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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12376 scientific papers returned from the database with the search filters currently being used below.

Targeted knockdown of insulin-like growth factor binding protein-2 (IGFBP-2) disrupts cardiovascular development in zebrafish embryos

Authors:
Wood AW, Schlueter PJ, Duan C
Citation:
Mol Endocrinol. 2005 Apr;19(4):1024-34. Epub 2004 Dec 23.
Epub:
Not Epub
Abstract:
Insulin-like growth factor binding protein-2 (IGFBP-2) is an evolutionarily conserved protein that binds insulin-like growth...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wood AW, Schlueter PJ, Duan C. Targeted knockdown of insulin-like growth factor binding protein-2 (IGFBP-2) disrupts cardiovascular development in zebrafish embryos. Mol Endocrinol. 2005 Apr;19(4):1024-34. Epub 2004 Dec 23..

Targeted Skipping of Human Dystrophin Exons in Transgenic Mouse Model Systemically for Antisense Drug Development

Authors:
Wu B, Benrashid E, Lu P, Cloer C, Zillmer A, Shaban M, Lu QL
Citation:
PLoS ONE. 2011;6(5):e19906. doi:10.1371/journal.pone.0019906
Epub:
Not Epub
Abstract:
Antisense therapy has recently been demonstrated with great potential for targeted exon skipping and restoration of dystrophin...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mouse hDMD, cell cultures
Citation Extract:
Wu B, Benrashid E, Lu P, Cloer C, Zillmer A, Shaban M, Lu QL. Targeted Skipping of Human Dystrophin Exons in Transgenic Mouse Model Systemically for Antisense Drug Development. PLoS ONE. 2011;6(5):e19906. doi:10.1371/journal.pone.0019906.

The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo

Authors:
Wood JD, Landers JA, Bingley M, McDermott CJ, Thomas-McArthur V, Gleadall LJ, Shaw PJ, Cunliffe VT
Citation:
Hum Mol Genet. 2006 Sep 15;15(18):2763-71. Epub 2006 Aug 7.
Epub:
Not Epub
Abstract:
Hereditary spastic paraplegia (HSP) is a collection of neurological disorders characterised by developmental failure or...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wood JD, Landers JA, Bingley M, McDermott CJ, Thomas-McArthur V, Gleadall LJ, Shaw PJ, Cunliffe VT. The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo. Hum Mol Genet. 2006 Sep 15;15(18):2763-71. Epub 2006 Aug 7..

The protein tyrosine phosphatase Pez regulates TGFbeta, epithelial mesenchymal transition, and organ development

Authors:
Wyatt L, Wadham C, Crocker LA, Lardelli M, Khew-Goodall Y
Citation:
J Cell Biol. 2007 Sep 24;178(7):1223-35
Epub:
Not Epub
Abstract:
Epithelial-mesenchymal transition (EMT), crucial during embryogenesis for new tissue and organ formation, is also considered to...
Organism or Cell Type:
zebrafish
Citation Extract:
Wyatt L, Wadham C, Crocker LA, Lardelli M, Khew-Goodall Y. The protein tyrosine phosphatase Pez regulates TGFbeta, epithelial mesenchymal transition, and organ development. J Cell Biol. 2007 Sep 24;178(7):1223-35.

The Snail repressor is required for PMC ingression in the sea urchin embryo. Development. 2007 Mar;134(6):1061-70

Authors:
Wu SY, McClay DR
Citation:
Epub 2007 Feb 7
Epub:
Not Epub
Abstract:
In metazoans, the epithelial-mesenchymal transition (EMT) is a crucial process for placing the mesoderm beneath the ectoderm....
Organism or Cell Type:
sea urchin
Citation Extract:
Wu SY, McClay DR. The Snail repressor is required for PMC ingression in the sea urchin embryo. Development. 2007 Mar;134(6):1061-70. Epub 2007 Feb 7.

The tight junction scaffolding protein cingulin regulates neural crest cell migration

Authors:
Wu CY, Jhingory S, Taneyhill LA
Citation:
Dev. Dyn. 2011 [Epub ahead of print] doi:10.1002/dvdy.22735
Epub:
Not Epub
Abstract:
Neural crest cells give rise to a diverse range of structures during vertebrate development. These cells initially exist in the...
Delivery Method:
Electroporation
Organism or Cell Type:
chick embryo
Citation Extract:
Wu CY, Jhingory S, Taneyhill LA. The tight junction scaffolding protein cingulin regulates neural crest cell migration. Dev. Dyn. 2011 [Epub ahead of print] doi:10.1002/dvdy.22735.

The you Gene Encodes an EGF-CUB Protein Essential for Hedgehog Signaling in Zebrafish

Authors:
Woods IG, Talbot WS
Citation:
PLoS Biol. 2005 Jan 11;3(3):e66 [Epub ahead of print]
Epub:
Not Epub
Abstract:
Hedgehog signaling is required for many aspects of development in vertebrates and invertebrates. Misregulation of the Hedgehog...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Woods IG, Talbot WS. The you Gene Encodes an EGF-CUB Protein Essential for Hedgehog Signaling in Zebrafish. PLoS Biol. 2005 Jan 11;3(3):e66 [Epub ahead of print].

Toward an oligonucleotide therapy for Duchenne muscular dystrophy: A complex development challenge

Authors:
Wood MJA
Citation:
Sci. Transl. Med. 2010;2:25ps15
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (AO)–mediated exon skipping is a promising new therapy for Duchenne muscular dystrophy (DMD),...
Citation Extract:
Wood MJA. Toward an oligonucleotide therapy for Duchenne muscular dystrophy: A complex development challenge. Sci. Transl. Med. 2010;2:25ps15.

Twist is an essential regulator of the skeletogenic gene regulatory network in the sea urchin embryo

Authors:
Wu SY, Yang YP, McClay DR
Citation:
Dev Biol. 2008 Apr 15. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Recent work on the sea urchin endomesoderm gene regulatory network (GRN) offers many opportunities to study the specification...
Organism or Cell Type:
sea urchin
Citation Extract:
Wu SY, Yang YP, McClay DR. Twist is an essential regulator of the skeletogenic gene regulatory network in the sea urchin embryo. Dev Biol. 2008 Apr 15. [Epub ahead of print].

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development

Authors:
Wysocka J, Swigut T, Milne TA, Dou Y, Zhang X, Burlingame AL, Roeder RG, Brivanlou AH, Allis CD
Citation:
Cell. 2005 Jun 17;121(6):859-72
Epub:
Not Epub
Abstract:
Histone H3 lysine 4 (K4) methylation has been linked to the transcriptional activation in a variety of eukaryotic species. Here...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Wysocka J, Swigut T, Milne TA, Dou Y, Zhang X, Burlingame AL, Roeder RG, Brivanlou AH, Allis CD. WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell. 2005 Jun 17;121(6):859-72.

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