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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish

Authors:
Wu Q, Zhang J, Koh W, Yu Q, Zhu X, Amsterdam A, Davis GE, Arnaout MA, Xiong JW
Citation:
FASEB J. 2015 Dec;29(12):4989-5005. doi: 10.1096/fj.15-273409. Epub 2015 Aug 26
Epub:
Not Epub
Abstract:
Talin (tln) binds and activates integrins to couple extracellular matrix-bound integrins to the cytoskeleton; however, its role...
Link:
www.fasebj.org/doi/full/10.1096/fj.15-273409
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wu Q, Zhang J, Koh W, Yu Q, Zhu X, Amsterdam A, Davis GE, Arnaout MA, Xiong JW. Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish. FASEB J. 2015 Dec;29(12):4989-5005. doi: 10.1096/fj.15-273409. Epub 2015 Aug 26.

GIPC proteins negatively modulate Plexind1 signaling during vascular development

Authors:
Carretero-Ortega J, Chhangawala Z, Hunt S, Narvaez C, Menéndez-González J, Gay CM, Zygmunt T, Li X, Torres-Vázquez J
Citation:
Elife. 2019 May 3;8. pii: e30454. doi: 10.7554/eLife.30454
Epub:
Not Epub
Abstract:
Semaphorins (SEMAs) and their Plexin (PLXN) receptors are central regulators of metazoan cellular communication. SEMA-PLXND1...
Link:
https://elifesciences.org/articles/30454
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Carretero-Ortega J, Chhangawala Z, Hunt S, Narvaez C, Menéndez-González J, Gay CM, Zygmunt T, Li X, Torres-Vázquez J. GIPC proteins negatively modulate Plexind1 signaling during vascular development. Elife. 2019 May 3;8. pii: e30454. doi: 10.7554/eLife.30454.

Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio)

Authors:
Tuttle M, Dalman MR, Liu Q, Londraville RL
Citation:
PeerJ. 2019;7:e6848 doi:10.7717/peerj.6848
Epub:
Not Epub
Abstract:
We analyzed microarray expression data to highlight biological pathways that respond to embryonic zebrafish Leptin-a (lepa)...
Link:
https://peerj.com/articles/6848/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tuttle M, Dalman MR, Liu Q, Londraville RL. Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio). PeerJ. 2019;7:e6848 doi:10.7717/peerj.6848.

Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides in vitro and in mdx Mice

Authors:
Wang M, Wu B, Shah SN, Lu P, Lu Q
Citation:
Molec Ther Nucl Acids. 2019;16:663-674 doi:10.1016/j.omtn.2019.04.023
Epub:
Yes
Abstract:
Antisense oligonucleotide (AO) therapy has been the specific treatment for Duchenne muscular dystrophy with ongoing clinical...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(19)30096-4
Delivery Method:
Endo-Porter, aminoglycoside
Organism or Cell Type:
cell culture, mice mdx
Citation Extract:
Wang M, Wu B, Shah SN, Lu P, Lu Q. Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides in vitro and in mdx Mice. Molec Ther Nucl Acids. 2019;16:663-674 doi:10.1016/j.omtn.2019.04.023.

BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress

Authors:
Fernando TM, Marullo R, Pera Gresely B, Phillip JM, Yang SN, Lundell-Smith G, Torregroza I, Ahn H, Evans T, Győrffy B, Privé GG, Hirano M, Melnick AM, Cerchietti L
Citation:
Cancer Discov. 2019 May;9(5):662-679. doi: 10.1158/2159-8290.CD-17-1444. Epub 2019 Feb 18
Epub:
Not Epub
Abstract:
Several lines of evidence link the canonical oncogene BCL6 to stress response. Here we demonstrate that BCL6 evolved in...
Link:
http://cancerdiscovery.aacrjournals.org/content/9/5/662
Organism or Cell Type:
zebrafish
Citation Extract:
Fernando TM, Marullo R, Pera Gresely B, Phillip JM, Yang SN, Lundell-Smith G, Torregroza I, Ahn H, Evans T, Győrffy B, Privé GG, Hirano M, Melnick AM, Cerchietti L. BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress. Cancer Discov. 2019 May;9(5):662-679. doi: 10.1158/2159-8290.CD-17-1444. Epub 2019 Feb 18.

