delhi metallo-β- lactamase (NDM-1... Delivery Method:
peptide-linked Organism or Cell Type:
Escherichia coli Citation Extract: Sully EK, Geller BL, Li L, Moody CM, Bailey SM, Moore AL, Wong M, Nordmann P, Daly SM, Sturge CR, Greenberg DE. Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogens in vitro and in vivo. J Antimicrob Chemother. 2016 Dec 20. pii: dkw476. doi: 10.1093/jac/dkw476. [Epub ahead of print]. |
Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy
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Citation:
PLoS Biol. 2016 Sep 15;14(9):e1002552. doi: 10.1371/journal.pbio.1002552. eCollection 2016 Sep Epub:
Not Epub Abstract:
The lack of effective and well-tolerated therapies against antibiotic-resistant bacteria is a global public health problem... Delivery Method:
Peptide-linked Organism or Cell Type:
cell culture: Escherichia coli, Klebsiella pneumoniae, Salmonella enterica, Acinetobacter baumannii, Pseudomonas aeruginosa, Burkholderia cenocepacia Citation Extract: Ayhan DH, Tamer YT, Akbar M, Bailey SM, Wong M, Daly SM, Greenberg DE, Toprak E. Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy. PLoS Biol. 2016 Sep 15;14(9):e1002552. doi: 10.1371/journal.pbio.1002552. eCollection 2016 Sep. |
Gene-Silencing Antisense Oligomers Inhibit Acinetobacter Growth In Vitro and In Vivo
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Citation:
J Infect Dis. 2013;[Epub ahead of print] doi:10.1093/infdis/jit460 Epub:
Not Epub Abstract:
Background. Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) are synthetic DNA/RNA analogues that silence... Delivery Method:
Peptide-coupled Organism or Cell Type:
Mice Citation Extract: Geller BL, Marshall-Batty K, Schnell FJ, McKnight MM, Iversen PL, Greenberg DE. Gene-Silencing Antisense Oligomers Inhibit Acinetobacter Growth In Vitro and In Vivo. J Infect Dis. 2013;[Epub ahead of print] doi:10.1093/infdis/jit460 . |
Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes
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Citation:
PNAS. 2011;108(40):16582-7 doi:10.1073/pnas.1112561108 Epub:
Not Epub Abstract:
Basic peptides covalently linked to nucleic acids, or chemically modified nucleic acids, enable the insertion of such a... Delivery Method:
peptide-coupled Organism or Cell Type:
Bacteria, various Citation Extract: Wesolowski D, Tae HS, Gandotra N, Llopis P, Shen N, Altman S. Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes. PNAS. 2011;108(40):16582-7 doi:10.1073/pnas.1112561108. |
Combined effect of a peptide-morpholino oligonucleotide conjugate and a cell-penetrating peptide as an antibiotic
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Citation:
PNAS. 2013 May 21;110(21):8686-9. doi: 10.1073/pnas.1306911110. Epub 2013 May 6 Epub:
Not Epub Abstract:
A cell-penetrating peptide (CPP)–morpholino oligonucleotide (MO) conjugate (PMO) that has an antibiotic effect in culture had... Delivery Method:
peptide-coupled Organism or Cell Type:
Bacteria, various Citation Extract: Wesolowski D, Alonso D, Altman S. Combined effect of a peptide-morpholino oligonucleotide conjugate and a cell-penetrating peptide as an antibiotic. PNAS. 2013 May 21;110(21):8686-9. doi: 10.1073/pnas.1306911110. Epub 2013 May 6. |