Barhl2 maintains T-cell factors as repressors, and thereby switches off the Wnt/β-Catenin response driving Spemann organizer formation

Authors:
Sena E, Rocques N, Borday C, Amin HSM, Parain K, Sitbon D, Chesneau A, Durand BC
Citation:
Development. 2019 Apr 29. pii: dev.173112. doi: 10.1242/dev.173112. [Epub ahead of print]
Epub:
Yes
Abstract:
A hallmark of Wnt/β-Catenin signaling is the extreme diversity of its transcriptional response, which varies depending on cell...
Link:
http://dev.biologists.org/content/early/2019/04/26/dev.173112
Citation Extract:
Sena E, Rocques N, Borday C, Amin HSM, Parain K, Sitbon D, Chesneau A, Durand BC. Barhl2 maintains T-cell factors as repressors, and thereby switches off the Wnt/β-Catenin response driving Spemann organizer formation. Development. 2019 Apr 29. pii: dev.173112. doi: 10.1242/dev.173112. [Epub ahead of print].

A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis

Authors:
Xue Y, Liu D, Cui G, Ding Y, Ai D, Gao S, Zhang Y, Suo S, Wang X, Lv P, Zhou C, Li Y, Chen X, Peng G, Jing N, Han JJ, Liu F
Citation:
Cell Rep. 2019 Apr 30;27(5):1567-1578.e5. doi: 10.1016/j.celrep.2019.04.030
Epub:
Not Epub
Abstract:
In vertebrates, hematopoiesis occurring in different niches is orchestrated by intrinsic and extrinsic regulators. Previous...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30495-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xue Y, Liu D, Cui G, Ding Y, Ai D, Gao S, Zhang Y, Suo S, Wang X, Lv P, Zhou C, Li Y, Chen X, Peng G, Jing N, Han JJ, Liu F. A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Rep. 2019 Apr 30;27(5):1567-1578.e5. doi: 10.1016/j.celrep.2019.04.030.

Chemical screens in a zebrafish model of CHARGE syndrome identifies small molecules that ameliorates disease like phenotypes in embryo

Authors:
Asad Z, Sachidanandan C
Citation:
Eur J Med Genet. 2019 Apr 30. pii: S1769-7212(19)30015-1. doi: 10.1016/j.ejmg.2019.04.018. [Epub ahead of print]
Epub:
Yes
Abstract:
CHARGE syndrome is an autosomal dominant congenital disorder caused primarily by mutations in the CHD7 gene. Using a small...
Link:
https://www.sciencedirect.com/science/article/pii/S1769721219300151
Organism or Cell Type:
zebrafish
Citation Extract:
Asad Z, Sachidanandan C. Chemical screens in a zebrafish model of CHARGE syndrome identifies small molecules that ameliorates disease like phenotypes in embryo. Eur J Med Genet. 2019 Apr 30. pii: S1769-7212(19)30015-1. doi: 10.1016/j.ejmg.2019.04.018. [Epub ahead of print].

Combinatorial control of gene function with wavelength-selective caged morpholinos

Authors:
Pattanayak S, Vázquez-Maldonado LA, Deiters A, Chen JK
Citation:
Meth Enzymol. 2019;624:69-88. doi: 10.1016/bs.mie.2019.04.007
Epub:
Yes
Abstract:
Caged morpholino oligonucleotides (cMOs) are useful research tools in developmental biology because they allow spatiotemporal...
Link:
https://www.sciencedirect.com/science/article/pii/S0076687919301223
Citation Extract:
Pattanayak S, Vázquez-Maldonado LA, Deiters A, Chen JK. Combinatorial control of gene function with wavelength-selective caged morpholinos. Meth Enzymol. 2019;624:69-88. doi: 10.1016/bs.mie.2019.04.007.

The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage

Authors:
Baek S, Oh TG, Secker G, Sutton DL, Okuda KS, Paterson S, Bower NI, Toubia J, Koltowska K, Capon SJ, Baillie GJ, Simons C, Muscat GEO, Lagendijk AK, Smith KA, Harvey NL, Hogan BM
Citation:
Dev Cell. 2019 Apr 22;49(2):279-292.e5. doi:10.1016/j.devcel.2019.03.017
Epub:
Not Epub
Abstract:
The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification....
Link:
https://www.sciencedirect.com/science/article/abs/pii/S153458071930228X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Baek S, Oh TG, Secker G, Sutton DL, Okuda KS, Paterson S, Bower NI, Toubia J, Koltowska K, Capon SJ, Baillie GJ, Simons C, Muscat GEO, Lagendijk AK, Smith KA, Harvey NL, Hogan BM. The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage. Dev Cell. 2019 Apr 22;49(2):279-292.e5. doi:10.1016/j.devcel.2019.03.017.

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